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References from Computational prioritization of megalin-aminoglycoside recognition and gentamicin-associated cellular stress responses. Local targets link to admitted publications; unresolved targets remain external evidence.
“Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria. 1944”
2005 · External reference
Aminoglycosides: an overview
10.1101/cshperspect.a027029 · 2016 · External reference
Potential for the development of a new generation of aminoglycoside antibiotics
10.1007/s11094-021-02510-0 · 2021 · External reference
Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection
10.1155/2011/937861 · 2011 · External reference
Mechanism and prevention of ototoxicity induced by aminoglycosides
10.3389/fncel.2021.692762 · 2021 · External reference
Towards the prevention of aminoglycoside-related hearing loss
2017 · External reference
The relationship between the structure and toxicity of aminoglycoside antibiotics
10.1016/j.bmcl.2020.127218 · 2020 · External reference
Programmed cell death pathways in hearing loss: a review of apoptosis, autophagy and programmed necrosis
10.1111/cpr.12915 · 2020 · External reference
Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity
10.1371/journal.pone.0022347 · 2011 · External reference
Effects of androgen receptor inhibition on kanamycin-induced hearing loss in rats
10.3390/ijms22105307 · 2021 · External reference
Estrogen and the inner ear: Megalin knockout mice suffer progressive hearing loss
10.1096/fj.07-9171com · 2008 · External reference
Screening mammalian cochlear hair cells to identify critical processes in aminoglycoside-mediated damage
10.3389/fncel.2018.00179 · 2018 · External reference
Preventing ototoxic hearing loss by inhibiting histone deacetylases
10.1038/cddis.2015.252 · 2015 · External reference
Neomycin toxicity revisited
10.1001/archsurg.1976.01360250098021 · 1976 · External reference
Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats insight from the nmr structure of the wth complement type repeat domain alone and in complex with gentamicin
10.1074/jbc.m112.434159 · 2013 · External reference
Complete cloning and sequencing of rat gp330/'megalin,' a distinctive member of the low density lipoprotein receptor gene family (endocytosis receptor/glomerular antigen/heymann nephritis/membranous nephropathy/kidney proximal tubule)
10.1073/pnas.91.21.9725 · 1994 · External reference
Cryo-EM structures elucidate the multiligand receptor nature of megalin
10.1073/pnas.2318859121 · 2024 · External reference
New developments in aminoglycoside therapy and ototoxicity
10.1016/j.heares.2011.05.008 · 2011 · External reference
Neomycin, a new antibiotic active against streptomycin-resistant bacteria, including tuberculosis organisms
10.1126/science.109.2830.305 · 1949 · External reference
Study of streptomycin-induced ototoxicity: protocol for a longitudinal study
10.1186/s40064-016-2429-5 · 2016 · External reference
Unresolved reference
2006 · External reference
Aminoglycoside-induced ototoxicity
10.2174/138161207779313731 · 2007 · External reference
Neomycin-induced deafness in neonatal mice
10.1016/j.jneumeth.2023.109852 · 2023 · External reference
Production and isolation of a new antibiotic kanamycin
1957 · External reference
Increase in glutamate-aspartate transporter (GLAST) mRNA during kanamycin-induced cochlear insult in rats
10.1016/s0378-5955(99)00050-7 · 1999 · External reference
Injectable paromomycin for visceral leishmaniasis in India
10.1056/nejmoa066536 · 2007 · External reference
Unresolved reference
2021 · External reference
Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use
10.1038/s41598-019-38634-3 · 2019 · External reference
Gentamicin, a new antibiotic complex from Micromonospora
10.1021/jm00340a034 · 1963 · External reference
Drug-induced hearing loss: listening to the latest advances
10.1016/j.therap.2023.10.011 · 2024 · External reference
Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses
10.1111/j.1476-5381.2012.01890.x · 2012 · External reference
Cochlear inner hair cell ribbon synapse is the primary target of ototoxic aminoglycoside stimuli
10.1007/s12035-013-8454-2 · 2013 · External reference
A selective antibiotic for Lyme disease
10.1016/j.cell.2021.09.011 · 2021 · External reference
