Research graph
References from Gene therapy in Huntington’s disease (HD). Local targets link to admitted publications; unresolved targets remain external evidence.
Data from ENROLL-HD: is the prevalence of juvenile and pediatric Huntington’s disease overestimated?
10.1016/j.parkreldis.2021.05.012 · 2021 · External reference
Guofang Xue, The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets
10.3389/fnagi.2024.1347987 · 2024 · External reference
Mitochondria and reactive oxygen species
10.1161/hypertensionaha.109.130054 · 2009 · External reference
RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA
10.1186/s40035-017-0101-9 · 2017 · External reference
Unresolved reference
2025 · External reference
CRISPR/Cas9 Mediated Therapeutic Approach in Huntington’s Disease
10.1007/s12035-022-03150-5 · 2023 · External reference
Astrocyte-neuron metabolic relationships: for better and for worse
10.1016/j.tins.2010.12.001 · 2011 · External reference
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
10.1038/s41587-019-0205-0 · 2019 · External reference
Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks
10.1016/j.jconrel.2023.07.027 · 2023 · External reference
Clinical management of neuropsychiatric symptoms of huntington disease: expert-based consensus guidelines on agitation, anxiety, apathy, psychosis and sleep disorders
10.3233/jhd-180293 · 2018 · External reference
Psychotropic medication use in Huntington’s disease: a retrospective cohort study
10.1016/j.parkreldis.2022.11.004 · 2022 · External reference
Rapid eye movement sleep disturbances in Huntington disease
10.1001/archneur.65.4.482 · 2008 · External reference
Juvenile Parkinson’s disease and its response to L-dopa therapy
10.1007/bf02251243 · 1990 · External reference
International guidelines for the treatment of Huntington’s disease
10.3389/fneur.2019.00710 · 2019 · External reference
The frequency of huntington disease and huntington disease-like 2 in the South African population
10.1159/000444020 · 2016 · External reference
Prevalence of juvenile-onset and pediatric Huntington’s disease and their availability and ability to participate in trials: a Dutch population and Enroll-HD observational study
10.3233/jhd-240034 · 2024 · External reference
Juvenile-Onset Huntington Disease Pathophysiology and Neurodevelopment: a Review
10.1002/mds.28823 · 2022 · External reference
Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity
10.1523/jneurosci.5831-12.2013 · 2013 · External reference
Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology
10.1016/j.neuron.2016.11.035 · 2017 · External reference
Huntingtin and the Synapse
10.3389/fncel.2021.689332 · 2021 · External reference
The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington’s disease
10.1016/j.jns.2020.117022 · 2020 · External reference
Huntingtin aggregation and toxicity in Huntington’s disease
10.1016/s0140-6736(03)13304-1 · 2003 · External reference
Huntington disease
10.1038/nrdp.2015.5 · 2015 · External reference
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
10.1523/jneurosci.13-10-04181.1993 · 1993 · External reference
Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner
10.1523/jneurosci.2126-08.2008 · 2008 · External reference
D1R- and D2R-Medium-Sized Spiny Neurons Diversity: insights Into Striatal Vulnerability to Huntington’s Disease Mutation
10.3389/fncel.2021.628010 · 2021 · External reference
Calcium signaling and neurodegenerative diseases
10.1016/j.molmed.2009.01.001 · 2009 · External reference
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington’s disease
10.1084/jem.20080178 · 2008 · External reference
The effects of modafinil on mood and cognition in Huntington’s disease
10.1007/s00213-008-1068-0 · 2008 · External reference
Pharmacologic Approaches for the Management of Apathy in Neurodegenerative Disorders
10.3389/fphar.2019.01581 · 2020 · External reference
Mutant huntingtin in glial cells exacerbates neurological symptoms of huntington disease mice
10.1074/jbc.m109.083287 · 2010 · External reference
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS
10.1038/s41591-019-0674-1 · 2020 · External reference
Mitochondrial Permeability Transition: a Molecular Lesion with Multiple Drug Targets
10.1016/j.tips.2018.11.004 · 2019 · External reference
Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
10.1073/pnas.92.15.7105 · 1995 · External reference
Recent advances in the management of choreas
10.1177/1756285612471700 · 2013 · External reference
A Systematic Review of Rehabilitation for Corticobulbar Symptoms in Adults with Huntington’s Disease
10.3233/jhd-190384 · 2020 · External reference
Late-onset Huntington’s disease with 40–42 CAG expansion
10.1007/s10072-019-04177-8 · 2020 · External reference
Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease
10.1016/j.jconrel.2024.01.011 · 2024 · External reference
Treating the whole body in Huntington’s disease
10.1016/s1474-4422(15)00177-5 · 2015 · External reference
Huntingtin as an essential integrator of intracellular vesicular trafficking
10.1016/j.tcb.2009.01.005 · 2009 · External reference
Huntingtin facilitates dynein/dynactin-mediated vesicle transport
10.1073/pnas.0610628104 · 2007 · External reference
The role of dopamine in huntington’s disease
10.1016/b978-0-444-63425-2.00010-6 · 2014 · External reference
What do we know about late onset Huntington’s disease?
