Research graph
References from Cryo-electron microscopy in membrane protein structural biology. Local targets link to admitted publications; unresolved targets remain external evidence.
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster
10.7554/elife.84424 · 2023 · External reference
Hurdles and advancements in experimental membrane protein structural biology
10.1016/j.jsb.2025.108251 · 2025 · External reference
Crystal structure of the entire respiratory complex i
10.1038/nature11871 · 2013 · External reference
Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor
10.1038/s41586-018-0660-7 · 2018 · External reference
High-resolution structures of multiple 5-HT3aR-setron complexes reveal a novel mechanism of competitive inhibition
10.7554/elife.57870 · 2020 · External reference
Developments, applications, and prospects of cryo-electron microscopy
10.1002/pro.3805 · 2020 · External reference
Ion channels: from conductance to structure
10.1016/j.neuron.2008.10.035 · 2008 · External reference
Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons
10.1085/jgp.60.5.588 · 1972 · External reference
Changes in membrane protein structural biology
10.3390/biology9110401 · 2020 · External reference
The binding change mechanism for ATP synthase - some probabilities and possibilities
10.1016/0005-2728(93)90063-l · 1993 · External reference
The ATP synthase - a splendid molecular machine
10.1146/annurev.biochem.66.1.717 · 1997 · External reference
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides
10.1126/science.ade3332 · 2023 · External reference
Structure of inhibitor-bound mammalian complex I
10.1038/s41467-020-18950-3 · 2020 · External reference
The lateral pressure profile in membranes: a physical mechanism of general anesthesia
10.1021/bi9627323 · 1997 · External reference
TRPV1 structures in distinct conformations reveal activation mechanisms
10.1038/nature12823 · 2013 · External reference
Cryo electron microscopy to determine the structure of macromolecular complexes
10.1016/j.ymeth.2015.11.023 · 2016 · External reference
The road to the structure of the mitochondrial respiratory chain supercomplex
10.1042/bst20190930 · 2020 · External reference
Molecular properties of voltage-sensitive sodium channels
10.1146/annurev.bi.55.070186.004513 · 1986 · External reference
Ion channel voltage sensors: structure, function, and pathophysiology
10.1016/j.neuron.2010.08.021 · 2010 · External reference
Single-particle cryo-EM at crystallographic resolution
10.1016/j.cell.2015.03.049 · 2015 · External reference
Membrane protein structural biology in the era of single particle cryo-EM
10.1016/j.sbi.2018.08.008 · 2018 · External reference
Single-particle cryo-EM-How did it get here and where will it go
10.1126/science.aat4346 · 2018 · External reference
High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor
10.1126/science.1150577 · 2007 · External reference
Core architecture of a bacterial type II secretion system
10.1038/s41467-019-13301-3 · 2019 · External reference
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain
10.1038/s41467-022-29594-w · 2022 · External reference
Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors
10.1016/j.str.2012.04.010 · 2012 · External reference
Cork-in-bottle mechanism of inhibitor binding to mammalian complex I
10.1126/sciadv.abg4000 · 2021 · External reference
Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy
10.1038/s41467-022-30506-1 · 2022 · External reference
CryoEM Reveals the Complexity and Diversity of ATP Synthases
10.3389/fmicb.2022.864006 · 2022 · External reference
Structural mechanism of C-type inactivation in K+ channels
10.1038/nature09153 · 2010 · External reference
Et tu, Grotthuss! and other unfinished stories
10.1016/j.bbabio.2005.12.001 · 2006 · External reference
Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system
10.1016/j.str.2022.12.003 · 2023 · External reference
Structure of the adenosine A2A receptor in complex with ZM241385 and the xanthines XAC and caffeine
10.1016/j.str.2011.06.014 · 2011 · External reference
The structure of the potassium channel: molecular basis of K+ conduction and selectivity
10.1126/science.280.5360.69 · 1998 · External reference
