Research graph
References from Protein structural biology in precision medicine and clinical translation. Local targets link to admitted publications; unresolved targets remain external evidence.
Efficacy and safety of ensartinib in the treatment of non-small cell lung cancer: A systematic review of clinical trials
2025 · External reference
A structural biology community assessment of AlphaFold2 applications
10.1038/s41594-022-00849-w · 2022 · External reference
Recent advances in liquid chromatography–mass spectrometry (LC–MS) applications in biological and applied sciences
10.1002/ansa.70024 · 2025 · External reference
Molecular recognition of protein-ligand complexes: applications to drug design
10.1021/cr960370z · 1997 · External reference
Defactinib with avutometinib in patients with solid tumors: the phase 1 FRAME trial
10.1038/s41591-025-03763-y · 2025 · External reference
UniProt: the universal protein knowledgebase in 2021
10.1093/nar/gkaa1100 · 2021 · External reference
A structure-based drug discovery paradigm
10.3390/ijms20112783 · 2019 · External reference
The Protein Data Bank
10.1093/nar/28.1.235 · 2000 · External reference
The current role and evolution of X-ray crystallography in drug discovery and development
10.1080/17460441.2023.2246881 · 2023 · External reference
Avutometinib and Defactinib: First Approval
10.1007/s40265-025-02215-8 · 2025 · External reference
Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry
10.1107/s2052252517009241 · 2017 · External reference
Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
10.1038/s41388-024-03077-2 · 2024 · External reference
10.1093/nar/gky1004
10.1093/nar/gky1004 · External reference
Antibodies, viruses and vaccines
10.1038/nri891 · 2002 · External reference
Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design
10.1146/annurev-immunol-041015-055515 · 2016 · External reference
Analysis of shared underlying mechanism in neurodegenerative disease
10.3389/fnagi.2022.1006089 · 2022 · External reference
Small-angle X-ray scattering studies of enzymes
10.1016/j.cbpa.2022.102232 · 2023 · External reference
The origin, evolution and structure of the protein world
10.1042/bj20082063 · 2009 · External reference
Proteomes are of proteoforms: embracing the complexity
10.3390/proteomes9030038 · 2021 · External reference
Learning and actioning general principles of cancer cell drug sensitivity
10.1038/s41467-025-56827-5 · 2025 · External reference
Structural biology: a golden era
10.1371/journal.pbio.3002187 · 2023 · External reference
In silico approaches for drug repurposing in oncology: a scoping review
10.3389/fphar.2024.1400029 · 2024 · External reference
Protein-misfolding diseases and chaperone-based therapeutic approaches
10.1111/j.1742-4658.2006.05181.x · 2006 · External reference
Deep Learning–Based Multi-Omics Integration Robustly Predicts Survival in Liver Cancer
10.1158/1078-0432.ccr-17-0853 · 2018 · External reference
Human metabolic enzymes deficiency: a genetic mutation based approach
10.1155/2016/9828672 · 2016 · External reference
Reliability of docking-based virtual screening for GPCR ligands with homology modeled structures: a case study of the angiotensin II type I receptor
10.1021/acschemneuro.8b00489 · 2019 · External reference
The pathogenesis of IgA nephropathy and implications for treatment
10.1038/s41581-024-00885-3 · 2025 · External reference
Opportunities and obstacles for deep learning in biology and medicine
10.1098/rsif.2017.0387 · 2018 · External reference
Antibodies to watch in 2025
10.1080/19420862.2024.2443538 · 2025 · External reference
Protein biophysics: current limitations and prospects
10.3934/biophy.2025018 · 2025 · External reference
Advances in the clinical application of high-throughput proteomics
10.14218/erhm.2024.00006 · 2024 · External reference
The AlphaFold Database of Protein Structures: A Biologist’s Guide
10.1016/j.jmb.2021.167336 · 2022 · External reference
Mechanical unfolding of alpha- and beta-helical protein motifs
