Research graph
References from Proteolysis-programmed reopening of bilayer hydrogel actuators. Local targets link to admitted publications; unresolved targets remain external evidence.
Review of the gastrointestinal tract: from macro to micro
10.1016/j.soncn.2008.10.002 · 2009 · External reference
Formation of trypsin from crystalline trypsinogen by means of enterokinase
10.1085/jgp.22.4.429 · 1939 · External reference
Trypsin detection strategies: a review
10.1080/10408347.2020.1846490 · 2022 · External reference
The complex role of trypsin in pancreatitis
10.1053/j.gastro.2019.12.025 · 2020 · External reference
Trypsin, elastase, plasmin and MMP-9 activity in the serum during the human ageing process
10.1093/ageing/afn039 · 2008 · External reference
Enterokinase and trypsin activities in pancreatic insufficiency and diseases of the small intestine
10.1016/s0016-5085(76)80486-6 · 1976 · External reference
Advanced oral drug delivery systems: current challenges and emerging technologies
10.1016/j.apsb.2025.11.036 · 2026 · External reference
Foundations of gastrointestinal-based drug delivery and future developments
10.1038/s41575-021-00539-w · 2022 · External reference
Challenges and recent progress in oral drug delivery systems for biopharmaceuticals
10.3390/pharmaceutics11030129 · 2019 · External reference
Unresolved reference
2003 · External reference
Adherence to medication
10.1056/nejmra050100 · 2005 · External reference
Development of a drug delivery system based on chitosan nanoparticles for oral administration of interferon-α
10.1021/acs.biomac.7b00959 · 2017 · External reference
Oral delivery of proteins and peptides: challenges, status quo and future perspectives
10.1016/j.apsb.2021.04.001 · 2021 · External reference
Oral delivery of peptides: opportunities and issues for translation
10.1016/j.addr.2016.10.005 · 2016 · External reference
Advances in oral drug delivery for regional targeting in the gastrointestinal tract-influence of physiological, pathophysiological and pharmaceutical factors
10.3389/fphar.2020.00524 · 2020 · External reference
Ingestible devices for long-term gastrointestinal residency: a review
10.1088/2516-1091/ac1731 · 2021 · External reference
Intestinal retentive systems–recent advances and emerging approaches
10.1039/d3tb01842c · 2024 · External reference
Soft actuators for real-world applications
10.1038/s41578-021-00389-7 · 2022 · External reference
Shape-memory hydrogels: evolution of structural principles to enable shape switching of hydrophilic polymer networks
10.1021/acs.accounts.6b00584 · 2017 · External reference
Chitosan–lysozyme conjugates for enzyme-triggered hydrogel degradation in tissue engineering applications
10.1021/acsami.8b15591 · 2018 · External reference
Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
10.1021/acs.chemrev.7b00094 · 2017 · External reference
Stimuli-responsive polymers and their applications
10.1039/c6py01585a · 2017 · External reference
Bioactuators based on stimulus-responsive hydrogels and their emerging biomedical applications
10.1038/s41427-019-0165-3 · 2019 · External reference
Toward tunable protein-driven hydrogel lens
2023 · External reference
Dual pH-responsive hydrogel actuator for lipophilic drug delivery
10.1021/acsami.9b21713 · 2020 · External reference
Highly bidirectional bendable actuator engineered by LCST–UCST bilayer hydrogel with enhanced interface
10.1021/acsami.0c17085 · 2020 · External reference
Bioinspired bilayer structural color hydrogel actuator with multienvironment responsiveness and survivability
10.1002/smtd.201900519 · 2019 · External reference
Reduced graphene oxide-containing smart hydrogels with excellent electro-response and mechanical properties for soft actuators
10.1021/acsami.7b01710 · 2017 · External reference
Soft robotic manipulation and locomotion with a 3D printed electroactive hydrogel
10.1021/acsami.8b04250 · 2018 · External reference
Design and functionality of trypsin-triggered, expandable bovine serum albumin-polyethylene glycol diacrylate hydrogel actuators
2024 · External reference
