Research graph
References from Thyroid hormone transporters and the brain. Local targets link to admitted publications; unresolved targets remain external evidence.
Expression of thyroid hormone transporters in the human hypothalamus
10.1210/jc.2010-2750 · 2011 · External reference
Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary
10.1530/eje.1.02111 · 2006 · External reference
Adult mice lacking Mct8 and Dio2 proteins present alterations in peripheral thyroid hormone levels and severe brain and motor skill impairments
10.1089/thy.2019.0068 · 2019 · External reference
Thyroid hormones in brain development and function
2000 · External reference
Thyroid hormone transporters--functions and clinical implications
10.1038/nrendo.2015.66 · 2015 · External reference
Selective expression of the large neutral amino acid transporter at the blood-brain barrier
10.1073/pnas.96.21.12079 · 1999 · External reference
Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells
10.1002/glia.21116 · 2011 · External reference
Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3'-triiodo-L-thyronine
10.1210/en.2008-1616 · 2009 · External reference
MCT8 expression in human fetal cerebral cortex is reduced in severe intrauterine growth restriction
10.1530/joe-13-0400 · 2014 · External reference
An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum
10.1210/endo-110-2-367 · 1982 · External reference
Estradiol and the development of the cerebral cortex: An unexpected role?
10.3389/fnins.2018.00245 · 2018 · External reference
A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene
10.1086/380999 · 2004 · External reference
Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice
10.1210/en.2006-0390 · 2006 · External reference
Tissue-specific patterns of changes in 3,5,3'-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. which are the regulatory mechanisms?
10.1016/s0300-9084(99)80095-9 · 1999 · External reference
Thyroid hormone transport by the heterodimeric human system L amino acid transporter
10.1210/endo.142.10.8418 · 2001 · External reference
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
10.1074/jbc.m300909200 · 2003 · External reference
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
10.1016/s0140-6736(04)17226-7 · 2004 · External reference
Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10
10.1210/me.2007-0112 · 2008 · External reference
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1
10.1016/j.cell.2025.06.032 · 2025 · External reference
MCT8 deficiency: The road to therapies for a rare disease
10.3389/fnins.2020.00380 · 2020 · External reference
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration
10.1038/s41467-025-56628-w · 2025 · External reference
The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain
10.1073/pnas.94.19.10391 · 1997 · External reference
Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability
10.1210/edrv.22.4.0435 · 2001 · External reference
Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine
10.1039/b926588k · 2010 · External reference
Adeno associated virus 9-Based gene therapy delivers a functional monocarboxylate transporter 8, improving thyroid hormone availability to the brain of Mct8-deficient mice
10.1089/thy.2016.0060 · 2016 · External reference
Characterization of thyroid hormone transport in synaptosomes from rat brain
10.1016/0303-7207(89)90213-x · 1989 · External reference
Thyroid hormone availability in the human fetal brain: Novel entry pathways and role of radial glia
10.1007/s00429-019-01896-8 · 2019 · External reference
Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination
10.1210/jc.2014-2162 · 2014 · External reference
AAV9-MCT8 delivery at juvenile stage ameliorates neurological and behavioral deficits in a mouse model of MCT8-deficiency
10.1089/thy.2022.0034 · 2022 · External reference
Expression pattern of thyroid hormone transporters in the postnatal mouse brain