10.3233/jhd-170247 · 2017 · External reference
Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons
10.1016/j.nbd.2005.12.007 · 2006 · External reference
Risk factors for the onset and progression of Huntington disease
10.1016/j.neuro.2017.01.005 · 2017 · External reference
Identification of preexisting adaptive immunity to Cas9 proteins in humans
10.1038/s41591-018-0326-x · 2019 · External reference
Dopamine imbalance in Huntington’s disease: a mechanism for the lack of behavioral flexibility
10.3389/fnins.2013.00114 · 2013 · External reference
Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
2023 · External reference
Latest advances on new promising molecular-based therapeutic approaches for Huntington’s disease
10.2478/jtim-2023-0142 · 2024 · External reference
Reassessing mirtazapine and akathisia: a case report on its efficacy in treating severe, treatment-resistant akathisia and a review of the evidence
10.1177/2050313x241299947 · 2024 · External reference
Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington’s disease
2024 · External reference
CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington’s disease
10.1016/j.nbd.2009.07.014 · 2009 · External reference
Indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease
10.1186/s40734-017-0051-5 · 2017 · External reference
Cognitive rehabilitation, self-management, psychotherapeutic and caregiver support interventions in progressive neurodegenerative conditions: a scoping review
10.3233/nre-172353 · 2019 · External reference
Treatment strategies for dystonia
10.1517/14656560903426171 · 2010 · External reference
Emerging Issues in AAV-Mediated In Vivo Gene Therapy
10.1016/j.omtm.2017.11.007 · 2018 · External reference
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
10.1038/emboj.2008.133 · 2008 · External reference
AAV1/2-mediated BDNF gene therapy in a transgenic rat model of Huntington’s disease
10.1038/gt.2015.113 · 2016 · External reference
Clinical and Molecular Features of Late Onset Huntington Disease in a Peruvian Cohort
10.3233/jhd-140119 · 2015 · External reference
The many faces of autophagy dysfunction in Huntington’s disease: from mechanism to therapy
10.1016/j.drudis.2014.02.014 · 2014 · External reference
A role for autophagy in Huntington’s disease
10.1016/j.nbd.2018.08.010 · 2019 · External reference
The choreography of neuroinflammation in Huntington’s disease
10.1016/j.it.2015.04.007 · 2015 · External reference
Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications
10.1016/j.apsb.2024.10.004 · 2025 · External reference
RNA Interference: a Tool for Querying Nervous System Function and an Emerging Therapy
10.1016/j.neuron.2007.02.020 · 2007 · External reference
A novel triplet-primed pcr assay to detect the full range of trinucleotide cag repeats in the huntingtin gene (Htt)
10.3390/ijms22041689 · 2021 · External reference
Review of deutetrabenazine: a novel treatment for chorea associated with Huntington’s disease
10.2147/dddt.s138828 · 2018 · External reference
Role of hypokinesia and bradykinesia in gait disturbances in Huntington’s disease: a biomechanical study
10.1007/s00415-005-0929-2 · 2006 · External reference
Astrocyte molecular signatures in Huntington’s disease
10.1126/scitranslmed.aaw8546 · 2019 · External reference
Relationship between the use of benzodiazepines and falls in older adults: a systematic review
10.1016/j.maturitas.2017.04.002 · 2017 · External reference
Therapy development in Huntington disease: from current strategies to emerging opportunities
10.1002/ajmg.a.38494 · 2018 · External reference
Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin
10.1016/j.celrep.2018.07.106 · 2018 · External reference
Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum
10.1016/j.nbd.2017.12.015 · 2018 · External reference
The potential of gene editing for Huntington’s disease
10.1016/j.tins.2023.02.005 · 2023 · External reference
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
10.1101/gad.1673408 · 2008 · External reference
Inactivation of the mouse huntington’s disease gene homolog Hdh
10.1126/science.7618107 · 1995 · External reference
Guidance on antipsychotic selection for agitation and aggressive behavior in persons with Huntington’s disease
