Research graph
References from Gene therapy in Alzheimer’s disease (AD). Local targets link to admitted publications; unresolved targets remain external evidence.
High-dose AAV gene therapy deaths
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Modeling Alzheimer’s Disease in Caenorhabditis elegans
10.3390/biomedicines10020288 · 2022 · External reference
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
10.1038/s41593-020-0650-6 · 2020 · External reference
ApolipoproteinE4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice
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Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human β-amyloid precursor protein
10.1016/s0006-8993(02)03262-6 · 2002 · External reference
Gene therapy clinical trials, where do we go? An overview
10.1016/j.biopha.2022.113324 · 2022 · External reference
Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer’s disease pathology in transgenic mouse model
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Probing the Biology of Alzheimer’s Disease in Mice
10.1016/j.neuron.2010.04.031 · 2010 · External reference
Current and Future Treatments in Alzheimer’s Disease
10.1055/s-0039-1678581 · 2019 · External reference
The role of APOE in transgenic mouse models of AD
10.1016/j.neulet.2019.134285 · 2019 · External reference
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
10.1186/s13195-022-01144-y · 2023 · External reference
miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease
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Genetics of Alzheimer disease
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Temporal and regional progression of Alzheimer’s disease‐like pathology in 3xTg‐AD mice
10.1111/acel.12873 · 2019 · External reference
Transport pathways for clearance of human Alzheimer’s amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system
10.1038/sj.jcbfm.9600419 · 2007 · External reference
New insights into the genetic etiology of Alzheimer’s disease and related dementias
10.1038/s41588-022-01024-z · 2022 · External reference
Reducing human Apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice
10.1523/jneurosci.0033-12.2012 · 2012 · External reference
Intraneuronal Aβ causes the onset of early Alzheimer’s disease-related cognitive deficits in transgenic mice
10.1016/j.neuron.2005.01.040 · 2005 · External reference
Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons
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APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
10.1038/s41586-022-05439-w · 2022 · External reference
APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s disease
10.1038/s41380-021-01076-3 · 2021 · External reference
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice
10.1093/brain/awx272 · 2017 · External reference
The Relationship between the Aberrant Long Non-Coding RNA-Mediated Competitive Endogenous RNA Network and Alzheimer’s Disease Pathogenesis
10.3390/ijms23158497 · 2022 · External reference
TREM2 regulates microglial cell activation in response to demyelination in vivo
10.1007/s00401-015-1388-1 · 2015 · External reference
Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice
10.1210/en.2007-1346 · 2008 · External reference
Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Aβ deposits in APP + PS1 transgenic mice
10.1038/mt.2008.148 · 2008 · External reference
Postmortem analysis in a clinical trial of AAV2-NGF gene therapy for Alzheimer’s disease identifies a need for improved vector delivery
10.1089/hum.2019.367 · 2020 · External reference
Advances in epigenetics link genetics to the environment and disease
10.1038/s41586-019-1411-0 · 2019 · External reference
A mouse model of Alzheimer’s disease displays increased susceptibility to kindling and seizure-associated death
10.1111/epi.12993 · 2015 · External reference
Intranasal interferon beta improves memory and modulates inflammatory responses in a mutant APP-overexpressing rat model of Alzheimer’s disease
10.1016/j.brainresbull.2019.06.015 · 2019 · External reference
Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration
10.1523/jneurosci.15-04-02819.1995 · 1995 · External reference
Transfer of three transcription factors via a lentiviral vector ameliorates spatial learning and memory impairment in a mouse model of Alzheimer’s disease
10.1016/j.gene.2016.04.032 · 2016 · External reference
Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
10.1074/jbc.m100710200 · 2001 · External reference
N-Acetyl Aspartate: a Marker for Neuronal Loss or Mitochondrial Dysfunction
10.1159/000017321 · 1998 · External reference
Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer’s Disease: from Early to Advanced Pathological Stages
10.1371/journal.pone.0130177 · 2015 · External reference
Memory recovery through gene therapy with a single chain antibody fragment selective for Aβ oligomers in a model of Alzheimer’s disease in rats