Structure of the adenosine-bound human adenosine A1 receptor-Gi complex
10.1038/s41586-018-0236-6 · 2018 · External reference
Glycine receptor mechanism elucidated by electron cryo-microscopy
10.1038/nature14853 · 2015 · External reference
Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism
10.1038/s41574-024-00957-1 · 2024 · External reference
Cryo-electron microscopy of vitrified specimens
10.1017/s0033583500004297 · 1988 · External reference
Structure of the membrane domain of respiratory complex i
10.1038/nature10330 · 2011 · External reference
W. Lu, Structure of the human lipid-gated cation channel TRPC3
10.7554/elife.36852 · 2018 · External reference
Inactivation of the Kv2.1 channel through electromechanical coupling
10.1038/s41586-023-06582-8 · 2023 · External reference
Single-particle reconstruction of biological macromolecules in electron microscopy-30 years
10.1017/s0033583509990059 · 2009 · External reference
Atypical mechanism of conduction in potassium channels
10.1073/pnas.0903226106 · 2009 · External reference
Structures of TRPV1 bound by hyperthermia-inducing analgesics
10.1016/j.celrep.2025.116765 · 2026 · External reference
Cryo-EM structures of GPCRs coupled to G s, G i and G o
10.1016/j.mce.2019.02.006 · 2019 · External reference
Structure determination of GPCRs: Cryo-EM compared with X-ray crystallography
10.1042/bst20210431 · 2021 · External reference
GABAA receptors: structure, function, pharmacology, and related disorders
10.1186/s43141-021-00224-0 · 2021 · External reference
In vivo structure of the Legionella type II secretion system by electron cryotomography
10.1038/s41564-019-0603-6 · 2019 · External reference
Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases
10.3389/fmolb.2016.00043 · 2016 · External reference
Conformational transitions and allosteric modulation in a heteromeric glycine receptor
10.1038/s41467-023-37106-7 · 2023 · External reference
Sur la décomposition de l’eau et des corps qu’elle tient en dissolution à l’aide de l’électricité galvanique
1806 · External reference
Structure of a bacterial ATP synthase
10.7554/elife.43128 · 2019 · External reference
Structures of the calcium-activated, non-selective cation channel TRPM4
10.1038/nature24997 · 2017 · External reference
New insights into GPCR coupling and dimerisation from cryo-EM structures
10.1016/j.sbi.2023.102574 · 2023 · External reference
Structure of a complete ATP synthase dimer reveals the molecular basis of inner mitochondrial membrane morphology
10.1016/j.molcel.2016.05.037 · 2016 · External reference
Structure, mechanism, and regulation of the chloroplast ATP synthase
10.1126/science.aat4318 · 2018 · External reference
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
10.1016/s0022-2836(05)80271-2 · 1990 · External reference
Three-dimensional model of purple membrane obtained by electron microscopy
10.1038/257028a0 · 1975 · External reference
Stabilization of G protein-coupled receptors by point mutations
10.3389/fphar.2015.00082 · 2015 · External reference
In situ molecular architecture of the Salmonella type III secretion machine
10.1016/j.cell.2017.02.022 · 2017 · External reference
W. Lü, Physiological temperature drives TRPM4 ligand recognition and gating
10.1038/s41586-024-07436-7 · 2024 · External reference
Structure of the full-length TRPV2 channel by cryo-EM
10.1038/ncomms11130 · 2016 · External reference
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist
10.1126/science.1164772 · 2008 · External reference
The principle of gating charge movement in a voltage-dependent K+ channel
10.1038/nature01581 · 2003 · External reference
X-ray structure of a voltage-dependent K+ channel
10.1038/nature01580 · 2003 · External reference
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
10.1038/nature14656 · 2015 · External reference
Direct structural insights into GABAA receptor pharmacology
10.1016/j.tibs.2021.01.011 · 2021 · External reference
Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation
10.7554/elife.68710 · 2021 · External reference
CryoEM of bacterial secretion systems
10.1016/j.sbi.2018.08.007 · 2018 · External reference
Direct knock-on of desolvated ions governs strict ion selectivity in K+ channels
10.1038/s41557-018-0105-9 · 2018 · External reference