10.1080/14737175.2024.2376836 · 2024 · External reference
Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice
10.15252/emmm.201910889 · 2020 · External reference
Huntington’s Disease and the Striatal Medium Spiny Neuron: cell-Autonomous and Non-Cell-Autonomous Mechanisms of Disease
10.1007/s13311-012-0112-2 · 2012 · External reference
CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model
10.1016/j.omtn.2019.07.009 · 2019 · External reference
Protective Effects of Antioxidants in Huntington’s Disease: an Extensive Review
10.1007/s12640-018-9989-9 · 2019 · External reference
Genetic topography and cortical cell loss in Huntington’s disease link development and neurodegeneration
10.1093/brain/awad275 · 2023 · External reference
Huntington’s Disease Clinical Trials Corner: April 2022
10.3233/jhd-229002 · 2022 · External reference
Huntington’s Disease Clinical Trials Corner: November 2022
10.3233/jhd-229006 · 2022 · External reference
Huntington’s Disease Clinical Trials Corner: March 2024
10.3233/jhd-240017 · 2024 · External reference
Huntington’s Disease Clinical Trials Corner: August 2023
10.3233/jhd-239001 · 2023 · External reference
Glutamate toxicity in the striatum of the R6/2 Huntington’s disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters
10.1016/j.nbd.2008.12.017 · 2009 · External reference
AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington’s Disease Minipig Model
10.1016/j.ymthe.2018.06.021 · 2018 · External reference
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington’s disease subjects
10.1093/hmg/ddq212 · 2010 · External reference
Huntington’s Disease Clinical Trials Update: september 2024
10.1177/18796397241293955 · 2024 · External reference
Huntington’s disease clinical trials update: march 2025
10.1177/18796397251337000 · 2025 · External reference
Novel Imaging Biomarkers for Huntington’s Disease and Other Hereditary Choreas
10.1007/s11910-018-0890-y · 2018 · External reference
Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
10.1038/s41467-021-24862-7 · 2021 · External reference
Current and Possible Future Therapeutic Options for Huntington’s Disease
10.1177/11795735221092517 · 2022 · External reference
Unresolved reference
2008 · External reference
Huntington’s Disease
10.1101/cshperspect.a007476 · 2011 · External reference
Mitochondrial quality control in neurodegenerative diseases: focus on Parkinson’s disease and Huntington’s disease
2018 · External reference
Tetrabenazine as anti-chorea therapy in Huntington Disease: an open-label continuation study. Huntington Study Group/TETRA-HD Investigators
10.1186/1471-2377-9-62 · 2009 · External reference
Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease
10.2147/ndt.s6430 · 2010 · External reference
Effect of deutetrabenazine on chorea among patients with huntington disease: A randomized clinical trial
10.1001/jama.2016.8655 · 2016 · External reference
Long-Term Efficacy and Safety of Deutetrabenazine for Chorea in Huntington’s Disease: results From the ARC-HD Open-label Study
10.1017/s1092852920002655 · 2021 · External reference
Physical Therapy and Exercise Interventions in Huntington’s Disease: a Mixed Methods Systematic Review
10.3233/jhd-170260 · 2017 · External reference
Supplemental Treatment for Huntington’s Disease with miR-132 that Is Deficient in Huntington’s Disease Brain
10.1016/j.omtn.2018.01.007 · 2018 · External reference
Natural history and burden of Huntington’s disease in the UK: a population-based cohort study
10.1111/ene.15385 · 2022 · External reference
Biological and clinical manifestations of juvenile Huntington’s disease: a retrospective analysis
10.1016/s1474-4422(18)30294-1 · 2018 · External reference
Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors
10.1136/jmg.2009.066399 · 2009 · External reference
The challenges and strategies of antisense oligonucleotide drug delivery
10.3390/biomedicines9040433 · 2021 · External reference
Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice
10.1073/pnas.1206506109 · 2012 · External reference
Huntington disease: advances in the understanding of its mechanisms
10.1016/j.prdoa.2020.100056 · 2020 · External reference
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
