Research graph
References from Integrating structural and omics data for drug discovery. Local targets link to admitted publications; unresolved targets remain external evidence.
Graph neural network-based drug-drug interaction prediction
10.1038/s41598-025-12936-1 · 2025 · External reference
AI-driven polypharmacology in small-molecule drug discovery
10.3390/ijms26146996 · 2025 · External reference
Machine learning for drug-target interaction prediction: a comprehensive review of models, challenges, and computational strategies
10.1016/j.csbj.2025.12.033 · 2026 · External reference
Advancing drug safety in drug development: bridging computational predictions for enhanced toxicity prediction
10.1021/acs.chemrestox.3c00352 · 2024 · External reference
Challenges and opportunities in the network medicine of complex diseases
10.1016/j.medj.2025.100920 · 2026 · External reference
Designing RNA sequencing experiments: a practical guide to reproducible gene expression analysis
10.1016/j.csbj.2025.12.015 · 2026 · External reference
The role of pharmacogenomics in advancing personalised medicine: implications for drug efficacy safety and clinical practice integration
10.70749/ijbr.v3i5.1407 · 2025 · External reference
Biological breakthroughs and drug discovery revolution via cryo-electron microscopy of membrane proteins
10.3390/membranes15120368 · 2025 · External reference
Circulating tumor DNA to monitor treatment response in solid tumors and advance precision oncology
10.1038/s41698-025-00876-y · 2025 · External reference
10.1101/2025.09.04.674143
10.1101/2025.09.04.674143 · External reference
The current role and evolution of X-ray crystallography in drug discovery and development
10.1080/17460441.2023.2246881 · 2023 · External reference
PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins
10.1186/s13059-020-02089-x · 2020 · External reference
Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
10.1038/s41388-024-03077-2 · 2024 · External reference
An introduction to types of quasi-experimental designs
10.1097/01.naj.0001081740.74815.20 · 2024 · External reference
Decrypting allostery in membrane-bound K-Ras4B using complementary in silico approaches based on unbiased molecular dynamics simulations
10.1021/jacs.3c11396 · 2024 · External reference
Revisiting the genome-wide significance threshold for common variant GWAS
10.1093/g3journal/jkaa056 · 2021 · External reference
Protein-level batch-effect correction enhances robustness in MS-based proteomics
2025 · External reference
Genetic mutations and epigenetic modifications: driving cancer and informing precision medicine
10.1155/2017/9620870 · 2017 · External reference
Advances and trends in omics technology development
10.3389/fmed.2022.911861 · 2022 · External reference
Advancing targeted protein degradation for cancer therapy
10.1038/s41568-021-00365-x · 2021 · External reference
Affinity measurement of strong ligands with NMR spectroscopy: limitations and ways to overcome them
10.1016/j.pnmrs.2023.07.001 · 2023 · External reference
Thermodynamics and kinetics of drug-target binding by molecular simulation
10.1021/acs.chemrev.0c00534 · 2020 · External reference
Biomarker-driven approaches to bone metastases: from molecular mechanisms to clinical applications
10.3390/biomedicines13051160 · 2025 · External reference
Integrated network pharmacology approach for drug combination discovery: a multi-cancer case study
10.3390/cancers14082043 · 2022 · External reference
Mathematical modeling and inference of epidermal growth factor-induced mitogen-activated protein kinase cell signaling pathways
10.3390/ijms251810204 · 2024 · External reference
Network-based approaches for modeling disease regulation and progression
10.1016/j.csbj.2022.12.022 · 2023 · External reference
Use and misuse of corrections for multiple testing
10.1016/j.metip.2023.100120 · 2023 · External reference
Biological interacting units identified in human protein networks reveal tissue-functional diversification and its impact on disease
10.1016/j.csbj.2022.07.006 · 2022 · External reference