Aided porous medium emulsification for functional hydrogel microparticles synthesis
2024 · External reference
Ingestible hydrogel device
10.1038/s41467-019-08355-2 · 2019 · External reference
Untethered microgrippers for precision medicine
2024 · External reference
Stimuli-responsive theragrippers for chemomechanical controlled release
10.1002/anie.201311047 · 2014 · External reference
Self-folding thermo-magnetically responsive soft microgrippers
10.1021/am508621s · 2015 · External reference
Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
10.1126/sciadv.abb4133 · 2020 · External reference
Self-folding single cell grippers
10.1021/nl500136a · 2014 · External reference
Tetherless thermobiochemically actuated microgrippers
10.1073/pnas.0807698106 · 2009 · External reference
Pick-and-place using chemically actuated microgrippers
10.1021/ja806961p · 2008 · External reference
Untethered microgrippers for biopsy in the upper urinary tract
10.1002/adhm.202401407 · 2024 · External reference
Oral, ultra–long-lasting drug delivery: application toward malaria elimination goals
10.1126/scitranslmed.aag2374 · 2016 · External reference
A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
10.1126/scitranslmed.aau6267 · 2019 · External reference
Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine
10.1073/pnas.2004746117 · 2020 · External reference
Self-sustainable autonomous soft actuators
10.1038/s42004-024-01142-1 · 2024 · External reference
A review on recent advances of protein-polymer hydrogels
10.1016/j.eurpolymj.2021.110881 · 2022 · External reference
Enzyme-catalyzed formation and structure characteristics of a protein-based hydrogel
10.1021/jp8041389 · 2008 · External reference
PenTag, a versatile platform for synthesizing protein-polymer biohybrid materials
2024 · External reference
3D-printed PEGMA-co-(PNIPAM crosslinked with PEGDA) hydrogels by digital light processing in aqueous media
10.1557/s43579-025-00732-x · 2025 · External reference
Synthesis and characterization of poly (ethylene glycol) based thermo-responsive hydrogels for cell sheet engineering
10.3390/ma9100854 · 2016 · External reference
Tailoring PNIPAM hydrogels for large temperature-triggered changes in mechanical properties
10.1007/s00396-019-04470-0 · 2019 · External reference
Thermal stability of bovine serum albumin DSC study
10.1023/a:1022851809481 · 2003 · External reference
Heat-induced self-assembling of BSA at the isoelectric point
10.1016/j.ijbiomac.2021.02.112 · 2021 · External reference
Synthesis of stimuli-responsive poly (ethylene glycol) diacrylate/methacrylic acid-based nanogels and their application as drug delivery vehicle
10.1007/s00396-014-3422-6 · 2015 · External reference
Design of tough adhesive from commodity thermoplastics through dynamic crosslinking
10.1126/sciadv.abk2451 · 2021 · External reference
Solid-phase interfacial synthesis of dual-imprinted colloid particles for multifunctional nanomedicine development
10.1016/j.colcom.2020.100267 · 2020 · External reference
A boronic acid–rich dendrimer with robust and unprecedented efficiency for cytosolic protein delivery and CRISPR-Cas9 gene editing
10.1126/sciadv.aaw8922 · 2019 · External reference
A novel polysaccharide gel bead enabled oral enzyme delivery with sustained release in small intestine
10.1016/j.foodhyd.2018.05.039 · 2018 · External reference
In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil
10.1016/s0928-0987(02)00081-7 · 2002 · External reference
A novel pH-sensitive hydrogels for potential colon-specific drug delivery: characterization and in vitro release studies
10.1002/star.201000120 · 2011 · External reference
Novel dual coated apocynin nanoparticles: mucoadhesive and pH-based targeted drug release approach for ulcerative colitis treatment
10.1007/s12668-025-02210-z · 2026 · External reference
Mucus-mimicking mucin-based hydrogels by tandem chemical and physical crosslinking
10.1002/mabi.202400028 · 2024 · External reference
Point by point comparison of two thermosensitive polymers exhibiting a similar LCST: is the age of poly (NIPAM) over?