Architecture, function, and substrates of the type II secretion system
10.1128/ecosalplus.esp-0034-2018 · 2019 · External reference
Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs
10.1038/s41467-020-17364-5 · 2020 · External reference
Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs
10.1038/s41467-022-32594-5 · 2022 · External reference
Ion permeation in K+ channels occurs by direct Coulomb knock-on
10.1126/science.1254840 · 2014 · External reference
Structure and mechanisms of F-Type ATP synthases
10.1146/annurev-biochem-013118-110903 · 2019 · External reference
Cryo-EM of mitochondrial complex I and ATP synthase
10.1146/annurev-biophys-060724-110838 · 2025 · External reference
Atomic model of plant light-harvesting complex by electron crystallography
10.1038/367614a0 · 1994 · External reference
The resolution revolution
10.1126/science.1251652 · 2014 · External reference
Forty years in cryoEM of membrane proteins
10.1093/jmicro/dfab041 · 2022 · External reference
Direct visualization of electric-field-stimulated ion conduction in a potassium channel
10.1016/j.cell.2024.12.006 · 2025 · External reference
Molecular structure of human katp in complex with ATP and ADP
10.7554/elife.32481 · 2017 · External reference
From selective permeation to physiology in potassium channels
10.1093/function/zqaf050 · 2025 · External reference
BK channel activation: structural and functional insights
10.1016/j.tins.2010.06.004 · 2010 · External reference
Regulation of membrane protein structure and function by their lipid nano-environment
10.1038/s41580-022-00524-4 · 2023 · External reference
Structural basis for pH gating of the two-pore domain K+ channel TASK2
10.1038/s41586-020-2770-2 · 2020 · External reference
Structure of a pancreatic ATP-sensitive potassium channel
10.1016/j.cell.2016.12.028 · 2017 · External reference
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
10.1038/nature12822 · 2013 · External reference
G protein-coupled receptors: a century of research and discovery
10.1161/circresaha.124.323067 · 2024 · External reference
Membrane protein structural biology: The high throughput challenge
10.1016/s1047-8477(03)00045-5 · 2003 · External reference
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel
10.1126/science.1116269 · 2005 · External reference
Voltage sensor of Kv1.2: structural basis of electromechanical coupling
10.1126/science.1116270 · 2005 · External reference
Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers
2022 · External reference
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes
10.1126/science.aaw5188 · 2019 · External reference
Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating
10.7554/elife.24149 · 2017 · External reference
GABAA receptor signalling mechanisms revealed by structural pharmacology
10.1038/s41586-018-0832-5 · 2019 · External reference
Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs
10.7554/elife.37558 · 2018 · External reference
Crystal structure of a human GABAA receptor
10.1038/nature13293 · 2014 · External reference
Energetic optimization of ion conduction rate by the K+selectivity filter
10.1038/35102000 · 2001 · External reference
Purification, characterization and crystallization of the F-ATPase from Paracoccus denitrificans
10.1098/rsob.150119 · 2015 · External reference
Structure of ATP synthase from Paracoccus denitrificans determined by X-ray crystallography at 4.0 Å resolution
10.1073/pnas.1517542112 · 2015 · External reference
ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
10.1038/s41467-020-20381-z · 2021 · External reference
Human TRPV1 structure and inhibition by the analgesic SB-366791
10.1038/s41467-023-38162-9 · 2023 · External reference
Direct observation of the rotation of F1-ATPase
10.1038/386299a0 · 1997 · External reference
Structural mechanisms of GABAA receptor autoimmune encephalitis
10.1016/j.cell.2022.06.025 · 2022 · External reference
Mechanisms underlying C-type Inactivation in Kv channels: lessons from structures of human Kv1.3 and fly Shaker-IR channels
10.3389/fphar.2022.924289 · 2022 · External reference
Recovery from slow inactivation in K+ channels is controlled by water molecules
10.1038/nature12395 · 2013 · External reference
How many drug targets are there?
