Research graph
References from Spatio-temporal mechanosensitive phagocytic response of retinal pigment epithelial cells to reversible changes in substrate stiffness. Local targets link to admitted publications; unresolved targets remain external evidence.
The cell biology of the retinal pigment epithelium
10.1016/j.preteyeres.2020.100846 · 2020 · External reference
The retinal pigment epithelium in visual function
10.1152/physrev.00021.2004 · 2005 · External reference
Phagocytosis by the retinal pigment epithelium: recognition, resolution, recycling
10.3389/fimmu.2020.604205 · 2020 · External reference
Retinal pigment epithelium and age-related macular degeneration: a review of major disease mechanisms
10.1111/ceo.13834 · 2020 · External reference
Age-related macular degeneration
10.1038/s41572-021-00265-2 · 2021 · External reference
Retinitis pigmentosa
10.1016/s0140-6736(06)69740-7 · 2006 · External reference
Biomechanical Properties of retina and choroid: a comprehensive review of techniques and translational relevance
10.1038/s41433-021-01437-w · 2021 · External reference
The dynamic nature of Bruch’s membrane
10.1016/j.preteyeres.2009.08.003 · 2010 · External reference
A comparison of the elastic properties of Human choroid and sclera
10.1016/0014-4835(88)90053-x · 1988 · External reference
Laminin-defined mechanical status modulates retinal pigment epithelium phagocytosis
10.1038/s44319-025-00475-9 · 2025 · External reference
Dynamic human retinal pigment epithelium (RPE) and choroid architecture based on single-cell transcriptomic landscape analysis
10.1016/j.gendis.2022.11.007 · 2023 · External reference
Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs
10.1126/scitranslmed.aat5580 · 2019 · External reference
Spatiotemporal live-cell analysis of photoreceptor outer segment membrane ingestion by the retinal pigment epithelium reveals actin-regulated scission
10.1523/jneurosci.1726-22.2023 · 2023 · External reference
Biomimetic hydrogel platform reveals active force transduction from retinal pigment epithelium to photoreceptors
10.1016/j.actbio.2025.09.002 · 2025 · External reference
Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium
10.1085/jgp.202112916 · 2022 · External reference
Super-resolution near-infrared autofluorescence microscopy depicts melanin containing organelles of the retinal pigment epithelium in human donor eyes
10.1167/iovs.66.13.50 · 2025 · External reference
Kinetic studies of rod outer segment binding and ingestion by cultured rat RPE cells
10.1016/s0014-4835(87)80105-7 · 1987 · External reference
The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells
10.1073/pnas.0702504104 · 2007 · External reference
Protective responses to sublytic complement in the retinal pigment epithelium
10.1073/pnas.1523061113 · 2016 · External reference
Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis
10.1083/jcb.201410112 · 2015 · External reference
Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization
10.1186/s13287-017-0652-9 · 2017 · External reference
The effect of polymer stiffness on magnetization reversal of magnetorheological elastomers
10.1063/5.0086761 · 2022 · External reference
10.1021/acsomega.2c06529
10.1021/acsomega.2c06529 · External reference
Magnetic field tuning of mechanical properties of Ultrasoft PDMS-based magnetorheological elastomers for biological applications
10.1088/2399-7532/ac1b7e · 2021 · External reference
Micropatterned magneto-rheological elastomers to drive changes in cardiomyocyte alignment
10.3791/68271 · 2025 · External reference
Tunable and reversible substrate stiffness reveals a dynamic mechanosensitivity of cardiomyocytes
10.1021/acsami.9b02446 · 2019 · External reference
Differential protein profiling of primary versus immortalized Human RPE cells identifies expression patterns associated with cytoskeletal remodeling and cell survival
10.1021/pr050420t · 2006 · External reference
Claudins regulate gene and protein expression of the retinal pigment epithelium independent of their association with tight junctions
10.1016/j.exer.2020.108157 · 2020 · External reference
Spatial control of draper receptor signaling initiates apoptotic cell engulfment
10.1083/jcb.201711175 · 2018 · External reference
Spatial control of draper receptor signaling initiates apoptotic cell engulfment
10.1083/jcb.201711175 · 2018 · External reference
The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis
10.1091/mbc.e13-04-0212 · 2014 · External reference
Understanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture
10.1016/j.exer.2014.01.010 · 2014 · External reference
Clearance phagocytosis by the retinal pigment epithelium during photoreceptor outer segment renewal: molecular mechanisms and relation to retinal inflammation
10.1111/imr.13264 · 2023 · External reference
