Research graph
References from Natural compounds in wound healing strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
Revolutionizing wound healing: Exploring s
10.1021/acs.molpharmaceut.3c01072 · 2024 · External reference
Reactive oxygen species (ROS)-mediated antibacterial oxidative therapies: Available methods to generate ROS and a Novel Option Proposal
10.3390/ijms25137182 · 2024 · External reference
Medicinal plants and bioactive compounds: Traditional and modern approaches to wound healing
10.55640/ijmsdh-11-02-03 · 2025 · External reference
Technologies for solubility, dissolution and permeation enhancement of natural compounds
10.3390/ph15060653 · 2022 · External reference
Exploring the interplay of antioxidants, inflammation, and oxidative stress: Mechanisms, therapeutic potential, and clinical implications
10.3390/diseases13090309 · 2025 · External reference
Polymicrobial infections and biofilms: Clinical significance and eradication strategies
10.3390/antibiotics11121731 · 2022 · External reference
Harnessing natural compounds and external stimuli for advanced wound healing: A review of combination therapy strategies
10.1016/j.jddst.2024.106172 · 2024 · External reference
Keratinocyte growth factor-based strategies for wound re-epithelialization
10.1089/ten.teb.2021.0030 · 2022 · External reference
Oxidative stress in melanoma: Beneficial antioxidant and pro-oxidant therapeutic strategies
10.3390/cancers15113038 · 2023 · External reference
Natural compounds and biomimetic engineering to influence fibroblast behavior in wound healing
10.3390/ijms25063274 · 2024 · External reference
Chinese medicine boosts regenerative medicine in stem cell - based therapy
10.1186/s13287-025-04618-6 · 2025 · External reference
Macrophage metabolism: A wound-healing perspective
10.1111/imcb.12237 · 2019 · External reference
Epigenetic regulation of macrophage polarization in wound healing
10.1093/burnst/tkac057 · 2023 · External reference
Role of the skin immune system in wound healing
10.3390/cells13070624 · 2024 · External reference
Monocytes and macrophages: Origin, homing, differentiation, and functionality during inflammation
10.1016/j.heliyon.2024.e29686 · 2024 · External reference
The Role of the extracellular matrix (ECM) in wound healing: A review
10.3390/biomimetics7030087 · 2022 · External reference
Therapeutic reprogramming toward regenerative medicine
10.1021/acs.chemrev.4c00332 · 2025 · External reference
Plant bioactive compounds: Extraction, biological activities, immunological, nutritional aspects, food application, and human health benefits—A comprehensive review
10.3389/fnut.2025.1659743 · 2025 · External reference
Approaches to enhancing antioxidant defense in plants
10.3390/antiox11050925 · 2022 · External reference
Engineering biomaterials to tailor the microenvironment for macrophage–endothelium interactions
10.1038/s41578-023-00591-9 · 2023 · External reference
Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing
10.4239/wjd.v16.i11.111400 · 2025 · External reference
Cutaneous wound healing: An update from physiopathology to current therapies
10.3390/life11070665 · 2021 · External reference
Macrophage-mediated inflammation in skin wound healing
10.3390/cells11192953 · 2022 · External reference
Polyphenols mitigating inflammatory mechanisms in inflammatory bowel disease (IBD): Focus on the NF-ƙB and JAK/STAT pathways
10.1007/s10787-024-01607-8 · 2025 · External reference
Cellular and molecular mechanisms of wound repair: From biology to therapeutic innovation
10.3390/cells14231850 · 2025 · External reference
Understanding and advancing wound healing in the era of multi-omic technology
10.3390/bioengineering13010051 · 2025 · External reference
MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits
10.1016/j.bbapap.2005.08.017 · 2005 · External reference
Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: A comprehensive review
10.1007/s10787-024-01635-4 · 2025 · External reference
The potential role of bioactive plant-based polyphenolic compounds and their delivery systems—as a promising opportunity for a new therapeutic solution for acute and chronic wound healing
10.1007/s40495-022-00296-7 · 2022 · External reference
Therapeutic potential of nanocarrier-mediated delivery of phytoconstituents for wound healing: Their current status and future perspective
10.1208/s12249-023-02616-6 · 2023 · External reference
Medicinal plants and human health: A comprehensive review of bioactive compounds, therapeutic effects, and applications
10.1007/s11101-025-10194-7 · 2026 · External reference
Phytochemicals and regulation of NF-kB in inflammatory bowel diseases: An overview of in vitro and in vivo effects
10.3390/metabo13010096 · 2023 · External reference
Redox signaling-mediated tumor extracellular matrix remodeling: Pleiotropic regulatory mechanisms
10.1007/s13402-023-00884-9 · 2024 · External reference
Advanced wound healing with stimuli-responsive nanozymes: Mechanisms, design and applications
10.1186/s12951-025-03558-w · 2025 · External reference
Flavonoids as promising natural compounds for combating bacterial infections
10.3390/ijms26062455 · 2025 · External reference
Construction of multifunctional wound dressings with their application in chronic wound treatment
10.1039/d2bm00620k · 2022 · External reference
The study of the extracellular matrix in chronic inflammation: A way to prevent cancer initiation?