The isolation of a second antibiotic from Streptomyces hygroscopicus
10.1021/ja01544a032 · 1958 · External reference
Exploration of the relationship between cumulative exposure to tobramycin and ototoxicity in patients with cystic fibrosis
10.1016/j.jcf.2023.04.002 · 2023 · External reference
Ototoxicity in cystic fibrosis patients receiving intravenous tobramycin for acute pulmonary exacerbation: ototoxicity following tobramycin treatment
10.1016/j.jcf.2020.11.020 · 2021 · External reference
Aminoglycosides-related ototoxicity: mechanisms, risk factors, and prevention in pediatric patients
2023 · External reference
Long term streptomycin toxicity in the treatment of Buruli ulcer: follow-up of participants in the BURULICO drug trial
10.1371/journal.pntd.0002739 · 2014 · External reference
Risk of nephrotoxicity in patients with drug-resistant tuberculosis treated with kanamycin/capreomycin with or without concomitant use of tenofovir-containing antiretroviral therapy
10.1097/qai.0000000000001705 · 2018 · External reference
Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor
10.1681/asn.2004080631 · 2005 · External reference
An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin
10.1093/toxsci/kfq267 · 2011 · External reference
Unresolved reference
2017 · External reference
Expression of hygR in transgenic mice causes resistance to toxic effects of hygromycin B in vivo
10.1016/s0022-3565(24)36687-x · 1997 · External reference
Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin
10.1056/nejm198005153022002 · 1980 · External reference
Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity
10.1016/0378-5955(91)90062-e · 1991 · External reference
Cytotoxic effect of aminoglycoside antibiotics on the mammalian cell lines
10.1080/10934529.2020.1830653 · 2021 · External reference
Exploration of antibiotic activity of aminoglycosides, in particular ribostamycin alone and in combination with ethylenediaminetetraacetic acid against pathogenic bacteria
10.3389/fmicb.2020.01718 · 2020 · External reference
Studies of the rate constant of L-DOPA oxidation and decarboxylation by HPLC
10.1007/s10337-012-2229-1 · 2012 · External reference
Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity
10.1073/pnas.0811258106 · 2008 · External reference
Multinuclear nuclear magnetic resonance spectroscopy is used to determine rapidly and accurately the individual pKa values of 2-Deoxystreptamine, neamine, neomycin, paromomycin, and streptomycin
10.1021/acsomega.0c05138 · 2021 · External reference
Experimental determination of the pKa values of clinically relevant aminoglycoside antibiotics: toward establishing pKa-Activity relationships
10.1021/acsomega.3c09226 · 2024 · External reference
CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM simulations using the CHARMM36 additive force field
10.1021/acs.jctc.5b00935 · 2016 · External reference
CHARMM-GUI: a web-based graphical user interface for CHARMM
10.1002/jcc.20945 · 2008 · External reference
Heterogeneous parallelization and acceleration of molecular dynamics simulations in GROMACS
10.1063/5.0018516 · 2020 · External reference
GROMACS: a message-passing parallel molecular dynamics implementation
10.1016/0010-4655(95)00042-e · 1995 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
Electrostatics of nanosystems: application to microtubules and the ribosome
10.1073/pnas.181342398 · 2001 · External reference
Improvements to the APBS biomolecular solvation software suite
10.1002/pro.3280 · 2018 · External reference
PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
10.1093/nar/gkh381 · 2004 · External reference
All-atom empirical potential for molecular modeling and dynamics studies of proteins
10.1021/jp973084f · 1998 · External reference
Improved treatment of ligands and coupling effects in empirical calculation and rationalization of pKa values
10.1021/ct200133y · 2011 · External reference
On the nonpolar hydration free energy of proteins: surface area and continuum solvent models for the solute-solvent interaction energy
10.1021/ja029833a · 2003 · External reference
VMD: visual molecular dynamics
10.1016/0263-7855(96)00018-5 · 1996 · External reference
Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
Structures of LRP2 reveal a molecular machine for endocytosis
10.1016/j.cell.2023.01.016 · 2023 · External reference
