Research graph
References from Structural biology of protein misfolding and aggregation: from disease to therapeutic innovations. Local targets link to admitted publications; unresolved targets remain external evidence.
Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis
10.1056/nejmoa1716153 · 2018 · External reference
Aggregation of full-length immunoglobulin light chains from systemic light chain amyloidosis (AL) patients is remodeled by epigallocatechin-3-gallate
10.1074/jbc.m116.750323 · 2017 · External reference
The formation and stabilization of protein structure
10.1042/bj1280737 · 1972 · External reference
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
10.1242/jcs.180737 · 2016 · External reference
Mutant p53 aggregates into prion-like amyloid oligomers and fibrils
10.1074/jbc.m112.340638 · 2012 · External reference
Protective effect of curcumin on thermally aggregated bovine serum albumin
10.1007/s12013-025-01810-6 · 2025 · External reference
10.1101/2023.01.19.524732
10.1101/2023.01.19.524732 · External reference
Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in alzheimer’s disease mouse models
10.1523/jneurosci.0284-14.2014 · 2014 · External reference
Doxycycline for Alzheimer’s disease: fighting β-amyloid oligomers and neuroinflammation
10.3389/fphar.2019.00738 · 2019 · External reference
β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner
10.1016/j.ydbio.2016.03.012 · 2016 · External reference
Observation of β-Amyloid peptide oligomerization by pressure-jump NMR spectroscopy
10.1021/jacs.9b06970 · 2019 · External reference
Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly
10.1126/science.2188360 · 1990 · External reference
Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides
10.1002/mus.20503 · 2006 · External reference
Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation
10.15252/embr.201744617 · 2018 · External reference
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
10.1038/nn.2660 · 2010 · External reference
Altering the association properties of insulin by amino acid replacement
10.1093/protein/5.6.527 · 1992 · External reference
A receptor-mediated pathway for cholesterol homeostasis
10.1126/science.3513311 · 1986 · External reference
Two randomized phase 3 studies of aducanumab in early Alzheimer’s disease
10.14283/jpad.2022.30 · 2022 · External reference
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
10.1073/pnas.1121005109 · 2012 · External reference
α-Synuclein promotes SNARE-complex assembly in vivo and in vitro
10.1126/science.1195227 · 2010 · External reference
Relative influence of hydrophobicity and net charge in the aggregation of two homologous proteins
10.1021/bi030135s · 2003 · External reference
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
10.1073/pnas.96.24.14088 · 1999 · External reference
Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: implications for impaired mitochondrial biogenesis and synaptic damage
10.1016/j.bbadis.2011.04.006 · 2011 · External reference
The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway
10.1111/febs.12813 · 2014 · External reference
Gelsolin–derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187
10.1038/ng1092-157 · 1992 · External reference
Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-β stability, oligomerization, and aggregation
10.1074/jbc.m110.177246 · 2011 · External reference
Hsp90 relieves heat stress-induced damage in mouse kidneys: involvement of antiapoptotic PKM2-AKT and autophagic HIF-1α signaling
10.3390/ijms21051646 · 2020 · External reference
Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: the new molecular mechanism of ibudilast and its implication for neuroprotective therapy
10.1016/j.bbrc.2020.03.051 · 2020 · External reference
Protein quality control and aggregation in the endoplasmic reticulum: from basic to bedside
2023 · External reference
Protein misfolding, functional amyloid, and human disease
10.1146/annurev.biochem.75.101304.123901 · 2006 · External reference
Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide
10.1371/journal.pone.0195339 · 2018 · External reference
Mutant A53T α-Synuclein induces neuronal death by increasing mitochondrial autophagy
10.1074/jbc.m110.132514 · 2011 · External reference
Protein quality control by molecular chaperones in neurodegeneration
10.3389/fnins.2017.00185 · 2017 · External reference
Safety and efficacy of RNAi therapy for transthyretin amyloidosis
10.1056/nejmoa1208760 · 2013 · External reference
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
10.1073/pnas.1218402110 · 2013 · External reference
Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants
10.1074/jbc.m800247200 · 2008 · External reference
10.1101/2022.09.20.508793
10.1101/2022.09.20.508793 · External reference
Aggregation of γ-crystallins associated with human cataracts via domain swapping at the C-terminal β-strands
10.1073/pnas.1019152108 · 2011 · External reference
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
10.1074/jbc.m500997200 · 2005 · External reference
A role for synaptic zinc in activity-dependent aβ oligomer formation and accumulation at excitatory synapses
10.1523/jneurosci.5980-08.2009 · 2009 · External reference
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
10.1073/pnas.0903691106 · 2009 · External reference
Interactions between amyloid-β and tau fragments promote aberrant aggregates: implications for amyloid toxicity
10.1021/jp506258g · 2014 · External reference
Protein folding and misfolding
10.1038/nature02261 · 2003 · External reference
Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathologic observations
10.1016/j.jcf.2014.09.012 · 2015 · External reference
X-ray diffraction studies on amyloid filaments
10.1177/16.11.673 · 1968 · External reference
Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
10.1523/jneurosci.5699-09.2010 · 2010 · External reference
Mechanism of reversible self-association of a monoclonal antibody: role of electrostatic and hydrophobic interactions
10.1002/jps.24237 · 2015 · External reference
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation
10.1038/s41467-025-62751-5 · 2025 · External reference
Genetics of cystic fibrosis: basics
10.1016/s0929-693x(20)30043-9 · 2020 · External reference