10.3390/cancers14235903 · 2022 · External reference
Imperfect wound healing sets the stage for chronic diseases
10.1126/science.adp2974 · 2024 · External reference
Pro-inflammatory and anti-inflammatory interleukins in periodontitis: Molecular roles, immune crosstalk, and therapeutic perspectives
10.3390/ijms262010094 · 2025 · External reference
Oxidative stress and redox signaling in the pathophysiology of liver diseases
10.1002/j.2040-4603.2022.tb00210.x · 2022 · External reference
Multiple strategies for the application of medicinal plant-derived bioactive compounds in controlling microbial biofilm and virulence properties
10.3390/antibiotics14060555 · 2025 · External reference
Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance
10.3390/microorganisms10020303 · 2022 · External reference
Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents
10.3390/molecules27020349 · 2022 · External reference
Strategies for enhancing vascularization of biomaterial-based scaffold in bone regeneration
10.1002/tcr.202200008 · 2022 · External reference
Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes
10.3389/fimmu.2023.1216321 · 2023 · External reference
Recent advances in bioactive wound dressings
10.1111/wrr.13233 · 2025 · External reference
Macrophages, inflammation, and insulin resistance
10.1146/annurev-physiol-021909-135846 · 2010 · External reference
Toxicity testing in the era of induced pluripotent stem cells: A perspective regarding the use of patient-specific induced pluripotent stem cell–derived cardiomyocytes for cardiac safety evaluation
10.1016/j.cotox.2020.04.001 · 2020 · External reference
Biology and therapeutic targeting of vascular endothelial growth factor A
10.1038/s41580-023-00631-w · 2023 · External reference
Natural and synthetic polymeric biomaterials for application in wound management
10.3390/jfb14090455 · 2023 · External reference
Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions
10.1007/s10787-024-01602-z · 2025 · External reference
Metalloproteinases and their inhibitors: Potential for the development of new therapeutics
10.3390/cells9051313 · 2020 · External reference
Advancements in wound healing: Integrating biomolecules, drug delivery carriers, and targeted therapeutics for enhanced tissue repair
10.1007/s00203-024-03910-y · 2024 · External reference
Advancements in skin delivery of natural bioactive products for wound management: A brief review of two decades
10.3390/pharmaceutics14051072 · 2022 · External reference
Extracellular matrix turnover: Phytochemicals target and modulate the dual role of matrix metalloproteinases (<scp>MMPs</scp>) in liver fibrosis
10.1002/ptr.7959 · 2023 · External reference
Synergistic effects of incorporated additives in multifunctional dressings for chronic wound healing: An updated comprehensive review
10.1111/wrr.13238 · 2025 · External reference
The multi-faceted potential of plant-derived metabolites as antimicrobial agents against multidrug-resistant pathogens
10.1016/j.micpath.2018.01.043 · 2018 · External reference
Nrf2 Activation: Involvement in central nervous system traumatic injuries. A promising therapeutic target of natural compounds
10.3390/ijms24010199 · 2022 · External reference
Nanotechnology-based biomedical devices in the cancer diagnostics and therapy
10.1007/s12032-025-02602-x · 2025 · External reference
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
10.1038/s41569-023-00946-3 · 2024 · External reference
A comprehensive review of natural compounds for wound healing: targeting bioactivity perspective
10.3390/ijms23179573 · 2022 · External reference
A comprehensive review of free radicals, oxidative stress, and antioxidants: Overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds
10.1155/2024/5594386 · 2024 · External reference
The wound microbiota: Microbial mechanisms of impaired wound healing and infection
10.1038/s41579-024-01035-z · 2024 · External reference
Reactive oxygen species and antioxidants in wound healing: Mechanisms and therapeutic potential
10.1111/iwj.70330 · 2025 · External reference
Potential of natural bioactives in wound healing: A comprehensive review
10.14719/pst.8055 · 2025 · External reference
Plant-derived bioactive compounds as key players in the modulation of immune-related conditions
10.1007/s11101-024-09955-7 · 2025 · External reference
Applications of injectable hemostatic materials in wound healing: Principles, strategies, performance requirements, and future perspectives
10.7150/thno.86930 · 2023 · External reference
Macrophages as multifaceted orchestrators of tissue repair: Bridging inflammation, regeneration, and therapeutic innovation
10.2147/jir.s527764 · 2025 · External reference