Phagocytosis of retinal rod and cone photoreceptors
2010 · External reference
Substrate stiffness reduces particle uptake by epithelial cells and macrophages in a size-dependent manner through mechanoregulation
10.1039/d2nr03792k · 2022 · External reference
Modulation of immune responses by particle size and shape
10.3389/fimmu.2020.607945 · 2021 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Unresolved reference
External reference
Ilastik: interactive machine learning for (Bio)Image analysis
10.1038/s41592-019-0582-9 · 2019 · External reference
CellProfiler 4: improvements in speed, utility and usability
10.1186/s12859-021-04344-9 · 2021 · External reference
Cellpose: a generalist algorithm for cellular segmentation
10.1038/s41592-020-01018-x · 2021 · External reference
Cellpose as a reliable method for single-cell segmentation of autofluorescence microscopy images
10.1038/s41598-024-82639-6 · 2025 · External reference
10.1214/ss/1177011137
10.1214/ss/1177011137 · External reference
MCMC techniques for parameter estimation of ODE based models in Systems biology
10.3389/fams.2019.00055 · 2019 · External reference
Understanding the Metropolis-Hastings algorithm
10.1080/00031305.1995.10476177 · 1995 · External reference
Dissecting particle uptake heterogeneity in a cell population using bayesian analysis
10.1016/j.bpj.2020.01.043 · 2020 · External reference
Bayesian paired comparison with the bpcs package
10.3758/s13428-021-01714-2 · 2022 · External reference
Unresolved reference
External reference
An unsupervised approach for overlapping cervical cell cytoplasm segmentation
2016 · External reference
Detection and tracking of overlapping cell nuclei for large scale mitosis analyses
10.1186/s12859-016-1030-9 · 2016 · External reference
Automating cell counting in fluorescent microscopy through deep learning with C-ResUnet
10.1038/s41598-021-01929-5 · 2021 · External reference
The influence of substrate elastic modulus on retinal pigment epithelial cell phagocytosis
10.1016/j.jbiomech.2014.06.021 · 2014 · External reference
Apoptotic cell clearance: basic biology and therapeutic potential
10.1038/nri3607 · 2014 · External reference
The influence of substrate elastic modulus on retinal pigment epithelial cell phagocytosis
10.1016/j.jbiomech.2014.06.021 · 2014 · External reference
Physical constraints and forces involved in phagocytosis
10.3389/fimmu.2020.01097 · 2020 · External reference
Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics
10.1038/ncomms1792 · 2012 · External reference
Quantified F-actin morphology is predictive of phagocytic capacity of stem cell-derived retinal pigment epithelium
10.1016/j.stemcr.2018.01.017 · 2018 · External reference
Coupling of Β2 integrins to Actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis
10.1038/s41556-019-0414-2 · 2019 · External reference
A mechanical perspective on phagocytic cup formation
10.1016/j.ceb.2020.05.011 · 2020 · External reference
Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis
10.1083/jcb.202012042 · 2022 · External reference
Mechanics of neutrophil phagocytosis: behavior of the cortical tension
10.1242/jcs.02275 · 2005 · External reference
Plasma membrane tension orchestrates membrane trafficking, cytoskeletal remodeling, and biochemical signaling during phagocytosis
10.1073/pnas.1301766110 · 2013 · External reference
Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice
10.1167/iovs.13-12450 · 2013 · External reference
Analysis of the RPE sheet in the Rd10 retinal degeneration model
10.1007/978-1-4614-0631-0_81 · 2012 · External reference
Morphometric analysis of retinal pigment epithelial cells from C57BL/6J mice during aging
10.1167/iovs.62.2.32 · 2021 · External reference
Intercellular calcium signaling induced by ATP potentiates macrophage phagocytosis
10.1016/j.celrep.2019.03.011 · 2019 · External reference
Inflammatory cytokines protect retinal pigment epithelial cells from oxidative stress-induced death
10.1371/journal.pone.0064619 · 2013 · External reference
Cytokine effects on phagocytosis of rod outer segments by retinal pigment epithelial cells of normal and dystrophic rats
10.3109/02713689609000760 · 1996 · External reference
Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration
10.1186/s13024-017-0175-y · 2017 · External reference
Phagocytosis of rod outer segments by retinal pigment epithelial cells requires Αvβ5 integrin for binding but not for internalization
10.1073/pnas.94.24.12932 · 1997 · External reference
MERTK-dependent ensheathment of photoreceptor outer segments by Human pluripotent stem cell-derived retinal pigment epithelium
10.1016/j.stemcr.2020.02.004 · 2020 · External reference
Substrate viscoelasticity affects Human macrophage morphology and phagocytosis
10.1039/d2sm01683d · 2023 · External reference