Cryo-EM structures of tau filaments from Alzheimer's disease
10.1038/nature23002 · 2017 · External reference
Secondary nucleation and accessible surface in insulin amyloid fibril formation
10.1021/jp710131u · 2008 · External reference
The impact of the E46K mutation on the properties of α-synuclein in its monomelic and oligomeric states
10.1021/bi7000246 · 2007 · External reference
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
10.1186/s40478-022-01469-7 · 2022 · External reference
Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
10.1017/s0033583516000172 · 2017 · External reference
Ganglioside lipids accelerate α-synuclein amyloid formation
10.1016/j.bbapap.2018.07.004 · 2018 · External reference
The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth
10.1371/journal.pcbi.1007767 · 2020 · External reference
Investigating the aggregation and prionogenic properties of human cancer-related proteins
10.1080/10985549.2025.2481054 · 2025 · External reference
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells
10.1073/pnas.1102645108 · 2011 · External reference
Cytotoxicity of insulin within its self-assembly and amyloidogenic pathways
10.1016/j.jmb.2007.04.053 · 2007 · External reference
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila
2003 · External reference
The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
10.1038/nm1295-1291 · 1995 · External reference
Molecular chaperones in protein folding and proteostasis
10.1038/nature10317 · 2011 · External reference
Oxidative stress induces amyloid-like aggregate formation of NACP/α- synuclein in vitro
10.1097/00001756-199903170-00011 · 1999 · External reference
Nilotinib reverses loss of dopamine neurons and improvesmotorbehavior via autophagic degradation of α-synuclein in parkinson's disease models
10.1093/hmg/ddt192 · 2013 · External reference
The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy
10.1016/j.bbadis.2019.07.007 · 2019 · External reference
VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration
10.1038/sj.cdd.4400907 · 2001 · External reference
Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis
10.1016/0140-6736(93)93127-m · 1993 · External reference
Hsu, characterization of BRCA1-associated protein-1 (BAP1) aggregation properties induced by cancer-associated mutations
10.1002/cbic.202500372 · 2025 · External reference
Protein glycation by glyoxal promotes amyloid formation by islet amyloid polypeptide
10.1016/j.bpj.2019.05.013 · 2019 · External reference
Pathological mechanisms of amyotrophic lateral sclerosis
10.4103/1673-5374.382985 · 2024 · External reference
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress-mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
10.2337/db07-0197 · 2007 · External reference
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
10.1074/jbc.c000447200 · 2000 · External reference
Molten globule of hemoglobin proceeds into aggregates and advanced glycated end products
10.1371/journal.pone.0072075 · 2013 · External reference
Histological prevalence of β2-microglobulin amyloidosis in hemodialysis: a prospective post-mortem study
10.1038/ki.1997.262 · 1997 · External reference
Amyloid formation under physiological conditions proceeds via a native-like folding intermediate
10.1038/nsmb1058 · 2006 · External reference
Antioxidant potential of curcumin—a meta-analysis of randomized clinical trials
10.3390/antiox9111092 · 2020 · External reference
Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide
10.1073/pnas.93.14.7283 · 1996 · External reference
Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein
2023 · External reference
Serine-129 phosphorylated α-synuclein drives mitochondrial dysfunction and calcium dysregulation in Parkinson’s disease model
10.3389/fnagi.2025.1538166 · 2025 · External reference
Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification
10.1080/19420862.2019.1658493 · 2019 · External reference
The dynamics of oxygenation to Aβ fibrils using an azobenzene–boron complex type photocatalyst and light energy
10.1038/s41598-025-10880-8 · 2025 · External reference
4-hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
10.1016/s0306-4522(97)00065-1 · 1997 · External reference
The prion protein as a receptor for amyloid-γ 2
10.1038/nature09217 · 2010 · External reference
A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy
10.1016/s0006-3495(03)74550-0 · 2003 · External reference
Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
10.1038/nm1021 · 2004 · External reference
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model
2013 · External reference
Lysosome-mitochondrial crosstalk in cellular stress and disease
10.3390/antiox14020125 · 2025 · External reference
Pathways of cellular proteostasis in aging and disease
10.1083/jcb.201709072 · 2018 · External reference
Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques
10.1073/pnas.261562998 · 2001 · External reference
C9ORF72 gene GGGGCC hexanucleotide expansion: a high clinical variability from amyotrophic lateral sclerosis to frontotemporal dementia
10.3390/jpm13091396 · 2023 · External reference
Mutations of the prion protein gene
10.1007/s00415-002-0896-9 · 2002 · External reference
Multistep aggregation pathway of human interIeukin-1 receptor antagonist: kinetic, structural, and morphological characterization
10.1016/j.bpj.2008.10.002 · 2009 · External reference
Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations
10.1038/s41392-025-02439-w · 2025 · External reference
Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis
10.1056/nejmoa013354 · 2002 · External reference
Natural history and outcome in systemic AA amyloidosis
10.1056/nejmoa070265 · 2007 · External reference
A three-stage kinetic model of amyloid fibrillation
10.1529/biophysj.106.098608 · 2007 · External reference
Aggregation and cellular toxicity of pathogenic or non-pathogenic proteins
2020 · External reference
Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
10.1073/pnas.0406976102 · 2005 · External reference
Delivery of quantum Dot-siRNA nanoplexes in SK-N-SH cells for BACE1 gene silencing and intracellular imaging
2012 · External reference
Hereditary renal amyloidosis with a variant lysozyme p.Trp82Arg in a Chinese family: case report and literature review
