Research graph
References from Poly(2-oxazoline)s and poly(2-oxazine)s: An overview of stealth properties, pharmacokinetics, and immunogenicity. Local targets link to admitted publications; unresolved targets remain external evidence.
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PEGylated therapeutics in the clinic
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Maintaining safety with SARS-CoV-2 vaccines
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Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats
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Anti-poly(ethylene glycol)(PEG) antibodies: from where are we coming and where are we going
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Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process
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Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement
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Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors
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Anti-PEG antibodies in the clinic: current issues and beyond PEGylation
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Polyethylene glycol immunogenicity: theoretical, clinical, and practical aspects of anti-polyethylene glycol antibodies
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The curious case of anti-PEG antibodies
10.1039/d5nr02301g · 2025 · External reference
Anti-PEG antibodies and their biological impact on PEGylated drugs: challenges and strategies for optimization
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Effects of PEG antibodies on in vivo performance of LNP-mRNA vaccines
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Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout
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Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer
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Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer
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Polyethylene glycol immunogenicity in nanomedicine
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PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective
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Anti-PEG antibodies in nanomedicine: mechanisms, risks, and opportunities
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A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse
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Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection
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Anti-PEG IgM is a major contributor to the accelerated blood clearance of polyethylene glycol-conjugated protein
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PEG that reaction: a case series of allergy to polyethylene glycol
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Antibodies against poly(ethylene glycol) activate innate immune cells and induce hypersensitivity reactions to PEGylated nanomedicines
10.1021/acsnano.2c12193 · 2023 · External reference
Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: a report from the children’s oncology group
10.1002/pbc.26873 · 2018 · External reference
Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. Coli asparaginase in children with acute lymphocytic leukemia
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Reporting of allergic reactions during Pfizer-BioNTech BNTT162B2 vaccination in Israel
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Anti-PEG antibodies boosted in humans by SARS-CoV-2 lipid nanoparticle mRNA vaccine
10.1021/acsnano.2c04543 · 2022 · External reference
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice
10.1016/j.jconrel.2023.01.012 · 2023 · External reference
Measurement of pre-existing IgG and IgM antibodies against polyethylene glycol in healthy individuals
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Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma
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Anti-PEG antibodies before and after a first dose of Comirnaty®(mRNA-LNP-based SARS-CoV-2 vaccine)
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Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID-19 vaccine
10.1111/cea.13874 · 2021 · External reference
Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit?
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Assessment of allergic and anaphylactic reactions to mRNA COVID-19 vaccines with confirmatory testing in a US regional health system
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Hypersensitivity to polyethylene glycol in adults and children: an emerging challenge
2021 · External reference
First-dose mRNA COVID-19 vaccine allergic reactions: limited role for excipient skin testing
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COVID-19 vaccines in children with cow’s milk and food allergies
10.3390/nu13082637 · 2021 · External reference
Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: evidence for immunogenicity of PEG
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Allergic reactions to the first COVID-19 vaccine: a potential role of polyethylene glycol?
10.1111/all.14711 · 2021 · External reference
Development of anti-PEG IgG/IgM/IgE ELISA assays for profiling anti-PEG immunoglobulin response in PEG-sensitized individuals and patients with alpha-gal allergy
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Evaluating the role of anti-PEG antibodies in hypersensitivity to PEG-Asparaginase through clinically relevant cut-points defined by ELISA and Surface Plasmon resonance
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Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products
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2018 · External reference
The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes
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Poly(vinyl pyrrolidone) derivatives as PEG alternatives for stealth, non-toxic and less immunogenic siRNA-containing lipoplex delivery
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Peptosomes for vaccination: combining antigen and adjuvant in polypept(o)ide-based polymersomes
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Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery
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Evaluation of blood clearance rates and biodistribution of poly(2-oxazoline)-grafted liposomes
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μPET imaging of the pharmacokinetic behavior of medium and high molar mass 89Zr-labeled poly(2-ethyl-2-oxazoline) in comparison to poly(ethylene glycol)
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Poly(2-methyl-2-oxazoline) as a polyethylene glycol alternative for lipid nanoparticle formulation
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Micelles based on HPMA copolymers
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Polymeric nanoparticles with neglectable protein corona
2020 · External reference
Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration
10.1016/j.ijpharm.2013.07.059 · 2013 · External reference
Comparison of linear and hyperbranched polyether lipids for liposome shielding by 18F-radiolabeling and positron emission tomography
10.1021/acs.biomac.8b00115 · 2018 · External reference
Polyglycerol for half-life extension of proteins—alternative to PEGylation?