10.1039/c8sm02046a · 2019 · External reference
Sunvozertinib: First Approval
10.1007/s40265-023-01959-5 · 2023 · External reference
Personalized prediction of anticancer potential of non-oncology drugs through learning from genome derived molecular pathways
10.1038/s41698-025-00813-z · 2025 · External reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings
10.1021/acs.jcim.1c00203 · 2021 · External reference
Fragment-based drug discovery
10.1021/jm040031v · 2004 · External reference
Artificial intelligence driven protein design and sustainable nanomedicine for advanced theranostics
10.1016/j.bioactmat.2026.01.036 · 2026 · External reference
Precision medicine—are we there yet? A narrative review of precision medicine’s applicability in primary care
10.3390/jpm14040418 · 2024 · External reference
Structures of filaments from Pick’s disease reveal a novel tau protein fold
10.1038/s41586-018-0454-y · 2018 · External reference
Unresolved reference
External reference
Cryo-EM structures of tau filaments from Alzheimer's disease
10.1038/nature23002 · 2017 · External reference
NMR methods for structural studies of large monomeric and multimeric proteins
10.1016/j.sbi.2013.06.016 · 2013 · External reference
Insights into Disease-Associated Mutations in the Human Proteome through Protein Structural Analysis
10.1016/j.str.2015.03.028 · 2015 · External reference
Proteomics and its current application in biomedical area: concise review
10.1155/2024/4454744 · 2024 · External reference
Bacteria use structural imperfect mimicry to hijack the host interactome
10.1371/journal.pcbi.1008395 · 2020 · External reference
Identification of key ferroptosis-related genes and therapeutic target in nasopharyngeal carcinoma
10.3389/fgene.2025.1595456 · 2025 · External reference
Fragment-based drug discovery using NMR spectroscopy
10.1007/s10858-013-9740-z · 2013 · External reference
Taletrectinib: First Approval
10.1007/s40265-025-02256-z · 2026 · External reference
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
10.1016/s0140-6736(20)30183-5 · 2020 · External reference
Catalyzing protein folding by chaperones
10.3390/biology14101450 · 2025 · External reference
X-ray crystallography
2013 · External reference
Proteostasis failure in neurodegenerative diseases: focus on oxidative stress
10.1155/2020/5497046 · 2020 · External reference
Structural biology helps interpret variants of uncertain significance in genes causing endocrine and metabolic disorders
10.1210/js.2018-00077 · 2018 · External reference
Recombinant Enzyme Therapies: A Pioneering Approach to Combat Oxidative Stress-Related Diseases
2026 · External reference
Protein species and moonlighting proteins: very small changes in a protein's covalent structure can change its biochemical function
10.1016/j.jprot.2015.10.003 · 2016 · External reference
High-resolution protein modeling through Cryo-EM and AI: current trends and future perspectives – a review
10.3389/fmolb.2025.1688455 · 2025 · External reference
Dynamic allostery drives autocrine and paracrine TGF-β signaling
10.1016/j.cell.2024.08.036 · 2024 · External reference
The p53 pathway: origins, inactivation in cancer, and emerging therapeutic approaches
10.1146/annurev-biochem-060815-014710 · 2016 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Nogapendekin alfa Inbakicept: First Approval
10.1007/s40265-024-02060-1 · 2024 · External reference
Protein structure determination by racemic and quasi-racemic x-ray crystallography
2026 · External reference
Advances in structure-based vaccine design
10.1016/j.coviro.2013.05.010 · 2013 · External reference
Integrative analysis of 111 reference human epigenomes
10.1038/nature14248 · 2015 · External reference
Investigating cryptic binding sites by molecular dynamics simulations
10.1021/acs.accounts.9b00613 · 2020 · External reference
Tislelizumab: First Approval
10.1007/s40265-020-01286-z · 2020 · External reference
Nuclear magnetic resonance spectroscopy in clinical metabolomics and personalized medicine: current challenges and perspectives
