Research graph
References from Ribonucleases and drug design. Local targets link to admitted publications; unresolved targets remain external evidence.
Eosinophil granule proteins: form and function
10.1074/jbc.r113.546218 · 2014 · External reference
Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin
10.4049/jimmunol.131.6.2977 · 1983 · External reference
Comparative toxicity of purified human eosinophil granule cationic proteins for schistosomula of Schistosoma mansoni
10.4269/ajtmh.1985.34.735 · 1985 · External reference
Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children
10.1371/journal.pone.0029465 · 2011 · External reference
Amino acid sequence of an anti-tumor protein from Rana pipiens oocytes and early embryos. Homology to pancreatic ribonucleases
10.1016/s0021-9258(18)52427-3 · 1991 · External reference
Ribonucleases as potential modalities in anticancer therapy
10.1016/j.ejphar.2009.06.067 · 2009 · External reference
A ribonuclease inhibitor resistant dimer of human pancreatic ribonuclease displays specific antitumor activity
10.1016/j.ijbiomac.2017.10.067 · 2018 · External reference
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug
10.1073/pnas.1815071116 · 2019 · External reference
Mammalian antimicrobial proteins and peptides: overview on the RNase A superfamily members involved in innate host defence
10.1039/b617527a · 2007 · External reference
Role of the N terminus in RNase a homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity
10.1006/jmbi.1996.0218 · 1996 · External reference
The antipathogen activities of eosinophil cationic protein
10.2174/138920108784567353 · 2008 · External reference
Structural determinants of the eosinophil cationic protein antimicrobial activity
10.1515/hsz-2012-0160 · 2012 · External reference
Both aromatic and cationic residues contribute to the membrane-lytic and bactericidal activity of eosinophil cationic protein
10.1021/bi0273011 · 2003 · External reference
Rnase L triggers autophagy in response to viral infections
10.1128/jvi.00270-12 · 2012 · External reference
MCPIP1 negatively regulate cellular antiviral innate immune responses through DUB and disruption of TRAF3-TBK1-IKKε complex
10.1016/j.bbrc.2018.06.083 · 2018 · External reference
The ribonuclease a superfamily of mammals and birds: identifying new members and tracing evolutionary histories
10.1016/j.ygeno.2004.10.008 · 2005 · External reference
Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism
10.1021/bi201075b · 2011 · External reference
Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by onconase in A375 melanoma cells correlates with the downregulation of specific onco-proteins
10.3390/ijms23031647 · 2022 · External reference
ISG20, an actor of the innate immune response
10.1016/j.biochi.2007.03.006 · 2007 · External reference
ISG20: an enigmatic antiviral RNase targeting multiple viruses
10.1002/2211-5463.13382 · 2022 · External reference
Ribonuclease Inhibitor: structure and function
10.1016/s0079-6603(05)80009-1 · 2005 · External reference
Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population
10.1186/s12936-018-2205-9 · 2018 · External reference
Recombinant human eosinophil-derived neurotoxin/RNase 2 functions as an effective antiviral agent against respiratory syncytial virus
10.1086/515322 · 1998 · External reference
The flexibility of a distant loop modulates active site motion and product release in ribonuclease A
10.1021/bi900830g · 2009 · External reference
Antimicrobial synergy of a ribonuclease and a peptide secreted by human cells
10.1021/acsinfecdis.0c00594 · 2020 · External reference
Influenza virus inactivated by artificial ribonucleases as a prospective killed virus vaccine
10.1016/j.vaccine.2012.02.051 · 2012 · External reference
Bovine seminal ribonuclease triggers Beclin1-mediated autophagic cell death in pancreatic cancer cells
10.1016/j.bbamcr.2014.01.025 · 2014 · External reference
Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner
10.1016/j.bbamcr.2014.12.016 · 2015 · External reference
Polyamine derivatives as selective RNaseA mimics
10.1093/nar/gkh157 · 2004 · External reference
Perturbation of the conformational dynamics of an active-site loop alters enzyme activity
10.1016/j.str.2015.10.011 · 2015 · External reference
Leukotriene B 4 -mediated release of antimicrobial peptides against cytomegalovirus Is BLT1 dependent
10.1089/vim.2006.0099 · 2007 · External reference
Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells
10.1016/j.cell.2016.06.042 · 2016 · External reference