10.1021/ja065324n · 2006 · External reference
Snapshot of phase transition in thermoresponsive hydrogel PNIPAM: role in drug delivery and tissue engineering
10.1007/s13233-016-4052-2 · 2016 · External reference
Enhancement of chondrogenesis of adipose-derived stem cells in HA-PNIPAAm-CL hydrogel for cartilage regeneration in rabbits
2018 · External reference
Thermosensitive PNIPAM-based hydrogel crosslinked by composite nanoparticles as rapid wound-healing dressings
10.1021/acs.biomac.2c01380 · 2023 · External reference
The effect of the printing temperature on 4D DLP printed pNIPAM hydrogels
10.1039/d2sm00201a · 2022 · External reference
Effect of synthesis temperature on characteristics of PNIPAM/alginate IPN hydrogel beads
10.1002/app.41814 · 2015 · External reference
Dependence of shrinking kinetics of poly(N-isopropylacrylamide) gels on preparation temperature
10.1016/s0032-3861(02)00089-7 · 2002 · External reference
Thermal-responsive poly (N-isopropyl acrylamide)/sodium alginate hydrogels: preparation, swelling behaviors, and mechanical properties
10.1007/s00396-016-3951-2 · 2016 · External reference
Bovine serum albumin-based hydrogels: preparation, properties and biological applications
10.1016/j.cej.2024.154651 · 2024 · External reference
Detection of sub-nanomolar concentration of trypsin by thickness-shear mode acoustic biosensor and spectrophotometry
10.3390/bios11040117 · 2021 · External reference
A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
10.1016/0168-3659(87)90034-4 · 1987 · External reference
Whey protein powder analysis by mid-infrared spectroscopy
10.3390/foods10051033 · 2021 · External reference
Enzymatic hydrolysis of whey proteins. Hydrolysis of α-lactalbumin and β-lactoglobulin in buffer solutions by proteolytic enzymes
1991 · External reference
An improved trypsin digestion method minimizes digestion-induced modifications on proteins
10.1016/j.ab.2009.05.018 · 2009 · External reference
Comparison of selective hydrolysis of α-lactalbumin by acid Protease A and Protease M as alternative to pepsin: potential for β-lactoglobulin purification in whey proteins
10.1017/s0022029919000086 · 2019 · External reference
A new method for isolation of native α-lactalbumin from sweet whey
10.1016/j.idairyj.2007.06.004 · 2008 · External reference
Thermal modifications of structure and codenaturation of α-lactalbumin and β-lactoglobulin induce changes of solubility and susceptibility to proteases
2002 · External reference
A user’s guide to degradation testing of polyethylene glycol-based hydrogels: from in vitro to in vivo studies
10.1002/jbm.a.37609 · 2024 · External reference
Time-related enzyme concentrations in duodenal aspirates after ingestion of a test meal
10.3109/00365527709181345 · 1977 · External reference
Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review
10.1016/j.progpolymsci.2014.07.010 · 2014 · External reference
Molecular and cellular cues governing nanomaterial–mucosae interactions: from nanomedicine to nanotoxicology
10.1039/c8cs00948a · 2020 · External reference
Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B coculture models to predict intestinal and colonic permeability compared to Caco-2 monoculture
10.1021/acs.molpharmaceut.6b01165 · 2017 · External reference
ISO 10993: biological evaluation of medical devices
2022 · External reference
Pig models on intestinal development and therapeutics
10.1007/s00726-017-2497-z · 2017 · External reference
Biodegradable thermomagnetically responsive soft untethered grippers
10.1021/acsami.8b15646 · 2019 · External reference
Hydrogel actuators and sensors for biomedical soft robots: brief overview with impending challenges
10.3390/biomimetics3030015 · 2018 · External reference
Advances and challenges of hydrogel materials for robotic and sensing applications
10.1021/acs.chemmater.2c01960 · 2022 · External reference
Biopsy with thermally-responsive untethered microtools
10.1002/adma.201203348 · 2013 · External reference
Genetically programmed shape-morphing of engineered living materials