2021 · External reference
Asymmetric predictive relationships across histone modifications
10.1038/s42256-022-00455-x · 2022 · External reference
Opportunities and challenges in design and optimization of protein function
10.1038/s41580-024-00718-y · 2024 · External reference
Mechanical signaling: molecular mechanisms, biological functions, diseases, and therapeutic targets
10.1002/mco2.70523 · 2025 · External reference
Exploiting an Interleukin-15 Heterodimeric Agonist (N803) for Effective Immunotherapy of Solid Malignancies
10.3390/cells12121611 · 2023 · External reference
Unresolved reference
External reference
MSV3d: database of human MisSense variants mapped to 3D protein structure
10.1093/database/bas018 · 2012 · External reference
Monoclonal Antibodies (mAbs) and Proteins: The Biologic Drugs Approved by the Food and Drug Administration (FDA) in 2024
10.3390/biomedicines13081962 · 2025 · External reference
Structure-function relations of human hemoglobins
10.1080/08998280.2006.11928171 · 2017 · External reference
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
10.1021/acs.chemrev.8b00532 · 2019 · External reference
Multiplex assessment of protein variant abundance by massively parallel sequencing
10.1038/s41588-018-0122-z · 2018 · External reference
Targeting protein–protein interfaces with peptides: the contribution of chemical combinatorial peptide library approaches
10.3390/ijms24097842 · 2023 · External reference
Uncovering protein function: from classification to complexes
10.1042/ebc20200108 · 2022 · External reference
Interactome3D: adding structural details to protein networks
10.1038/nmeth.2289 · 2013 · External reference
dSysMap: exploring the edgetic role of disease mutations
10.1038/nmeth.3289 · 2015 · External reference
Functional and structural insights into RAS effector proteins
10.1016/j.molcel.2024.06.027 · 2024 · External reference
An Intravenous Brain-Penetrant Enzyme Therapy for Mucopolysaccharidosis II
10.1056/nejmoa2508681 · 2026 · External reference
From proteomics to personalized medicine: the road ahead
10.1586/14789450.2016.1158107 · 2016 · External reference
Assessing molecular docking tools: understanding drug discovery and design
10.1186/s43094-025-00862-y · 2025 · External reference
Depemokimab, the first ultra-long-acting anti-IL-5 monoclonal antibody for severe eosinophilic asthma
10.1016/j.medj.2024.10.022 · 2024 · External reference
Allostery in disease and in drug discovery
10.1016/j.cell.2013.03.034 · 2013 · External reference
AlphaFold, artificial intelligence (AI), and allostery
10.1021/acs.jpcb.2c04346 · 2022 · External reference
Computing the Dynamic Supramolecular Structural Proteome
10.1371/journal.pcbi.1005290 · 2017 · External reference
PhyreRisk: A Dynamic Web Application to Bridge Genomics, Proteomics and 3D Structural Data to Guide Interpretation of Human Genetic Variants
10.1016/j.jmb.2019.04.043 · 2019 · External reference
Treatment of Neuronal Ceroid Lipofuscinosis Type 2 with Cerliponase Alfa: A Systematic Review and Single-Arm Meta-Analysis of Two Studies
10.1177/08830738251389180 · 2026 · External reference
The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases
10.1093/nar/gkt1115 · 2014 · External reference
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
10.1038/nature12796 · 2013 · External reference
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
10.1002/pro.3978 · 2021 · External reference
Structure-based drug designing and immunoinformatics approach for SARS-CoV-2
10.1126/sciadv.abb8097 · 2020 · External reference
U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors
10.1158/1078-0432.ccr-20-1630 · 2020 · External reference
Pharmacological chaperone therapy for lysosomal storage diseases
10.4155/fmc.14.40 · 2014 · External reference
Cross-linking mass spectrometry for investigating protein conformations and protein-protein interactions-a method for all seasons
10.1021/acs.chemrev.1c00786 · 2022 · External reference
