Research graph
References from Structural biology approaches in vaccine development. Local targets link to admitted publications; unresolved targets remain external evidence.
B-cell epitope mapping for the design of vaccines and effective diagnostics
10.1016/j.trivac.2016.04.003 · 2016 · External reference
Design of a peptide-based vaccine against human respiratory syncytial virus using a reverse vaccinology approach: evaluation of immunogenicity, antigenicity, allergenicity, and toxicity
10.3389/fimmu.2025.1546254 · 2025 · External reference
Vaccine design and development: exploring the interface with computational biology and AI
10.1080/08830185.2024.2374546 · 2024 · External reference
Structural vaccinology for viral vaccine design
10.3389/fmicb.2019.00738 · 2019 · External reference
Computational epitope-based vaccine design with bioinformatics approach; a review
10.1016/j.heliyon.2025.e41714 · 2025 · External reference
9 - Artificial intelligence in vaccine development
2026 · External reference
Unresolved reference
External reference
Mosaic HIV-1 glycoprotein nanoparticles elicit antibody responses
10.1371/journal.ppat.1012558 · 2024 · External reference
What are the most powerful immunogen design vaccine strategies?: Reverse vaccinology 2.0 shows great promise
10.1101/cshperspect.a030262 · 2017 · External reference
Principles and practical applications of structure-based vaccine design
10.1016/j.coi.2022.102209 · 2022 · External reference
Self-assembling protein nanoparticles and virus like particles display β-barrel antigen
10.1371/journal.pone.0273322 · 2022 · External reference
Development of receptor binding domain (RBD)-conjugated nanoparticle vaccines with broad neutralization against SARS-CoV-2 delta and other variants
10.1002/advs.202105378 · 2022 · External reference
Virus-like particles as vaccine
10.18388/abp.2014_1875 · 2014 · External reference
Proof of principle for epitope-focused vaccine design
10.1038/nature12966 · 2014 · External reference
Structural vaccinology: a three-dimensional view for vaccine development
10.2174/15680266113136660187 · 2013 · External reference
Nanoparticle-based vaccines: opportunities and limitations
2020 · External reference
Contributions of mass spectrometry to structural immunology
10.1002/(sici)1096-9888(200004)35:4<493::aid-jms987>3.0.co;2-i · 2000 · External reference
Cryo-EM of viruses and vaccine design
10.1073/pnas.1609721113 · 2016 · External reference
Using crystallography tools to improve vaccine formulations
10.1107/s205225252101071x · 2022 · External reference
Epitope mapping: the first step in developing epitope-based vaccines
10.2165/00063030-200721030-00002 · 2007 · External reference
Structure-based vaccine antigen design
10.1146/annurev-med-121217-094234 · 2019 · External reference
Quantitative NMR for the structural analysis of novel bivalent glycoconjugates as vaccine candidates
10.1016/j.jpba.2022.114721 · 2022 · External reference
Non-propagating, recombinant vesicular stomatitis virus vectors encoding respiratory syncytial virus proteins generate potent humoral and cellular immunity against RSV and are protective in mice
10.1016/j.imlet.2012.12.005 · 2013 · External reference
Reverse vaccinology and its applications
2020 · External reference
Historical advances in structural and molecular biology and how they impacted vaccine development
10.1016/j.jmb.2023.168113 · 2023 · External reference
Structural characterization and modeling of a respiratory syncytial virus fusion glycoprotein nanoparticle vaccine in solution
10.1021/acs.molpharmaceut.0c00986 · 2021 · External reference
Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope
10.1016/j.str.2017.11.017 · 2018 · External reference
Cryo-EM studies of virus-antibody immune complexes
10.1007/s12250-019-00190-5 · 2020 · External reference
Structural and computational biology in the design of immunogenic vaccine antigens
10.1155/2015/156241 · 2015 · External reference
Self-assembling protein nanoparticles in the design of vaccines
10.1016/j.csbj.2015.11.001 · 2016 · External reference
Cryo-electron microscopy structure of S-trimer, a subunit vaccine candidate for COVID-19
10.1128/jvi.00194-21 · 2021 · External reference
Nanoparticle vaccines based on the RBD of SARS-CoV-2
10.1016/j.immuni.2020.11.015 · 2020 · External reference
Protein crystallography in vaccine research and development
10.3390/ijms160613106 · 2015 · External reference
Applications of molecular dynamics simulations in immunology: a useful computational method in aiding vaccine design
10.2174/157016406780655568 · 2006 · External reference
Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus
10.1126/science.1243283 · 2013 · External reference
Antibody binding modulates conformational exchange in domain III of dengue virus e protein
10.1128/jvi.02314-15 · 2016 · External reference
Unresolved reference
2019 · External reference
Mass spectrometry and peptide-based vaccine development
10.1038/sj.clpt.6100389 · 2007 · External reference
Epitope-based vaccine design: a comprehensive overview of bioinformatics approaches
10.1016/j.drudis.2020.03.006 · 2020 · External reference
T-cell epitope vaccine design by immunoinformatics
10.1098/rsob.120139 · 2013 · External reference
Structure-based vaccine design in HIV: Blind men and the elephant?