Implementing findable, accessible, interoperable, reusable (FAIR) principles in child and adolescent mental health research: mixed methods approach
10.2196/59113 · 2024 · External reference
H3K4me3, H3K9ac, H3K27ac, H3K27me3 and H3K9me3 histone tags suggest distinct regulatory evolution of open and condensed chromatin landmarks
10.3390/cells8091034 · 2019 · External reference
Machine learning-driven multiscale modeling: bridging the scales with a next-generation simulation infrastructure
10.1021/acs.jctc.2c01018 · 2023 · External reference
Multi-omics integration for the design of novel therapies and the identification of novel biomarkers
10.3390/proteomes11040034 · 2023 · External reference
Advances in personalized medicine: translating genomic insights into targeted therapies for cancer treatment
10.21037/atm-25-34 · 2025 · External reference
Costs and causes of oncology drug attrition with the example of insulin-like growth factor-1 receptor inhibitors
10.1001/jamanetworkopen.2023.24977 · 2023 · External reference
Accurate prediction of synergistic drug combination using a multi-source information fusion framework
10.1186/s12915-025-02302-y · 2025 · External reference
Novel targets, novel treatments: the changing landscape of non-small cell lung cancer
10.3390/cancers15102855 · 2023 · External reference
Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists
10.1038/s41467-024-49626-x · 2024 · External reference
Integrative multi-omics approach for improving causal gene identification
10.1002/gepi.22601 · 2025 · External reference
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation
10.1016/j.cell.2024.06.014 · 2024 · External reference
Network-based analyses of multiomics data in biomedicine
10.1186/s13040-025-00452-x · 2025 · External reference
GROMACS in the cloud: a global supercomputer to speed up alchemical drug design
10.1021/acs.jcim.2c00044 · 2022 · External reference
Kinase inhibitor treatment of patients with advanced cancer results in high tumor drug concentrations and in specific alterations of the tumor phosphoproteome
10.3390/cancers12020330 · 2020 · External reference
Computational frameworks integrating deep learning and statistical models in mining multimodal omics data
10.1016/j.jbi.2024.104629 · 2024 · External reference
1H-Detected Biomolecular NMR under Fast Magic-Angle Spinning
10.1021/acs.chemrev.1c00918 · 2022 · External reference
A recent update on small-molecule kinase inhibitors for targeted cancer therapy and their therapeutic insights from mass spectrometry-based proteomic analysis
10.1111/febs.16442 · 2023 · External reference
Evaluation of connectivity map shows limited reproducibility in drug repositioning
10.1038/s41598-021-97005-z · 2021 · External reference
Bridging discovery and treatment: cancer biomarker
10.3390/cancers17223720 · 2025 · External reference
Comparative analysis of cross-validation techniques: LOOCV, K-folds cross-validation, and repeated K-folds cross-validation in machine learning models
10.11648/j.ajtas.20241305.13 · 2024 · External reference
Dynamics-based drug discovery by time-resolved cryo-EM
10.1016/j.sbi.2025.103001 · 2025 · External reference
Untargeted metabolomic study by liquid chromatography–mass spectrometry in brain tissues on the effects of combined cocaine and ethanol self-administration in male and female young rats
10.1016/j.chroma.2023.464047 · 2023 · External reference
Tracing the evolution of sequencing into the era of genomic medicine
10.1038/s41576-025-00884-5 · 2025 · External reference
Epigenetic regulators in cancer therapy and progression
10.1038/s41698-025-01003-7 · 2025 · External reference
Enhancing structural insights for advanced drug discovery by mitigating protein crystal damage
10.1080/17460441.2025.2605354 · 2026 · External reference
Context-specific regulation and function of mRNA alternative polyadenylation
10.1038/s41580-022-00507-5 · 2022 · External reference
Advancements in single-cell RNA sequencing and spatial transcriptomics: transforming biomedical research
10.3389/abp.2025.13922 · 2025 · External reference
Revolutionizing personalized medicine: synergy with multi-omics data generation, main hurdles, and future perspectives