Structural insight into protein–protein interactions between intestinal microbiome and host
10.1016/j.sbi.2022.102354 · 2022 · External reference
Multi-omics based and AI-driven drug repositioning for epigenetic therapy in female malignancies
10.1186/s12967-025-06856-x · 2025 · External reference
Sunvozertinib: a Promising Oral EGFR Inhibitor Approved for NSCLC with EGFR Ex20ins Mutations
10.1007/s10637-025-01588-7 · 2025 · External reference
Predict impact of single amino acid change upon protein structure
10.1186/1471-2164-13-s4-s4 · 2012 · External reference
Datopotamab deruxtecan: A novel antibody drug conjugate for triple-negative breast cancer
10.1016/j.heliyon.2024.e28385 · 2024 · External reference
The rise of molecular glues
10.1016/j.cell.2020.12.020 · 2021 · External reference
Structures of α-synuclein filaments from multiple system atrophy
10.1038/s41586-020-2317-6 · 2020 · External reference
Targeting drug resistance in colorectal cancer using peptide-based scaffolds: new frontiers in colorectal cancer therapy
2026 · External reference
A review on protein misfolding, aggregation and strategies to prevent related ailments
10.1016/j.ijbiomac.2017.07.116 · 2017 · External reference
Protein acylation: mechanisms, biological functions and therapeutic targets
10.1038/s41392-022-01245-y · 2022 · External reference
X-rays in the cryo-EM era: structural biology’s dynamic future
2015 · External reference
Enzyme technology in the food industry: molecular mechanisms, applications, and sustainable innovations
10.1002/fsn3.70927 · 2025 · External reference
DeepChrome: deep-learning for predicting gene expression from histone modifications
10.1093/bioinformatics/btw427 · 2016 · External reference
Antibody-Drug Conjugates as Novel Therapeutic Agents for Non-Small Cell Lung Carcinoma with or without Alterations in Oncogenic Drivers
10.1007/s40259-024-00660-7 · 2024 · External reference
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients
10.15252/emmm.202012697 · 2020 · External reference
Three-dimensional modeling of protein interactions and complexes is going ‘omics
10.1016/j.sbi.2011.01.005 · 2011 · External reference
Personalized Drug Therapy: Innovative Concept Guided With Proteoformics
10.1016/j.mcpro.2024.100737 · 2024 · External reference
The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets
10.1093/nar/gkaa1074 · 2021 · External reference
Unfreezing structural biology for drug discovery
10.1038/s41589-025-02047-3 · 2026 · External reference
Biophysical and mechanistic models for disease-causing protein variants
10.1016/j.tibs.2019.01.003 · 2019 · External reference
Clinical acquired resistance to krasg12c inhibition through a novel kras switch-ii pocket mutation and polyclonal alterations converging on ras–mapk reactivation
10.1158/2159-8290.cd-21-0365 · 2021 · External reference
On-demand biomanufacturing through synthetic biology approach
10.1016/j.mtbio.2022.100518 · 2023 · External reference
[EGFR Exon 20 Insertion Mutation: Research Status and New Treatment Strategies]
2024 · External reference
Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research
10.1016/j.neuron.2024.05.012 · 2024 · External reference
Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies
10.1038/s41413-025-00487-0 · 2026 · External reference
TP53 mutations in cancer: molecular features and therapeutic opportunities (Review)
10.3892/ijmm.2024.5448 · 2024 · External reference
Protein-Protein Docking: From Interaction to Interactome
10.1016/j.bpj.2014.08.033 · 2014 · External reference
10.1093/nar/gkaf1187
10.1093/nar/gkaf1187 · External reference
PDBe-KB: collaboratively defining the biological context of structural data
10.1093/nar/gkab988 · 2022 · External reference
Engineering an allosteric control of protein function
10.1021/acs.jpcb.0c11640 · 2021 · External reference
Transforming clinical research: the power of high-throughput omics integration
10.3390/proteomes12030025 · 2024 · External reference
Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
10.1016/j.cell.2020.02.058 · 2020 · External reference
Exploring human diseases and biological mechanisms by protein structure prediction and modeling
2016 · External reference
DeepDTAF: a deep learning method to predict protein–ligand binding affinity
10.1093/bib/bbab072 · 2021 · External reference
Pharmacokinetic Properties of a Once-Weekly Fixed-Ratio Combination of Insulin Icodec and Semaglutide Compared with Separate Administration of Each Component in Individuals with Type 2 Diabetes Mellitus
10.1007/s40261-024-01405-8 · 2024 · External reference
A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial
10.1038/s41591-025-03743-2 · 2025 · External reference
Ferroptosis research based on bibliometric and visual analysis: mechanism exploration and clinical application prospects in gastric cancer, prostate cancer, leukemia, and brain tumors
10.3389/fmed.2025.1640497 · 2025 · External reference
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions
10.1007/s00262-018-2160-x · 2018 · External reference
Development and mechanistic evaluation of cathepsin B-activatable peptide-drug conjugate PROTACs for targeted protein degradation in malignant tumors: advancing precision protein degradation therapeutics in oncology
10.1002/smll.202506562 · 2026 · External reference
Electrostatic interactions in protein structure, folding, binding, and condensation
10.1021/acs.chemrev.7b00305 · 2018 · External reference
Recent advances in liquid chromatography–mass spectrometry (LC–MS) applications in biological and applied sciences
10.1002/ansa.70024 · ExternalCitation · doi-reference
Enzyme technology in the food industry: molecular mechanisms, applications, and sustainable innovations
10.1002/fsn3.70927 · ExternalCitation · doi-reference
Mechanical signaling: molecular mechanisms, biological functions, diseases, and therapeutic targets
10.1002/mco2.70523 · ExternalCitation · doi-reference
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
10.1002/pro.3978 · ExternalCitation · doi-reference
Development and mechanistic evaluation of cathepsin B-activatable peptide-drug conjugate PROTACs for targeted protein degradation in malignant tumors: advancing precision protein degradation therapeutics in oncology
10.1002/smll.202506562 · ExternalCitation · doi-reference
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions
10.1007/s00262-018-2160-x · ExternalCitation · doi-reference
Sunvozertinib: a Promising Oral EGFR Inhibitor Approved for NSCLC with EGFR Ex20ins Mutations
10.1007/s10637-025-01588-7 · ExternalCitation · doi-reference
Fragment-based drug discovery using NMR spectroscopy
10.1007/s10858-013-9740-z · ExternalCitation · doi-reference
Antibody-Drug Conjugates as Novel Therapeutic Agents for Non-Small Cell Lung Carcinoma with or without Alterations in Oncogenic Drivers
10.1007/s40259-024-00660-7 · ExternalCitation · doi-reference
Pharmacokinetic Properties of a Once-Weekly Fixed-Ratio Combination of Insulin Icodec and Semaglutide Compared with Separate Administration of Each Component in Individuals with Type 2 Diabetes Mellitus
10.1007/s40261-024-01405-8 · ExternalCitation · doi-reference
Tislelizumab: First Approval
10.1007/s40265-020-01286-z · ExternalCitation · doi-reference
Sunvozertinib: First Approval
10.1007/s40265-023-01959-5 · ExternalCitation · doi-reference
Nogapendekin alfa Inbakicept: First Approval
10.1007/s40265-024-02060-1 · ExternalCitation · doi-reference
Avutometinib and Defactinib: First Approval
10.1007/s40265-025-02215-8 · ExternalCitation · doi-reference
Taletrectinib: First Approval
10.1007/s40265-025-02256-z · ExternalCitation · doi-reference
Artificial intelligence driven protein design and sustainable nanomedicine for advanced theranostics
10.1016/j.bioactmat.2026.01.036 · ExternalCitation · doi-reference
Protein-Protein Docking: From Interaction to Interactome
10.1016/j.bpj.2014.08.033 · ExternalCitation · doi-reference
Small-angle X-ray scattering studies of enzymes
