Research graph
References from Thyroid hormones and neurodegenerative diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Primary hypothyroidism and alzheimer's disease: A tale of two
10.1007/s10571-023-01392-y · 2023 · External reference
Local thyroid hormone action in brain development
10.3390/ijms241512352 · 2023 · External reference
The association between subclinical thyroid dysfunction and dementia: The health, aging and body composition (health ABC) study
10.1111/cen.13458 · 2017 · External reference
Thyroid hormone: Sex-dependent role in nervous system regulation and disease
10.1186/s13293-021-00367-2 · 2021 · External reference
Thyroid hormone transport and transporters
10.1016/bs.vh.2017.04.005 · 2018 · External reference
Moderation of thyroid hormones for the relationship between amyloid and tau pathology
10.1186/s13195-024-01534-4 · 2024 · External reference
Thyroid function in the euthyroid range and adverse outcomes in older adults
10.1210/jc.2014-3586 · 2015 · External reference
Thyroid hormone supplementation restores spatial memory, hippocampal markers of neuroinflammation, plasticity-related signaling molecules, and β-amyloid peptide load in hypothyroid rats
10.1007/s12035-018-1111-z · 2019 · External reference
Thyroid function and the risk of dementia: The rotterdam study
10.1212/wnl.0000000000003227 · 2016 · External reference
Thyroid dysfunction and risk of parkinson's disease: A systematic review and meta-analysis [systematic review]
10.3389/fendo.2022.863281 · 2022 · External reference
Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells
10.1073/pnas.1210626110 · 2013 · External reference
Circadian rhythm of TSH levels in subjects with alzheimer's disease (AD)
10.1007/s40520-013-0025-x · 2013 · External reference
Molecular aspects of thyroid hormone actions
10.1210/er.2009-0007 · 2010 · External reference
Tetrameric transthyretin as a protective factor against alzheimer's disease
10.1007/s12035-024-04442-8 · 2025 · External reference
Thyroid hormones, dementia, and atrophy of the medial temporal lobe
10.1210/jc.2006-0449 · 2006 · External reference
Chapter ten - thyroid hormone biosynthesis and its role in brain development and maintenance
2024 · External reference
The hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
10.1038/ncb1272 · 2005 · External reference
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
10.1073/pnas.0706754104 · 2007 · External reference
Prevalence and risk factors of thyroid dysfunction in older adults in the community
10.1038/s41598-019-49540-z · 2019 · External reference
A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene
10.1086/380999 · 2004 · External reference
Graves' disease and toxic nodular goiter, aggravated by duration of hyperthyroidism, are associated with alzheimer's and vascular dementia: A registry-based long-term follow-up of two large cohorts
10.1089/thy.2019.0672 · 2020 · External reference
Hyperthyroid dementia: Clinicoradiological findings and response to treatment
10.1016/s0022-510x(00)00487-1 · 2001 · External reference
Hormonal regulation of oxidative phosphorylation in the brain in health and disease
10.3390/cells10112937 · 2021 · External reference
Role of thyroid hormone receptor subtypes α and β on gene expression in the cerebral cortex and striatum of postnatal mice
10.1210/en.2012-2189 · 2013 · External reference
Rapid nongenomic actions of thyroid hormone
10.1073/pnas.0601600103 · 2006 · External reference
Prevalence of thyroid dysfunction and its impact on cognition in older Mexican adults: (SADEM study)
10.1007/s40618-017-0654-6 · 2017 · External reference
Pathophysiology and clinical features of neuropsychiatric manifestations of thyroid disease
10.1210/jendso/bvab194 · 2022 · External reference
Perspectives on thyroid hormone action in adult neurogenesis
10.1111/jnc.13093 · 2015 · External reference
The association between thyroid diseases and alzheimer's disease in a national health screening cohort in Korea