Immunohistochemical localization of megalin and cubilin in the human inner ear
10.1016/j.brainres.2018.09.016 · 2018 · External reference
In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective
2022 · External reference
Neomycin toxicity revisited
10.1001/archsurg.1976.01360250098021 · ExternalCitation · doi-reference
CHARMM-GUI: a web-based graphical user interface for CHARMM
10.1002/jcc.20945 · ExternalCitation · doi-reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · ExternalCitation · doi-reference
Improvements to the APBS biomolecular solvation software suite
10.1002/pro.3280 · ExternalCitation · doi-reference
Studies of the rate constant of L-DOPA oxidation and decarboxylation by HPLC
10.1007/s10337-012-2229-1 · ExternalCitation · doi-reference
Potential for the development of a new generation of aminoglycoside antibiotics
10.1007/s11094-021-02510-0 · ExternalCitation · doi-reference
Cochlear inner hair cell ribbon synapse is the primary target of ototoxic aminoglycoside stimuli
10.1007/s12035-013-8454-2 · ExternalCitation · doi-reference
GROMACS: a message-passing parallel molecular dynamics implementation
10.1016/0010-4655(95)00042-e · ExternalCitation · doi-reference
VMD: visual molecular dynamics
10.1016/0263-7855(96)00018-5 · ExternalCitation · doi-reference
Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity
10.1016/0378-5955(91)90062-e · ExternalCitation · doi-reference
The relationship between the structure and toxicity of aminoglycoside antibiotics
10.1016/j.bmcl.2020.127218 · ExternalCitation · doi-reference
Immunohistochemical localization of megalin and cubilin in the human inner ear
10.1016/j.brainres.2018.09.016 · ExternalCitation · doi-reference
A selective antibiotic for Lyme disease
10.1016/j.cell.2021.09.011 · ExternalCitation · doi-reference
Structures of LRP2 reveal a molecular machine for endocytosis
10.1016/j.cell.2023.01.016 · ExternalCitation · doi-reference
New developments in aminoglycoside therapy and ototoxicity
10.1016/j.heares.2011.05.008 · ExternalCitation · doi-reference
Ototoxicity in cystic fibrosis patients receiving intravenous tobramycin for acute pulmonary exacerbation: ototoxicity following tobramycin treatment
10.1016/j.jcf.2020.11.020 · ExternalCitation · doi-reference
Exploration of the relationship between cumulative exposure to tobramycin and ototoxicity in patients with cystic fibrosis
10.1016/j.jcf.2023.04.002 · ExternalCitation · doi-reference
Neomycin-induced deafness in neonatal mice
10.1016/j.jneumeth.2023.109852 · ExternalCitation · doi-reference
Drug-induced hearing loss: listening to the latest advances
10.1016/j.therap.2023.10.011 · ExternalCitation · doi-reference
Expression of hygR in transgenic mice causes resistance to toxic effects of hygromycin B in vivo
10.1016/s0022-3565(24)36687-x · ExternalCitation · doi-reference
Increase in glutamate-aspartate transporter (GLAST) mRNA during kanamycin-induced cochlear insult in rats
10.1016/s0378-5955(99)00050-7 · ExternalCitation · doi-reference
CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM simulations using the CHARMM36 additive force field
10.1021/acs.jctc.5b00935 · ExternalCitation · doi-reference
Multinuclear nuclear magnetic resonance spectroscopy is used to determine rapidly and accurately the individual pKa values of 2-Deoxystreptamine, neamine, neomycin, paromomycin, and streptomycin
10.1021/acsomega.0c05138 · ExternalCitation · doi-reference
Experimental determination of the pKa values of clinically relevant aminoglycoside antibiotics: toward establishing pKa-Activity relationships
10.1021/acsomega.3c09226 · ExternalCitation · doi-reference
Improved treatment of ligands and coupling effects in empirical calculation and rationalization of pKa values
10.1021/ct200133y · ExternalCitation · doi-reference
The isolation of a second antibiotic from Streptomyces hygroscopicus
10.1021/ja01544a032 · ExternalCitation · doi-reference
On the nonpolar hydration free energy of proteins: surface area and continuum solvent models for the solute-solvent interaction energy
10.1021/ja029833a · ExternalCitation · doi-reference
Gentamicin, a new antibiotic complex from Micromonospora
10.1021/jm00340a034 · ExternalCitation · doi-reference
All-atom empirical potential for molecular modeling and dynamics studies of proteins
10.1021/jp973084f · ExternalCitation · doi-reference