10.2174/138161210794079173 · 2010 · External reference
History of vaccination
10.1073/pnas.1400472111 · 2014 · External reference
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
10.1084/jem.20151960 · 2016 · External reference
Identification of vaccine targets in pathogens and design of a vaccine using computational approaches
10.1038/s41598-021-96863-x · 2021 · External reference
Epitope-focused vaccine design against influenza A and B viruses
10.1016/j.coi.2016.06.002 · 2016 · External reference
Functionalizing ferritin nanoparticles for vaccine development
10.3390/pharmaceutics13101621 · 2021 · External reference
T cell responses to viral infections – opportunities for peptide vaccination
10.3389/fimmu.2014.00171 · 2014 · External reference
The combination of artificial intelligence and systems biology for intelligent vaccine design
10.1080/17460441.2020.1791076 · 2020 · External reference
Artificial intelligence methodologies in structural biology
10.1016/j.sbi.2025.103156 · 2025 · External reference
Understanding binding between donepezil and human ferritin: molecular docking and molecular dynamics simulation approach
10.1080/07391102.2020.1851302 · 2022 · External reference
T-Cell epitope-based vaccines: a promising strategy for prevention of infectious diseases
10.3390/vaccines12101181 · 2024 · External reference
Computational tools for modern vaccine development
10.1080/21645515.2019.1670035 · 2020 · External reference
Development of a ferritin-based nanoparticle vaccine against SARS-CoV-2 Omicron variant
10.1038/s41392-022-01041-8 · 2022 · External reference
Progress in the development of structure-based vaccines
10.1007/978-1-0716-1892-9_2 · 2022 · External reference
Epitope mapping of antibody-antigen interactions with X-ray crystallography
10.1007/978-1-4939-7841-0_2 · 2018 · External reference
Viral emerging diseases: challenges in developing vaccination strategies
10.3389/fimmu.2020.02130 · 2020 · External reference
Mapping conformational epitopes by NMR spectroscopy
10.1016/j.coviro.2021.04.001 · 2021 · External reference
Structure-based reverse vaccinology failed in the case of HIV because it disregarded accepted immunological theory
10.3390/ijms17091591 · 2016 · External reference
The application of MD simulation to lead identification, vaccine design, and structural studies in combat against leishmaniasis - a review
10.2174/1389557523666230901105231 · 2024 · External reference
Innovations in structure-based antigen design and immune monitoring for next generation vaccines
10.1016/j.coi.2020.03.013 · 2020 · External reference
50 Years of structural immunology
10.1016/j.jbc.2021.100745 · 2021 · External reference
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
10.1126/science.abb2507 · 2020 · External reference
Designing epitope-focused vaccines via antigen reorientation
2022 · External reference
S–6P exhibits better immunogenicity than S–2 P at lower doses of COVID-19 mRNA vaccines
10.1016/j.dcit.2024.100017 · 2024 · External reference
Contributions of mass spectrometry to structural immunology
10.1002/(sici)1096-9888(200004)35:4<493::aid-jms987>3.0.co;2-i · ExternalCitation · doi-reference
Development of receptor binding domain (RBD)-conjugated nanoparticle vaccines with broad neutralization against SARS-CoV-2 delta and other variants
10.1002/advs.202105378 · ExternalCitation · doi-reference
Progress in the development of structure-based vaccines
10.1007/978-1-0716-1892-9_2 · ExternalCitation · doi-reference
Epitope mapping of antibody-antigen interactions with X-ray crystallography
10.1007/978-1-4939-7841-0_2 · ExternalCitation · doi-reference
Cryo-EM studies of virus-antibody immune complexes
10.1007/s12250-019-00190-5 · ExternalCitation · doi-reference