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Blood retention and antigenicity of polycarboxybetaine-modified liposomes
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Zwitteration as an alternative to PEGylation
10.1021/la200227b · 2011 · External reference
Revealing the immunogenic risk of polymers
10.1002/anie.201808615 · 2018 · External reference
Zwitterionic stealth peptide-protected gold nanoparticles enable long circulation without the accelerated blood clearance phenomenon
10.1039/c7bm00747g · 2018 · External reference
Sulfoxide-containing polymer-coated nanoparticles demonstrate minimal protein fouling and improved blood circulation
10.1002/advs.202000406 · 2020 · External reference
Poly(N-methyl-N-vinylacetamide): a strong alternative to PEG for lipid-based nanocarriers delivering siRNA
2024 · External reference
10.1002/advs.77145 · 2026 · Admitted local publication
Pharmapolymers in the 21st century: synthetic polymers in drug delivery applications
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Poly(ethylene glycol) alternatives in biomedical applications
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PEG: will it come back to you? Polyethelyne glycol immunogenicity, COVID vaccines, and the case for new PEG derivatives and alternatives
10.3389/fbioe.2022.879988 · 2022 · External reference
The importance of poly(ethylene glycol) alternatives for overcoming PEG immunogenicity in drug delivery and bioconjugation
10.3390/polym12020298 · 2020 · External reference
Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics
10.1039/c0py00406e · 2011 · External reference
From PEGylation to next-generation polymers: overcoming biological barriers–a review
10.3390/molecules31040675 · 2026 · External reference
Poly(2-oxazoline)s based biomaterials: a comprehensive and critical update
10.1016/j.biomaterials.2018.05.022 · 2018 · External reference
Poly(2-oxazoline) and poly(2-oxazine)-based nanomedicines: advancements, opportunities and challenges
10.1016/j.jconrel.2026.114838 · 2026 · External reference
Drug delivery systems based on poly(2-oxazoline)s and poly(2-oxazine)s
10.1002/adtp.201900168 · 2020 · External reference
Poly(2-oxazoline)s: a polymer class with numerous potential applications
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Poly (2-Oxazoline)s–are they more advantageous for biomedical applications than other polymers?
10.1002/marc.201200453 · 2012 · External reference
Poly(2-oxazolines) in biological and biomedical application contexts
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Poly(2-oxazoline)-and poly(2-oxazine)-based self-assemblies, polyplexes, and drug nanoformulations—an update
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Synthesis and characterization of poly(2-ethyl 2-oxazoline)-conjugates with proteins and drugs: suitable alternatives to PEG-conjugates?
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Poly(2-oxazoline)s: synthesis and biomedical applications
10.1007/s13233-023-00116-x · 2023 · External reference
Poly(2-oxazoline)-based drug delivery systems for cancer therapy
10.1016/j.eurpolymj.2025.114292 · 2025 · External reference
Homopolymerization of 2-alkyl- and 2-aryl-2-oxazolines
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Defined high molar mass poly(2-oxazoline)s
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Biocompatibility and Immunocompatibility assessment of poly(2-Oxazolines)
2013 · External reference
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Biocompatibility of poly(2-alkyl-2-oxazoline) brush surfaces for adherent lung cell lines
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Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)
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Poly(2-ethyl-2-oxazoline) as alternative for the stealth polymer poly(ethylene glycol): comparison of in vitro cytotoxicity and Hemocompatibility
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Polyoxazolines for nonfouling surface coatings—a direct comparison to the gold standard PEG
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Poly (2-oxazoline) functionalized surfaces: from modification to application
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Poly(2-oxazoline)-based Thermoresponsive Stomatocytes
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Thermoresponsive poly(2-Oxazoline)s with pH-degradable Acetal side chains as potential drug delivery vehicles
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Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides
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Design strategies for functionalized poly(2-oxazoline)s and derived materials
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Poly(2-oxazoline)s and click chemistry: a versatile toolbox toward multi-functional polymers
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Unraveling Structure–Reactivity and Structure–Property Relationships for the Amidation of Methyl Ester-Functionalized Poly(2-Oxazoline)s
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Living polymerization of 2-Ethylthio-2-oxazoline and Postpolymerization diversification
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Straightforward route to Superhydrophilic poly(2-oxazoline)s via acylation of well-defined Polyethylenimine
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Short guanidinium-functionalized poly(2-oxazoline)s displaying potent therapeutic efficacy on drug-resistant fungal infections
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Amphiphilic poly(2-oxazoline) copolymers as self-assembled carriers for drug delivery applications
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Immunomodulatory efficiency of poly(2-oxazolines)
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Tailoring cationic poly(2-oxazoline)s: minimizing toxicity and immunogenic response for biological applications
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Clinical safety and performance of GATT-patch for hemostasis in minimal to moderate bleeding during open liver surgery
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Next generation hemostatic materials based on NHS-ester functionalized poly(2-oxazoline)s
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Structural basis of polyethylene glycol recognition by antibody
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Species differences in opsonization and phagocyte recognition of preclinical poly-2-alkyl-2-oxazoline-coated nanoparticles
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Intelligent stealth andrographolide imprinted drug carrier of poly(2-ethyl-2-oxazoline) with multi-stimuli responsiveness and A549 lung cancer cell cytotoxicity
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Naturally equipped urinary exosomes coated poly (2−ethyl−2−oxazoline)−poly (D, L−lactide) nanocarriers for the pre−clinical translation of breast cancer
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Alternating stealth polymer coatings between administrations minimizes toxic and antibody immune responses towards nanomedicine treatment regimens
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A high capacity polymeric micelle of paclitaxel: implication of high dose drug therapy to safety and in vivo anti-cancer activity
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Substituting poly(ethylene glycol) lipids with poly(2-ethyl-2-oxazoline) lipids improves lipid nanoparticle repeat dosing
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Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity
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