Recent development in nanoencapsulation and delivery of natural bioactives through chitosan scaffolds for various biological applications
10.1016/j.ijbiomac.2022.08.098 · 2022 · External reference
The biological processes during wound healing
10.2217/rme-2020-0066 · 2021 · External reference
PI3K–AKT-targeting breast cancer treatments: Natural products and synthetic compounds
10.3390/biom13010093 · 2023 · External reference
Multi-targeted pharmacological actions and nanodelivery strategies of Garcinia cambogia: From molecular mechanisms to disease treatment
10.3389/fchem.2025.1692386 · 2025 · External reference
Insights into macrophage polarization and <scp>M1</scp>/<scp>M2</scp>balance in diabetic foot ulcers
10.1111/1753-0407.70205 · 2026 · External reference
Regulation of nuclear factor erythroid-2-related factor 2 as a potential therapeutic target in intracerebral hemorrhage
10.3389/fnmol.2022.995518 · 2022 · External reference
New insights into fibrosis from the ECM degradation perspective: The macrophage-MMP-ECM interaction
10.1186/s13578-022-00856-w · 2022 · External reference
Flavonoids as potential wound-healing molecules: Emphasis on pathways perspective
10.3390/ijms24054607 · 2023 · External reference
Oxidative stress and redox signaling in the pathophysiology of liver diseases
10.1002/j.2040-4603.2022.tb00210.x · ExternalCitation · doi-reference
Extracellular matrix turnover: Phytochemicals target and modulate the dual role of matrix metalloproteinases (<scp>MMPs</scp>) in liver fibrosis
10.1002/ptr.7959 · ExternalCitation · doi-reference
Strategies for enhancing vascularization of biomaterial-based scaffold in bone regeneration
10.1002/tcr.202200008 · ExternalCitation · doi-reference
Advancements in wound healing: Integrating biomolecules, drug delivery carriers, and targeted therapeutics for enhanced tissue repair
10.1007/s00203-024-03910-y · ExternalCitation · doi-reference
Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions
10.1007/s10787-024-01602-z · ExternalCitation · doi-reference
Polyphenols mitigating inflammatory mechanisms in inflammatory bowel disease (IBD): Focus on the NF-ƙB and JAK/STAT pathways
10.1007/s10787-024-01607-8 · ExternalCitation · doi-reference
Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: A comprehensive review
10.1007/s10787-024-01635-4 · ExternalCitation · doi-reference
Plant-derived bioactive compounds as key players in the modulation of immune-related conditions
10.1007/s11101-024-09955-7 · ExternalCitation · doi-reference
Medicinal plants and human health: A comprehensive review of bioactive compounds, therapeutic effects, and applications
10.1007/s11101-025-10194-7 · ExternalCitation · doi-reference
Nanotechnology-based biomedical devices in the cancer diagnostics and therapy
10.1007/s12032-025-02602-x · ExternalCitation · doi-reference
Redox signaling-mediated tumor extracellular matrix remodeling: Pleiotropic regulatory mechanisms
10.1007/s13402-023-00884-9 · ExternalCitation · doi-reference
The potential role of bioactive plant-based polyphenolic compounds and their delivery systems—as a promising opportunity for a new therapeutic solution for acute and chronic wound healing
10.1007/s40495-022-00296-7 · ExternalCitation · doi-reference
MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits
10.1016/j.bbapap.2005.08.017 · ExternalCitation · doi-reference
Toxicity testing in the era of induced pluripotent stem cells: A perspective regarding the use of patient-specific induced pluripotent stem cell–derived cardiomyocytes for cardiac safety evaluation
10.1016/j.cotox.2020.04.001 · ExternalCitation · doi-reference
Monocytes and macrophages: Origin, homing, differentiation, and functionality during inflammation
10.1016/j.heliyon.2024.e29686 · ExternalCitation · doi-reference
Recent development in nanoencapsulation and delivery of natural bioactives through chitosan scaffolds for various biological applications
10.1016/j.ijbiomac.2022.08.098 · ExternalCitation · doi-reference
Harnessing natural compounds and external stimuli for advanced wound healing: A review of combination therapy strategies
10.1016/j.jddst.2024.106172 · ExternalCitation · doi-reference
The multi-faceted potential of plant-derived metabolites as antimicrobial agents against multidrug-resistant pathogens
10.1016/j.micpath.2018.01.043 · ExternalCitation · doi-reference
Therapeutic reprogramming toward regenerative medicine
10.1021/acs.chemrev.4c00332 · ExternalCitation · doi-reference
Revolutionizing wound healing: Exploring s
10.1021/acs.molpharmaceut.3c01072 · ExternalCitation · doi-reference
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
10.1038/s41569-023-00946-3 · ExternalCitation · doi-reference
