Research graph
References from Thyroid hormone signaling in neurodevelopment. Local targets link to admitted publications; unresolved targets remain external evidence.
New insights into cholinergic neuron diversity
10.3389/fnmol.2019.00204 · 2019 · External reference
Local thyroid hormone action in brain development
10.3390/ijms241512352 · 2023 · External reference
Control of thyroid hormone action in the developing rat brain
10.1089/105072503770867219 · 2003 · External reference
Thyroid hormone action by genomic and nongenomic molecular mechanisms
2025 · External reference
Thyroid hormone action by genomic and nongenomic molecular mechanisms
10.1007/978-1-0716-4252-8_2 · 2025 · External reference
Unresolved reference
2012 · External reference
Hypomyelinating disorders: An MRI approach
10.1016/j.nbd.2015.10.015 · 2016 · External reference
Allan-herndon-dudley syndrome: A novel pathogenic variant of the SLC16A2 gene
2022 · External reference
Thyroid hormones in brain development and function
2000 · External reference
Unresolved reference
2024 · External reference
Deiodinases: Implications of the local control of thyroid hormone action
10.1172/jci29812 · 2006 · External reference
Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders
10.1038/s41380-022-01687-4 · 2022 · External reference
Effects of intrauterine growth restriction (IUGR) on growth and body composition compared to constitutionally small infants
10.3390/nu15194158 · 2023 · External reference
Thyroid hormone biosynthesis and release
10.1016/j.mce.2017.01.038 · 2017 · External reference
Effects of thyroid status on regional brain volumes: A diagnostic and genetic imaging study in UK biobank
10.1210/clinem/dgaa903 · 2021 · External reference
Thyroid hormone-Otx2 signaling is required for embryonic ventral midbrain neural stem cells differentiated into dopamine neurons
10.1089/scd.2014.0489 · 2015 · External reference
Triac treatment prevents neurodevelopmental and locomotor impairments in thyroid hormone transporter Mct8/Oatp1c1 deficient mice
10.3390/ijms24043452 · 2023 · External reference
Thyroid hormone analogues: Promising therapeutic avenues to improve the neurodevelopmental outcomes of intrauterine growth restriction
10.1111/jnc.16124 · 2024 · External reference
Chapter ten - thyroid hormone biosynthesis and its role in brain development and maintenance
2024 · External reference
Deiodination and peripheral metabolism of thyroid hormone
2019 · External reference
Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice
10.1210/en.2014-1085 · 2014 · External reference
Effects of intrauterine growth restriction on embryonic hippocampal dentate gyrus neurogenesis and postnatal critical period of synaptic plasticity that govern learning and memory function
10.3389/fnins.2023.1092357 · 2023 · External reference
Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression
10.26508/lsa.202302091 · 2023 · External reference
Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development
10.1038/s41598-024-59533-2 · 2024 · External reference
Effectiveness and safety of the tri-iodothyronine analogue triac in children and adults with MCT8 deficiency: An international, single-arm, open-label, phase 2 trial
10.1016/s2213-8587(19)30155-x · 2019 · External reference
Neurovascular unit disruption and blood–brain barrier leakage in MCT8 deficiency
10.1186/s12987-023-00481-w · 2023 · External reference
Reduced gray matter brain volume and cortical thickness in adults with type 1 diabetes and neuropathy
10.1016/j.neures.2021.10.002 · 2022 · External reference
Impact of intrauterine growth restriction on cognitive and motor development at 2 years of age
10.3389/fphys.2018.01278 · 2018 · External reference
Myelin repair stimulated by CNS-selective thyroid hormone action
10.1172/jci.insight.126329 · 2019 · External reference
The role of thyroid hormone in the regulation of cerebellar development
10.3803/enm.2021.1150 · 2021 · External reference
Effect of executive function on event-based prospective memory for different forms of learning disabilities
2021 · External reference
The colorful diversity of thyroid hormone metabolites
10.1159/000497141 · 2019 · External reference
Thyroid hormones act as modulators of inflammation through their nuclear receptors
10.3389/fendo.2022.937099 · 2022 · External reference
Overcoming monocarboxylate transporter 8 (MCT8)-deficiency to promote human oligodendrocyte differentiation and myelination