2014 · External reference
Movement disorders in MCT8 deficiency/allan-herndon-dudley syndrome
10.1016/j.ymgme.2021.12.003 · 2022 · External reference
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis
10.1172/jci70324 · 2014 · External reference
Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter
10.1210/me.2001-0309 · 2002 · External reference
Expanding the phenotypic spectrum of allan-herndon-dudley syndrome in patients with SLC16A2 mutations
10.1111/dmcn.14332 · 2019 · External reference
Thyroid hormone transport by 4F2hc-IU12 heterodimers expressed in xenopus oocytes
10.1677/joe.0.163r005 · 1999 · External reference
Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier
10.1210/en.2008-0378 · 2008 · External reference
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie allan-herndon-dudley syndrome
10.1172/jci.insight.174645 · 2024 · External reference
Mutated thyroid hormone transporter OATP1C1 associates with severe brain hypometabolism and juvenile neurodegeneration
10.1089/thy.2018.0595 · 2018 · External reference
Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: High affinity transporter for thyroxine
10.1074/jbc.m306933200 · 2003 · External reference
Structural insights into thyroid hormone transporter MCT8
10.1038/s41467-025-58131-8 · 2025 · External reference
Molecular mechanism of thyroxine transport by monocarboxylate transporters
10.1038/s41467-025-59751-w · 2025 · External reference
Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8
10.1172/jci28253 · 2007 · External reference
Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation
10.1210/en.2008-0430 · 2008 · External reference
Monocarboxylate transporter 8 deficiency: From pathophysiological understanding to therapy development
10.3389/fendo.2021.723750 · 2021 · External reference
Estrogen and thyroid hormone receptor interactions: Physiological flexibility by molecular specificity
10.1152/physrev.00014.2002 · 2002 · External reference
Modeling psychomotor retardation using iPSCs from MCT8-Deficient patients indicates a prominent role for the blood-brain barrier
10.1016/j.stem.2017.04.002 · 2017 · External reference
Evidence for a homodimeric structure of human monocarboxylate transporter 8
10.1210/en.2009-0699 · 2009 · External reference
Thyroid hormone transporters MCT8 and OATP1C1 are expressed in pyramidal neurons and interneurons in the adult motor cortex of human and macaque brain
2023 · External reference
Thyroid hormone transporters MCT8 and OATP1C1 are expressed in projection neurons and interneurons of basal ganglia and motor thalamus in the adult human and macaque brains
10.3390/ijms24119643 · 2023 · External reference
Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in allan-herndon-dudley syndrome
10.1523/jneurosci.6055-08.2009 · 2009 · External reference
Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells
10.1002/glia.21116 · ExternalCitation · doi-reference
Thyroid hormone availability in the human fetal brain: Novel entry pathways and role of radial glia
10.1007/s00429-019-01896-8 · ExternalCitation · doi-reference
Characterization of thyroid hormone transport in synaptosomes from rat brain
10.1016/0303-7207(89)90213-x · ExternalCitation · doi-reference
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1
10.1016/j.cell.2025.06.032 · ExternalCitation · doi-reference
Modeling psychomotor retardation using iPSCs from MCT8-Deficient patients indicates a prominent role for the blood-brain barrier
10.1016/j.stem.2017.04.002 · ExternalCitation · doi-reference
Movement disorders in MCT8 deficiency/allan-herndon-dudley syndrome
10.1016/j.ymgme.2021.12.003 · ExternalCitation · doi-reference
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
10.1016/s0140-6736(04)17226-7 · ExternalCitation · doi-reference
Tissue-specific patterns of changes in 3,5,3'-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. which are the regulatory mechanisms?