Epitope-focused vaccine design against influenza A and B viruses
10.1016/j.coi.2016.06.002 · ExternalCitation · doi-reference
Innovations in structure-based antigen design and immune monitoring for next generation vaccines
10.1016/j.coi.2020.03.013 · ExternalCitation · doi-reference
Principles and practical applications of structure-based vaccine design
10.1016/j.coi.2022.102209 · ExternalCitation · doi-reference
Mapping conformational epitopes by NMR spectroscopy
10.1016/j.coviro.2021.04.001 · ExternalCitation · doi-reference
Self-assembling protein nanoparticles in the design of vaccines
10.1016/j.csbj.2015.11.001 · ExternalCitation · doi-reference
S–6P exhibits better immunogenicity than S–2 P at lower doses of COVID-19 mRNA vaccines
10.1016/j.dcit.2024.100017 · ExternalCitation · doi-reference
Epitope-based vaccine design: a comprehensive overview of bioinformatics approaches
10.1016/j.drudis.2020.03.006 · ExternalCitation · doi-reference
Computational epitope-based vaccine design with bioinformatics approach; a review
10.1016/j.heliyon.2025.e41714 · ExternalCitation · doi-reference
Non-propagating, recombinant vesicular stomatitis virus vectors encoding respiratory syncytial virus proteins generate potent humoral and cellular immunity against RSV and are protective in mice
10.1016/j.imlet.2012.12.005 · ExternalCitation · doi-reference
Nanoparticle vaccines based on the RBD of SARS-CoV-2
10.1016/j.immuni.2020.11.015 · ExternalCitation · doi-reference
50 Years of structural immunology
10.1016/j.jbc.2021.100745 · ExternalCitation · doi-reference
Historical advances in structural and molecular biology and how they impacted vaccine development
10.1016/j.jmb.2023.168113 · ExternalCitation · doi-reference
Quantitative NMR for the structural analysis of novel bivalent glycoconjugates as vaccine candidates
10.1016/j.jpba.2022.114721 · ExternalCitation · doi-reference
Artificial intelligence methodologies in structural biology
10.1016/j.sbi.2025.103156 · ExternalCitation · doi-reference
Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope
10.1016/j.str.2017.11.017 · ExternalCitation · doi-reference
B-cell epitope mapping for the design of vaccines and effective diagnostics
10.1016/j.trivac.2016.04.003 · ExternalCitation · doi-reference
Structural characterization and modeling of a respiratory syncytial virus fusion glycoprotein nanoparticle vaccine in solution
10.1021/acs.molpharmaceut.0c00986 · ExternalCitation · doi-reference
Proof of principle for epitope-focused vaccine design
10.1038/nature12966 · ExternalCitation · doi-reference
Development of a ferritin-based nanoparticle vaccine against SARS-CoV-2 Omicron variant
10.1038/s41392-022-01041-8 · ExternalCitation · doi-reference
Identification of vaccine targets in pathogens and design of a vaccine using computational approaches
10.1038/s41598-021-96863-x · ExternalCitation · doi-reference
Mass spectrometry and peptide-based vaccine development
10.1038/sj.clpt.6100389 · ExternalCitation · doi-reference
History of vaccination
10.1073/pnas.1400472111 · ExternalCitation · doi-reference
Cryo-EM of viruses and vaccine design
10.1073/pnas.1609721113 · ExternalCitation · doi-reference
Understanding binding between donepezil and human ferritin: molecular docking and molecular dynamics simulation approach
10.1080/07391102.2020.1851302 · ExternalCitation · doi-reference
Vaccine design and development: exploring the interface with computational biology and AI
10.1080/08830185.2024.2374546 · ExternalCitation · doi-reference
The combination of artificial intelligence and systems biology for intelligent vaccine design
10.1080/17460441.2020.1791076 · ExternalCitation · doi-reference