10.1186/s12882-019-1496-6 · 2019 · External reference
The transcription factor bZIP60 links the unfolded protein response to the heat stress response in maize
10.1105/tpc.20.00260 · 2020 · External reference
The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer
10.3233/jad-2008-14212 · 2008 · External reference
The hydrophobic effect in protein folding
10.1096/fasebj.9.7.7737462 · 1995 · External reference
Heat shock response relieves ER stress
10.1038/emboj.2008.42 · 2008 · External reference
Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation
10.1111/j.1460-9568.2007.05955.x · 2007 · External reference
Focal-type, but not diffuse-type, amyloid beta plaques are correlated with Alzheimer’s neuropathology, cognitive dysfunction, and neuroinflammation in the human hippocampus
10.1007/s12264-022-00927-5 · 2022 · External reference
, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
10.1016/0092-8674(93)90585-e · 1993 · External reference
Structure-activity relationship of amyloid fibrils
10.1016/j.febslet.2009.07.003 · 2009 · External reference
Amyotrophic lateral sclerosis: a clinical review
10.1111/ene.14393 · 2020 · External reference
Partially unfolded states of β-microglobulin and amyloid formation in vitro
10.1021/bi000276j · 2000 · External reference
Structural properties of an amyloid precursor of β2-microglobulin
10.1038/nsb791 · 2002 · External reference
Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP
10.1038/s41467-022-30238-2 · 2022 · External reference
Donanemab in early Alzheimer’s disease
10.1056/nejmoa2100708 · 2021 · External reference
Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion
10.1007/s00401-012-1043-z · 2013 · External reference
Some candidate drugs for pharmacotherapy of Alzheimer’s disease
10.3390/ph14050458 · 2021 · External reference
Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease
10.1111/j.1365-2613.2007.00568.x · 2008 · External reference
Secondary structural change of bovine serum albumin in thermal denaturation up to 130 °C and protective effect of sodium dodecyl sulfate on the change
10.1021/jp8067624 · 2008 · External reference
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
10.1186/s13024-023-00617-4 · 2023 · External reference
Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins
10.1007/s12013-011-9200-x · 2011 · External reference
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
10.1038/s41467-017-02299-1 · 2018 · External reference
Structure of the cross-β spine of amyloid-like fibrils
10.1038/nature03680 · 2005 · External reference
Folding of Cu/Zn superoxide dismutase suggests structural hotspots for gain of neurotoxic function in ALS: parallels to precursors in amyloid disease
10.1073/pnas.0601696103 · 2006 · External reference
Disrupted transcriptional networks by mutant atrophin-1 in a cell culture model of dentatorubral-pallidoluysian atrophy [Internet]
10.1101/2025.08.08.669318 · 2025 · External reference
Folding funnels and frustration in off-lattice minimalist protein landscapes
10.1073/pnas.95.11.5921 · 1998 · External reference
Hyperglycemia and hyperlipidemia are associated with endothelial dysfunction during the development of type 2 diabetes
10.1139/y07-026 · 2007 · External reference
Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions
10.1074/jbc.m113.498246 · 2014 · External reference
Theory of protein folding
10.1016/j.sbi.2004.01.009 · 2004 · External reference
A phase II study to evaluate the safety and efficacy of prasinezumab in early Parkinson's disease (PASADENA): rationale, design, and baseline data
10.3389/fneur.2021.705407 · 2021 · External reference
Evolutionarily conserved proline residues impede the misfolding of the mouse prion protein by destabilizing an aggregation-competent partially unfolded form
10.1016/j.jmb.2022.167854 · 2022 · External reference
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions
10.1523/jneurosci.5922-09.2010 · 2010 · External reference
Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes
10.1128/mcb.05460-11 · 2011 · External reference
Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington's disease
2021 · External reference
Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain
10.1017/s1462399411002134 · 2012 · External reference
Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: in vitro evidence
10.3390/pharmaceutics11110572 · 2019 · External reference
Sequestration of TDP-43216-414aggregates by cytoplasmic expression of the proSAAS chaperone
10.1021/acschemneuro.2c00156 · 2022 · External reference
Conformational and aggregation properties of the 1-93 fragment of apolipoprotein A-I
10.1002/pro.2534 · 2014 · External reference
Mutation in the α-synuclein gene identified in families with Parkinson's disease
10.1126/science.276.5321.2045 · 1997 · External reference
The aggregation inhibitor peptide qbp1 as a therapeutic molecule for the polyglutamine neurodegenerative diseases
10.4061/2011/265084 · 2011 · External reference
Neurodegenerative diseases and prions
10.1056/nejm200105173442006 · 2001 · External reference
Depletion of dopamine in Parkinson’s disease and relevant therapeutic options: a review of the literature
10.3934/neuroscience.2023017 · 2023 · External reference
Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice
10.1016/j.nbd.2021.105293 · 2021 · External reference
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease
10.1093/hmg/ddy154 · 2018 · External reference
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
10.1038/srep00603 · 2012 · External reference
Fiber-dependent amyloid formation as catalysis of an existing reaction pathway
10.1073/pnas.0703306104 · 2007 · External reference
C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasm
10.1038/s41598-022-08724-w · 2022 · External reference
Uncovering the mechanism of aggregation of human transthyretin
10.1074/jbc.m115.659912 · 2015 · External reference
Genetic risk in chronic pancreatitis: the misfolding-dependent pathway
10.1097/mog.0000000000000380 · 2017 · External reference
S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin
10.1016/s0002-9440(10)64848-1 · 2000 · External reference
Proteostasis collapse is a driver of cell aging and death