10.17981/jacn.4.1.2023.2 · 2023 · External reference
APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress
10.1016/s0197-4580(02)00016-7 · 2002 · External reference
Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation
10.1073/pnas.98.4.1941 · 2001 · External reference
Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport
10.1523/jneurosci.17-07-02295.1997 · 1997 · External reference
Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia
10.1016/j.neurobiolaging.2013.12.023 · 2014 · External reference
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families
10.1126/science.8346443 · 1993 · External reference
Reduction of cortical TrkA but not p75 NTR protein in early-stage Alzheimer’s disease
10.1002/ana.20233 · 2004 · External reference
Locus‐specific mutation databases for neurodegenerative brain diseases
10.1002/humu.22117 · 2012 · External reference
Apolipoprotein E polymorphism and atherosclerosis
10.1161/01.atv.8.1.1 · 1988 · External reference
Aged Tg2576 mice are impaired on social memory and open field habituation tests
10.1016/j.bbr.2008.09.042 · 2009 · External reference
apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain
10.1172/jci36663 · 2008 · External reference
Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice
10.1371/journal.pone.0012974 · 2010 · External reference
Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer’s disease
10.1073/pnas.0409072102 · 2005 · External reference
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
10.1038/s41551-021-00759-0 · 2022 · External reference
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
10.1038/s41551-021-00759-0 · 2022 · External reference
Upper airway dysfunction of tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei
10.1523/jneurosci.5261-09.2010 · 2010 · External reference
Degradation of the Alzheimer’s Amyloid β Peptide by Endothelin-converting Enzyme
10.1074/jbc.m007579200 · 2001 · External reference
Alzheimer’s disease β-amyloid peptide is increased in mice deficient in endothelin-converting enzyme
10.1074/jbc.c200642200 · 2003 · External reference
Neprilysin: an enzyme candidate to slow the progression of Alzheimer’s disease
10.2353/ajpath.2008.070620 · 2008 · External reference
Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease
10.1007/s11481-016-9721-6 · 2017 · External reference
A portrait of Alzheimer secretases - New features and familiar faces
10.1126/science.1064638 · 2001 · External reference
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
10.1073/pnas.0230450100 · 2003 · External reference
Role of Genetics and Epigenetics in the Pathogenesis of Alzheimer’s Disease and Frontotemporal Dementia
10.3233/jad-170702 · 2018 · External reference
Modeling the complex pathology of Alzheimer’s disease in Drosophila
10.1016/j.expneurol.2015.05.013 · 2015 · External reference
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
10.1038/329065a0 · 1987 · External reference
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
10.1186/s13024-020-00394-4 · 2020 · External reference
“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician
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Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
10.1038/s41597-021-01054-y · 2021 · External reference
Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases
10.3390/antiox9111095 · 2020 · External reference
Differences in Synaptic Dysfunction between rTg4510 and APP/PS1 Mouse Models of Alzheimer’s Disease
10.3233/jad-170457 · 2018 · External reference
Gender-Specific Neuroimmunoendocrine Aging in a Triple-Transgenic 3×Tg-AD Mouse Model for Alzheimer’s Disease and Its Relation with Longevity
10.1159/000156475 · 2008 · External reference
Investigation of the Molecular Role of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease
10.1007/s12031-021-01824-8 · 2022 · External reference
Rodent models for Alzheimer disease
10.1038/s41583-018-0054-8 · 2018 · External reference
Animal models of Alzheimer’s disease and frontotemporal dementia
10.1038/nrn2420 · 2008 · External reference
A TgCRND8 Mouse Model of Alzheimer’s Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve
10.3233/jad-150587 · 2016 · External reference
Neprilysin and Aβ clearance: impact of the APP intracellular domain in NEP regulation and implications in Alzheimer’s disease
10.3389/fnagi.2013.00098 · 2013 · External reference
Myelin changes at the early stage of 5XFAD mice
10.1016/j.brainresbull.2017.12.013 · 2018 · External reference
Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer’s disease
10.1002/jnr.21944 · 2009 · External reference
The genetic architecture of Alzheimer’s disease: beyond APP, PSENS and APOE
10.1016/j.neurobiolaging.2010.03.025 · 2012 · External reference
Sex specific molecular networks and key drivers of Alzheimer’s disease