10.1016/j.ebiom.2017.10.016 · 2017 · External reference
Reversible inactivation of the tumor suppressor PTEN by H2O2
10.1074/jbc.m111899200 · 2002 · External reference
Consensus paper: Cerebellar development
10.1007/s12311-015-0724-2 · 2016 · External reference
NKX2-1 is required in the embryonic septum for cholinergic system development, learning, and memory
10.1016/j.celrep.2017.07.053 · 2017 · External reference
Mood and behavior regulation: Interaction of lithium and dopaminergic system
10.1007/s00210-023-02437-1 · 2023 · External reference
Single-cell imaging of the cell cycle reveals CDC25B-induced heterogeneity of G1 phase length in neural progenitor cells
10.1242/dev.199660 · 2022 · External reference
Deletion of the thyroid hormone receptor α1 prevents the structural alterations of the cerebellum induced by hypothyroidism
10.1073/pnas.062413299 · 2002 · External reference
Deiodinase and brain development
2016 · External reference
Differential effect of intrauterine growth restriction on childhood neurodevelopment: A systematic review
10.1111/1471-0528.13435 · 2015 · External reference
Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome
2022 · External reference
Therapeutic advances in overcoming intrauterine growth restriction induced metabolic syndrome
2023 · External reference
Selective inhibition of genomic and non-genomic effects of thyroid hormone regulates muscle cell differentiation and metabolic behavior
10.3390/ijms22137175 · 2021 · External reference
Cannibalized erythroblasts accelerate developmental neurogenesis by regulating mitochondrial dynamics
10.1016/j.celrep.2021.108942 · 2021 · External reference
Cholinergic regulation of object recognition memory
10.3389/fnbeh.2022.996089 · 2022 · External reference
Thyroid hormones and fetal neurological development
10.1530/joe-10-0444 · 2011 · External reference
Mechanisms of fetal adaptation to chronic hypoxia following placental insufficiency: A review
10.1159/000525717 · 2022 · External reference
Reduced white matter fractional anisotropy mediates cortical thickening in adults born preterm with very low birthweight
10.1016/j.neuroimage.2018.11.050 · 2019 · External reference
Hypotonic male infant and MCT8 deficiency - A diagnosis to think about
10.1186/1471-2431-14-252 · 2014 · External reference
Deiodinases and the three types of thyroid hormone deiodination reactions
10.3803/enm.2021.1198 · 2021 · External reference
Neurodevelopmental outcomes following intrauterine growth restriction and very preterm birth
10.1016/j.jpeds.2021.07.002 · 2021 · External reference
How synaptic pruning shapes neural wiring during development and, possibly, in disease
10.1073/pnas.2010281117 · 2020 · External reference
T3 levels and thyroid hormone signaling
10.3389/fendo.2022.1044691 · 2022 · External reference
Hypothyroidism and cognitive disorders during development and adulthood: Implications in the central nervous system
10.1007/s12035-018-1270-y · 2019 · External reference
Thyroid disorders and movement disorders—Asystematic review
10.1002/mdc3.13656 · 2023 · External reference
Thyroid hormone metabolites and analogues
10.1007/s12020-019-02025-5 · 2019 · External reference
3,5-Diiodothyronine: A novel thyroid hormone metabolite and potent modulator of energy metabolism
10.3389/fendo.2018.00427 · 2018 · External reference
Desire, disease, and the origins of the dopaminergic system
10.1093/schbul/sbm170 · 2008 · External reference
Thyroid hormones in the brain and their impact in recovery mechanisms after stroke
2019 · External reference
Structural insights into thyroid hormone receptors
10.1210/endocr/bqae154 · 2024 · External reference
Structural insights into thyroid hormone transporter MCT8
10.1038/s41467-025-58131-8 · 2025 · External reference
Main factors involved in thyroid hormone action
10.3390/molecules26237337 · 2021 · External reference
Monocarboxylate transporter 8 deficiency: From pathophysiological understanding to therapy development
2021 · External reference
Therapeutic applications of thyroid hormone analogues
10.1016/j.ando.2020.03.004 · 2021 · External reference
Thyroid hormones and brain development: A focus on the role of mitochondria as regulators of developmental time
10.3390/cells14030150 · 2025 · External reference
Redox-mediated rewiring of signalling pathways: The role of a cellular clock in brain health and disease
10.3390/antiox12101873 · 2023 · External reference