10.3390/biomedicines12122750 · 2024 · External reference
The potential role of metabolomics in drug-induced liver injury (DILI) assessment
10.3390/metabo12060564 · 2022 · External reference
The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture
10.1038/s41467-025-64347-5 · 2025 · External reference
Mechanistic and data-driven models of cell signaling: tools for fundamental discovery and rational design of therapy
10.1016/j.coisb.2021.05.010 · 2021 · External reference
New insights into protein–protein interaction modulators in drug discovery and therapeutic advance
10.1038/s41392-024-02036-3 · 2024 · External reference
Integrative computational approaches for discovery and evaluation of lead compound for drug design
10.3389/fddsv.2024.1362456 · 2024 · External reference
Advances in computational drug repurposing, driver genes, and therapeutics in lung adenocarcinoma
10.3390/biom15101373 · 2025 · External reference
Deep learning for small-molecule drug discovery: From molecular design to clinical translation
2025 · External reference
GWAS advancements to investigate disease associations and biological mechanisms
10.1002/ctd2.296 · 2024 · External reference
Perspectives on phenotypic screening−screen design and assay technology special interest group
10.1016/j.slasd.2024.02.001 · 2024 · External reference
Artificial intelligence in drug discovery and development
10.1016/j.drudis.2020.10.010 · 2021 · External reference
Genome-wide association studies: utility and limitations for research in physiology
10.1113/jp284241 · 2023 · External reference
Beyond single biomarkers: multi-omics strategies to predict immunotherapy outcomes in blood cancers
10.1007/s10238-025-01902-w · 2025 · External reference
AlphaFold and the future of structural biology
10.1107/s2052252523004943 · 2023 · External reference
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
10.1038/s41589-023-01459-3 · 2024 · External reference
Ångström-resolution fluorescence microscopy
10.1038/s41586-023-05925-9 · 2023 · External reference
CellEKT: a robust chemical proteomics workflow to profile cellular target engagement of kinase inhibitors
10.1016/j.mcpro.2025.100961 · 2025 · External reference
A comprehensive review of feature based methods for drug target interaction prediction
10.1016/j.jbi.2019.103159 · 2019 · External reference
Molecular dynamics simulations in drug discovery and pharmaceutical development
10.3390/pr9010071 · 2021 · External reference
Gene expression and protein abundance: Just how associated are these molecular traits?
10.1016/j.biotechadv.2025.108720 · 2026 · External reference
Genomic, transcriptomic and epigenomic analysis towards the understanding of porcine semen quality traits. Past, current and future trends
10.1016/j.anireprosci.2024.107543 · 2024 · External reference
Targeting pathological ERK1/2 signaling in cancer and beyond
10.1016/j.molmed.2025.08.001 · 2025 · External reference
The future of integrated structural biology
10.1016/j.str.2024.08.014 · 2024 · External reference
Synthetic biology in natural product biosynthesis
10.1021/acs.chemrev.4c00567 · 2025 · External reference
Determination of pleiotropic effect of warfarin in VKORC1 and CYP2C9 genotypes in patients with heart valve replacement
10.3389/fcvm.2022.895169 · 2022 · External reference
Unresolved reference
2023 · External reference
High-throughput computational screening for lead discovery and development
10.1016/bs.apha.2025.01.001 · 2025 · External reference
Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management
10.1038/s41392-023-01469-6 · 2023 · External reference
Bioinformatics models in drug delivery: predicting biomaterial-biological interactions for targeted therapies
10.1016/j.nxnano.2025.100335 · 2026 · External reference
Utilizing molecular dynamics simulations, machine learning, Cryo-EM, and NMR spectroscopy to predict and validate protein dynamics
10.3390/ijms25179725 · 2024 · External reference
Multi-omics data integration, interpretation, and its application
10.1177/1177932219899051 · 2020 · External reference
Why 90% of clinical drug development fails and how to improve it?