10.3389/fendo.2022.815063 · 2022 · External reference
Alzheimer disease
10.1038/s41572-021-00269-y · 2021 · External reference
Brain functional connectivity in patients with hyperthyroidism after anti-thyroid treatment
10.1111/jne.13075 · 2022 · External reference
Thyroid dysfunction and alzheimer's disease, a vicious circle
2024 · External reference
Changes in resting-state cerebral activity in patients with hyperthyroidism: a short-term follow-up functional MR imaging study
10.1038/s41598-017-10747-7 · 2017 · External reference
The protective role of nutritional antioxidants against oxidative stress in thyroid disorders
2023 · External reference
Oxidative stress in graves' disease
10.1159/000337976 · 2012 · External reference
EMAS position statement: Thyroid disease and menopause
10.1016/j.maturitas.2024.107991 · 2024 · External reference
Role of thyroid hormone in neurodegenerative disorders of older people
10.3390/cells14020140 · 2025 · External reference
The role of c-Abl tyrosine kinase in brain and its pathologies
10.3390/cells12162041 · 2023 · External reference
Thyroid hormone regulation of metabolism
10.1152/physrev.00030.2013 · 2014 · External reference
Thyroid hormone receptors and resistance to thyroid hormone disorders
10.1038/nrendo.2014.143 · 2014 · External reference
The effect of chronic cerebral hypoperfusion on the pathology of alzheimer's disease: A positron emission tomography study in rats
2019 · External reference
Subclinical hypothyroidism and cognitive impairment: systematic review and meta-analysis
10.1210/jc.2015-2046 · 2015 · External reference
Selective persistent reduction in choline acetyltransferase activity in basal forebrain of the rat after thyroid deficiency during early life
10.1016/0006-8993(87)90556-7 · 1987 · External reference
Neonatal hyperthyroidism disrupts hippocampal LTP and spatial learning
10.1007/bf00231740 · 1991 · External reference
Associations between thyroid hormones and cognitive impairment in patients with parkinson's disease
10.1523/eneuro.0239-24.2024 · 2024 · External reference
DNA recognition by thyroid hormone and retinoic acid receptors: 3, 4, 5 rule modified
10.1016/j.mce.2009.11.010 · 2010 · External reference
The impact of autoimmune thyroid disease on cognitive and psychiatric disorders: Focus on clinical, pre-clinical and molecular studies
10.1530/etj-24-0406 · 2025 · External reference
Altered thyroid hormone profile in patients with alzheimer's disease
10.1016/j.psyneuen.2020.104844 · 2020 · External reference
Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of alzheimer's disease
10.1016/j.psyneuen.2018.09.002 · 2019 · External reference
The disturbance of thyroid-associated hormone and its receptors in brain and blood circulation existed in the early stage of mouse model of alzheimer's disease
2023 · External reference
Subclinical thyroid dysfunction and the risk of cognitive decline: A meta-analysis of prospective cohort studies
10.1210/jc.2016-2129 · 2016 · External reference
Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier
10.1210/en.2008-0378 · 2008 · External reference
The role of thyroid dysfunction in alzheimer's disease: A systematic review and meta-analysis
10.14283/jpad.2023.20 · 2023 · External reference
Hyperthyroidism in aging
2000 · External reference
Thyroid disease and cognition
10.1016/j.ecl.2014.02.006 · 2014 · External reference
Relationship between TSH levels and cognition in the young adult: An analysis of the human connectome project data
10.1210/clinem/dgac189 · 2022 · External reference
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
10.1038/s41580-022-00456-z · 2022 · External reference
Thyroid function and cognitive decline: A narrative review
10.1016/j.eprac.2024.07.013 · 2024 · External reference
Thyroid function and the risk of alzheimer disease: The framingham study
10.1001/archinte.168.14.1514 · 2008 · External reference