10.1073/pnas.1906592116 · 2019 · External reference
Crucial role of nonspecific interactions in amyloid nucleation
10.1073/pnas.1410159111 · 2014 · External reference
Activation of parkin by a molecular glue
10.1038/s41467-024-51889-3 · 2024 · External reference
Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice
10.1093/hmg/ddh175 · 2004 · External reference
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
10.1038/s41467-022-32951-4 · 2022 · External reference
Mutant protein kinase Cγ found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death
10.1074/jbc.m501716200 · 2005 · External reference
The protofilament substructure of amyloid fibrils11Edited by F. E. Cohen
10.1006/jmbi.2000.3908 · 2000 · External reference
A C-terminally truncated TDP-43 splice isoform exhibits neuronal specific cytoplasmic aggregation and contributes to TDP-43 pathology in ALS
10.3389/fnins.2022.868556 · 2022 · External reference
HSP-90/kinase complexes are stabilized by the large PPIase FKB-6
10.1038/s41598-021-91667-5 · 2021 · External reference
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
10.1016/j.molcel.2025.08.022 · 2025 · External reference
Self-replication of prion protein fragment 89-230 amyloid fibrils accelerated by prion protein fragment 107-143 aggregates
10.3390/ijms21197410 · 2020 · External reference
Methylene blue inhibits formation of tau fibrils but not of granular tau oligomers: a plausible key to understanding failure of a clinical trial for Alzheimer’s disease
10.3233/jad-181001 · 2019 · External reference
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease
2013 · External reference
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
10.1073/pnas.95.11.6469 · 1998 · External reference
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
10.1073/pnas.100110097 · 2000 · External reference
Kinetic analysis of the multistep aggregation pathway of human transthyretin
2018 · External reference
Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells
10.1007/s00018-013-1385-2 · 2013 · External reference
Defects axonal elongation and neuronal migration in mice with disrupted tau and map1b genes
10.1083/jcb.150.5.989 · 2000 · External reference
Expression analysis of molecular chaperones associated with disaggregation complex in rotenone-induced Parkinsonian rat model
10.1016/j.biocel.2025.106752 · 2025 · External reference
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
10.1016/s0092-8674(00)80835-1 · 2000 · External reference
Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response [Internet]
10.1073/pnas.1619234114 · 2017 · External reference
Accumulation of protein aggregates induces autolytic programmed cell death in hybrid tobacco cells expressing hybrid lethality
10.1038/s41598-019-46619-5 · 2019 · External reference
Lecanemab in early Alzheimer's disease
10.1056/nejmoa2212948 · 2023 · External reference
Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson’s disease and parkinsonism-dementia of Guam
10.1038/s41419-024-07258-5 · 2024 · External reference
Islet amyloid polypeptide exerts a novel autocrine action in β-cell signaling and proliferation
10.1096/fj.15-270553 · 2015 · External reference
Protein aggregation in neurodegenerative diseases
10.1097/cm9.0000000000003802 · 2025 · External reference
The disease-specific structural pattern in Parkinson’s disease and its cortical characteristics associated with gene function: a 7-Tesla MRI study
10.1007/s00415-025-13035-x · 2025 · External reference
Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme
10.1016/j.ijbiomac.2018.09.165 · 2019 · External reference
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
10.1038/35102591 · 2001 · External reference
Sir2 links the unfolded protein response and the heat shock response in a stress response network
10.1016/j.bbrc.2015.01.021 · 2015 · External reference
IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
10.4049/jimmunol.1002854 · 2011 · External reference
Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice
10.1074/jbc.m112.359000 · 2012 · External reference
Identifying the role of co-aggregation of Alzheimer’s amyloid-β with amorphous protein aggregates of non-amyloid proteins
10.1016/j.xcrp.2022.101028 · 2022 · External reference
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER
10.1016/j.celrep.2024.114358 · 2024 · External reference
Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly
10.1073/pnas.0711664105 · 2008 · External reference
Neurodegeneration caused by polyglutamine expansion is regulated by P-glycoprotein in Drosophila melanogaster
10.1534/genetics.113.155077 · 2013 · External reference
Visualization and classification of amyloid β supramolecular assemblies
10.1021/bi701842n · 2007 · External reference
Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor
10.1038/emboj.2008.23 · 2008 · External reference
Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology
10.1111/febs.13722 · 2016 · External reference
Detection of p53 protein aggregation in cancer cell lines and tumor samples
2015 · External reference
Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation
10.1073/pnas.1208228109 · 2012 · External reference
Glycyrrhizic acid combined with human adipose-derived MSCs synergistically alleviates the MPP+/MPTP-induced parkinson’s disease by inducing autophagy through PI3K/AKT/HIF-1α pathway
10.1186/s13287-025-04626-6 · 2025 · External reference
Mouse oocytes sequester aggregated proteins in degradative super-organelles
10.1016/j.cell.2024.01.031 · 2024 · External reference
Protein folding in a specialized compartment: the endoplasmic reticulum
10.1016/s0969-2126(99)80112-9 · 1999 · External reference
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1
10.1128/jvi.01416-09 · 2010 · External reference
Characterization of individual α-synuclein oligomers formed at different stages of protein aggregation by atomic force microscopy-infrared spectroscopy
10.1021/acs.analchem.0c00593 · 2020 · External reference
Exploration of the misfolding mechanism of transthyretin monomer: insights from hybrid-resolution simulations and markov state model analysis
10.3390/biom9120889 · 2019 · External reference