10.1016/j.apsb.2022.02.002 · 2022 · External reference
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
10.1038/s41588-021-00885-0 · 2021 · External reference
Pharmacogenetic testing for adverse drug reaction prevention: systematic review of economic evaluations and the appraisal of quality matters for clinical practice and implementation
10.1186/s12913-021-07025-8 · 2021 · External reference
Cryptic binding sites on proteins: definition, detection, and druggability
10.1016/j.cbpa.2018.05.003 · 2018 · External reference
Merging ligand-based and structure-based methods in drug discovery: an overview of combined virtual screening approaches
10.3390/molecules25204723 · 2020 · External reference
Phenotypic drug discovery: recent successes, lessons learned and new directions
10.1038/s41573-022-00472-w · 2022 · External reference
Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer
2025 · External reference
Genetic heterogeneity: challenges, impacts, and methods through an associative lens
10.1002/gepi.22497 · 2022 · External reference
Innovative strategies for anti-fibrotic drugs discovery from traditional Chinese medicine
2025 · External reference
Structure-based virtual screening in drug discovery
2023 · External reference
DNA methylation in human diseases
10.1016/j.heliyon.2024.e32366 · 2024 · External reference
Kinase atlas: druggability analysis of potential allosteric sites in kinases
10.1021/acs.jmedchem.9b00089 · 2019 · External reference
The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics
10.1371/journal.pcbi.0030059 · 2007 · External reference
10.1101/2025.10.13.682238
10.1101/2025.10.13.682238 · External reference
Lipidomics—paving the road towards better insight and precision medicine in rare metabolic diseases
10.3390/ijms24021709 · 2023 · External reference
Graph neural networks in modern AI-aided drug discovery
10.1021/acs.chemrev.5c00461 · 2025 · External reference
Artificial intelligence-driven drug toxicity prediction: advances, challenges, and future directions
10.3390/toxics13070525 · 2025 · External reference
Protein posttranslational modifications in health and diseases: functions, regulatory mechanisms, and therapeutic implications
10.1002/mco2.261 · 2023 · External reference
Costs and causes of oncology drug attrition with the example of insulin-like growth factor-1 receptor inhibitors
10.1001/jamanetworkopen.2023.24977 · ExternalCitation · doi-reference
GWAS advancements to investigate disease associations and biological mechanisms
10.1002/ctd2.296 · ExternalCitation · doi-reference
Genetic heterogeneity: challenges, impacts, and methods through an associative lens
10.1002/gepi.22497 · ExternalCitation · doi-reference
Integrative multi-omics approach for improving causal gene identification
10.1002/gepi.22601 · ExternalCitation · doi-reference
Protein posttranslational modifications in health and diseases: functions, regulatory mechanisms, and therapeutic implications
10.1002/mco2.261 · ExternalCitation · doi-reference
Beyond single biomarkers: multi-omics strategies to predict immunotherapy outcomes in blood cancers
10.1007/s10238-025-01902-w · ExternalCitation · doi-reference
High-throughput computational screening for lead discovery and development
10.1016/bs.apha.2025.01.001 · ExternalCitation · doi-reference
Genomic, transcriptomic and epigenomic analysis towards the understanding of porcine semen quality traits. Past, current and future trends
10.1016/j.anireprosci.2024.107543 · ExternalCitation · doi-reference
Why 90% of clinical drug development fails and how to improve it?
10.1016/j.apsb.2022.02.002 · ExternalCitation · doi-reference
Gene expression and protein abundance: Just how associated are these molecular traits?