10.1016/j.cbpa.2022.102232 · ExternalCitation · doi-reference
Allostery in disease and in drug discovery
10.1016/j.cell.2013.03.034 · ExternalCitation · doi-reference
Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
10.1016/j.cell.2020.02.058 · ExternalCitation · doi-reference
The rise of molecular glues
10.1016/j.cell.2020.12.020 · ExternalCitation · doi-reference
Dynamic allostery drives autocrine and paracrine TGF-β signaling
10.1016/j.cell.2024.08.036 · ExternalCitation · doi-reference
Advances in structure-based vaccine design
10.1016/j.coviro.2013.05.010 · ExternalCitation · doi-reference
Datopotamab deruxtecan: A novel antibody drug conjugate for triple-negative breast cancer
10.1016/j.heliyon.2024.e28385 · ExternalCitation · doi-reference
A review on protein misfolding, aggregation and strategies to prevent related ailments
10.1016/j.ijbiomac.2017.07.116 · ExternalCitation · doi-reference
PhyreRisk: A Dynamic Web Application to Bridge Genomics, Proteomics and 3D Structural Data to Guide Interpretation of Human Genetic Variants
10.1016/j.jmb.2019.04.043 · ExternalCitation · doi-reference
The AlphaFold Database of Protein Structures: A Biologist’s Guide
10.1016/j.jmb.2021.167336 · ExternalCitation · doi-reference
Protein species and moonlighting proteins: very small changes in a protein's covalent structure can change its biochemical function
10.1016/j.jprot.2015.10.003 · ExternalCitation · doi-reference
Personalized Drug Therapy: Innovative Concept Guided With Proteoformics
10.1016/j.mcpro.2024.100737 · ExternalCitation · doi-reference
Depemokimab, the first ultra-long-acting anti-IL-5 monoclonal antibody for severe eosinophilic asthma
10.1016/j.medj.2024.10.022 · ExternalCitation · doi-reference
Functional and structural insights into RAS effector proteins
10.1016/j.molcel.2024.06.027 · ExternalCitation · doi-reference
On-demand biomanufacturing through synthetic biology approach
10.1016/j.mtbio.2022.100518 · ExternalCitation · doi-reference
Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research
10.1016/j.neuron.2024.05.012 · ExternalCitation · doi-reference
Three-dimensional modeling of protein interactions and complexes is going ‘omics
10.1016/j.sbi.2011.01.005 · ExternalCitation · doi-reference
NMR methods for structural studies of large monomeric and multimeric proteins
10.1016/j.sbi.2013.06.016 · ExternalCitation · doi-reference
Structural insight into protein–protein interactions between intestinal microbiome and host
10.1016/j.sbi.2022.102354 · ExternalCitation · doi-reference
Insights into Disease-Associated Mutations in the Human Proteome through Protein Structural Analysis
10.1016/j.str.2015.03.028 · ExternalCitation · doi-reference
Biophysical and mechanistic models for disease-causing protein variants
10.1016/j.tibs.2019.01.003 · ExternalCitation · doi-reference
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
10.1016/s0140-6736(20)30183-5 · ExternalCitation · doi-reference
Investigating cryptic binding sites by molecular dynamics simulations
10.1021/acs.accounts.9b00613 · ExternalCitation · doi-reference
Cross-linking mass spectrometry for investigating protein conformations and protein-protein interactions-a method for all seasons
10.1021/acs.chemrev.1c00786 · ExternalCitation · doi-reference
Electrostatic interactions in protein structure, folding, binding, and condensation
10.1021/acs.chemrev.7b00305 · ExternalCitation · doi-reference
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
10.1021/acs.chemrev.8b00532 · ExternalCitation · doi-reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings
10.1021/acs.jcim.1c00203 · ExternalCitation · doi-reference
Engineering an allosteric control of protein function
10.1021/acs.jpcb.0c11640 · ExternalCitation · doi-reference
AlphaFold, artificial intelligence (AI), and allostery
10.1021/acs.jpcb.2c04346 · ExternalCitation · doi-reference
Reliability of docking-based virtual screening for GPCR ligands with homology modeled structures: a case study of the angiotensin II type I receptor