Engineering biomaterials to tailor the microenvironment for macrophage–endothelium interactions
10.1038/s41578-023-00591-9 · ExternalCitation · doi-reference
The wound microbiota: Microbial mechanisms of impaired wound healing and infection
10.1038/s41579-024-01035-z · ExternalCitation · doi-reference
Biology and therapeutic targeting of vascular endothelial growth factor A
10.1038/s41580-023-00631-w · ExternalCitation · doi-reference
Construction of multifunctional wound dressings with their application in chronic wound treatment
10.1039/d2bm00620k · ExternalCitation · doi-reference
Keratinocyte growth factor-based strategies for wound re-epithelialization
10.1089/ten.teb.2021.0030 · ExternalCitation · doi-reference
Epigenetic regulation of macrophage polarization in wound healing
10.1093/burnst/tkac057 · ExternalCitation · doi-reference
Insights into macrophage polarization and <scp>M1</scp>/<scp>M2</scp>balance in diabetic foot ulcers
10.1111/1753-0407.70205 · ExternalCitation · doi-reference
Macrophage metabolism: A wound-healing perspective
10.1111/imcb.12237 · ExternalCitation · doi-reference
Reactive oxygen species and antioxidants in wound healing: Mechanisms and therapeutic potential
10.1111/iwj.70330 · ExternalCitation · doi-reference
Recent advances in bioactive wound dressings
10.1111/wrr.13233 · ExternalCitation · doi-reference
Synergistic effects of incorporated additives in multifunctional dressings for chronic wound healing: An updated comprehensive review
10.1111/wrr.13238 · ExternalCitation · doi-reference
Imperfect wound healing sets the stage for chronic diseases
10.1126/science.adp2974 · ExternalCitation · doi-reference
Macrophages, inflammation, and insulin resistance
10.1146/annurev-physiol-021909-135846 · ExternalCitation · doi-reference
A comprehensive review of free radicals, oxidative stress, and antioxidants: Overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds
10.1155/2024/5594386 · ExternalCitation · doi-reference
Advanced wound healing with stimuli-responsive nanozymes: Mechanisms, design and applications
10.1186/s12951-025-03558-w · ExternalCitation · doi-reference
Chinese medicine boosts regenerative medicine in stem cell - based therapy
10.1186/s13287-025-04618-6 · ExternalCitation · doi-reference
New insights into fibrosis from the ECM degradation perspective: The macrophage-MMP-ECM interaction
10.1186/s13578-022-00856-w · ExternalCitation · doi-reference
Therapeutic potential of nanocarrier-mediated delivery of phytoconstituents for wound healing: Their current status and future perspective
10.1208/s12249-023-02616-6 · ExternalCitation · doi-reference
Potential of natural bioactives in wound healing: A comprehensive review
10.14719/pst.8055 · ExternalCitation · doi-reference
Macrophages as multifaceted orchestrators of tissue repair: Bridging inflammation, regeneration, and therapeutic innovation
10.2147/jir.s527764 · ExternalCitation · doi-reference
The biological processes during wound healing
10.2217/rme-2020-0066 · ExternalCitation · doi-reference
Multi-targeted pharmacological actions and nanodelivery strategies of Garcinia cambogia: From molecular mechanisms to disease treatment
10.3389/fchem.2025.1692386 · ExternalCitation · doi-reference
Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes
10.3389/fimmu.2023.1216321 · ExternalCitation · doi-reference
Regulation of nuclear factor erythroid-2-related factor 2 as a potential therapeutic target in intracerebral hemorrhage
10.3389/fnmol.2022.995518 · ExternalCitation · doi-reference
Plant bioactive compounds: Extraction, biological activities, immunological, nutritional aspects, food application, and human health benefits—A comprehensive review
10.3389/fnut.2025.1659743 · ExternalCitation · doi-reference
Polymicrobial infections and biofilms: Clinical significance and eradication strategies
10.3390/antibiotics11121731 · ExternalCitation · doi-reference
Multiple strategies for the application of medicinal plant-derived bioactive compounds in controlling microbial biofilm and virulence properties
10.3390/antibiotics14060555 · ExternalCitation · doi-reference
Approaches to enhancing antioxidant defense in plants
10.3390/antiox11050925 · ExternalCitation · doi-reference
Understanding and advancing wound healing in the era of multi-omic technology
10.3390/bioengineering13010051 · ExternalCitation · doi-reference
PI3K–AKT-targeting breast cancer treatments: Natural products and synthetic compounds
10.3390/biom13010093 · ExternalCitation · doi-reference
The Role of the extracellular matrix (ECM) in wound healing: A review
10.3390/biomimetics7030087 · ExternalCitation · doi-reference
The study of the extracellular matrix in chronic inflammation: A way to prevent cancer initiation?