Neurodevelopmental and neurophysiological actions of thyroid hormone
10.1111/j.1365-2826.2008.01733.x · 2008 · External reference
Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain
10.1186/s12974-018-1392-1 · 2019 · External reference
Unresolved reference
2024 · External reference
Thyroid hormone nuclear receptors and molecular actions
2018 · External reference
Timing of thyroid hormone action in the developing brain: Clinical observations and experimental findings
10.1111/j.1365-2826.2004.01243.x · 2004 · External reference
Thyroid disorders and movement disorders—Asystematic review
10.1002/mdc3.13656 · ExternalCitation · doi-reference
Thyroid hormone action by genomic and nongenomic molecular mechanisms
10.1007/978-1-0716-4252-8_2 · ExternalCitation · doi-reference
Mood and behavior regulation: Interaction of lithium and dopaminergic system
10.1007/s00210-023-02437-1 · ExternalCitation · doi-reference
Thyroid hormone metabolites and analogues
10.1007/s12020-019-02025-5 · ExternalCitation · doi-reference
Hypothyroidism and cognitive disorders during development and adulthood: Implications in the central nervous system
10.1007/s12035-018-1270-y · ExternalCitation · doi-reference
Consensus paper: Cerebellar development
10.1007/s12311-015-0724-2 · ExternalCitation · doi-reference
Therapeutic applications of thyroid hormone analogues
10.1016/j.ando.2020.03.004 · ExternalCitation · doi-reference
NKX2-1 is required in the embryonic septum for cholinergic system development, learning, and memory
10.1016/j.celrep.2017.07.053 · ExternalCitation · doi-reference
Cannibalized erythroblasts accelerate developmental neurogenesis by regulating mitochondrial dynamics
10.1016/j.celrep.2021.108942 · ExternalCitation · doi-reference
Overcoming monocarboxylate transporter 8 (MCT8)-deficiency to promote human oligodendrocyte differentiation and myelination
10.1016/j.ebiom.2017.10.016 · ExternalCitation · doi-reference
Neurodevelopmental outcomes following intrauterine growth restriction and very preterm birth
10.1016/j.jpeds.2021.07.002 · ExternalCitation · doi-reference
Thyroid hormone biosynthesis and release
10.1016/j.mce.2017.01.038 · ExternalCitation · doi-reference
Hypomyelinating disorders: An MRI approach
10.1016/j.nbd.2015.10.015 · ExternalCitation · doi-reference
Reduced gray matter brain volume and cortical thickness in adults with type 1 diabetes and neuropathy
10.1016/j.neures.2021.10.002 · ExternalCitation · doi-reference
Reduced white matter fractional anisotropy mediates cortical thickening in adults born preterm with very low birthweight
10.1016/j.neuroimage.2018.11.050 · ExternalCitation · doi-reference
Effectiveness and safety of the tri-iodothyronine analogue triac in children and adults with MCT8 deficiency: An international, single-arm, open-label, phase 2 trial
10.1016/s2213-8587(19)30155-x · ExternalCitation · doi-reference
Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders
10.1038/s41380-022-01687-4 · ExternalCitation · doi-reference
Structural insights into thyroid hormone transporter MCT8
10.1038/s41467-025-58131-8 · ExternalCitation · doi-reference
Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development
10.1038/s41598-024-59533-2 · ExternalCitation · doi-reference
Deletion of the thyroid hormone receptor α1 prevents the structural alterations of the cerebellum induced by hypothyroidism
10.1073/pnas.062413299 · ExternalCitation · doi-reference
How synaptic pruning shapes neural wiring during development and, possibly, in disease
10.1073/pnas.2010281117 · ExternalCitation · doi-reference
Reversible inactivation of the tumor suppressor PTEN by H2O2
10.1074/jbc.m111899200 · ExternalCitation · doi-reference
Control of thyroid hormone action in the developing rat brain
10.1089/105072503770867219 · ExternalCitation · doi-reference
Thyroid hormone-Otx2 signaling is required for embryonic ventral midbrain neural stem cells differentiated into dopamine neurons
10.1089/scd.2014.0489 · ExternalCitation · doi-reference
Desire, disease, and the origins of the dopaminergic system
10.1093/schbul/sbm170 · ExternalCitation · doi-reference
Differential effect of intrauterine growth restriction on childhood neurodevelopment: A systematic review
10.1111/1471-0528.13435 · ExternalCitation · doi-reference
Timing of thyroid hormone action in the developing brain: Clinical observations and experimental findings