10.1002/adfm.78503 · 2026 · External reference
Enzymatically triggered actuation of miniaturized tools
10.1021/ja106218s · 2010 · External reference
Autonomous hydrogel actuators programmed by endogenous biochemical logic for dual-stage morphing and drug release
2026 · External reference
4D printing of multi-stimuli responsive protein-based hydrogels for autonomous shape transformations
10.1002/adfm.202011012 · 2021 · External reference
Untethered shape-changing devices in the gastrointestinal tract
10.1080/17425247.2023.2291450 · 2023 · External reference
Self-regulating hydrogel actuators
10.1021/acs.chemrev.5c00358 · 2025 · External reference
Necrobotics: biotic materials as ready-to-use actuators
2022 · External reference
Enzyme-triggered folding of hydrogels: toward a mimic of the venus flytrap
10.1021/acsami.6b05024 · 2016 · External reference
Shape morphing of hydrogels by harnessing enzyme enabled mechanoresponse
10.1038/s41467-023-44607-y · 2024 · External reference
Mechanics and drug release from poroviscoelastic hydrogels: experiments and modeling
10.1016/j.ejpb.2020.05.020 · 2020 · External reference
Mechanical force-triggered drug delivery
10.1021/acs.chemrev.6b00369 · 2016 · External reference
The reversible transformation of β-lactoglobulin at pH 7.51
10.1021/ja01524a054 · 1959 · External reference
Experimental determination of the rate of autolysis of trypsin at 37 °C
10.1007/bf00157369 · 1996 · External reference
Relationship of motility to flow of contents in the human small intestine
10.1016/0016-5085(82)90314-6 · 1982 · External reference
Hydrogels in soft robotics: past, present, and future
10.1021/acsnano.3c12200 · 2024 · External reference
Advances in 4D printing: materials and applications
10.1002/adfm.201805290 · 2019 · External reference
Digital light processing 3D printing of hydrogels: a minireview
10.1039/d2me00066k · 2022 · External reference
Ionic shape-morphing microrobotic end-effectors for environmentally adaptive targeting, releasing, and sampling
10.1038/s41467-020-20697-w · 2021 · External reference
Capsule-in-Capsule technology
2010 · External reference
Next generation capsules: emerging technologies in capsule fabrication and targeted oral drug delivery
10.1016/j.ejps.2025.107277 · 2025 · External reference
Proteolytic activity and characteristics of skipjack tuna trypsin loaded alginate–chitosan beads as affected by drying methods and trehalose/glycerol
10.1111/ijfs.16039 · 2023 · External reference
Constructions and properties of physically cross-linked hydrogels based on natural polymers
10.1080/15583724.2022.2137525 · 2023 · External reference
Cross-linking in hydrogels-a review
2014 · External reference
Poly (oligo (ethylene glycol) methacrylate)-based polymers in biomedical applications: preparation and applications
10.1021/acs.biomac.5c00145 · 2025 · External reference
Polyethylene glycol-like brush polymer conjugate of a protein drug does not induce an antipolymer immune response and has enhanced pharmacokinetics than its Polyethylene glycol counterpart
10.1002/advs.202103672 · 2022 · External reference
Thermoresponsive oligo (ethylene glycol)-methacrylate-based polymers and microgels
10.1039/b921150k · 2010 · External reference
Biodegradable, thermoresponsive PNIPAM-based hydrogel scaffolds for the sustained release of levofloxacin
10.1039/c6ra03045a · 2016 · External reference
Temperature-sensitive hydrogels by graft polymerization of chitosan and N-isopropylacrylamide for drug release
10.3109/10837450.2011.644298 · 2013 · External reference
Biodegradable thermoresponsive hydrogels for aqueous encapsulation and controlled release of hydrophilic model drugs
10.1021/bm050116t · 2005 · External reference
Biodegradable thermomagnetically responsive soft untethered grippers
10.1021/acsami.8b15646 · 2019 · External reference
Synthesis and water-swelling of thermo-responsive poly(ester urethane)s containing poly(ε-caprolactone), poly(ethylene glycol) and poly(propylene glycol)
10.1016/j.biomaterials.2008.04.015 · 2008 · External reference