Nitric oxide might be an inducing factor in cognitive impairment in alzheimer's disease via downregulating the monocarboxylate transporter 1
10.1016/j.niox.2019.07.006 · 2019 · External reference
Increased risk of dementia in hypothyroidism: A danish nationwide register-based study
10.1111/cen.14424 · 2021 · External reference
Unresolved reference
External reference
Thyroid disorders as a risk factor for neurodegenerative proteinopathies: A large-scale propensity score-matched analysis
2025 · External reference
Hypothyroidism causes endoplasmic reticulum stress in adult rat hippocampus: A mechanism associated with hippocampal damage
10.1155/2018/2089404 · 2018 · External reference
Thyroid hormone action in adult neurogliogenic niches: The known and unknown
10.3389/fendo.2024.1347802 · 2024 · External reference
Association of thyroid dysfunction with cognitive function: An individual participant data analysis
10.1001/jamainternmed.2021.5078 · 2021 · External reference
The role of thyroid hormones as inductors of oxidative stress and neurodegeneration
10.1155/2013/218145 · 2013 · External reference
Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats
10.3892/mmr.2014.2825 · 2015 · External reference
Association of hypothyroidism and the risk of cognitive dysfunction: A meta-analysis
10.3390/jcm11226726 · 2022 · External reference
No causal relationship between thyroid function and parkinson's disease: A bidirectional mendelian randomization study
10.1007/s10072-023-07176-y · 2024 · External reference
Disrupted functional connectivity of the hippocampus in patients with hyperthyroidism: Evidence from resting-state fMRI
10.1016/j.ejrad.2014.07.003 · 2014 · External reference
Trends in prevalence of thyroid dysfunction and its associations with mortality among US participants, 1988-2012
10.1210/clinem/dgad558 · 2024 · External reference
Structural and functional alterations of hippocampal subfields in patients with adult-onset primary hypothyroidism
10.1210/clinem/dgae070 · 2024 · External reference
fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism
10.1093/brain/awl215 · 2006 · External reference
Impaired learning and memory generated by hyperthyroidism is rescued by restoration of AMPA and NMDA receptors function
10.1016/j.nbd.2022.105807 · 2022 · External reference
Thyroid function and the risk of alzheimer disease: The framingham study
10.1001/archinte.168.14.1514 · ExternalCitation · doi-reference
Association of thyroid dysfunction with cognitive function: An individual participant data analysis
10.1001/jamainternmed.2021.5078 · ExternalCitation · doi-reference
Neonatal hyperthyroidism disrupts hippocampal LTP and spatial learning
10.1007/bf00231740 · ExternalCitation · doi-reference
No causal relationship between thyroid function and parkinson's disease: A bidirectional mendelian randomization study
10.1007/s10072-023-07176-y · ExternalCitation · doi-reference
Primary hypothyroidism and alzheimer's disease: A tale of two
10.1007/s10571-023-01392-y · ExternalCitation · doi-reference
Thyroid hormone supplementation restores spatial memory, hippocampal markers of neuroinflammation, plasticity-related signaling molecules, and β-amyloid peptide load in hypothyroid rats
10.1007/s12035-018-1111-z · ExternalCitation · doi-reference
Tetrameric transthyretin as a protective factor against alzheimer's disease
10.1007/s12035-024-04442-8 · ExternalCitation · doi-reference
Circadian rhythm of TSH levels in subjects with alzheimer's disease (AD)
10.1007/s40520-013-0025-x · ExternalCitation · doi-reference
Prevalence of thyroid dysfunction and its impact on cognition in older Mexican adults: (SADEM study)
10.1007/s40618-017-0654-6 · ExternalCitation · doi-reference
Selective persistent reduction in choline acetyltransferase activity in basal forebrain of the rat after thyroid deficiency during early life
10.1016/0006-8993(87)90556-7 · ExternalCitation · doi-reference
Thyroid hormone transport and transporters
10.1016/bs.vh.2017.04.005 · ExternalCitation · doi-reference