Viral genome cleavage with artificial ribonucleases: a new method to inactivate RNA-containing viruses
10.1134/s1607672909040140 · 2009 · External reference
The expansion and functional diversification of the mammalian ribonuclease a superfamily epitomizes the efficiency of multigene families at generating biological novelty
10.1093/gbe/evt161 · 2013 · External reference
Biological activities of secretory RNases: focus on their oligomerization to design antitumor drugs
10.3389/fimmu.2019.02626 · 2019 · External reference
The crystal structure of the domain-swapped dimer of onconase highlights some catalytic and antitumor activity features of the enzyme
10.1016/j.ijbiomac.2021.09.095 · 2021 · External reference
The mammalian secreted RNases: mechanisms of action in host defence
10.1177/1753425912446955 · 2013 · External reference
The role of antimicrobial peptides in animal defenses
10.1073/pnas.97.16.8856 · 2000 · External reference
Rnase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A
10.1006/bbrc.2001.4503 · 2001 · External reference
A human ribonuclease variant and ERK-pathway inhibitors exhibit highly synergistic toxicity for cancer cells
10.1158/1535-7163.mct-18-0724 · 2018 · External reference
Angiogenins: a new class of microbicidal proteins involved in innate immunity
10.1038/ni888 · 2003 · External reference
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
10.1038/nri3719 · 2014 · External reference
Ribonucleases as antiviral agents
10.1134/s0026893314040050 · 2014 · External reference
Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis
2000 · External reference
Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain
10.1038/s41598-024-71687-7 · 2024 · External reference
Bacterial strategies of resistance to antimicrobial peptides
10.1098/rstb.2015.0292 · 2016 · External reference
The role of eosinophils in host defense against helminth parasites
10.1016/j.jaci.2003.10.050 · 2004 · External reference
The ribonuclease a superfamily in humans: canonical RNases as the buttress of innate immunity
10.3390/ijms17081278 · 2016 · External reference
Increased eosinophil activity in acute Plasmodium falciparum infection—association with cerebral malaria
10.1046/j.1365-2249.1998.00586.x · 1998 · External reference
RNASE4 promotes malignant progression and chemoresistance in hypoxic glioblastoma via activation of AXL/AKT and NF-κB/cIAPs signaling pathways
10.62347/udbj5986 · 2024 · External reference
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
2021 · External reference
Lysozyme and RNases as anti-HIV components in β-core preparations of human chorionic gonadotropin
10.1073/pnas.96.6.2678 · 1999 · External reference
Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein
10.4049/jimmunol.142.12.4428 · 1989 · External reference
Host defence RNases as antiviral agents against enveloped single stranded RNA viruses
10.1080/21505594.2021.1871823 · 2021 · External reference
MCPIP1 reduces HBV-RNA by targeting its epsilon structure
2020 · External reference
In vivo evaluation of ECP peptide analogues for the treatment of Acinetobacter baumannii infection
10.3390/biomedicines10020386 · 2022 · External reference
In silico prediction and in vitro characterization of multifunctional human RNase3
10.1155/2013/170398 · 2013 · External reference
MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation
10.1093/nar/gkt019 · 2013 · External reference
Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma
10.1016/j.jhep.2020.09.030 · 2021 · External reference
Functional evolution of ribonuclease inhibitor: insights from birds and reptiles
10.1016/j.jmb.2014.06.007 · 2014 · External reference
Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology
10.1042/bcj20170173 · 2017 · External reference
Immune modulation by human secreted RNases at the extracellular space
2018 · External reference
Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages
10.1007/s00018-022-04229-x · 2022 · External reference
Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogens
10.3109/1040841x.2011.645519 · 2012 · External reference
RNase l amplifies interferon signaling by inducing protein kinase r-mediated antiviral stress granules
10.1128/jvi.00205-20 · 2020 · External reference
Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells
10.1016/j.canlet.2006.09.018 · 2007 · External reference
Relationship between response rate and median survival in patients with advanced nonsmall cell lung-cancer - comparison of onconase(r) with other anticancer agents
1995 · External reference