Preventing ototoxic hearing loss by inhibiting histone deacetylases
10.1038/cddis.2015.252 · ExternalCitation · doi-reference
Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use
10.1038/s41598-019-38634-3 · ExternalCitation · doi-reference
Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin
10.1056/nejm198005153022002 · ExternalCitation · doi-reference
Injectable paromomycin for visceral leishmaniasis in India
10.1056/nejmoa066536 · ExternalCitation · doi-reference
Heterogeneous parallelization and acceleration of molecular dynamics simulations in GROMACS
10.1063/5.0018516 · ExternalCitation · doi-reference
Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity
10.1073/pnas.0811258106 · ExternalCitation · doi-reference
Electrostatics of nanosystems: application to microtubules and the ribosome
10.1073/pnas.181342398 · ExternalCitation · doi-reference
Cryo-EM structures elucidate the multiligand receptor nature of megalin
10.1073/pnas.2318859121 · ExternalCitation · doi-reference
Complete cloning and sequencing of rat gp330/'megalin,' a distinctive member of the low density lipoprotein receptor gene family (endocytosis receptor/glomerular antigen/heymann nephritis/membranous nephropathy/kidney proximal tubule)
10.1073/pnas.91.21.9725 · ExternalCitation · doi-reference
Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats insight from the nmr structure of the wth complement type repeat domain alone and in complex with gentamicin
10.1074/jbc.m112.434159 · ExternalCitation · doi-reference
Cytotoxic effect of aminoglycoside antibiotics on the mammalian cell lines
10.1080/10934529.2020.1830653 · ExternalCitation · doi-reference
PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
10.1093/nar/gkh381 · ExternalCitation · doi-reference
An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin
10.1093/toxsci/kfq267 · ExternalCitation · doi-reference
Estrogen and the inner ear: Megalin knockout mice suffer progressive hearing loss
10.1096/fj.07-9171com · ExternalCitation · doi-reference
Risk of nephrotoxicity in patients with drug-resistant tuberculosis treated with kanamycin/capreomycin with or without concomitant use of tenofovir-containing antiretroviral therapy
10.1097/qai.0000000000001705 · ExternalCitation · doi-reference
Aminoglycosides: an overview
10.1101/cshperspect.a027029 · ExternalCitation · doi-reference
Programmed cell death pathways in hearing loss: a review of apoptosis, autophagy and programmed necrosis
10.1111/cpr.12915 · ExternalCitation · doi-reference
Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses
10.1111/j.1476-5381.2012.01890.x · ExternalCitation · doi-reference
Neomycin, a new antibiotic active against streptomycin-resistant bacteria, including tuberculosis organisms
10.1126/science.109.2830.305 · ExternalCitation · doi-reference
Tissue-based map of the human proteome
10.1126/science.1260419 · ExternalCitation · doi-reference
Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection
10.1155/2011/937861 · ExternalCitation · doi-reference
Study of streptomycin-induced ototoxicity: protocol for a longitudinal study
10.1186/s40064-016-2429-5 · ExternalCitation · doi-reference
Long term streptomycin toxicity in the treatment of Buruli ulcer: follow-up of participants in the BURULICO drug trial
10.1371/journal.pntd.0002739 · ExternalCitation · doi-reference
Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity
10.1371/journal.pone.0022347 · ExternalCitation · doi-reference
Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor
10.1681/asn.2004080631 · ExternalCitation · doi-reference
Aminoglycoside-induced ototoxicity
10.2174/138161207779313731 · ExternalCitation · doi-reference
Exploration of antibiotic activity of aminoglycosides, in particular ribostamycin alone and in combination with ethylenediaminetetraacetic acid against pathogenic bacteria
10.3389/fmicb.2020.01718 · ExternalCitation · doi-reference
Screening mammalian cochlear hair cells to identify critical processes in aminoglycoside-mediated damage
10.3389/fncel.2018.00179 · ExternalCitation · doi-reference
Mechanism and prevention of ototoxicity induced by aminoglycosides
10.3389/fncel.2021.692762 · ExternalCitation · doi-reference
Effects of androgen receptor inhibition on kanamycin-induced hearing loss in rats
10.3390/ijms22105307 · ExternalCitation · doi-reference