Thyroid disease and cognition
10.1016/j.ecl.2014.02.006 · ExternalCitation · doi-reference
Disrupted functional connectivity of the hippocampus in patients with hyperthyroidism: Evidence from resting-state fMRI
10.1016/j.ejrad.2014.07.003 · ExternalCitation · doi-reference
Thyroid function and cognitive decline: A narrative review
10.1016/j.eprac.2024.07.013 · ExternalCitation · doi-reference
EMAS position statement: Thyroid disease and menopause
10.1016/j.maturitas.2024.107991 · ExternalCitation · doi-reference
DNA recognition by thyroid hormone and retinoic acid receptors: 3, 4, 5 rule modified
10.1016/j.mce.2009.11.010 · ExternalCitation · doi-reference
Impaired learning and memory generated by hyperthyroidism is rescued by restoration of AMPA and NMDA receptors function
10.1016/j.nbd.2022.105807 · ExternalCitation · doi-reference
Nitric oxide might be an inducing factor in cognitive impairment in alzheimer's disease via downregulating the monocarboxylate transporter 1
10.1016/j.niox.2019.07.006 · ExternalCitation · doi-reference
Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of alzheimer's disease
10.1016/j.psyneuen.2018.09.002 · ExternalCitation · doi-reference
Altered thyroid hormone profile in patients with alzheimer's disease
10.1016/j.psyneuen.2020.104844 · ExternalCitation · doi-reference
Hyperthyroid dementia: Clinicoradiological findings and response to treatment
10.1016/s0022-510x(00)00487-1 · ExternalCitation · doi-reference
The hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
10.1038/ncb1272 · ExternalCitation · doi-reference
Thyroid hormone receptors and resistance to thyroid hormone disorders
10.1038/nrendo.2014.143 · ExternalCitation · doi-reference
Alzheimer disease
10.1038/s41572-021-00269-y · ExternalCitation · doi-reference
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
10.1038/s41580-022-00456-z · ExternalCitation · doi-reference
Changes in resting-state cerebral activity in patients with hyperthyroidism: a short-term follow-up functional MR imaging study
10.1038/s41598-017-10747-7 · ExternalCitation · doi-reference
Prevalence and risk factors of thyroid dysfunction in older adults in the community
10.1038/s41598-019-49540-z · ExternalCitation · doi-reference
Rapid nongenomic actions of thyroid hormone
10.1073/pnas.0601600103 · ExternalCitation · doi-reference
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
10.1073/pnas.0706754104 · ExternalCitation · doi-reference
Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells
10.1073/pnas.1210626110 · ExternalCitation · doi-reference
A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene
10.1086/380999 · ExternalCitation · doi-reference
Graves' disease and toxic nodular goiter, aggravated by duration of hyperthyroidism, are associated with alzheimer's and vascular dementia: A registry-based long-term follow-up of two large cohorts
10.1089/thy.2019.0672 · ExternalCitation · doi-reference
fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism
10.1093/brain/awl215 · ExternalCitation · doi-reference
The association between subclinical thyroid dysfunction and dementia: The health, aging and body composition (health ABC) study
10.1111/cen.13458 · ExternalCitation · doi-reference
Increased risk of dementia in hypothyroidism: A danish nationwide register-based study
10.1111/cen.14424 · ExternalCitation · doi-reference
Perspectives on thyroid hormone action in adult neurogenesis
10.1111/jnc.13093 · ExternalCitation · doi-reference
Brain functional connectivity in patients with hyperthyroidism after anti-thyroid treatment
10.1111/jne.13075 · ExternalCitation · doi-reference
Thyroid hormone regulation of metabolism
10.1152/physrev.00030.2013 · ExternalCitation · doi-reference
The role of thyroid hormones as inductors of oxidative stress and neurodegeneration
10.1155/2013/218145 · ExternalCitation · doi-reference
Hypothyroidism causes endoplasmic reticulum stress in adult rat hippocampus: A mechanism associated with hippocampal damage