Computational tools for modern vaccine development
10.1080/21645515.2019.1670035 · ExternalCitation · doi-reference
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
10.1084/jem.20151960 · ExternalCitation · doi-reference
T-cell epitope vaccine design by immunoinformatics
10.1098/rsob.120139 · ExternalCitation · doi-reference
What are the most powerful immunogen design vaccine strategies?: Reverse vaccinology 2.0 shows great promise
10.1101/cshperspect.a030262 · ExternalCitation · doi-reference
Using crystallography tools to improve vaccine formulations
10.1107/s205225252101071x · ExternalCitation · doi-reference
Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus
10.1126/science.1243283 · ExternalCitation · doi-reference
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
10.1126/science.abb2507 · ExternalCitation · doi-reference
Cryo-electron microscopy structure of S-trimer, a subunit vaccine candidate for COVID-19
10.1128/jvi.00194-21 · ExternalCitation · doi-reference
Antibody binding modulates conformational exchange in domain III of dengue virus e protein
10.1128/jvi.02314-15 · ExternalCitation · doi-reference
Structure-based vaccine antigen design
10.1146/annurev-med-121217-094234 · ExternalCitation · doi-reference
Structural and computational biology in the design of immunogenic vaccine antigens
10.1155/2015/156241 · ExternalCitation · doi-reference
Self-assembling protein nanoparticles and virus like particles display β-barrel antigen
10.1371/journal.pone.0273322 · ExternalCitation · doi-reference
Mosaic HIV-1 glycoprotein nanoparticles elicit antibody responses
10.1371/journal.ppat.1012558 · ExternalCitation · doi-reference
Virus-like particles as vaccine
10.18388/abp.2014_1875 · ExternalCitation · doi-reference
Epitope mapping: the first step in developing epitope-based vaccines
10.2165/00063030-200721030-00002 · ExternalCitation · doi-reference
Structure-based vaccine design in HIV: Blind men and the elephant?
10.2174/138161210794079173 · ExternalCitation · doi-reference
The application of MD simulation to lead identification, vaccine design, and structural studies in combat against leishmaniasis - a review
10.2174/1389557523666230901105231 · ExternalCitation · doi-reference
Structural vaccinology: a three-dimensional view for vaccine development
10.2174/15680266113136660187 · ExternalCitation · doi-reference
Applications of molecular dynamics simulations in immunology: a useful computational method in aiding vaccine design
10.2174/157016406780655568 · ExternalCitation · doi-reference
T cell responses to viral infections – opportunities for peptide vaccination
10.3389/fimmu.2014.00171 · ExternalCitation · doi-reference
Viral emerging diseases: challenges in developing vaccination strategies
10.3389/fimmu.2020.02130 · ExternalCitation · doi-reference
Design of a peptide-based vaccine against human respiratory syncytial virus using a reverse vaccinology approach: evaluation of immunogenicity, antigenicity, allergenicity, and toxicity
10.3389/fimmu.2025.1546254 · ExternalCitation · doi-reference
Structural vaccinology for viral vaccine design
10.3389/fmicb.2019.00738 · ExternalCitation · doi-reference
Protein crystallography in vaccine research and development
10.3390/ijms160613106 · ExternalCitation · doi-reference
Structure-based reverse vaccinology failed in the case of HIV because it disregarded accepted immunological theory
10.3390/ijms17091591 · ExternalCitation · doi-reference
Functionalizing ferritin nanoparticles for vaccine development
10.3390/pharmaceutics13101621 · ExternalCitation · doi-reference
T-Cell epitope-based vaccines: a promising strategy for prevention of infectious diseases
10.3390/vaccines12101181 · ExternalCitation · doi-reference