10.1016/s0300-9084(99)80095-9 · ExternalCitation · doi-reference
Thyroid hormone transporters--functions and clinical implications
10.1038/nrendo.2015.66 · ExternalCitation · doi-reference
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration
10.1038/s41467-025-56628-w · ExternalCitation · doi-reference
Structural insights into thyroid hormone transporter MCT8
10.1038/s41467-025-58131-8 · ExternalCitation · doi-reference
Molecular mechanism of thyroxine transport by monocarboxylate transporters
10.1038/s41467-025-59751-w · ExternalCitation · doi-reference
Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine
10.1039/b926588k · ExternalCitation · doi-reference
The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain
10.1073/pnas.94.19.10391 · ExternalCitation · doi-reference
Selective expression of the large neutral amino acid transporter at the blood-brain barrier
10.1073/pnas.96.21.12079 · ExternalCitation · doi-reference
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
10.1074/jbc.m300909200 · ExternalCitation · doi-reference
Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: High affinity transporter for thyroxine
10.1074/jbc.m306933200 · ExternalCitation · doi-reference
A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene
10.1086/380999 · ExternalCitation · doi-reference
Adeno associated virus 9-Based gene therapy delivers a functional monocarboxylate transporter 8, improving thyroid hormone availability to the brain of Mct8-deficient mice
10.1089/thy.2016.0060 · ExternalCitation · doi-reference
Mutated thyroid hormone transporter OATP1C1 associates with severe brain hypometabolism and juvenile neurodegeneration
10.1089/thy.2018.0595 · ExternalCitation · doi-reference
Adult mice lacking Mct8 and Dio2 proteins present alterations in peripheral thyroid hormone levels and severe brain and motor skill impairments
10.1089/thy.2019.0068 · ExternalCitation · doi-reference
AAV9-MCT8 delivery at juvenile stage ameliorates neurological and behavioral deficits in a mouse model of MCT8-deficiency
10.1089/thy.2022.0034 · ExternalCitation · doi-reference
Expanding the phenotypic spectrum of allan-herndon-dudley syndrome in patients with SLC16A2 mutations
10.1111/dmcn.14332 · ExternalCitation · doi-reference
Estrogen and thyroid hormone receptor interactions: Physiological flexibility by molecular specificity
10.1152/physrev.00014.2002 · ExternalCitation · doi-reference
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie allan-herndon-dudley syndrome
10.1172/jci.insight.174645 · ExternalCitation · doi-reference
Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8
10.1172/jci28253 · ExternalCitation · doi-reference
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis
10.1172/jci70324 · ExternalCitation · doi-reference
Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability
10.1210/edrv.22.4.0435 · ExternalCitation · doi-reference
Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice
10.1210/en.2006-0390 · ExternalCitation · doi-reference
Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier
10.1210/en.2008-0378 · ExternalCitation · doi-reference
Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation
10.1210/en.2008-0430 · ExternalCitation · doi-reference
Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3'-triiodo-L-thyronine
10.1210/en.2008-1616 · ExternalCitation · doi-reference
Evidence for a homodimeric structure of human monocarboxylate transporter 8
10.1210/en.2009-0699 · ExternalCitation · doi-reference
An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum
10.1210/endo-110-2-367 · ExternalCitation · doi-reference
Thyroid hormone transport by the heterodimeric human system L amino acid transporter
10.1210/endo.142.10.8418 · ExternalCitation · doi-reference
Expression of thyroid hormone transporters in the human hypothalamus
10.1210/jc.2010-2750 · ExternalCitation · doi-reference
Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination
10.1210/jc.2014-2162 · ExternalCitation · doi-reference
Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter
10.1210/me.2001-0309 · ExternalCitation · doi-reference
Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10
10.1210/me.2007-0112 · ExternalCitation · doi-reference
Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in allan-herndon-dudley syndrome
10.1523/jneurosci.6055-08.2009 · ExternalCitation · doi-reference
Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary
10.1530/eje.1.02111 · ExternalCitation · doi-reference
MCT8 expression in human fetal cerebral cortex is reduced in severe intrauterine growth restriction
10.1530/joe-13-0400 · ExternalCitation · doi-reference
Thyroid hormone transport by 4F2hc-IU12 heterodimers expressed in xenopus oocytes
10.1677/joe.0.163r005 · ExternalCitation · doi-reference
Monocarboxylate transporter 8 deficiency: From pathophysiological understanding to therapy development
10.3389/fendo.2021.723750 · ExternalCitation · doi-reference
Estradiol and the development of the cerebral cortex: An unexpected role?
10.3389/fnins.2018.00245 · ExternalCitation · doi-reference
MCT8 deficiency: The road to therapies for a rare disease
10.3389/fnins.2020.00380 · ExternalCitation · doi-reference
Thyroid hormone transporters MCT8 and OATP1C1 are expressed in projection neurons and interneurons of basal ganglia and motor thalamus in the adult human and macaque brains
10.3390/ijms24119643 · ExternalCitation · doi-reference