10.1155/2018/2089404 · ExternalCitation · doi-reference
Oxidative stress in graves' disease
10.1159/000337976 · ExternalCitation · doi-reference
Moderation of thyroid hormones for the relationship between amyloid and tau pathology
10.1186/s13195-024-01534-4 · ExternalCitation · doi-reference
Thyroid hormone: Sex-dependent role in nervous system regulation and disease
10.1186/s13293-021-00367-2 · ExternalCitation · doi-reference
Relationship between TSH levels and cognition in the young adult: An analysis of the human connectome project data
10.1210/clinem/dgac189 · ExternalCitation · doi-reference
Trends in prevalence of thyroid dysfunction and its associations with mortality among US participants, 1988-2012
10.1210/clinem/dgad558 · ExternalCitation · doi-reference
Structural and functional alterations of hippocampal subfields in patients with adult-onset primary hypothyroidism
10.1210/clinem/dgae070 · ExternalCitation · doi-reference
Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier
10.1210/en.2008-0378 · ExternalCitation · doi-reference
Role of thyroid hormone receptor subtypes α and β on gene expression in the cerebral cortex and striatum of postnatal mice
10.1210/en.2012-2189 · ExternalCitation · doi-reference
Molecular aspects of thyroid hormone actions
10.1210/er.2009-0007 · ExternalCitation · doi-reference
Thyroid hormones, dementia, and atrophy of the medial temporal lobe
10.1210/jc.2006-0449 · ExternalCitation · doi-reference
Thyroid function in the euthyroid range and adverse outcomes in older adults
10.1210/jc.2014-3586 · ExternalCitation · doi-reference
Subclinical hypothyroidism and cognitive impairment: systematic review and meta-analysis
10.1210/jc.2015-2046 · ExternalCitation · doi-reference
Subclinical thyroid dysfunction and the risk of cognitive decline: A meta-analysis of prospective cohort studies
10.1210/jc.2016-2129 · ExternalCitation · doi-reference
Pathophysiology and clinical features of neuropsychiatric manifestations of thyroid disease
10.1210/jendso/bvab194 · ExternalCitation · doi-reference
Thyroid function and the risk of dementia: The rotterdam study
10.1212/wnl.0000000000003227 · ExternalCitation · doi-reference
The role of thyroid dysfunction in alzheimer's disease: A systematic review and meta-analysis
10.14283/jpad.2023.20 · ExternalCitation · doi-reference
Associations between thyroid hormones and cognitive impairment in patients with parkinson's disease
10.1523/eneuro.0239-24.2024 · ExternalCitation · doi-reference
The impact of autoimmune thyroid disease on cognitive and psychiatric disorders: Focus on clinical, pre-clinical and molecular studies
10.1530/etj-24-0406 · ExternalCitation · doi-reference
The association between thyroid diseases and alzheimer's disease in a national health screening cohort in Korea
10.3389/fendo.2022.815063 · ExternalCitation · doi-reference
Thyroid dysfunction and risk of parkinson's disease: A systematic review and meta-analysis [systematic review]
10.3389/fendo.2022.863281 · ExternalCitation · doi-reference
Thyroid hormone action in adult neurogliogenic niches: The known and unknown
10.3389/fendo.2024.1347802 · ExternalCitation · doi-reference
Hormonal regulation of oxidative phosphorylation in the brain in health and disease
10.3390/cells10112937 · ExternalCitation · doi-reference
The role of c-Abl tyrosine kinase in brain and its pathologies
10.3390/cells12162041 · ExternalCitation · doi-reference
Role of thyroid hormone in neurodegenerative disorders of older people
10.3390/cells14020140 · ExternalCitation · doi-reference
Local thyroid hormone action in brain development
10.3390/ijms241512352 · ExternalCitation · doi-reference
Association of hypothyroidism and the risk of cognitive dysfunction: A meta-analysis
10.3390/jcm11226726 · ExternalCitation · doi-reference
Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats
10.3892/mmr.2014.2825 · ExternalCitation · doi-reference