K. Shogen, phase II trial of a single weekly intravenous dose of ranpirnase in patients with unresectable malignant mesothelioma
10.1200/jco.2002.20.1.274 · 2002 · External reference
RNase T1 mimicking artificial ribonuclease
10.1093/nar/gkm143 · 2007 · External reference
Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo
10.1016/s0166-3542(03)00111-6 · 2003 · External reference
Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population
10.1007/s11033-020-05934-1 · 2020 · External reference
Mechanisms of antibiotic resistance
10.1128/microbiolspec.vmbf-0016-2015 · 2016 · External reference
Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
10.1016/s0140-6736(24)01867-1 · 2024 · External reference
The contribution of noncatalytic phosphate-binding subsites to the mechanism of bovine pancreatic ribonuclease A
10.1007/s000180050205 · 1998 · External reference
Human RNase 1 can extensively oligomerize through 3D domain swapping thanks to the crucial contribution of its C-terminus
10.1016/j.ijbiomac.2023.126110 · 2023 · External reference
Unresolved reference
External reference
Neonatal oxygen increases sensitivity to influenza a virus infection in adult mice by suppressing epithelial expression of Ear1
10.1016/j.ajpath.2012.05.005 · 2012 · External reference
The success of the RNase scaffold in the advance of biosciences and in evolution
10.1016/j.gene.2007.05.006 · 2007 · External reference
Testing a human antimicrobial RNase chimera against bacterial resistance
10.3389/fmicb.2019.01357 · 2019 · External reference
Two human host defense ribonucleases against mycobacteria, the eosinophil cationic protein (RNase 3) and RNase 7
10.1128/aac.00428-13 · 2013 · External reference
A novel RNase 3/ECP peptide for Pseudomonas aeruginosa biofilm eradication that combines antimicrobial, lipopolysaccharide binding, and cell-agglutinating activities
10.1128/aac.00830-16 · 2016 · External reference
Positional scanning library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides
10.1016/j.ejmech.2018.05.012 · 2018 · External reference
Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells
10.1016/j.bcp.2019.06.006 · 2019 · External reference
Ribonuclease A
10.1021/cr960427h · 1998 · External reference
Increased exposure of anionic phospholipids on the surface of tumor blood vessels
2002 · External reference
Recombinant human eosinophil cationic protein: ribonuclease activity is not essential for cytotoxicity
10.1074/jbc.270.14.7876 · 1995 · External reference
The eosinophil ribonucleases
10.1007/s000180050208 · 1998 · External reference
RNase A ribonucleases and host defense: an evolving story
10.1189/jlb.1107725 · 2008 · External reference
Eosinophil-derived neurotoxin/RNase 2: connecting the past, the present and the future
10.2174/138920108784567236 · 2008 · External reference
Eosinophil-derived neurotoxin (EDN/RNase 2) and the mouse eosinophil-associated RNases (mEars): expanding roles in promoting host defense
10.3390/ijms160715442 · 2015 · External reference
Eosinophils: changing perspectives in health and disease
10.1038/nri3341 · 2013 · External reference
Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition
10.1097/00002030-200303070-00002 · 2003 · External reference
Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity
10.2174/138920108784567344 · 2008 · External reference
Insight into the antifungal mechanism of action of human RNase N-terminus derived peptides
10.3390/ijms20184558 · 2019 · External reference
Rationally modified antimicrobial peptides from the N-terminal domain of human RNase 3 show exceptional serum stability
10.1021/acs.jmedchem.1c00795 · 2021 · External reference
HIV and ribozymes
10.1007/978-1-4939-2432-5_5 · 2015 · External reference
RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways
10.1074/jbc.m112.399964 · 2012 · External reference
Viral encounters with 2′,5′-oligoadenylate synthetase and RNase L during the interferon antiviral response
10.1128/jvi.01471-07 · 2007 · External reference
Role of unique basic residues in cytotoxic, antibacterial and antiparasitic activities of human eosinophil cationic protein
10.1515/bc.2011.037 · 2011 · External reference
Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes
10.1016/j.jmb.2007.04.071 · 2007 · External reference
The eight human “canonical” ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins
10.1016/j.febslet.2010.04.018 · 2010 · External reference
Human pancreatic-type and nonpancreatic-type ribonucleases: a direct side-by-side comparison of their catalytic properties