10.1016/j.cell.2004.06.018 · 2004 · External reference
RNA interference (RNAi)-based therapeutics for treatment of rare neurologic diseases
10.1016/j.mam.2022.101148 · 2023 · External reference
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
10.1038/ncb735 · 2002 · External reference
FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat
10.1093/hmg/ddy375 · 2019 · External reference
Stereopure ASOs: an unanticipated increase in selectivity for targeting mutant HTT
10.1016/j.omtn.2024.102312 · 2024 · External reference
Polyglutamine diseases and tansport problems
10.1001/archneur.62.1.46 · 2005 · External reference
Off-target effects in CRISPR/Cas9 gene editing
10.3389/fbioe.2023.1143157 · 2023 · External reference
Oxidative stress, mitochondrial damage and neurodegenerative diseases
2013 · External reference
The cryo-electron microscopy structure of huntingtin
10.1038/nature25502 · 2018 · External reference
Play it again, SAM: macrophages control peripheral fat metabolism
10.1016/j.it.2017.12.004 · 2018 · External reference
Neuroinflammation as a common feature of neurodegenerative disorders
10.3389/fphar.2019.01008 · 2019 · External reference
Botulinum Toxin in the Treatment of Cervical Dystonia
10.3389/dyst.2022.10655 · 2022 · External reference
Large animal models for Huntington’s disease research
2024 · External reference
Differential vulnerability of neurons in Huntington’s disease: the role of cell type-specific features
10.1111/j.1471-4159.2010.06672.x · 2010 · External reference
Glucose Metabolic Dysfunction in Neurodegenerative Diseases—New Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming
10.3390/ijms22115887 · 2021 · External reference
Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects
10.1007/s10495-019-01520-4 · 2019 · External reference
Proteostasis in Huntington’s disease: disease mechanisms and therapeutic opportunities
10.1038/aps.2018.11 · 2018 · External reference
The hunt for huntingtin function: interaction partners tell many different stories
10.1016/s0968-0004(03)00168-3 · 2003 · External reference
RNA interference improves motor and neuropathological abnormalities in a Huntington’s disease mouse model
10.1073/pnas.0501507102 · 2005 · External reference
Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment
10.1517/17425255.4.10.1265 · 2008 · External reference
KINECT 3: a phase 3 randomized, double-blind, placebo-controlled trial of valbenazine for tardive dyskinesia
10.1176/appi.ajp.2017.16091037 · 2017 · External reference
In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of huntington disease
10.1523/jneurosci.5599-08.2009 · 2009 · External reference
The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade
10.1186/s40478-022-01364-1 · 2022 · External reference
Microglia in neurodegeneration
10.1038/s41593-018-0242-x · 2018 · External reference
Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with β-tubulin: relevance to Huntington’s disease
10.1242/jcs.115.5.941 · 2002 · External reference
Genetic modifiers of Mendelian disease: huntington’s disease and the trinucleotide repeat disorders
10.1093/hmg/ddx261 · 2017 · External reference
De novo huntington disease caused by 26-44 CAG repeat expansion on a low-risk haplotype
10.1212/wnl.0b013e3182a4a4af · 2013 · External reference
A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in huntington’s disease
10.1093/hmg/ddt036 · 2013 · External reference
On Chorea
1872 · External reference
Cognition-oriented treatments and physical exercise on cognitive function in Huntington’s disease: a systematic review
10.1007/s00415-022-11516-x · 2023 · External reference
Clinical and Genetic Characteristics Associated With Survival Outcome in Late-Onset Huntington’s Disease in South Korea
10.3988/jcn.2023.0329 · 2024 · External reference
Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant HTT
10.1016/j.omtn.2024.102246 · 2024 · External reference
Genetic Modifiers in Neurodegeneration
10.1007/s40142-018-0133-1 · 2018 · External reference
Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific
10.1002/glia.23050 · 2017 · External reference
Neuroinflammation in Huntington’s disease: from animal models to clinical therapeutics
10.3389/fimmu.2022.1088124 · 2022 · External reference