10.1038/nrd2199 · 2006 · External reference
Crystal structure of rhodopsin: a G protein-coupled receptor
10.1126/science.289.5480.739 · 2000 · External reference
Cryo-EM structure of respiratory complex I at work
10.7554/elife.39213 · 2018 · External reference
High-resolution cryo-EM structures of respiratory complex I: mechanism, assembly, and disease
10.1126/sciadv.aax9484 · 2019 · External reference
Structure of the TRPA1 ion channel suggests regulatory mechanisms
10.1038/nature14367 · 2015 · External reference
Targeting cancer and immune cell metabolism with the complex I inhibitors metformin and IACS-010759
10.1002/1878-0261.13583 · 2024 · External reference
Molecular details of ruthenium red pore block in TRPV channels
10.1038/s44319-023-00050-0 · 2024 · External reference
Structural insights into TRPV2 activation by small molecules
10.1038/s41467-022-30083-3 · 2022 · External reference
Mitochondrial complex-1 as a therapeutic target for cardiac diseases
10.1007/s11010-024-05074-1 · 2025 · External reference
Crystal structure of the β2 adrenergic receptor–Gs protein complex
10.1038/nature10361 · 2011 · External reference
Structural insights into TRPV2 modulation by probenecid
10.1038/s41594-025-01494-9 · 2025 · External reference
Structure of the mitochondrial ATP synthase by electron cryomicroscopy
10.1093/emboj/cdg608 · 2003 · External reference
A bayesian view on cryo-EM structure determination
10.1016/j.jmb.2011.11.010 · 2012 · External reference
RELION: implementation of a bayesian approach to cryo-EM structure determination
10.1016/j.jsb.2012.09.006 · 2012 · External reference
Cryo-EM advances in GPCR structure determination
10.1093/jb/mvae029 · 2024 · External reference
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
10.1038/nature12120 · 2013 · External reference
Structure–function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating
10.1074/jbc.ra118.005066 · 2018 · External reference
Structure and gating mechanism of the transient receptor potential channel TRPV3
10.1038/s41594-018-0108-7 · 2018 · External reference
The six steps of the complete F1-ATPase rotary catalytic cycle
10.1038/s41467-021-25029-0 · 2021 · External reference
Assembly and architecture of the type III secretion sorting platform
10.1073/pnas.2218010119 · 2022 · External reference
Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc
10.1038/s41586-020-1954-0 · 2020 · External reference
Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse
10.1126/sciadv.adj5539 · 2023 · External reference
Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology
10.1038/s41586-023-06556-w · 2023 · External reference
Cryo-EM structure of a KCNQ1/CaM complex reveals insights into congenital long QT syndrome
10.1016/j.cell.2017.05.019 · 2017 · External reference
Forty sites of TRP channel regulation
10.1016/j.cbpa.2024.102550 · 2025 · External reference
Structure of the Shaker Kv channel and mechanism of slow C-type inactivation
10.1126/sciadv.abm7814 · 2022 · External reference
Cryo-EM structure of the open high-conductance Ca2+ -activated K+channel
10.1038/nature20608 · 2017 · External reference
Molecular structures of the human slo1 k+channel in complex with b4
10.7554/elife.51409 · 2019 · External reference
Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
10.7554/elife.46041 · 2019 · External reference
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug
2022 · External reference
Arrangement of rhodopsin transmembrane α-helices
10.1038/38316 · 1997 · External reference
Architecture of mammalian respiratory complex I
10.1038/nature13686 · 2014 · External reference
Wei Lü, Electron cryo-microscopy structure of a human TRPM4 channel
10.1038/nature24674 · 2017 · External reference
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
10.1038/s41591-022-02103-8 · 2023 · External reference
Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2
10.1126/science.add1268 · 2022 · External reference
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
10.1038/s41586-021-03540-0 · 2021 · External reference
Mechanism of gating and partial agonist action in the glycine receptor
10.1016/j.cell.2021.01.026 · 2021 · External reference
Membrane translocation process revealed by in situ structures of type II secretion system secretins
2023 · External reference
Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening
10.1073/pnas.1305167110 · 2013 · External reference
Evolving cryo-EM structural approaches for GPCR drug discovery
10.1016/j.str.2021.04.008 · 2021 · External reference
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
10.1126/science.aaw8250 · 2019 · External reference
Structural pharmacology of TRP channels
10.1016/j.jmb.2021.166914 · 2021 · External reference
Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors
10.1016/j.cell.2017.07.002 · 2017 · External reference