10.3390/cancers14235903 · ExternalCitation · doi-reference
Oxidative stress in melanoma: Beneficial antioxidant and pro-oxidant therapeutic strategies
10.3390/cancers15113038 · ExternalCitation · doi-reference
Macrophage-mediated inflammation in skin wound healing
10.3390/cells11192953 · ExternalCitation · doi-reference
Role of the skin immune system in wound healing
10.3390/cells13070624 · ExternalCitation · doi-reference
Cellular and molecular mechanisms of wound repair: From biology to therapeutic innovation
10.3390/cells14231850 · ExternalCitation · doi-reference
Metalloproteinases and their inhibitors: Potential for the development of new therapeutics
10.3390/cells9051313 · ExternalCitation · doi-reference
Exploring the interplay of antioxidants, inflammation, and oxidative stress: Mechanisms, therapeutic potential, and clinical implications
10.3390/diseases13090309 · ExternalCitation · doi-reference
A comprehensive review of natural compounds for wound healing: targeting bioactivity perspective
10.3390/ijms23179573 · ExternalCitation · doi-reference
Nrf2 Activation: Involvement in central nervous system traumatic injuries. A promising therapeutic target of natural compounds
10.3390/ijms24010199 · ExternalCitation · doi-reference
Flavonoids as potential wound-healing molecules: Emphasis on pathways perspective
10.3390/ijms24054607 · ExternalCitation · doi-reference
Natural compounds and biomimetic engineering to influence fibroblast behavior in wound healing
10.3390/ijms25063274 · ExternalCitation · doi-reference
Reactive oxygen species (ROS)-mediated antibacterial oxidative therapies: Available methods to generate ROS and a Novel Option Proposal
10.3390/ijms25137182 · ExternalCitation · doi-reference
Flavonoids as promising natural compounds for combating bacterial infections
10.3390/ijms26062455 · ExternalCitation · doi-reference
Pro-inflammatory and anti-inflammatory interleukins in periodontitis: Molecular roles, immune crosstalk, and therapeutic perspectives
10.3390/ijms262010094 · ExternalCitation · doi-reference
Natural and synthetic polymeric biomaterials for application in wound management
10.3390/jfb14090455 · ExternalCitation · doi-reference
Cutaneous wound healing: An update from physiopathology to current therapies
10.3390/life11070665 · ExternalCitation · doi-reference
Phytochemicals and regulation of NF-kB in inflammatory bowel diseases: An overview of in vitro and in vivo effects
10.3390/metabo13010096 · ExternalCitation · doi-reference
Development of antibiofilm therapeutics strategies to overcome antimicrobial drug resistance
10.3390/microorganisms10020303 · ExternalCitation · doi-reference
Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents
10.3390/molecules27020349 · ExternalCitation · doi-reference
Technologies for solubility, dissolution and permeation enhancement of natural compounds
10.3390/ph15060653 · ExternalCitation · doi-reference
Advancements in skin delivery of natural bioactive products for wound management: A brief review of two decades
10.3390/pharmaceutics14051072 · ExternalCitation · doi-reference
Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing
10.4239/wjd.v16.i11.111400 · ExternalCitation · doi-reference
Medicinal plants and bioactive compounds: Traditional and modern approaches to wound healing
10.55640/ijmsdh-11-02-03 · ExternalCitation · doi-reference
Applications of injectable hemostatic materials in wound healing: Principles, strategies, performance requirements, and future perspectives
10.7150/thno.86930 · ExternalCitation · doi-reference