Hsu, characterization of BRCA1-associated protein-1 (BAP1) aggregation properties induced by cancer-associated mutations
10.1002/cbic.202500372 · ExternalCitation · doi-reference
Mechanism of reversible self-association of a monoclonal antibody: role of electrostatic and hydrophobic interactions
10.1002/jps.24237 · ExternalCitation · doi-reference
Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides
10.1002/mus.20503 · ExternalCitation · doi-reference
Conformational and aggregation properties of the 1-93 fragment of apolipoprotein A-I
10.1002/pro.2534 · ExternalCitation · doi-reference
The protofilament substructure of amyloid fibrils11Edited by F. E. Cohen
10.1006/jmbi.2000.3908 · ExternalCitation · doi-reference
Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells
10.1007/s00018-013-1385-2 · ExternalCitation · doi-reference
Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion
10.1007/s00401-012-1043-z · ExternalCitation · doi-reference
Mutations of the prion protein gene
10.1007/s00415-002-0896-9 · ExternalCitation · doi-reference
The disease-specific structural pattern in Parkinson’s disease and its cortical characteristics associated with gene function: a 7-Tesla MRI study
10.1007/s00415-025-13035-x · ExternalCitation · doi-reference
Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins
10.1007/s12013-011-9200-x · ExternalCitation · doi-reference
Protective effect of curcumin on thermally aggregated bovine serum albumin
10.1007/s12013-025-01810-6 · ExternalCitation · doi-reference
Focal-type, but not diffuse-type, amyloid beta plaques are correlated with Alzheimer’s neuropathology, cognitive dysfunction, and neuroinflammation in the human hippocampus
10.1007/s12264-022-00927-5 · ExternalCitation · doi-reference
, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
10.1016/0092-8674(93)90585-e · ExternalCitation · doi-reference
Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis
10.1016/0140-6736(93)93127-m · ExternalCitation · doi-reference
Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: implications for impaired mitochondrial biogenesis and synaptic damage
10.1016/j.bbadis.2011.04.006 · ExternalCitation · doi-reference
The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy
10.1016/j.bbadis.2019.07.007 · ExternalCitation · doi-reference
Ganglioside lipids accelerate α-synuclein amyloid formation
10.1016/j.bbapap.2018.07.004 · ExternalCitation · doi-reference
Sir2 links the unfolded protein response and the heat shock response in a stress response network
10.1016/j.bbrc.2015.01.021 · ExternalCitation · doi-reference
Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: the new molecular mechanism of ibudilast and its implication for neuroprotective therapy
10.1016/j.bbrc.2020.03.051 · ExternalCitation · doi-reference
Expression analysis of molecular chaperones associated with disaggregation complex in rotenone-induced Parkinsonian rat model
10.1016/j.biocel.2025.106752 · ExternalCitation · doi-reference
Multistep aggregation pathway of human interIeukin-1 receptor antagonist: kinetic, structural, and morphological characterization
10.1016/j.bpj.2008.10.002 · ExternalCitation · doi-reference
Protein glycation by glyoxal promotes amyloid formation by islet amyloid polypeptide
10.1016/j.bpj.2019.05.013 · ExternalCitation · doi-reference
Mouse oocytes sequester aggregated proteins in degradative super-organelles
10.1016/j.cell.2024.01.031 · ExternalCitation · doi-reference
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER
10.1016/j.celrep.2024.114358 · ExternalCitation · doi-reference
Structure-activity relationship of amyloid fibrils
10.1016/j.febslet.2009.07.003 · ExternalCitation · doi-reference
Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme
10.1016/j.ijbiomac.2018.09.165 · ExternalCitation · doi-reference
Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathologic observations
10.1016/j.jcf.2014.09.012 · ExternalCitation · doi-reference
Cytotoxicity of insulin within its self-assembly and amyloidogenic pathways
10.1016/j.jmb.2007.04.053 · ExternalCitation · doi-reference
Evolutionarily conserved proline residues impede the misfolding of the mouse prion protein by destabilizing an aggregation-competent partially unfolded form
10.1016/j.jmb.2022.167854 · ExternalCitation · doi-reference
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
10.1016/j.molcel.2025.08.022 · ExternalCitation · doi-reference
Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice
10.1016/j.nbd.2021.105293 · ExternalCitation · doi-reference
Theory of protein folding
10.1016/j.sbi.2004.01.009 · ExternalCitation · doi-reference
Identifying the role of co-aggregation of Alzheimer’s amyloid-β with amorphous protein aggregates of non-amyloid proteins
10.1016/j.xcrp.2022.101028 · ExternalCitation · doi-reference
β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner
10.1016/j.ydbio.2016.03.012 · ExternalCitation · doi-reference
S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin
10.1016/s0002-9440(10)64848-1 · ExternalCitation · doi-reference
A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy
10.1016/s0006-3495(03)74550-0 · ExternalCitation · doi-reference
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
10.1016/s0092-8674(00)80835-1 · ExternalCitation · doi-reference
4-hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
10.1016/s0306-4522(97)00065-1 · ExternalCitation · doi-reference
Genetics of cystic fibrosis: basics
10.1016/s0929-693x(20)30043-9 · ExternalCitation · doi-reference
Protein folding in a specialized compartment: the endoplasmic reticulum
10.1016/s0969-2126(99)80112-9 · ExternalCitation · doi-reference
Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
10.1017/s0033583516000172 · ExternalCitation · doi-reference
Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain
10.1017/s1462399411002134 · ExternalCitation · doi-reference
Characterization of individual α-synuclein oligomers formed at different stages of protein aggregation by atomic force microscopy-infrared spectroscopy
10.1021/acs.analchem.0c00593 · ExternalCitation · doi-reference
Sequestration of TDP-43216-414aggregates by cytoplasmic expression of the proSAAS chaperone
10.1021/acschemneuro.2c00156 · ExternalCitation · doi-reference
Partially unfolded states of β-microglobulin and amyloid formation in vitro