Chemistry of ion coordination and hydration revealed by a K+channel-Fab complex at 2.0 Å resolution
10.1038/35102009 · 2001 · External reference
Recent advances of mitochondrial complex I inhibitors for cancer therapy: current status and future perspectives
10.1016/j.ejmech.2023.115219 · 2023 · External reference
Structure and mechanism of glycine receptor elucidated by cryo-electron microscopy
2022 · External reference
Structure of mammalian respiratory complex i
10.1038/nature19095 · 2016 · External reference
Structure of a human synaptic GABAA receptor
10.1038/s41586-018-0255-3 · 2018 · External reference
Cryo-electron microscopy structure of the TRPV2 ion channel
10.1038/nsmb.3159 · 2016 · External reference
Targeting cancer and immune cell metabolism with the complex I inhibitors metformin and IACS-010759
10.1002/1878-0261.13583 · ExternalCitation · doi-reference
Developments, applications, and prospects of cryo-electron microscopy
10.1002/pro.3805 · ExternalCitation · doi-reference
Mitochondrial complex-1 as a therapeutic target for cardiac diseases
10.1007/s11010-024-05074-1 · ExternalCitation · doi-reference
The binding change mechanism for ATP synthase - some probabilities and possibilities
10.1016/0005-2728(93)90063-l · ExternalCitation · doi-reference
Et tu, Grotthuss! and other unfinished stories
10.1016/j.bbabio.2005.12.001 · ExternalCitation · doi-reference
Forty sites of TRP channel regulation
10.1016/j.cbpa.2024.102550 · ExternalCitation · doi-reference
Single-particle cryo-EM at crystallographic resolution
10.1016/j.cell.2015.03.049 · ExternalCitation · doi-reference
Structure of a pancreatic ATP-sensitive potassium channel
10.1016/j.cell.2016.12.028 · ExternalCitation · doi-reference
In situ molecular architecture of the Salmonella type III secretion machine
10.1016/j.cell.2017.02.022 · ExternalCitation · doi-reference
Cryo-EM structure of a KCNQ1/CaM complex reveals insights into congenital long QT syndrome
10.1016/j.cell.2017.05.019 · ExternalCitation · doi-reference
Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors
10.1016/j.cell.2017.07.002 · ExternalCitation · doi-reference
Mechanism of gating and partial agonist action in the glycine receptor
10.1016/j.cell.2021.01.026 · ExternalCitation · doi-reference
Structural mechanisms of GABAA receptor autoimmune encephalitis
10.1016/j.cell.2022.06.025 · ExternalCitation · doi-reference
Direct visualization of electric-field-stimulated ion conduction in a potassium channel
10.1016/j.cell.2024.12.006 · ExternalCitation · doi-reference
Structures of TRPV1 bound by hyperthermia-inducing analgesics
10.1016/j.celrep.2025.116765 · ExternalCitation · doi-reference
Recent advances of mitochondrial complex I inhibitors for cancer therapy: current status and future perspectives
10.1016/j.ejmech.2023.115219 · ExternalCitation · doi-reference
A bayesian view on cryo-EM structure determination
10.1016/j.jmb.2011.11.010 · ExternalCitation · doi-reference
Structural pharmacology of TRP channels
10.1016/j.jmb.2021.166914 · ExternalCitation · doi-reference
RELION: implementation of a bayesian approach to cryo-EM structure determination
10.1016/j.jsb.2012.09.006 · ExternalCitation · doi-reference
Hurdles and advancements in experimental membrane protein structural biology
10.1016/j.jsb.2025.108251 · ExternalCitation · doi-reference
Cryo-EM structures of GPCRs coupled to G s, G i and G o
10.1016/j.mce.2019.02.006 · ExternalCitation · doi-reference
Structure of a complete ATP synthase dimer reveals the molecular basis of inner mitochondrial membrane morphology
10.1016/j.molcel.2016.05.037 · ExternalCitation · doi-reference
Ion channels: from conductance to structure
10.1016/j.neuron.2008.10.035 · ExternalCitation · doi-reference
Ion channel voltage sensors: structure, function, and pathophysiology
10.1016/j.neuron.2010.08.021 · ExternalCitation · doi-reference
CryoEM of bacterial secretion systems
10.1016/j.sbi.2018.08.007 · ExternalCitation · doi-reference
Membrane protein structural biology in the era of single particle cryo-EM
10.1016/j.sbi.2018.08.008 · ExternalCitation · doi-reference
New insights into GPCR coupling and dimerisation from cryo-EM structures
10.1016/j.sbi.2023.102574 · ExternalCitation · doi-reference
Structure of the adenosine A2A receptor in complex with ZM241385 and the xanthines XAC and caffeine
10.1016/j.str.2011.06.014 · ExternalCitation · doi-reference
Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors
10.1016/j.str.2012.04.010 · ExternalCitation · doi-reference
Evolving cryo-EM structural approaches for GPCR drug discovery
10.1016/j.str.2021.04.008 · ExternalCitation · doi-reference
Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system
10.1016/j.str.2022.12.003 · ExternalCitation · doi-reference
