Research graph
References from Evolutionary conservation and divergence of CXCL17 orthologs: functional evidence in reptiles and loss in the avian lineage. Local targets link to admitted publications; unresolved targets remain external evidence.
Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods
10.4049/jimmunol.176.4.2069 · 2006 · External reference
CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity
10.4049/jimmunol.1102903 · 2012 · External reference
CXCL17 is a major chemotactic factor for lung macrophages
10.4049/jimmunol.1400551 · 2014 · External reference
CXCL17 attenuates imiquimod-induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells
10.4049/jimmunol.1601607 · 2017 · External reference
CXCL17 chemokine-dependent mobilization of CXCR8(+)CD8(+) effector memory and tissue-resident memory T cells in the vaginal mucosa is associated with protection against genital herpes
10.4049/jimmunol.1701474 · 2018 · External reference
Cxcl17(-/-) mice develop exacerbated disease in a T cell-dependent autoimmune model
10.1002/jlb.3a0918-345rr · 2019 · External reference
CXCL17 is a proinflammatory chemokine and promotes neutrophil trafficking
10.1093/jleuko/qiae028 · 2024 · External reference
CXCL17 attenuates diesel exhaust emissions exposure-induced lung damage by regulating macrophage function
10.3390/toxics11080646 · 2023 · External reference
Characterization of prostate macrophage heterogeneity, foam cell markers, and CXCL17 upregulation in a mouse model of steroid hormone imbalance
10.1038/s41598-024-71137-4 · 2024 · External reference
Single-cell transcriptome analysis reveals DNMT1(+) epithelial cells promote lymphatic metastasis via CXCL17-mediated TAM infiltration
10.1186/s12967-026-08032-1 · 2026 · External reference
Role of mucosal chemokines in the development of tissue-resident CD4+ and CD8+ TRM cells to fend off herpes simplex infections
10.3389/fimmu.2026.1661640 · 2026 · External reference
VCC-1, a novel chemokine, promotes tumor growth
10.1016/j.bbrc.2006.08.194 · 2006 · External reference
CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
10.1053/j.gastro.2010.10.009 · 2011 · External reference
Overexpression of CXCL17 increases migration and invasion of A549 lung adenocarcinoma cells
10.3389/fphar.2024.1306273 · 2024 · External reference
OCT4 promotes lung cancer progression through upregulation of VEGF-correlated chemokine-1
10.7150/ijms.102505 · 2025 · External reference
Clinical significance of CXCL17 in cervical cancer
2026 · External reference
ENPP1-Regulated extracellular purine metabolism drives pancreatitis-mediated pancreatic cancer
10.1053/j.gastro.2025.09.032 · 2026 · External reference
SNRPC promotes chemoresistance in Wilms tumor via the NF-kappaB-CXCL17 axis regulating M2-Type TAMs infiltration and targeted nanotherapy research
10.1186/s13046-026-03680-z · 2026 · External reference
Tumor cells-derived CXCL17 is associated with up-regulated neutrophil to monocyte ratio and predicts poor prognosis in oral squamous cell carcinoma
2026 · External reference
Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17
10.4049/jimmunol.1401704 · 2015 · External reference
GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17?
10.1111/bph.14082 · 2018 · External reference
Evidence for the existence of a CXCL17 receptor distinct from GPR35
10.4049/jimmunol.1700884 · 2018 · External reference
CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans
10.1126/scisignal.abl3758 · 2024 · External reference
CXCL17 induces activation of human mast cells via MRGPRX2
10.1111/all.16036 · 2024 · External reference
CXCL17 activates three MAS-related G protein-coupled receptors independently of its conserved C-terminal fragment
10.1016/j.abb.2025.110666 · 2026 · External reference
A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS
10.1038/s41586-024-08043-2 · 2024 · External reference
Identification of orphan GPR25 as a receptor for the chemokine CXCL17
10.1111/febs.70117 · 2025 · External reference
Human CXCL17 binds and activates fish GPR25 orthologs
10.1016/j.biochi.2025.09.009 · 2025 · External reference
Evidence for a two-step model for activation of GPR25 by the chemoattractant CXCL17
10.1111/bcpt.70255 · 2026 · External reference
GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells
10.1126/sciimmunol.adu2089 · 2025 · External reference
CXCL17: the black sheep in the chemokine flock
10.3389/fimmu.2021.712897 · 2021 · External reference
What defines a chemokine? - the curious case of CXCL17
10.1016/j.cyto.2023.156224 · 2023 · External reference
The origin, evolution, and molecular diversity of the chemokine system
10.26508/lsa.202302471 · 2024 · External reference
Identification and functional characterization of two CXCL17 paralogs from zebrafish
10.1042/bcj20253418 · 2026 · External reference
Ancestral origin of the CXCL17–GPR25 system traced to the lobe-finned fish Latimeria chalumnae
10.1016/j.biochi.2026.03.011 · 2026 · External reference
Identification and functional characterization of CXCL17 orthologs in amphibians
10.1016/j.abb.2026.110797 · 2026 · External reference
10.64898/2026.03.04.709523
10.64898/2026.03.04.709523 · External reference
FAM237A, rather than peptide PEN and proCCK56-63, binds to and activates the orphan receptor GPR83
10.1111/febs.16765 · 2023 · External reference
Identifying the binding mechanism of LEAP2 to receptor GHSR1a
10.1111/febs.14763 · 2019 · External reference
Identifying key residues and key interactions for the binding of LEAP2 to receptor GHSR1a
10.1042/bcj20200228 · 2020 · External reference
Development of a novel ligand binding assay for relaxin family peptide receptor 3 and 4 using NanoLuc complementation
10.1007/s00726-018-2588-5 · 2018 · External reference
Conserved syntenic clusters of protein coding genes are missing in birds
10.1186/s13059-014-0565-1 · 2014 · External reference
Luciferase reporter assay system for deciphering GPCR pathways
10.2174/1875397301004010084 · 2010 · External reference
Principles and design of molecular tools for sensing and perturbing cell surface receptor activity
10.1021/acs.chemrev.4c00582 · 2025 · External reference
Discovery of biased dual-agonists of glucagon-like peptide 1 and glucagon receptors through mutation of a conserved aspartate
10.1021/acsmedchemlett.5c00668 · 2026 · External reference
Potent and biased agonists of class B1 GPCRs from a heterochiral design strategy
10.1038/s41557-026-02182-x · 2026 · External reference
Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties
10.3389/fcell.2025.1645031 · 2025 · External reference
Discovery of new difluorocyclobutyl derivatives as effective glucagon-like Peptide-1 receptor agonists with reduced hERG inhibitory activities
10.1021/acs.jmedchem.5c00231 · 2025 · External reference
Development of a selective agonist for relaxin family peptide receptor 3
10.1038/s41598-017-03465-7 · 2017 · External reference
Engineering of novel analogues that are more receptor-selective and potent than the native hormone, insulin-like peptide 5 (INSL5)
10.1021/acs.jmedchem.4c01422 · 2024 · External reference
Unusual orthologs shed new light on the binding mechanism of ghrelin to its receptor GHSR1a
10.1016/j.abb.2021.108872 · 2021 · External reference
Discovery of Ghrelin(1-8) analogues with improved stability and functional activity for PET imaging
10.1021/acsptsci.3c00088 · 2023 · External reference
Design, synthesis, and in vitro characterization of a tryptamine-based visible-light photoswitchable 5-HT(2A)R ligand showing efficacy preference for beta-Arrestin over Mini-Gq
10.1021/acs.jmedchem.5c00442 · 2025 · External reference