10.1186/s13024-023-00624-5 · 2023 · External reference
Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer׳s disease
10.1016/j.apsb.2018.12.010 · 2019 · External reference
F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice
10.1016/j.neuroscience.2012.07.038 · 2012 · External reference
Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: a Novel Therapeutic Approach to Alzheimer Disease
10.1371/journal.pmed.0040262 · 2007 · External reference
Adeno-associated virus 9-mediated Cdk5 inhibitory peptide reverses pathologic changes and behavioral deficits in the Alzheimer’s disease mouse model
10.1096/fj.201700064r · 2017 · External reference
Distinct brain pathologies associated with Alzheimer’s disease biomarker-related phospho-tau 181 and phospho-tau 217 in App knock-in mouse models of amyloid-β amyloidosis
10.1093/braincomms/fcac286 · 2022 · External reference
Novel activity of endothelin-converting enzyme: hydrolysis of bradykinin
10.1042/bj3270023 · 1997 · External reference
Proteopathic tau seeding predicts tauopathy in vivo
10.1073/pnas.1411649111 · 2014 · External reference
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF
10.1016/0896-6273(92)90184-f · 1992 · External reference
Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein
10.1074/jbc.m708362200 · 2008 · External reference
Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein
10.1016/j.bbrc.2009.05.131 · 2009 · External reference
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
10.1126/science.274.5284.99 · 1996 · External reference
Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice
10.1523/eneuro.0247-22.2022 · 2022 · External reference
Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age
10.1016/j.neurobiolaging.2021.12.009 · 2022 · External reference
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
10.1186/s13024-019-0337-1 · 2019 · External reference
Sendai virus vector‐mediated brain‐derived neurotrophic factor expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer’s disease
10.1002/jnr.22830 · 2012 · External reference
Altered CpG methylation in sporadic Alzheimer’s disease is associated with APP and MAPT dysregulation
10.1093/hmg/ddt451 · 2014 · External reference
Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain
10.1523/jneurosci.4792-03.2004 · 2004 · External reference
Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer’s disease
10.1111/ejn.13442 · 2016 · External reference
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer’s disease
10.1073/pnas.0600948103 · 2006 · External reference
CSF Abeta42/Abeta40 and Abeta42/Abeta38 ratios: better diagnostic markers of Alzheimer disease
10.1002/acn3.274 · 2016 · External reference
APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
10.1016/j.neurobiolaging.2003.09.008 · 2004 · External reference
Practical considerations for choosing a mouse model of Alzheimer’s disease
10.1186/s13024-017-0231-7 · 2017 · External reference
Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains
10.1016/j.neurobiolaging.2015.05.010 · 2015 · External reference
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer’s disease
10.1038/35050110 · 2000 · External reference
Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer’s disease
10.1016/j.neurobiolaging.2010.05.027 · 2012 · External reference
The Emerging Role of Autophagy-Associated lncRNAs in the Pathogenesis of Neurodegenerative Diseases
10.3390/ijms24119686 · 2023 · External reference
Synaptic basis of Alzheimer’s disease: focus on synaptic amyloid beta, P-tau and mitochondria
10.1016/j.arr.2020.101208 · 2021 · External reference
Hydrolysis of peptide hormones by endothelin-converting enzyme-1: a comparison with neprilysin
10.1074/jbc.274.7.4053 · 1999 · External reference
Increased Alzheimer’s disease-like pathology in the APP/ PS1δE9mouse model lacking Nrf2 through modulation of autophagy
10.1016/j.neurobiolaging.2014.09.004 · 2015 · External reference
Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form
10.1016/s0304-3940(03)00898-x · 2003 · External reference
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer’s disease
10.1073/pnas.0908397106 · 2009 · External reference
Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer’s disease as well as in wild-type mice
10.1016/j.bbr.2015.05.002 · 2015 · External reference
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer’s disease
10.1038/npp.2009.197 · 2010 · External reference
Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model
10.1016/j.nbd.2008.10.006 · 2009 · External reference
Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer’s disease
10.1016/s0166-4328(99)00037-6 · 1999 · External reference
DNA Methylation As an Epigenetic Mechanism in the Development of Multiple Sclerosis
10.32607/actanaturae.11043 · 2021 · External reference
AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
10.1038/gt.2011.126 · 2012 · External reference