10.1016/j.biotechadv.2025.108720 · ExternalCitation · doi-reference
Cryptic binding sites on proteins: definition, detection, and druggability
10.1016/j.cbpa.2018.05.003 · ExternalCitation · doi-reference
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation
10.1016/j.cell.2024.06.014 · ExternalCitation · doi-reference
Untargeted metabolomic study by liquid chromatography–mass spectrometry in brain tissues on the effects of combined cocaine and ethanol self-administration in male and female young rats
10.1016/j.chroma.2023.464047 · ExternalCitation · doi-reference
Mechanistic and data-driven models of cell signaling: tools for fundamental discovery and rational design of therapy
10.1016/j.coisb.2021.05.010 · ExternalCitation · doi-reference
Biological interacting units identified in human protein networks reveal tissue-functional diversification and its impact on disease
10.1016/j.csbj.2022.07.006 · ExternalCitation · doi-reference
Network-based approaches for modeling disease regulation and progression
10.1016/j.csbj.2022.12.022 · ExternalCitation · doi-reference
Designing RNA sequencing experiments: a practical guide to reproducible gene expression analysis
10.1016/j.csbj.2025.12.015 · ExternalCitation · doi-reference
Machine learning for drug-target interaction prediction: a comprehensive review of models, challenges, and computational strategies
10.1016/j.csbj.2025.12.033 · ExternalCitation · doi-reference
Artificial intelligence in drug discovery and development
10.1016/j.drudis.2020.10.010 · ExternalCitation · doi-reference
DNA methylation in human diseases
10.1016/j.heliyon.2024.e32366 · ExternalCitation · doi-reference
A comprehensive review of feature based methods for drug target interaction prediction
10.1016/j.jbi.2019.103159 · ExternalCitation · doi-reference
Computational frameworks integrating deep learning and statistical models in mining multimodal omics data
10.1016/j.jbi.2024.104629 · ExternalCitation · doi-reference
CellEKT: a robust chemical proteomics workflow to profile cellular target engagement of kinase inhibitors
10.1016/j.mcpro.2025.100961 · ExternalCitation · doi-reference
Challenges and opportunities in the network medicine of complex diseases
10.1016/j.medj.2025.100920 · ExternalCitation · doi-reference
Use and misuse of corrections for multiple testing
10.1016/j.metip.2023.100120 · ExternalCitation · doi-reference
Targeting pathological ERK1/2 signaling in cancer and beyond
10.1016/j.molmed.2025.08.001 · ExternalCitation · doi-reference
Bioinformatics models in drug delivery: predicting biomaterial-biological interactions for targeted therapies
10.1016/j.nxnano.2025.100335 · ExternalCitation · doi-reference
Affinity measurement of strong ligands with NMR spectroscopy: limitations and ways to overcome them
10.1016/j.pnmrs.2023.07.001 · ExternalCitation · doi-reference
Dynamics-based drug discovery by time-resolved cryo-EM
10.1016/j.sbi.2025.103001 · ExternalCitation · doi-reference
Perspectives on phenotypic screening−screen design and assay technology special interest group
10.1016/j.slasd.2024.02.001 · ExternalCitation · doi-reference
The future of integrated structural biology
10.1016/j.str.2024.08.014 · ExternalCitation · doi-reference
Advancing drug safety in drug development: bridging computational predictions for enhanced toxicity prediction
10.1021/acs.chemrestox.3c00352 · ExternalCitation · doi-reference
Thermodynamics and kinetics of drug-target binding by molecular simulation
10.1021/acs.chemrev.0c00534 · ExternalCitation · doi-reference
1H-Detected Biomolecular NMR under Fast Magic-Angle Spinning
10.1021/acs.chemrev.1c00918 · ExternalCitation · doi-reference
Synthetic biology in natural product biosynthesis
10.1021/acs.chemrev.4c00567 · ExternalCitation · doi-reference
Graph neural networks in modern AI-aided drug discovery
10.1021/acs.chemrev.5c00461 · ExternalCitation · doi-reference
GROMACS in the cloud: a global supercomputer to speed up alchemical drug design
10.1021/acs.jcim.2c00044 · ExternalCitation · doi-reference
Machine learning-driven multiscale modeling: bridging the scales with a next-generation simulation infrastructure
10.1021/acs.jctc.2c01018 · ExternalCitation · doi-reference
Kinase atlas: druggability analysis of potential allosteric sites in kinases
10.1021/acs.jmedchem.9b00089 · ExternalCitation · doi-reference
