Research graph
References from Upregulation of S100A8/A9 Potentiates Radiation-Induced Intestinal Injury via MAPK and NF-κB Signaling Pathways. Local targets link to admitted publications; unresolved targets remain external evidence.
Radiation enteropathy—pathogenesis, treatment and prevention
10.1038/nrgastro.2014.46 · 2014 · External reference
Gut microbiota controlling radiation-induced enteritis and intestinal regeneration
10.1016/j.tem.2023.05.006 · 2023 · External reference
Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration
10.1016/j.stem.2013.11.008 · 2014 · External reference
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis
10.1126/science.1166202 · 2010 · External reference
Mucosal macrophages govern intestinal regeneration in response to injury
10.1053/j.gastro.2025.01.252 · 2025 · External reference
Calprotectin: From biomarker to biological function
10.1136/gutjnl-2021-324855 · 2021 · External reference
Fecal detection of calprotectin subunits links inflammatory bowel disease activity with chronicity of intestinal inflammation
10.1053/j.gastro.2025.08.040 · 2025 · External reference
Mucosal calprotectin is associated with severity of aGI-GVHD and poor outcomes after allogeneic stem cell transplantation
10.1182/blood.2025029402 · 2026 · External reference
Identified S100A9 as a target for diagnosis and treatment of ulcerative colitis by bioinformatics analysis
10.1038/s41598-024-55944-3 · 2024 · External reference
Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models
10.1038/s41401-023-01188-2 · 2024 · External reference
Faecal calprotectin and lactoferrin as markers of acute radiation proctitis: A pilot study of eight stool markers
10.1080/00365520410003614 · 2004 · External reference
Faecal DNA and calprotectin as biomarkers of acute intestinal toxicity in patients undergoing pelvic radiotherapy
10.1111/j.1365-2036.2009.04019.x · 2009 · External reference
Can biological markers act as non-invasive, sensitive indicators of radiation-induced effects in the gastrointestinal mucosa?
10.1111/j.1365-2036.2008.03663.x · 2008 · External reference
DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod
10.1186/s12974-021-02317-6 · 2021 · External reference
Fibroblast growth factor 20 attenuates colitis by restoring impaired intestinal epithelial barrier integrity and modulating macrophage polarization via S100A9 in an NF-κB-dependent manner
10.1016/j.jcmgh.2025.101486 · 2025 · External reference
Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment
10.1038/s41392-026-02592-w · 2026 · External reference
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation
10.7150/ijbs.111128 · 2025 · External reference
Role of mucosal immunity and epithelial-vascular barrier in modulating gut homeostasis
10.1007/s11739-023-03329-1 · 2023 · External reference
Intestinal mucosal barrier function in health and disease
10.1038/nri2653 · 2009 · External reference
Pathological effects of ionizing radiation: Endothelial activation and dysfunction
10.1007/s00018-018-2956-z · 2019 · External reference
The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A9
10.3389/fimmu.2023.1110185 · 2023 · External reference
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells
10.3892/ijmm.2017.2987 · 2017 · External reference
S100A8/A9 in inflammation
10.3389/fimmu.2018.01298 · 2018 · External reference
S100A8 and S100A9: DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease
10.1155/2013/828354 · 2013 · External reference
S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury
10.1016/j.biopha.2023.115674 · 2023 · External reference
High BM plasma S100A8/A9 is associated with a perturbed microenvironment and poor prognosis in myelodysplastic syndromes
10.1182/bloodadvances.2022008958 · 2023 · External reference
S100A8/A9: From basic science to clinical application
10.1016/j.pharmthera.2016.07.015 · 2016 · External reference
Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction
10.1186/s13054-023-04652-x · 2023 · External reference
S100A9 links inflammation and repair in myocardial infarction
10.1161/circresaha.120.315865 · 2020 · External reference
URI is required to maintain intestinal architecture during ionizing radiation
10.1126/science.aaq1165 · 2019 · External reference
A novel S100A8/A9 induced fingerprint of mesenchymal stem cells associated with enhanced wound healing
10.1038/s41598-018-24425-9 · 2018 · External reference
S100A8 accelerates wound healing by promoting adipose stem cell proliferation and suppressing inflammation
10.1016/j.reth.2022.06.010 · 2022 · External reference
The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion
10.1038/ki.2014.216 · 2015 · External reference
Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction
10.1093/eurheartj/ehz461 · 2019 · External reference
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome
10.1016/j.stem.2008.03.009 · 2008 · External reference
Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21
10.1158/1541-7786.mcr-11-0052 · 2011 · External reference
p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome
10.1038/s41467-023-44390-w · 2024 · External reference
p53 promotes revival stem cells in the regenerating intestine after severe radiation injury
10.1038/s41467-024-47124-8 · 2024 · External reference
S100a8/9 (S100 calcium binding protein a8/9) promotes cardiac hypertrophy via upregulation of FGF23 (fibroblast growth factor 23) in mice
10.1161/jaha.122.028006 · 2024 · External reference
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
10.1136/gut.52.1.144 · 2003 · External reference