AAV2/1 CD74 gene transfer reduces β-amyloidosis and improves learning and memory in a mouse model of Alzheimer’s disease
10.1038/mt.2015.142 · 2015 · External reference
NGF gene transfer to intrinsic basal forebrain neurons increases cholinergic cell size and protects from age-related, spatial memory deficits in middle-aged rats
10.1016/s0006-8993(00)02634-2 · 2000 · External reference
Alterations in cholinergic and non‐cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with β‐amyloid plaque pathology
10.1016/j.ijdevneu.2003.08.001 · 2003 · External reference
Apo E structure determines VLDL clearance and atherosclerosis risk in mice
10.1172/jci6172 · 1999 · External reference
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer’s disease
10.1111/j.1601-183x.2005.00124.x · 2005 · External reference
Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age
10.1002/ana.21696 · 2009 · External reference
Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey
10.1523/jneurosci.10-12-03801.1990 · 1990 · External reference
Behavioural and psychological symptoms of dementia in mouse models of Alzheimer’s disease-related pathology
10.1016/j.neubiorev.2020.02.012 · 2020 · External reference
Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits
10.1038/s43587-023-00368-3 · 2023 · External reference
APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release
10.1016/j.celrep.2023.113252 · 2023 · External reference
Insulin resistance: a connecting link between Alzheimer’s disease and metabolic disorder
10.1007/s11011-020-00622-2 · 2021 · External reference
APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: a MRS and MRI study
10.1016/j.nicl.2017.06.009 · 2017 · External reference
Exploratory activity and spatial learning in 12-month-old APP695SWE/co+PS1/ΔE9mice with amyloid plaques
10.1016/j.neulet.2005.08.028 · 2005 · External reference
APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: a genetic screening study of familial and sporadic cases
10.1371/journal.pmed.1002270 · 2017 · External reference
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
10.1016/j.neuron.2016.09.022 · 2016 · External reference
Amyloid-β-activated microglia can induce compound proteinopathies
10.1093/brain/awae221 · 2024 · External reference
Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer’s disease
10.1093/aje/kwi202 · 2005 · External reference
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
10.1038/s41582-020-00435-y · 2021 · External reference
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
10.1073/pnas.1710311114 · 2017 · External reference
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
10.1038/s41392-021-00779-x · 2021 · External reference
Gene therapy in Aβ-induced cell and mouse models of Alzheimer’s disease through compensating defective mitochondrial complex I function
2024 · External reference
Study on Lentivirus-Mediated ABCA7 Improves Neurocognitive Function and Related Mechanisms in the C57BL/6 Mouse Model of Alzheimer’s Disease
10.1007/s12031-017-0889-x · 2017 · External reference
Expression of Neprilysin in Skeletal Muscle by Ultrasound-Mediated Gene Transfer (Sonoporation) Reduces Amyloid Burden for AD
10.1016/j.omtm.2019.12.012 · 2020 · External reference
Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
10.1371/journal.pone.0058752 · 2013 · External reference
AAV-based in vivo gene therapy for neurological disorders
10.1038/s41573-023-00766-7 · 2023 · External reference
ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
10.1186/1750-1326-8-16 · 2013 · External reference
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist
10.1016/j.neuron.2023.10.023 · 2024 · External reference
Apolipoprotein e and Alzheimer disease: risk, mechanisms and therapy
10.1038/nrneurol.2012.263 · 2013 · External reference
Alzheimer Disease: an Update on Pathobiology and Treatment Strategies
10.1016/j.cell.2019.09.001 · 2019 · External reference
Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study
10.1007/s00429-010-0295-4 · 2011 · External reference
P2Y1R silencing in Astrocytes Protected Neuroinflammation and Cognitive Decline in a Mouse Model of Alzheimer’s Disease
2024 · External reference
APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
10.1074/jbc.m306923200 · 2003 · External reference
Role of Nrf2 in Oxidative Stress and Toxicity
10.1146/annurev-pharmtox-011112-140320 · 2013 · External reference
Molecular Differences and Similarities between Alzheimer’s Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis
10.4137/bci.s13025 · 2013 · External reference
APOE4 confers transcriptomic and functional alterations to primary mouse microglia
10.1016/j.nbd.2022.105615 · 2022 · External reference
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer’s disease to AIDS
10.1194/jlr.r800069-jlr200 · 2009 · External reference
Alzheimer’s disease: clinical trials and drug development