10.1021/acschemneuro.8b00489 · ExternalCitation · doi-reference
Molecular recognition of protein-ligand complexes: applications to drug design
10.1021/cr960370z · ExternalCitation · doi-reference
Fragment-based drug discovery
10.1021/jm040031v · ExternalCitation · doi-reference
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
10.1038/nature12796 · ExternalCitation · doi-reference
Integrative analysis of 111 reference human epigenomes
10.1038/nature14248 · ExternalCitation · doi-reference
Cryo-EM structures of tau filaments from Alzheimer's disease
10.1038/nature23002 · ExternalCitation · doi-reference
Interactome3D: adding structural details to protein networks
10.1038/nmeth.2289 · ExternalCitation · doi-reference
dSysMap: exploring the edgetic role of disease mutations
10.1038/nmeth.3289 · ExternalCitation · doi-reference
Antibodies, viruses and vaccines
10.1038/nri891 · ExternalCitation · doi-reference
Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
10.1038/s41388-024-03077-2 · ExternalCitation · doi-reference
Protein acylation: mechanisms, biological functions and therapeutic targets
10.1038/s41392-022-01245-y · ExternalCitation · doi-reference
Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies
10.1038/s41413-025-00487-0 · ExternalCitation · doi-reference
Learning and actioning general principles of cancer cell drug sensitivity
10.1038/s41467-025-56827-5 · ExternalCitation · doi-reference
Opportunities and challenges in design and optimization of protein function
10.1038/s41580-024-00718-y · ExternalCitation · doi-reference
The pathogenesis of IgA nephropathy and implications for treatment
10.1038/s41581-024-00885-3 · ExternalCitation · doi-reference
Structures of filaments from Pick’s disease reveal a novel tau protein fold
10.1038/s41586-018-0454-y · ExternalCitation · doi-reference
Structures of α-synuclein filaments from multiple system atrophy
10.1038/s41586-020-2317-6 · ExternalCitation · doi-reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · ExternalCitation · doi-reference
Multiplex assessment of protein variant abundance by massively parallel sequencing
10.1038/s41588-018-0122-z · ExternalCitation · doi-reference
Unfreezing structural biology for drug discovery
10.1038/s41589-025-02047-3 · ExternalCitation · doi-reference
A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial
10.1038/s41591-025-03743-2 · ExternalCitation · doi-reference
Defactinib with avutometinib in patients with solid tumors: the phase 1 FRAME trial
10.1038/s41591-025-03763-y · ExternalCitation · doi-reference
A structural biology community assessment of AlphaFold2 applications
10.1038/s41594-022-00849-w · ExternalCitation · doi-reference
Personalized prediction of anticancer potential of non-oncology drugs through learning from genome derived molecular pathways
10.1038/s41698-025-00813-z · ExternalCitation · doi-reference
Asymmetric predictive relationships across histone modifications
10.1038/s42256-022-00455-x · ExternalCitation · doi-reference
Mechanical unfolding of alpha- and beta-helical protein motifs
10.1039/c8sm02046a · ExternalCitation · doi-reference
The origin, evolution and structure of the protein world
10.1042/bj20082063 · ExternalCitation · doi-reference
Uncovering protein function: from classification to complexes
10.1042/ebc20200108 · ExternalCitation · doi-reference
An Intravenous Brain-Penetrant Enzyme Therapy for Mucopolysaccharidosis II
10.1056/nejmoa2508681 · ExternalCitation · doi-reference
Structure-function relations of human hemoglobins
10.1080/08998280.2006.11928171 · ExternalCitation · doi-reference
The current role and evolution of X-ray crystallography in drug discovery and development
10.1080/17460441.2023.2246881 · ExternalCitation · doi-reference
Antibodies to watch in 2025
10.1080/19420862.2024.2443538 · ExternalCitation · doi-reference
DeepDTAF: a deep learning method to predict protein–ligand binding affinity
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