10.1111/j.1365-2826.2004.01243.x · ExternalCitation · doi-reference
Neurodevelopmental and neurophysiological actions of thyroid hormone
10.1111/j.1365-2826.2008.01733.x · ExternalCitation · doi-reference
Thyroid hormone analogues: Promising therapeutic avenues to improve the neurodevelopmental outcomes of intrauterine growth restriction
10.1111/jnc.16124 · ExternalCitation · doi-reference
The colorful diversity of thyroid hormone metabolites
10.1159/000497141 · ExternalCitation · doi-reference
Mechanisms of fetal adaptation to chronic hypoxia following placental insufficiency: A review
10.1159/000525717 · ExternalCitation · doi-reference
Myelin repair stimulated by CNS-selective thyroid hormone action
10.1172/jci.insight.126329 · ExternalCitation · doi-reference
Deiodinases: Implications of the local control of thyroid hormone action
10.1172/jci29812 · ExternalCitation · doi-reference
Hypotonic male infant and MCT8 deficiency - A diagnosis to think about
10.1186/1471-2431-14-252 · ExternalCitation · doi-reference
Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain
10.1186/s12974-018-1392-1 · ExternalCitation · doi-reference
Neurovascular unit disruption and blood–brain barrier leakage in MCT8 deficiency
10.1186/s12987-023-00481-w · ExternalCitation · doi-reference
Effects of thyroid status on regional brain volumes: A diagnostic and genetic imaging study in UK biobank
10.1210/clinem/dgaa903 · ExternalCitation · doi-reference
Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice
10.1210/en.2014-1085 · ExternalCitation · doi-reference
Structural insights into thyroid hormone receptors
10.1210/endocr/bqae154 · ExternalCitation · doi-reference
Single-cell imaging of the cell cycle reveals CDC25B-induced heterogeneity of G1 phase length in neural progenitor cells
10.1242/dev.199660 · ExternalCitation · doi-reference
Thyroid hormones and fetal neurological development
10.1530/joe-10-0444 · ExternalCitation · doi-reference
Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression
10.26508/lsa.202302091 · ExternalCitation · doi-reference
3,5-Diiodothyronine: A novel thyroid hormone metabolite and potent modulator of energy metabolism
10.3389/fendo.2018.00427 · ExternalCitation · doi-reference
T3 levels and thyroid hormone signaling
10.3389/fendo.2022.1044691 · ExternalCitation · doi-reference
Thyroid hormones act as modulators of inflammation through their nuclear receptors
10.3389/fendo.2022.937099 · ExternalCitation · doi-reference
Cholinergic regulation of object recognition memory
10.3389/fnbeh.2022.996089 · ExternalCitation · doi-reference
Effects of intrauterine growth restriction on embryonic hippocampal dentate gyrus neurogenesis and postnatal critical period of synaptic plasticity that govern learning and memory function
10.3389/fnins.2023.1092357 · ExternalCitation · doi-reference
New insights into cholinergic neuron diversity
10.3389/fnmol.2019.00204 · ExternalCitation · doi-reference
Impact of intrauterine growth restriction on cognitive and motor development at 2 years of age
10.3389/fphys.2018.01278 · ExternalCitation · doi-reference
Redox-mediated rewiring of signalling pathways: The role of a cellular clock in brain health and disease
10.3390/antiox12101873 · ExternalCitation · doi-reference
Thyroid hormones and brain development: A focus on the role of mitochondria as regulators of developmental time
10.3390/cells14030150 · ExternalCitation · doi-reference
Selective inhibition of genomic and non-genomic effects of thyroid hormone regulates muscle cell differentiation and metabolic behavior
10.3390/ijms22137175 · ExternalCitation · doi-reference
Triac treatment prevents neurodevelopmental and locomotor impairments in thyroid hormone transporter Mct8/Oatp1c1 deficient mice
10.3390/ijms24043452 · ExternalCitation · doi-reference
Local thyroid hormone action in brain development
10.3390/ijms241512352 · ExternalCitation · doi-reference
Main factors involved in thyroid hormone action
10.3390/molecules26237337 · ExternalCitation · doi-reference
Effects of intrauterine growth restriction (IUGR) on growth and body composition compared to constitutionally small infants
10.3390/nu15194158 · ExternalCitation · doi-reference
The role of thyroid hormone in the regulation of cerebellar development
10.3803/enm.2021.1150 · ExternalCitation · doi-reference
Deiodinases and the three types of thyroid hormone deiodination reactions
10.3803/enm.2021.1198 · ExternalCitation · doi-reference