Direct structural insights into GABAA receptor pharmacology
10.1016/j.tibs.2021.01.011 · ExternalCitation · doi-reference
BK channel activation: structural and functional insights
10.1016/j.tins.2010.06.004 · ExternalCitation · doi-reference
Cryo electron microscopy to determine the structure of macromolecular complexes
10.1016/j.ymeth.2015.11.023 · ExternalCitation · doi-reference
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
10.1016/s0022-2836(05)80271-2 · ExternalCitation · doi-reference
Membrane protein structural biology: The high throughput challenge
10.1016/s1047-8477(03)00045-5 · ExternalCitation · doi-reference
Cryo-electron microscopy of vitrified specimens
10.1017/s0033583500004297 · ExternalCitation · doi-reference
Single-particle reconstruction of biological macromolecules in electron microscopy-30 years
10.1017/s0033583509990059 · ExternalCitation · doi-reference
The lateral pressure profile in membranes: a physical mechanism of general anesthesia
10.1021/bi9627323 · ExternalCitation · doi-reference
Three-dimensional model of purple membrane obtained by electron microscopy
10.1038/257028a0 · ExternalCitation · doi-reference
Energetic optimization of ion conduction rate by the K+selectivity filter
10.1038/35102000 · ExternalCitation · doi-reference
Chemistry of ion coordination and hydration revealed by a K+channel-Fab complex at 2.0 Å resolution
10.1038/35102009 · ExternalCitation · doi-reference
Atomic model of plant light-harvesting complex by electron crystallography
10.1038/367614a0 · ExternalCitation · doi-reference
Arrangement of rhodopsin transmembrane α-helices
10.1038/38316 · ExternalCitation · doi-reference
Direct observation of the rotation of F1-ATPase
10.1038/386299a0 · ExternalCitation · doi-reference
X-ray structure of a voltage-dependent K+ channel
10.1038/nature01580 · ExternalCitation · doi-reference
The principle of gating charge movement in a voltage-dependent K+ channel
10.1038/nature01581 · ExternalCitation · doi-reference
Structural mechanism of C-type inactivation in K+ channels
10.1038/nature09153 · ExternalCitation · doi-reference
Structure of the membrane domain of respiratory complex i
10.1038/nature10330 · ExternalCitation · doi-reference
Crystal structure of the β2 adrenergic receptor–Gs protein complex
10.1038/nature10361 · ExternalCitation · doi-reference
Crystal structure of the entire respiratory complex i
10.1038/nature11871 · ExternalCitation · doi-reference
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
10.1038/nature12120 · ExternalCitation · doi-reference
Recovery from slow inactivation in K+ channels is controlled by water molecules
10.1038/nature12395 · ExternalCitation · doi-reference
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
10.1038/nature12822 · ExternalCitation · doi-reference
TRPV1 structures in distinct conformations reveal activation mechanisms
10.1038/nature12823 · ExternalCitation · doi-reference
Crystal structure of a human GABAA receptor
10.1038/nature13293 · ExternalCitation · doi-reference
Architecture of mammalian respiratory complex I
10.1038/nature13686 · ExternalCitation · doi-reference
Structure of the TRPA1 ion channel suggests regulatory mechanisms
10.1038/nature14367 · ExternalCitation · doi-reference
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
10.1038/nature14656 · ExternalCitation · doi-reference
Glycine receptor mechanism elucidated by electron cryo-microscopy
10.1038/nature14853 · ExternalCitation · doi-reference
Structure of mammalian respiratory complex i
10.1038/nature19095 · ExternalCitation · doi-reference
Cryo-EM structure of the open high-conductance Ca2+ -activated K+channel
10.1038/nature20608 · ExternalCitation · doi-reference
Wei Lü, Electron cryo-microscopy structure of a human TRPM4 channel
10.1038/nature24674 · ExternalCitation · doi-reference
Structures of the calcium-activated, non-selective cation channel TRPM4
10.1038/nature24997 · ExternalCitation · doi-reference
Structure of the full-length TRPV2 channel by cryo-EM
10.1038/ncomms11130 · ExternalCitation · doi-reference
How many drug targets are there?
10.1038/nrd2199 · ExternalCitation · doi-reference
Cryo-electron microscopy structure of the TRPV2 ion channel
10.1038/nsmb.3159 · ExternalCitation · doi-reference
Core architecture of a bacterial type II secretion system
10.1038/s41467-019-13301-3 · ExternalCitation · doi-reference
Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs
10.1038/s41467-020-17364-5 · ExternalCitation · doi-reference
Structure of inhibitor-bound mammalian complex I
10.1038/s41467-020-18950-3 · ExternalCitation · doi-reference
ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
10.1038/s41467-020-20381-z · ExternalCitation · doi-reference
The six steps of the complete F1-ATPase rotary catalytic cycle
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