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References from Thrombospondin-1 and Thrombospondin-2 are associated with biatrial fibrotic remodeling in human valvular heart disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study
10.1161/circulationaha.113.005119 · 2014 · External reference
Atrial fibrillation pathophysiology: implications for management
10.1161/circulationaha.111.019893 · 2011 · External reference
Atrial remodeling and atrial fibrillation: recent advances and translational perspectives
10.1016/j.jacc.2014.02.555 · 2014 · External reference
Atrial fibrosis in atrial fibrillation: Mechanisms, mapping techniques and clinical applications
10.1113/jp288680 · 2026 · External reference
Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation
10.1016/j.jacc.2007.09.064 · 2008 · External reference
Mechanisms of Atrial Fibrillation: How Our Knowledge Affects Clinical Practice
2023 · External reference
Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy: A Translational Perspective
10.1161/circresaha.120.316363 · 2020 · External reference
Atrial Fibrosis in Atrial Fibrillation: Mechanistic Insights, Diagnostic Challenges, and Emerging Therapeutic Targets
10.3390/ijms26010209 · 2024 · External reference
Histological validation of atrial structural remodelling in patients with atrial fibrillation
10.1093/eurheartj/ehad396 · 2023 · External reference
Atrial remodeling, fibrosis, and atrial fibrillation
10.1016/j.tcm.2014.12.015 · 2015 · External reference
Cardiac Fibrosis in Patients With Atrial Fibrillation: Mechanisms and Clinical Implications
10.1016/j.jacc.2015.06.1313 · 2015 · External reference
Cardiac Fibrosis: The Fibroblast Awakens
10.1161/circresaha.115.306565 · 2016 · External reference
The role of transforming growth factor (TGF)-β in the infarcted myocardium
10.21037/jtd.2016.11.19 · 2017 · External reference
Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases
2020 · External reference
Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy
10.1161/01.res.0000141019.20332.3e · 2004 · External reference
The interaction of Thrombospondins with extracellular matrix proteins
10.1007/s12079-009-0074-2 · 2009 · External reference
Thrombospondins in the Transition from Myocardial Infarction to Heart Failure
10.1016/j.yjmcc.2015.12.009 · 2016 · External reference
Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis
10.7554/elife.49923 · 2020 · External reference
Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism
10.1161/hypertensionaha.111.175323 · 2011 · External reference
Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease
10.1016/j.matbio.2017.12.009 · 2018 · External reference
Left Atrial Myocardium in Arterial Hypertension
10.3390/cells11193157 · 2022 · External reference
The Atrium in Atrial Fibrillation - A Clinical Review on How to Manage Atrial Fibrotic Substrates
10.3389/fcvm.2022.879984 · 2022 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
10.1373/clinchem.2008.112797 · 2009 · External reference
NIH Image to ImageJ: 25 years of image analysis
10.1038/nmeth.2089 · 2012 · External reference
The thrombospondins
10.1101/cshperspect.a009712 · 2011 · External reference
Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction
10.1186/s12872-021-02322-w · 2021 · External reference
Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease
10.1016/j.jacbts.2024.01.010 · 2024 · External reference
Lack of thrombospondin-2 reduces fibrosis and increases vascularity around cardiac cell grafts
10.1016/j.carpath.2012.03.005 · 2013 · External reference
Thrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-κB Pathway
10.2147/jir.s314747 · 2021 · External reference
Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation
10.1161/circulationaha.108.846782 · 2009 · External reference
Cardiac fibrosis and arrhythmogenesis: the road to repair is paved with perils
10.1016/j.yjmcc.2013.10.018 · 2014 · External reference
A Smad transcriptional corepressor
10.1016/s0092-8674(00)80712-6 · 1999 · External reference
Epicardial and endothelial cell activation concurs with extracellular matrix remodeling in atrial fibrillation
10.1002/ctm2.558 · 2021 · External reference
Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease
10.1161/circresaha.111.259960 · 2012 · External reference
Arrhythmogenic implications of fibroblast-myocyte interactions
10.1161/circep.110.957647 · 2012 · External reference
Thrombospondins: A Role in Cardiovascular Disease
10.3390/ijms18071540 · 2017 · External reference
Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms
10.1016/j.matbio.2012.01.006 · 2012 · External reference
Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway
10.1007/s10753-017-0601-x · 2017 · External reference
Thrombospondin-1: multiple paths to inflammation
10.1155/2011/296069 · 2011 · External reference
Thrombospondin 1-CD47 Signalling Modulates Vascular Smooth Muscle Cell Senescence in Chronic Kidney Disease
10.3390/ijms27020755 · 2026 · External reference
CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis
10.1161/atvbaha.122.318904 · 2023 · External reference
Signal Transducer and Activator of Transcription 3/MicroRNA-21 Feedback Loop Contributes to Atrial Fibrillation by Promoting Atrial Fibrosis in a Rat Sterile Pericarditis Model
10.1161/circep.115.003396 · 2016 · External reference
WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death
10.1074/jbc.m809757200 · 2009 · External reference
TNFα induces inflammatory stress response in microvascular endothelial cells via Akt- and P38 MAP kinase-mediated thrombospondin-1 expression
10.1007/s11010-015-2440-0 · 2015 · External reference
The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta
10.1074/jbc.274.19.13586 · 1999 · External reference
The molecular mechanism of thrombospondin family members in cardiovascular diseases
10.3389/fcvm.2024.1337586 · 2024 · External reference
Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure
10.1161/circresaha.124.325402 · 2025 · External reference