10.1006/abbi.1994.1318 · 1994 · External reference
Structure-function relationships in human ribonucleases: main distinctive features of the major RNase types
10.1016/s0014-5793(97)00086-0 · 1997 · External reference
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation
10.1016/j.molcel.2011.09.012 · 2011 · External reference
Design, RNA cleavage and antiviral activity of new artificial ribonucleases derived from mono-, di- and tripeptides connected by linkers of different hydrophobicity
10.1016/j.bmc.2016.02.007 · 2016 · External reference
Knockout of the ribonuclease inhibitor gene leaves human cells vulnerable to secretory ribonucleases
10.1021/acs.biochem.6b01003 · 2016 · External reference
Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariea and schistosomes
10.1016/s0001-706x(96)00038-1 · 1996 · External reference
Topography studies on the membrane interaction mechanism of the eosinophil cationic protein
10.1021/bi061190e · 2007 · External reference
Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans
10.1021/bi702065b · 2008 · External reference
Bactericidal activity engineered on human pancreatic ribonuclease and onconase
10.1021/mp8001914 · 2009 · External reference
Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment
10.1042/bj20082330 · 2009 · External reference
Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7
10.1016/j.bbamem.2009.01.013 · 2009 · External reference
Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region
10.1021/bm100334u · 2010 · External reference
Connecting peptide physicochemical and antimicrobial properties by a rational prediction model
10.1371/journal.pone.0016968 · 2011 · External reference
Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization
10.1021/jm200701g · 2011 · External reference
Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation
10.1371/journal.ppat.1003005 · 2012 · External reference
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus
10.1042/bj20130123 · 2013 · External reference
Angiogenin/Ribonuclease 5 Is an EGFR ligand and a serum biomarker for erlotinib sensitivity in pancreatic cancer
10.1016/j.ccell.2018.02.012 · 2018 · External reference
Killing of Plasmodium falciparum by eosinophil secretory products
10.1128/iai.55.4.877-881.1987 · 1987 · External reference
A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity
10.1016/s0021-9258(18)82252-9 · 1993 · External reference
The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation
2019 · External reference
ANG promotes proliferation and invasion of the cell of lung squamous carcinoma by Directly Up-regulating HMGA2
10.7150/jca.14440 · 2016 · External reference
Expression of human ACE2 N-terminal domain, part of the receptor for SARS-CoV-2, in fusion with maltose-binding protein, E. coli ribonuclease I and human RNase A
10.3389/fmicb.2021.660149 · 2021 · External reference
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells
10.1182/blood-2003-01-0151 · 2003 · External reference
Plexin-B2 mediates physiologic and pathologic functions of angiogenin
10.1016/j.cell.2017.10.005 · 2017 · External reference
RNA drugs and RNA targets for small molecules: principles, progress, and challenges
10.1124/pr.120.019554 · 2020 · External reference
ISG20: an enigmatic antiviral RNase targeting multiple viruses
10.1002/2211-5463.13382 · ExternalCitation · doi-reference
Human pancreatic-type and nonpancreatic-type ribonucleases: a direct side-by-side comparison of their catalytic properties
10.1006/abbi.1994.1318 · ExternalCitation · doi-reference
Rnase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A
10.1006/bbrc.2001.4503 · ExternalCitation · doi-reference
Role of the N terminus in RNase a homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity
10.1006/jmbi.1996.0218 · ExternalCitation · doi-reference
HIV and ribozymes
10.1007/978-1-4939-2432-5_5 · ExternalCitation · doi-reference
Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages
10.1007/s00018-022-04229-x · ExternalCitation · doi-reference
The contribution of noncatalytic phosphate-binding subsites to the mechanism of bovine pancreatic ribonuclease A
10.1007/s000180050205 · ExternalCitation · doi-reference
The eosinophil ribonucleases
10.1007/s000180050208 · ExternalCitation · doi-reference
Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population
10.1007/s11033-020-05934-1 · ExternalCitation · doi-reference
Neonatal oxygen increases sensitivity to influenza a virus infection in adult mice by suppressing epithelial expression of Ear1