10.1016/s1474-4422(10)70119-8 · 2010 · External reference
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer’s Disease
10.1016/j.neuron.2018.02.029 · 2018 · External reference
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal control
10.1016/j.neuron.2013.07.037 · 2013 · External reference
Early Structural and Functional Defects in Synapses and Myelinated Axons in Stratum Lacunosum Moleculare in Two Preclinical Models for Tauopathy
10.1371/journal.pone.0087605 · 2014 · External reference
Contributions of sex and genotype to exploratory behavior differences in an aged humanized APOE mouse model of late-onset Alzheimer’s disease
10.1101/lm.053588.122 · 2022 · External reference
Pathological tau disrupts ongoing network activity
10.1016/j.neuron.2015.01.025 · 2015 · External reference
Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus–seropositive individuals
10.1212/wnl.43.3_part_1.509 · 1993 · External reference
Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo
10.1073/pnas.1031520100 · 2003 · External reference
Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons
10.1016/0169-328x(86)90020-3 · 1986 · External reference
N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology
10.1016/j.pneurobio.2006.12.003 · 2007 · External reference
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β
10.1038/s43587-021-00073-z · 2021 · External reference
Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: implications for Alzheimer’s Disease
10.1016/j.neuron.2006.07.027 · 2006 · External reference
Intravenous Transplantation of Human Umbilical Cord Blood Mononuclear Cells Overexpressing Nerve Growth Factor Improves Spatial Memory in APP/PS1 Transgenic Mice with a Model of Alzheimer’s Disease
10.1007/s12668-017-0497-9 · 2018 · External reference
Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery
10.1016/j.expneurol.2008.10.004 · 2009 · External reference
Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease
10.1038/s41593-018-0101-9 · 2018 · External reference
Viral and nonviral delivery systems for gene delivery
10.4103/2277-9175.98152 · 2012 · External reference
Harnessing Genetic Complexity to Enhance Translatability of Alzheimer’s Disease Mouse Models: a Path toward Precision Medicine
10.1016/j.neuron.2018.11.040 · 2019 · External reference
Gene therapy in Alzheimer’s disease - potential for disease modification
10.1111/j.1582-4934.2010.01038.x · 2010 · External reference
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
10.1093/jnen/64.2.113 · 2005 · External reference
Autophagy failure in Alzheimer’s disease-locating the primary defect
10.1016/j.nbd.2011.01.021 · 2011 · External reference
Autophagy and neuronal cell death in neurological disorders
10.1101/cshperspect.a008839 · 2012 · External reference
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
10.1016/j.neuron.2019.12.007 · 2020 · External reference
Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer’s disease
10.1016/j.bbr.2017.09.009 · 2018 · External reference
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer’s Disease Mutations: potential Factors in Amyloid Plaque Formation
10.1523/jneurosci.1202-06.2006 · 2006 · External reference
Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: a MODEL-AD Study
10.3389/fnagi.2021.713726 · 2021 · External reference
Triple-transgenic model of Alzheimer’s Disease with plaques and tangles: intracellular Aβ and synaptic dysfunction
10.1016/s0896-6273(03)00434-3 · 2003 · External reference
TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis
10.4049/jimmunol.1102836 · 2012 · External reference
Glia-Neurotrophic Factor Relationships: possible Role in Pathobiology of Neuroinflammation-Related Brain Disorders
10.3390/ijms24076321 · 2023 · External reference
Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer’s disease pathology in aged squirrel monkeys
10.1093/brain/awab129 · 2021 · External reference
Leptin gene therapy attenuates neuronal damages evoked by amyloid-β and rescues memory deficits in APP/PS1 mice
10.1038/gt.2013.85 · 2014 · External reference
Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice
10.1016/j.nbd.2010.10.002 · 2011 · External reference
Effects of Transplanted Umbilical Cord Blood Mononuclear Cells Overexpressing GDNF on Spatial Memory and Hippocampal Synaptic Proteins in a Mouse Model of Alzheimer’s Disease
10.3233/jad-190150 · 2019 · External reference
Neuronal neprilysin overexpression is associated with attenuation of Aβ-related spatial memory deficit
10.1016/j.nbd.2006.08.003 · 2006 · External reference
TREM2 sustains microglial expansion during aging and response to demyelination
10.1172/jci77983 · 2015 · External reference
Dementia, and Cortical Deposition of β-Amyloid Protein
10.1056/nejm199511093331902 · 1995 · External reference
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