10.1021/bi000276j · ExternalCitation · doi-reference
Relative influence of hydrophobicity and net charge in the aggregation of two homologous proteins
10.1021/bi030135s · ExternalCitation · doi-reference
The impact of the E46K mutation on the properties of α-synuclein in its monomelic and oligomeric states
10.1021/bi7000246 · ExternalCitation · doi-reference
Visualization and classification of amyloid β supramolecular assemblies
10.1021/bi701842n · ExternalCitation · doi-reference
Observation of β-Amyloid peptide oligomerization by pressure-jump NMR spectroscopy
10.1021/jacs.9b06970 · ExternalCitation · doi-reference
Interactions between amyloid-β and tau fragments promote aberrant aggregates: implications for amyloid toxicity
10.1021/jp506258g · ExternalCitation · doi-reference
Secondary nucleation and accessible surface in insulin amyloid fibril formation
10.1021/jp710131u · ExternalCitation · doi-reference
Secondary structural change of bovine serum albumin in thermal denaturation up to 130 °C and protective effect of sodium dodecyl sulfate on the change
10.1021/jp8067624 · ExternalCitation · doi-reference
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
10.1038/35102591 · ExternalCitation · doi-reference
Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor
10.1038/emboj.2008.23 · ExternalCitation · doi-reference
Heat shock response relieves ER stress
10.1038/emboj.2008.42 · ExternalCitation · doi-reference
Histological prevalence of β2-microglobulin amyloidosis in hemodialysis: a prospective post-mortem study
10.1038/ki.1997.262 · ExternalCitation · doi-reference
Protein folding and misfolding
10.1038/nature02261 · ExternalCitation · doi-reference
Structure of the cross-β spine of amyloid-like fibrils
10.1038/nature03680 · ExternalCitation · doi-reference
The prion protein as a receptor for amyloid-γ 2
10.1038/nature09217 · ExternalCitation · doi-reference
Molecular chaperones in protein folding and proteostasis
10.1038/nature10317 · ExternalCitation · doi-reference
Cryo-EM structures of tau filaments from Alzheimer's disease
10.1038/nature23002 · ExternalCitation · doi-reference
Gelsolin–derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187
10.1038/ng1092-157 · ExternalCitation · doi-reference
Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
10.1038/nm1021 · ExternalCitation · doi-reference
The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
10.1038/nm1295-1291 · ExternalCitation · doi-reference
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
10.1038/nn.2660 · ExternalCitation · doi-reference
Structural properties of an amyloid precursor of β2-microglobulin
10.1038/nsb791 · ExternalCitation · doi-reference
Amyloid formation under physiological conditions proceeds via a native-like folding intermediate
10.1038/nsmb1058 · ExternalCitation · doi-reference
Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations
10.1038/s41392-025-02439-w · ExternalCitation · doi-reference
Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson’s disease and parkinsonism-dementia of Guam
10.1038/s41419-024-07258-5 · ExternalCitation · doi-reference
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
10.1038/s41467-017-02299-1 · ExternalCitation · doi-reference
Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP
10.1038/s41467-022-30238-2 · ExternalCitation · doi-reference
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
10.1038/s41467-022-32951-4 · ExternalCitation · doi-reference
Activation of parkin by a molecular glue
10.1038/s41467-024-51889-3 · ExternalCitation · doi-reference
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation
10.1038/s41467-025-62751-5 · ExternalCitation · doi-reference
Accumulation of protein aggregates induces autolytic programmed cell death in hybrid tobacco cells expressing hybrid lethality
10.1038/s41598-019-46619-5 · ExternalCitation · doi-reference
HSP-90/kinase complexes are stabilized by the large PPIase FKB-6
10.1038/s41598-021-91667-5 · ExternalCitation · doi-reference
C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasm
10.1038/s41598-022-08724-w · ExternalCitation · doi-reference
The dynamics of oxygenation to Aβ fibrils using an azobenzene–boron complex type photocatalyst and light energy
10.1038/s41598-025-10880-8 · ExternalCitation · doi-reference
VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration
10.1038/sj.cdd.4400907 · ExternalCitation · doi-reference
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
10.1038/srep00603 · ExternalCitation · doi-reference
The formation and stabilization of protein structure
10.1042/bj1280737 · ExternalCitation · doi-reference
Neurodegenerative diseases and prions
10.1056/nejm200105173442006 · ExternalCitation · doi-reference
Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis
10.1056/nejmoa013354 · ExternalCitation · doi-reference
Natural history and outcome in systemic AA amyloidosis
10.1056/nejmoa070265 · ExternalCitation · doi-reference
Safety and efficacy of RNAi therapy for transthyretin amyloidosis
10.1056/nejmoa1208760 · ExternalCitation · doi-reference
Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis
10.1056/nejmoa1716153 · ExternalCitation · doi-reference
Donanemab in early Alzheimer’s disease
10.1056/nejmoa2100708 · ExternalCitation · doi-reference
Lecanemab in early Alzheimer's disease
10.1056/nejmoa2212948 · ExternalCitation · doi-reference
Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
10.1073/pnas.0406976102 · ExternalCitation · doi-reference
Folding of Cu/Zn superoxide dismutase suggests structural hotspots for gain of neurotoxic function in ALS: parallels to precursors in amyloid disease
10.1073/pnas.0601696103 · ExternalCitation · doi-reference
Fiber-dependent amyloid formation as catalysis of an existing reaction pathway
10.1073/pnas.0703306104 · ExternalCitation · doi-reference
Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly
10.1073/pnas.0711664105 · ExternalCitation · doi-reference
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
10.1073/pnas.0903691106 · ExternalCitation · doi-reference
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
10.1073/pnas.100110097 · ExternalCitation · doi-reference