From Pathogenesis to Therapeutics: a Review of 150 Years of Huntington’s Disease Research
10.3390/ijms241613021 · 2023 · External reference
Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington’s disease model
2024 · External reference
Challenges in scaling up AAV-based gene therapy manufacturing
10.1016/j.tibtech.2023.04.002 · 2023 · External reference
Dynamics of Cortical Degeneration Over a Decade in Huntington’s Disease
10.1016/j.biopsych.2020.11.009 · 2021 · External reference
Seven cases of huntington’s disease in childhood and levodopa induced improvement in the hypokinetic — rigid form
10.1016/0303-8467(80)90017-7 · 1980 · External reference
The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain
10.1016/j.str.2020.06.008 · 2020 · External reference
Insights into the Pathogenesis of Neurodegenerative Diseases: focus on Mitochondrial Dysfunction and Oxidative Stress
10.3390/ijms222111847 · 2021 · External reference
Molecular Pathophysiological Mechanisms in Huntington’s Disease
10.3390/biomedicines10061432 · 2022 · External reference
Clinical Markers May Identify Patients at Risk for Early Parkinson’s Disease Dementia: a Prospective Study
10.1177/15333175211021369 · 2021 · External reference
Primary cilia and autophagic dysfunction in Huntington’s disease
10.1038/cdd.2015.80 · 2015 · External reference
Altered regulation of striatal neuronal N-methyl-D-aspartate receptor trafficking by palmitoylation in Huntington disease mouse model
10.3389/fnsyn.2019.00003 · 2019 · External reference
Irritability in Huntington’s Disease
10.3233/jhd-200397 · 2020 · External reference
Huntington’s Disease-Related Mortality Patterns: a Two-Decade Analysis of Mortality Trends in the United States, from 1999–2019
10.3233/jhd-240037 · 2024 · External reference
Epidemiology of Huntington disease
10.1016/b978-0-12-801893-4.00003-1 · 2017 · External reference
Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites
2021 · External reference
Cellular Analysis of Silencing the Huntington’s Disease Gene Using AAV9 Mediated Delivery of Artificial Micro RNA into the Striatum of Q140/Q140 Mice
10.3233/jhd-160215 · 2016 · External reference
AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease
10.1016/j.ymthe.2004.02.016 · 2004 · External reference
The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease
10.1016/j.ajhg.2015.12.018 · 2016 · External reference
Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease
10.1016/j.tins.2017.05.002 · 2017 · External reference
Oligonucleotide therapies for disorders of the nervous system
10.1038/nbt.3784 · 2017 · External reference
The role of IκB kinase complex in the neurobiology of Huntington’s disease
10.1016/j.nbd.2011.04.015 · 2011 · External reference
Survival of Korean Huntington’s Disease Patients
10.14802/jmd.16022 · 2016 · External reference
Posttranscriptional regulation of FAN1 by miR-124-3p at rs3512 underlies onset-delaying genetic modification in Huntington’s disease
10.1073/pnas.2322924121 · 2024 · External reference
Dysfunctional striatal dopamine signaling in Huntington’s disease
10.1002/jnr.24495 · 2019 · External reference
Huntingtin Aggregates and Mitochondrial Pathology in Skeletal Muscle but not Heart of Late-Stage R6/2 Mice
10.3233/jhd-180324 · 2019 · External reference
Sustained Therapeutic Reversal of Huntington’s Disease by Transient Repression of Huntingtin Synthesis
10.1016/j.neuron.2012.05.009 · 2012 · External reference
Late-onset Huntington’s disease: diagnostic and prognostic considerations
10.1016/j.parkreldis.2014.03.017 · 2014 · External reference
Huntington’s disease: pathogenesis to animal models
10.1016/s1734-1140(10)70238-3 · 2010 · External reference
Huntingtin and the molecular pathogenesis of Huntington’s disease
10.1038/sj.embor.7400250 · 2004 · External reference
Wild-type huntingtin protects neurons from excitotoxicity
10.1111/j.1471-4159.2005.03605.x · 2006 · External reference
Function and therapeutic value of astrocytes in neurological diseases
10.1038/s41573-022-00390-x · 2022 · External reference
Identification of genetic factors that modify clinical onset of huntington’s disease
10.1016/j.cell.2015.07.003 · 2015 · External reference