10.1016/j.ajpath.2012.05.005 · ExternalCitation · doi-reference
Bovine seminal ribonuclease triggers Beclin1-mediated autophagic cell death in pancreatic cancer cells
10.1016/j.bbamcr.2014.01.025 · ExternalCitation · doi-reference
Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner
10.1016/j.bbamcr.2014.12.016 · ExternalCitation · doi-reference
Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7
10.1016/j.bbamem.2009.01.013 · ExternalCitation · doi-reference
MCPIP1 negatively regulate cellular antiviral innate immune responses through DUB and disruption of TRAF3-TBK1-IKKε complex
10.1016/j.bbrc.2018.06.083 · ExternalCitation · doi-reference
Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells
10.1016/j.bcp.2019.06.006 · ExternalCitation · doi-reference
ISG20, an actor of the innate immune response
10.1016/j.biochi.2007.03.006 · ExternalCitation · doi-reference
Design, RNA cleavage and antiviral activity of new artificial ribonucleases derived from mono-, di- and tripeptides connected by linkers of different hydrophobicity
10.1016/j.bmc.2016.02.007 · ExternalCitation · doi-reference
Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells
10.1016/j.canlet.2006.09.018 · ExternalCitation · doi-reference
Angiogenin/Ribonuclease 5 Is an EGFR ligand and a serum biomarker for erlotinib sensitivity in pancreatic cancer
10.1016/j.ccell.2018.02.012 · ExternalCitation · doi-reference
Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells
10.1016/j.cell.2016.06.042 · ExternalCitation · doi-reference
Plexin-B2 mediates physiologic and pathologic functions of angiogenin
10.1016/j.cell.2017.10.005 · ExternalCitation · doi-reference
Positional scanning library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides
10.1016/j.ejmech.2018.05.012 · ExternalCitation · doi-reference
Ribonucleases as potential modalities in anticancer therapy
10.1016/j.ejphar.2009.06.067 · ExternalCitation · doi-reference
The eight human “canonical” ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins
10.1016/j.febslet.2010.04.018 · ExternalCitation · doi-reference
The success of the RNase scaffold in the advance of biosciences and in evolution
10.1016/j.gene.2007.05.006 · ExternalCitation · doi-reference
A ribonuclease inhibitor resistant dimer of human pancreatic ribonuclease displays specific antitumor activity
10.1016/j.ijbiomac.2017.10.067 · ExternalCitation · doi-reference
The crystal structure of the domain-swapped dimer of onconase highlights some catalytic and antitumor activity features of the enzyme
10.1016/j.ijbiomac.2021.09.095 · ExternalCitation · doi-reference
Human RNase 1 can extensively oligomerize through 3D domain swapping thanks to the crucial contribution of its C-terminus
10.1016/j.ijbiomac.2023.126110 · ExternalCitation · doi-reference
The role of eosinophils in host defense against helminth parasites
10.1016/j.jaci.2003.10.050 · ExternalCitation · doi-reference
Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma
10.1016/j.jhep.2020.09.030 · ExternalCitation · doi-reference
Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes
10.1016/j.jmb.2007.04.071 · ExternalCitation · doi-reference
Functional evolution of ribonuclease inhibitor: insights from birds and reptiles
10.1016/j.jmb.2014.06.007 · ExternalCitation · doi-reference
MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation
10.1016/j.molcel.2011.09.012 · ExternalCitation · doi-reference
Perturbation of the conformational dynamics of an active-site loop alters enzyme activity
10.1016/j.str.2015.10.011 · ExternalCitation · doi-reference
Influenza virus inactivated by artificial ribonucleases as a prospective killed virus vaccine
10.1016/j.vaccine.2012.02.051 · ExternalCitation · doi-reference
The ribonuclease a superfamily of mammals and birds: identifying new members and tracing evolutionary histories
10.1016/j.ygeno.2004.10.008 · ExternalCitation · doi-reference
Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariea and schistosomes
10.1016/s0001-706x(96)00038-1 · ExternalCitation · doi-reference
Structure-function relationships in human ribonucleases: main distinctive features of the major RNase types
10.1016/s0014-5793(97)00086-0 · ExternalCitation · doi-reference
Amino acid sequence of an anti-tumor protein from Rana pipiens oocytes and early embryos. Homology to pancreatic ribonucleases
10.1016/s0021-9258(18)52427-3 · ExternalCitation · doi-reference
A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity
10.1016/s0021-9258(18)82252-9 · ExternalCitation · doi-reference
Ribonuclease Inhibitor: structure and function