Aggregation of γ-crystallins associated with human cataracts via domain swapping at the C-terminal β-strands
10.1073/pnas.1019152108 · ExternalCitation · doi-reference
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells
10.1073/pnas.1102645108 · ExternalCitation · doi-reference
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
10.1073/pnas.1121005109 · ExternalCitation · doi-reference
Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation
10.1073/pnas.1208228109 · ExternalCitation · doi-reference
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
10.1073/pnas.1218402110 · ExternalCitation · doi-reference
Crucial role of nonspecific interactions in amyloid nucleation
10.1073/pnas.1410159111 · ExternalCitation · doi-reference
Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response [Internet]
10.1073/pnas.1619234114 · ExternalCitation · doi-reference
Proteostasis collapse is a driver of cell aging and death
10.1073/pnas.1906592116 · ExternalCitation · doi-reference
Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques
10.1073/pnas.261562998 · ExternalCitation · doi-reference
Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide
10.1073/pnas.93.14.7283 · ExternalCitation · doi-reference
Folding funnels and frustration in off-lattice minimalist protein landscapes
10.1073/pnas.95.11.5921 · ExternalCitation · doi-reference
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
10.1073/pnas.95.11.6469 · ExternalCitation · doi-reference
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
10.1073/pnas.96.24.14088 · ExternalCitation · doi-reference
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
10.1074/jbc.c000447200 · ExternalCitation · doi-reference
Mutant A53T α-Synuclein induces neuronal death by increasing mitochondrial autophagy
10.1074/jbc.m110.132514 · ExternalCitation · doi-reference
Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-β stability, oligomerization, and aggregation
10.1074/jbc.m110.177246 · ExternalCitation · doi-reference
Mutant p53 aggregates into prion-like amyloid oligomers and fibrils
10.1074/jbc.m112.340638 · ExternalCitation · doi-reference
Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice
10.1074/jbc.m112.359000 · ExternalCitation · doi-reference
Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions
10.1074/jbc.m113.498246 · ExternalCitation · doi-reference
Uncovering the mechanism of aggregation of human transthyretin
10.1074/jbc.m115.659912 · ExternalCitation · doi-reference
Aggregation of full-length immunoglobulin light chains from systemic light chain amyloidosis (AL) patients is remodeled by epigallocatechin-3-gallate
10.1074/jbc.m116.750323 · ExternalCitation · doi-reference
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
10.1074/jbc.m500997200 · ExternalCitation · doi-reference
Mutant protein kinase Cγ found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death
10.1074/jbc.m501716200 · ExternalCitation · doi-reference
Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants
10.1074/jbc.m800247200 · ExternalCitation · doi-reference
Investigating the aggregation and prionogenic properties of human cancer-related proteins
10.1080/10985549.2025.2481054 · ExternalCitation · doi-reference
Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification
10.1080/19420862.2019.1658493 · ExternalCitation · doi-reference
Defects axonal elongation and neuronal migration in mice with disrupted tau and map1b genes
10.1083/jcb.150.5.989 · ExternalCitation · doi-reference
Pathways of cellular proteostasis in aging and disease
10.1083/jcb.201709072 · ExternalCitation · doi-reference
Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice
10.1093/hmg/ddh175 · ExternalCitation · doi-reference
Nilotinib reverses loss of dopamine neurons and improvesmotorbehavior via autophagic degradation of α-synuclein in parkinson's disease models
10.1093/hmg/ddt192 · ExternalCitation · doi-reference
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease
10.1093/hmg/ddy154 · ExternalCitation · doi-reference
Altering the association properties of insulin by amino acid replacement
10.1093/protein/5.6.527 · ExternalCitation · doi-reference
The hydrophobic effect in protein folding
10.1096/fasebj.9.7.7737462 · ExternalCitation · doi-reference
Islet amyloid polypeptide exerts a novel autocrine action in β-cell signaling and proliferation
10.1096/fj.15-270553 · ExternalCitation · doi-reference
Oxidative stress induces amyloid-like aggregate formation of NACP/α- synuclein in vitro
10.1097/00001756-199903170-00011 · ExternalCitation · doi-reference
Protein aggregation in neurodegenerative diseases
10.1097/cm9.0000000000003802 · ExternalCitation · doi-reference
Genetic risk in chronic pancreatitis: the misfolding-dependent pathway
10.1097/mog.0000000000000380 · ExternalCitation · doi-reference
10.1101/2022.09.20.508793
10.1101/2022.09.20.508793 · ExternalCitation · doi-reference
10.1101/2023.01.19.524732
10.1101/2023.01.19.524732 · ExternalCitation · doi-reference
Disrupted transcriptional networks by mutant atrophin-1 in a cell culture model of dentatorubral-pallidoluysian atrophy [Internet]
10.1101/2025.08.08.669318 · ExternalCitation · doi-reference
The transcription factor bZIP60 links the unfolded protein response to the heat stress response in maize
10.1105/tpc.20.00260 · ExternalCitation · doi-reference
Amyotrophic lateral sclerosis: a clinical review
10.1111/ene.14393 · ExternalCitation · doi-reference
The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway
10.1111/febs.12813 · ExternalCitation · doi-reference
Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology
10.1111/febs.13722 · ExternalCitation · doi-reference
Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease
10.1111/j.1365-2613.2007.00568.x · ExternalCitation · doi-reference
Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation
10.1111/j.1460-9568.2007.05955.x · ExternalCitation · doi-reference
α-Synuclein promotes SNARE-complex assembly in vivo and in vitro
10.1126/science.1195227 · ExternalCitation · doi-reference
Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly
10.1126/science.2188360 · ExternalCitation · doi-reference
Mutation in the α-synuclein gene identified in families with Parkinson's disease
10.1126/science.276.5321.2045 · ExternalCitation · doi-reference