Decrypting allostery in membrane-bound K-Ras4B using complementary in silico approaches based on unbiased molecular dynamics simulations
10.1021/jacs.3c11396 · ExternalCitation · doi-reference
Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
10.1038/s41388-024-03077-2 · ExternalCitation · doi-reference
Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management
10.1038/s41392-023-01469-6 · ExternalCitation · doi-reference
New insights into protein–protein interaction modulators in drug discovery and therapeutic advance
10.1038/s41392-024-02036-3 · ExternalCitation · doi-reference
Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists
10.1038/s41467-024-49626-x · ExternalCitation · doi-reference
The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture
10.1038/s41467-025-64347-5 · ExternalCitation · doi-reference
Advancing targeted protein degradation for cancer therapy
10.1038/s41568-021-00365-x · ExternalCitation · doi-reference
Phenotypic drug discovery: recent successes, lessons learned and new directions
10.1038/s41573-022-00472-w · ExternalCitation · doi-reference
Tracing the evolution of sequencing into the era of genomic medicine
10.1038/s41576-025-00884-5 · ExternalCitation · doi-reference
Context-specific regulation and function of mRNA alternative polyadenylation
10.1038/s41580-022-00507-5 · ExternalCitation · doi-reference
Ångström-resolution fluorescence microscopy
10.1038/s41586-023-05925-9 · ExternalCitation · doi-reference
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
10.1038/s41588-021-00885-0 · ExternalCitation · doi-reference
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
10.1038/s41589-023-01459-3 · ExternalCitation · doi-reference
Evaluation of connectivity map shows limited reproducibility in drug repositioning
10.1038/s41598-021-97005-z · ExternalCitation · doi-reference
Graph neural network-based drug-drug interaction prediction
10.1038/s41598-025-12936-1 · ExternalCitation · doi-reference
Circulating tumor DNA to monitor treatment response in solid tumors and advance precision oncology
10.1038/s41698-025-00876-y · ExternalCitation · doi-reference
Epigenetic regulators in cancer therapy and progression
10.1038/s41698-025-01003-7 · ExternalCitation · doi-reference
The current role and evolution of X-ray crystallography in drug discovery and development
10.1080/17460441.2023.2246881 · ExternalCitation · doi-reference
Enhancing structural insights for advanced drug discovery by mitigating protein crystal damage
10.1080/17460441.2025.2605354 · ExternalCitation · doi-reference
Revisiting the genome-wide significance threshold for common variant GWAS
10.1093/g3journal/jkaa056 · ExternalCitation · doi-reference
An introduction to types of quasi-experimental designs
10.1097/01.naj.0001081740.74815.20 · ExternalCitation · doi-reference
10.1101/2025.09.04.674143
10.1101/2025.09.04.674143 · ExternalCitation · doi-reference
10.1101/2025.10.13.682238
10.1101/2025.10.13.682238 · ExternalCitation · doi-reference
AlphaFold and the future of structural biology
10.1107/s2052252523004943 · ExternalCitation · doi-reference
A recent update on small-molecule kinase inhibitors for targeted cancer therapy and their therapeutic insights from mass spectrometry-based proteomic analysis
10.1111/febs.16442 · ExternalCitation · doi-reference
Genome-wide association studies: utility and limitations for research in physiology
10.1113/jp284241 · ExternalCitation · doi-reference
Genetic mutations and epigenetic modifications: driving cancer and informing precision medicine
10.1155/2017/9620870 · ExternalCitation · doi-reference
Comparative analysis of cross-validation techniques: LOOCV, K-folds cross-validation, and repeated K-folds cross-validation in machine learning models
10.11648/j.ajtas.20241305.13 · ExternalCitation · doi-reference
Multi-omics data integration, interpretation, and its application
10.1177/1177932219899051 · ExternalCitation · doi-reference
Pharmacogenetic testing for adverse drug reaction prevention: systematic review of economic evaluations and the appraisal of quality matters for clinical practice and implementation
10.1186/s12913-021-07025-8 · ExternalCitation · doi-reference
Accurate prediction of synergistic drug combination using a multi-source information fusion framework
10.1186/s12915-025-02302-y · ExternalCitation · doi-reference
Network-based analyses of multiomics data in biomedicine