10.1016/s0079-6603(05)80009-1 · ExternalCitation · doi-reference
Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
10.1016/s0140-6736(24)01867-1 · ExternalCitation · doi-reference
Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo
10.1016/s0166-3542(03)00111-6 · ExternalCitation · doi-reference
Knockout of the ribonuclease inhibitor gene leaves human cells vulnerable to secretory ribonucleases
10.1021/acs.biochem.6b01003 · ExternalCitation · doi-reference
Rationally modified antimicrobial peptides from the N-terminal domain of human RNase 3 show exceptional serum stability
10.1021/acs.jmedchem.1c00795 · ExternalCitation · doi-reference
Antimicrobial synergy of a ribonuclease and a peptide secreted by human cells
10.1021/acsinfecdis.0c00594 · ExternalCitation · doi-reference
Both aromatic and cationic residues contribute to the membrane-lytic and bactericidal activity of eosinophil cationic protein
10.1021/bi0273011 · ExternalCitation · doi-reference
Topography studies on the membrane interaction mechanism of the eosinophil cationic protein
10.1021/bi061190e · ExternalCitation · doi-reference
Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism
10.1021/bi201075b · ExternalCitation · doi-reference
Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans
10.1021/bi702065b · ExternalCitation · doi-reference
The flexibility of a distant loop modulates active site motion and product release in ribonuclease A
10.1021/bi900830g · ExternalCitation · doi-reference
Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region
10.1021/bm100334u · ExternalCitation · doi-reference
Ribonuclease A
10.1021/cr960427h · ExternalCitation · doi-reference
Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization
10.1021/jm200701g · ExternalCitation · doi-reference
Bactericidal activity engineered on human pancreatic ribonuclease and onconase
10.1021/mp8001914 · ExternalCitation · doi-reference
Angiogenins: a new class of microbicidal proteins involved in innate immunity
10.1038/ni888 · ExternalCitation · doi-reference
Eosinophils: changing perspectives in health and disease
10.1038/nri3341 · ExternalCitation · doi-reference
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
10.1038/nri3719 · ExternalCitation · doi-reference
Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain
10.1038/s41598-024-71687-7 · ExternalCitation · doi-reference
Mammalian antimicrobial proteins and peptides: overview on the RNase A superfamily members involved in innate host defence
10.1039/b617527a · ExternalCitation · doi-reference
Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology
10.1042/bcj20170173 · ExternalCitation · doi-reference
Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment
10.1042/bj20082330 · ExternalCitation · doi-reference
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus
10.1042/bj20130123 · ExternalCitation · doi-reference
Increased eosinophil activity in acute Plasmodium falciparum infection—association with cerebral malaria
10.1046/j.1365-2249.1998.00586.x · ExternalCitation · doi-reference
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug
10.1073/pnas.1815071116 · ExternalCitation · doi-reference
Lysozyme and RNases as anti-HIV components in β-core preparations of human chorionic gonadotropin
10.1073/pnas.96.6.2678 · ExternalCitation · doi-reference
The role of antimicrobial peptides in animal defenses
10.1073/pnas.97.16.8856 · ExternalCitation · doi-reference
Recombinant human eosinophil cationic protein: ribonuclease activity is not essential for cytotoxicity
10.1074/jbc.270.14.7876 · ExternalCitation · doi-reference
RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways
10.1074/jbc.m112.399964 · ExternalCitation · doi-reference
Eosinophil granule proteins: form and function
10.1074/jbc.r113.546218 · ExternalCitation · doi-reference
Host defence RNases as antiviral agents against enveloped single stranded RNA viruses
10.1080/21505594.2021.1871823 · ExternalCitation · doi-reference
Recombinant human eosinophil-derived neurotoxin/RNase 2 functions as an effective antiviral agent against respiratory syncytial virus
10.1086/515322 · ExternalCitation · doi-reference
Leukotriene B 4 -mediated release of antimicrobial peptides against cytomegalovirus Is BLT1 dependent
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The expansion and functional diversification of the mammalian ribonuclease a superfamily epitomizes the efficiency of multigene families at generating biological novelty
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