A receptor-mediated pathway for cholesterol homeostasis
10.1126/science.3513311 · ExternalCitation · doi-reference
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1
10.1128/jvi.01416-09 · ExternalCitation · doi-reference
Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes
10.1128/mcb.05460-11 · ExternalCitation · doi-reference
Hyperglycemia and hyperlipidemia are associated with endothelial dysfunction during the development of type 2 diabetes
10.1139/y07-026 · ExternalCitation · doi-reference
Protein misfolding, functional amyloid, and human disease
10.1146/annurev.biochem.75.101304.123901 · ExternalCitation · doi-reference
X-ray diffraction studies on amyloid filaments
10.1177/16.11.673 · ExternalCitation · doi-reference
Hereditary renal amyloidosis with a variant lysozyme p.Trp82Arg in a Chinese family: case report and literature review
10.1186/s12882-019-1496-6 · ExternalCitation · doi-reference
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
10.1186/s13024-023-00617-4 · ExternalCitation · doi-reference
Glycyrrhizic acid combined with human adipose-derived MSCs synergistically alleviates the MPP+/MPTP-induced parkinson’s disease by inducing autophagy through PI3K/AKT/HIF-1α pathway
10.1186/s13287-025-04626-6 · ExternalCitation · doi-reference
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
10.1186/s40478-022-01469-7 · ExternalCitation · doi-reference
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
10.1242/jcs.180737 · ExternalCitation · doi-reference
The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth
10.1371/journal.pcbi.1007767 · ExternalCitation · doi-reference
Molten globule of hemoglobin proceeds into aggregates and advanced glycated end products
10.1371/journal.pone.0072075 · ExternalCitation · doi-reference
Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide
10.1371/journal.pone.0195339 · ExternalCitation · doi-reference
Two randomized phase 3 studies of aducanumab in early Alzheimer’s disease
10.14283/jpad.2022.30 · ExternalCitation · doi-reference
Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in alzheimer’s disease mouse models
10.1523/jneurosci.0284-14.2014 · ExternalCitation · doi-reference
Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
10.1523/jneurosci.5699-09.2010 · ExternalCitation · doi-reference
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions
10.1523/jneurosci.5922-09.2010 · ExternalCitation · doi-reference
A role for synaptic zinc in activity-dependent aβ oligomer formation and accumulation at excitatory synapses
10.1523/jneurosci.5980-08.2009 · ExternalCitation · doi-reference
Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation
10.15252/embr.201744617 · ExternalCitation · doi-reference
A three-stage kinetic model of amyloid fibrillation
10.1529/biophysj.106.098608 · ExternalCitation · doi-reference
Neurodegeneration caused by polyglutamine expansion is regulated by P-glycoprotein in Drosophila melanogaster
10.1534/genetics.113.155077 · ExternalCitation · doi-reference
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress-mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
10.2337/db07-0197 · ExternalCitation · doi-reference
Methylene blue inhibits formation of tau fibrils but not of granular tau oligomers: a plausible key to understanding failure of a clinical trial for Alzheimer’s disease
10.3233/jad-181001 · ExternalCitation · doi-reference
The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer
10.3233/jad-2008-14212 · ExternalCitation · doi-reference
Serine-129 phosphorylated α-synuclein drives mitochondrial dysfunction and calcium dysregulation in Parkinson’s disease model
10.3389/fnagi.2025.1538166 · ExternalCitation · doi-reference
A phase II study to evaluate the safety and efficacy of prasinezumab in early Parkinson's disease (PASADENA): rationale, design, and baseline data
10.3389/fneur.2021.705407 · ExternalCitation · doi-reference
Protein quality control by molecular chaperones in neurodegeneration
10.3389/fnins.2017.00185 · ExternalCitation · doi-reference
A C-terminally truncated TDP-43 splice isoform exhibits neuronal specific cytoplasmic aggregation and contributes to TDP-43 pathology in ALS
10.3389/fnins.2022.868556 · ExternalCitation · doi-reference
Doxycycline for Alzheimer’s disease: fighting β-amyloid oligomers and neuroinflammation
10.3389/fphar.2019.00738 · ExternalCitation · doi-reference
Lysosome-mitochondrial crosstalk in cellular stress and disease
10.3390/antiox14020125 · ExternalCitation · doi-reference
Antioxidant potential of curcumin—a meta-analysis of randomized clinical trials
10.3390/antiox9111092 · ExternalCitation · doi-reference
Exploration of the misfolding mechanism of transthyretin monomer: insights from hybrid-resolution simulations and markov state model analysis
10.3390/biom9120889 · ExternalCitation · doi-reference
Hsp90 relieves heat stress-induced damage in mouse kidneys: involvement of antiapoptotic PKM2-AKT and autophagic HIF-1α signaling
10.3390/ijms21051646 · ExternalCitation · doi-reference
Self-replication of prion protein fragment 89-230 amyloid fibrils accelerated by prion protein fragment 107-143 aggregates
10.3390/ijms21197410 · ExternalCitation · doi-reference
C9ORF72 gene GGGGCC hexanucleotide expansion: a high clinical variability from amyotrophic lateral sclerosis to frontotemporal dementia
10.3390/jpm13091396 · ExternalCitation · doi-reference
Some candidate drugs for pharmacotherapy of Alzheimer’s disease
10.3390/ph14050458 · ExternalCitation · doi-reference
Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery: in vitro evidence
10.3390/pharmaceutics11110572 · ExternalCitation · doi-reference
Depletion of dopamine in Parkinson’s disease and relevant therapeutic options: a review of the literature
10.3934/neuroscience.2023017 · ExternalCitation · doi-reference
IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
10.4049/jimmunol.1002854 · ExternalCitation · doi-reference
The aggregation inhibitor peptide qbp1 as a therapeutic molecule for the polyglutamine neurodegenerative diseases
10.4061/2011/265084 · ExternalCitation · doi-reference
Pathological mechanisms of amyotrophic lateral sclerosis
10.4103/1673-5374.382985 · ExternalCitation · doi-reference