10.1186/s13040-025-00452-x · ExternalCitation · doi-reference
PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins
10.1186/s13059-020-02089-x · ExternalCitation · doi-reference
The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics
10.1371/journal.pcbi.0030059 · ExternalCitation · doi-reference
Advances in personalized medicine: translating genomic insights into targeted therapies for cancer treatment
10.21037/atm-25-34 · ExternalCitation · doi-reference
Implementing findable, accessible, interoperable, reusable (FAIR) principles in child and adolescent mental health research: mixed methods approach
10.2196/59113 · ExternalCitation · doi-reference
Advancements in single-cell RNA sequencing and spatial transcriptomics: transforming biomedical research
10.3389/abp.2025.13922 · ExternalCitation · doi-reference
Determination of pleiotropic effect of warfarin in VKORC1 and CYP2C9 genotypes in patients with heart valve replacement
10.3389/fcvm.2022.895169 · ExternalCitation · doi-reference
Integrative computational approaches for discovery and evaluation of lead compound for drug design
10.3389/fddsv.2024.1362456 · ExternalCitation · doi-reference
Advances and trends in omics technology development
10.3389/fmed.2022.911861 · ExternalCitation · doi-reference
Advances in computational drug repurposing, driver genes, and therapeutics in lung adenocarcinoma
10.3390/biom15101373 · ExternalCitation · doi-reference
Revolutionizing personalized medicine: synergy with multi-omics data generation, main hurdles, and future perspectives
10.3390/biomedicines12122750 · ExternalCitation · doi-reference
Biomarker-driven approaches to bone metastases: from molecular mechanisms to clinical applications
10.3390/biomedicines13051160 · ExternalCitation · doi-reference
Kinase inhibitor treatment of patients with advanced cancer results in high tumor drug concentrations and in specific alterations of the tumor phosphoproteome
10.3390/cancers12020330 · ExternalCitation · doi-reference
Integrated network pharmacology approach for drug combination discovery: a multi-cancer case study
10.3390/cancers14082043 · ExternalCitation · doi-reference
Novel targets, novel treatments: the changing landscape of non-small cell lung cancer
10.3390/cancers15102855 · ExternalCitation · doi-reference
Bridging discovery and treatment: cancer biomarker
10.3390/cancers17223720 · ExternalCitation · doi-reference
H3K4me3, H3K9ac, H3K27ac, H3K27me3 and H3K9me3 histone tags suggest distinct regulatory evolution of open and condensed chromatin landmarks
10.3390/cells8091034 · ExternalCitation · doi-reference
Lipidomics—paving the road towards better insight and precision medicine in rare metabolic diseases
10.3390/ijms24021709 · ExternalCitation · doi-reference
Utilizing molecular dynamics simulations, machine learning, Cryo-EM, and NMR spectroscopy to predict and validate protein dynamics
10.3390/ijms25179725 · ExternalCitation · doi-reference
Mathematical modeling and inference of epidermal growth factor-induced mitogen-activated protein kinase cell signaling pathways
10.3390/ijms251810204 · ExternalCitation · doi-reference
AI-driven polypharmacology in small-molecule drug discovery
10.3390/ijms26146996 · ExternalCitation · doi-reference
Biological breakthroughs and drug discovery revolution via cryo-electron microscopy of membrane proteins
10.3390/membranes15120368 · ExternalCitation · doi-reference
The potential role of metabolomics in drug-induced liver injury (DILI) assessment
10.3390/metabo12060564 · ExternalCitation · doi-reference
Merging ligand-based and structure-based methods in drug discovery: an overview of combined virtual screening approaches
10.3390/molecules25204723 · ExternalCitation · doi-reference
Molecular dynamics simulations in drug discovery and pharmaceutical development
10.3390/pr9010071 · ExternalCitation · doi-reference
Multi-omics integration for the design of novel therapies and the identification of novel biomarkers
10.3390/proteomes11040034 · ExternalCitation · doi-reference
Artificial intelligence-driven drug toxicity prediction: advances, challenges, and future directions
10.3390/toxics13070525 · ExternalCitation · doi-reference
The role of pharmacogenomics in advancing personalised medicine: implications for drug efficacy safety and clinical practice integration
10.70749/ijbr.v3i5.1407 · ExternalCitation · doi-reference