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References from Mitochondrial pyruvate carrier inhibition restrains germinal center T follicular helper cells attenuating chronic graft-versus-host disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Indications for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation
10.1016/j.bbmt.2015.07.032 · 2015 · External reference
Immunobiology of allogeneic hematopoietic stem cell transplantation
10.1146/annurev.immunol.25.022106.141606 · 2007 · External reference
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets
10.1056/nejmra1703472 · 2017 · External reference
The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease
10.1016/j.bbmt.2016.09.023 · 2017 · External reference
Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans
10.1182/blood-2014-03-562231 · 2014 · External reference
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
10.1182/blood-2011-07-364414 · 2012 · External reference
FDA-approved therapies for chronic GVHD
10.1182/blood.2024026633 · 2025 · External reference
Clinical response to belumosudil in bronchiolitis obliterans syndrome: a combined analysis from 2 prospective trials
10.1182/bloodadvances.2022008095 · 2022 · External reference
Axatilimab in Patients With Lung Chronic Graft-versus-Host Disease and Related Bronchiolitis Obliterans Syndrome
2025 · External reference
Metabolic pathways in immune cell activation and quiescence
10.1016/j.immuni.2013.04.005 · 2013 · External reference
Metabolic adaptations of tissue-resident immune cells
10.1038/s41590-019-0407-0 · 2019 · External reference
The CD28 signaling pathway regulates glucose metabolism
10.1016/s1074-7613(02)00323-0 · 2002 · External reference
Metabolic regulation of T lymphocytes
10.1146/annurev-immunol-032712-095956 · 2013 · External reference
Metabolic Adaptations of CD4+ T Cells in Inflammatory Disease
10.3389/fimmu.2018.00540 · 2018 · External reference
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
2011 · External reference
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
10.1126/scisignal.aab2610 · 2015 · External reference
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
10.1016/j.cell.2018.10.001 · 2018 · External reference
Fatty acid synthase regulates the pathogenicity of Th17 cells
10.1189/jlb.3ab0417-159rr · 2017 · External reference
Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis
10.1172/jci125917 · 2019 · External reference
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells
10.1016/j.immuni.2019.05.014 · 2019 · External reference
Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states
10.1038/s41467-023-43427-4 · 2023 · External reference
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases
10.1016/j.immuni.2019.04.011 · 2019 · External reference
Follicular helper CD4 T cells (TFH)
10.1146/annurev-immunol-031210-101400 · 2011 · External reference
Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination
2016 · External reference
Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity
10.1073/pnas.1811702116 · 2019 · External reference
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis
10.3389/fimmu.2018.01973 · 2018 · External reference
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
10.1038/s41467-018-06686-0 · 2018 · External reference
HIF1α-Dependent Metabolic Signals Control the Differentiation of Follicular Helper T Cells
10.3390/cells8111450 · 2019 · External reference
Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo
10.1371/journal.pone.0023205 · 2011 · External reference
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
10.1016/j.cmet.2014.05.004 · 2014 · External reference
A new murine model for bronchiolitis obliterans post-bone marrow transplant
10.1164/rccm.200702-335oc · 2007 · External reference
In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses
10.1007/978-1-4939-2498-1_13 · 2015 · External reference
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
10.1016/j.immuni.2012.10.020 · 2013 · External reference
Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma
10.1186/s12964-020-00539-4 · 2020 · External reference
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
10.1038/s41598-018-24676-6 · 2018 · External reference
Development of novel mitochondrial pyruvate carrier inhibitors for breast cancer treatment
10.1016/j.jbc.2025.110486 · 2025 · External reference
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
10.1038/ni.2496 · 2013 · External reference
Abnormal T cell-dependent B-cell responses in SCID mice receiving allogeneic bone marrow in utero. Severe combined immune deficiency
10.1182/blood-2002-04-1232 · 2002 · External reference
Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease
10.1182/blood-2018-03-839993 · 2019 · External reference
Bcl-6 directly represses the gene program of the glycolysis pathway
10.1038/ni.2985 · 2014 · External reference
Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states
10.1038/s41467-023-43427-4 · 2023 · External reference
T follicular regulatory cells in the regulation of B cell responses
10.1016/j.it.2015.05.005 · 2015 · External reference
Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet
10.1186/1743-7075-5-33 · 2008 · External reference
The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis
10.3390/cancers13071488 · 2021 · External reference
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
10.1038/ni.3578 · 2016 · External reference
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis
10.1038/s41590-020-0598-4 · 2020 · External reference
The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells
10.1038/s41423-020-0446-3 · 2020 · External reference
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
10.1182/blood-2011-07-364414 · 2012 · External reference
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells
10.1016/j.immuni.2015.08.017 · 2015 · External reference
Normalization of CD4+ T cell metabolism reverses lupus
10.1126/scitranslmed.aaa0835 · 2015 · External reference
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
2007 · External reference
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system
10.1038/nature19334 · 2016 · External reference
The relationship between CD4+ T cell glycolysis and their functions
10.1016/j.tem.2023.03.006 · 2023 · External reference
Chronic graft-versus-host disease: biological insights from preclinical and clinical studies
10.1182/blood-2016-06-686618 · 2017 · External reference
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses
10.1038/s44318-025-00414-3 · 2025 · External reference
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways
2008 · External reference
Revving the engine: signal transduction fuels T cell activation
10.1016/j.immuni.2007.07.008 · 2007 · External reference
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
10.1172/jci76012 · 2015 · External reference
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
10.1016/j.cmet.2016.12.018 · 2017 · External reference
Fueling immunity: insights into metabolism and lymphocyte function
10.1126/science.1242454 · 2013 · External reference
MicroRNA-31 regulates T-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice
10.1182/bloodadvances.2021005103 · 2022 · External reference
mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation
10.1016/j.immuni.2016.08.017 · 2016 · External reference
Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer
10.1158/1535-7163.mct-13-0097 · 2013 · External reference
Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation
10.1172/jci82587 · 2016 · External reference
Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism
10.1182/blood-2015-10-678706 · 2016 · External reference
Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration
10.1186/s13024-018-0260-x · 2018 · External reference
Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study
10.1016/j.jhep.2019.10.023 · 2020 · External reference
Side effect profile of pharmacologic therapies for liver fibrosis in nonalcoholic fatty liver disease: a systematic review and network meta-analysis
10.1097/meg.0000000000002471 · 2023 · External reference
Genetically engineering glycolysis in T cells increases their antitumor function
2024 · External reference