CAG repeat, not polyglutamine length, determines timing of Huntington’s disease onset
10.1016/j.cell.2019.06.036 · 2019 · External reference
Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington’s disease mouse model
10.1016/j.nbd.2013.06.002 · 2013 · External reference
Interaction of Huntington disease protein with transcriptional activator Sp1
10.1128/mcb.22.5.1277-1287.2002 · 2002 · External reference
Huntingtin-protein interactions and the pathogenesis of Huntington’s disease
10.1016/j.tig.2004.01.008 · 2004 · External reference
CRISPR-Cas9-mediated homology-directed repair for precise gene editing
10.1016/j.omtn.2024.102344 · 2024 · External reference
Reactive astrocytes: production, function, and therapeutic potential
10.1016/j.immuni.2017.06.006 · 2017 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
Impaired glutamate uptake in the R6 Huntington’s disease transgenic mice
10.1006/nbdi.2001.0430 · 2001 · External reference
The first patient with sporadic Huntington’s disease due to a de novo (CAG)n expansion in China
10.2478/jtim-2022-0006 · 2022 · External reference
Customizable virus-like particles deliver CRISPR–Cas9 ribonucleoprotein for effective ocular neovascular and Huntington’s disease gene therapy
10.1038/s41565-024-01851-7 · 2025 · External reference
Motor onset and diagnosis in Huntington disease using the diagnostic confidence level
10.1007/s00415-015-7900-7 · 2015 · External reference
Huntingtin silencing delays onset and slows progression of Huntington’s disease: a biomarker study
10.1093/brain/awab190 · 2021 · External reference
An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin
10.1038/nn.3080 · 2012 · External reference
Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting
10.3389/fcell.2020.576592 · 2020 · External reference
Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution
10.15252/embj.201696380 · 2018 · External reference
Amantadine in Huntington’s disease: open-label video-blinded study
10.1007/s100720200081 · 2002 · External reference
Huntingtin promotes cell survival by preventing Pak2 cleavage
10.1242/jcs.050013 · 2009 · External reference
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes
10.1016/0092-8674(93)90585-e · 1993 · External reference
Cause or compensation?—Altered neuronal Ca2+ handling in Huntington’s disease
10.1111/cns.12817 · 2018 · External reference
Amantadine in the akinetic-rigid variant of Huntington’s disease
10.1345/aph.1e004 · 2004 · External reference
Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models
10.1007/s00424-018-2123-2 · 2018 · External reference
Impaired α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant Huntingtin
10.1074/jbc.m111.236521 · 2011 · External reference
The Huntington’s disease mutation impairs Huntingtin’s role in the transport of NF-κB from the synapse to the nucleus
10.1093/hmg/ddq358 · 2010 · External reference
Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
10.1038/nn.2528 · 2010 · External reference
Cognitive phenotype and neurodegeneration associated with Tau in Huntington’s disease
10.1002/acn3.52031 · 2024 · External reference
Antipsychotic-induced movement disorders: evaluation and treatment
2005 · External reference
Base editing of trinucleotide repeats that cause Huntington’s disease and Friedreich’s ataxia reduces somatic repeat expansions in patient cells and in mice
2025 · External reference
Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the httQ140/Q140 mouse model of Huntington’s disease
10.1016/j.nbd.2019.104637 · 2020 · External reference
Huntington’s disease: a clinical review
10.1111/ene.13413 · 2018 · External reference
Tominersen in Adults with Manifest Huntington’s Disease
10.1056/nejmc2300400 · 2023 · External reference
Huntington’s disease
2024 · External reference
Splice modulators target PMS1 to reduce somatic expansion of the Huntington’s disease-associated CAG repeat
10.1038/s41467-024-47485-0 · 2024 · External reference
Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and activates autophagy
10.1074/jbc.m113.536912 · 2014 · External reference
Prevalence and Incidence of Huntington’s Disease: an Updated Systematic Review and Meta‐Analysis
10.1002/mds.29228 · 2022 · External reference
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