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References from Infant dermatitis induces long-lasting innate immune imprinting associated with the exacerbated adult atopic dermatitis-like skin inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Four phenotypes of atopic dermatitis in Japanese children: a general population birth cohort study
10.1016/j.alit.2019.02.010 · 2019 · External reference
The natural course of atopic dermatitis from birth to age 7 years and the association with asthma
2004 · External reference
Longitudinal atopic dermatitis control and persistence vary with timing of disease onset in children: a cohort study
10.1016/j.jaad.2019.05.016 · 2019 · External reference
Developmental trajectories of atopic dermatitis with multiomics approaches in the infant gut: COCOA birth cohort
10.1016/j.jaci.2024.10.036 · 2025 · External reference
Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts
10.1016/j.jaci.2017.09.044 · 2018 · External reference
Age at onset and persistence of eczema are related to subsequent risk of asthma and hay fever from birth to 18 years of age
10.1111/pai.12714 · 2017 · External reference
The atopic March: fact or folklore?
10.1016/j.anai.2017.10.029 · 2018 · External reference
The atopic March and atopic multimorbidity: many trajectories, many pathways
10.1016/j.jaci.2018.11.006 · 2019 · External reference
Longitudinal atopic dermatitis endotypes: an atopic March paradigm that includes black children
10.1016/j.jaci.2021.09.036 · 2022 · External reference
Risk factors for moderate-severe asthma in children ages 5-11 years with early-onset atopic dermatitis
10.1016/j.jaip.2025.07.036 · 2025 · External reference
Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-ige-sensitised children in MeDALL: a population-based cohort study
10.1016/s2213-2600(13)70277-7 · 2014 · External reference
Incidence and remission of atopic dermatitis in a German birth cohort
10.1001/jamanetworkopen.2025.44324 · 2025 · External reference
Barrier dysfunction in the atopic march-how does atopic dermatitis lead to asthma in children?
10.1016/j.jaci.2020.04.014 · 2020 · External reference
Stratum corneum lipid and cytokine biomarkers at age 2 months predict the future onset of atopic dermatitis
10.1016/j.jaci.2023.02.013 · 2023 · External reference
Sensitization trajectories in childhood revealed by using a cluster analysis
10.1016/j.jaci.2017.01.041 · 2017 · External reference
Natural history of allergic sensitization in infants with early-onset atopic dermatitis: results from ORCA study
10.1111/pai.12287 · 2014 · External reference
The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice
10.1016/j.alit.2018.01.003 · 2018 · External reference
New insights into human atopic dermatitis provided by mouse models
10.1016/j.jaci.2021.07.016 · 2021 · External reference
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation
10.1126/scitranslmed.3005374 · 2013 · External reference
Basophils promote innate lymphoid cell responses in inflamed skin
10.4049/jimmunol.1401307 · 2014 · External reference
Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune Cascade
10.1038/ncomms3847 · 2013 · External reference
Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils
10.1073/pnas.1615973114 · 2017 · External reference
Basophils are important for development of allergic skin inflammation
10.1016/j.jaci.2024.01.022 · 2024 · External reference
Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene
10.1016/s1074-7613(01)00084-x · 2001 · External reference
Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity
10.4049/jimmunol.1101270 · 2012 · External reference
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
10.1038/nbt0102-87 · 2002 · External reference
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis
10.1073/pnas.0604575103 · 2006 · External reference
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation
10.1038/nature10329 · 2011 · External reference
Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases
10.1111/all.14863 · 2021 · External reference
Perinatal activation of the Interleukin-33 pathway promotes type 2 immunity in the developing lung
10.1016/j.immuni.2016.10.031 · 2016 · External reference
Tissue-resident group 2 innate lymphoid cells differentiate by layered ontogeny and in situ perinatal priming
10.1016/j.immuni.2019.04.019 · 2019 · External reference
Group 2 innate lymphoid cell activation in the neonatal lung drives type 2 immunity and allergen sensitization
10.1016/j.jaci.2016.12.984 · 2017 · External reference
Lung group 2 innate lymphoid cells are trained by endogenous IL-33 in the neonatal period
10.1172/jci.insight.135961 · 2020 · External reference
First-breath-induced type 2 pathways shape the lung immune environment
10.1016/j.celrep.2017.01.071 · 2017 · External reference
Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses
10.1016/j.jaci.2017.11.025 · 2018 · External reference
The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
10.4049/jimmunol.1003020 · 2011 · External reference
Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations
10.1016/j.jaci.2014.02.002 · 2014 · External reference
T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
10.1002/eji.201546119 · 2016 · External reference
IL-33 is a crucial amplifier of innate rather than acquired immunity
10.1073/pnas.1003059107 · 2010 · External reference
An Interleukin-33-Mast Cell-Interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers
10.1016/j.immuni.2015.06.021 · 2015 · External reference
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells
10.1016/j.immuni.2014.02.003 · 2014 · External reference
Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin
10.1038/s41598-021-85277-4 · 2021 · External reference
Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s
10.1111/all.15762 · 2023 · External reference
Laundry detergents enhance sensitization to Co-Inhaled allergens and exacerbate airway inflammation in mice
10.1111/all.70245 · 2026 · External reference
Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice
10.1016/j.jaci.2015.06.037 · 2016 · External reference
IL33 contributes to diesel pollution-mediated increase in experimental asthma severity
10.1111/all.14181 · 2020 · External reference
Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation
10.1016/j.chom.2023.12.006 · 2024 · External reference
Epidermal thymic stromal lymphopoietin predicts the development of atopic dermatitis during infancy
10.1016/j.jaci.2015.12.1306 · 2016 · External reference
Long-term efficacy and safety of topical therapy in pediatric moderate to severe atopic dermatitis (ROAD study)
10.1016/j.alit.2025.11.005 · 2026 · External reference
Executive summary: japanese guidelines for atopic dermatitis (ADGL) 2024
10.1016/j.alit.2025.01.003 · 2025 · External reference
Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation
10.1038/ncomms3675 · 2013 · External reference
Three-year Follow-Up of the PACI randomized controlled trial (PACI-ON): effects of early intervention for atopic dermatitis on atopic march
10.1111/all.70262 · 2026 · External reference
Potential preventive effects of proactive therapy on sensitization in moderate to severe childhood atopic dermatitis: a randomized, investigator-blnded, controlled study
10.1111/1346-8138.13408 · 2016 · External reference
Are the concepts of induction of remission and treatment of subclinical inflammation in atopic dermatitis clinically useful?
10.1016/j.jaci.2013.12.1079 · 2014 · External reference
Proactive treatment appears to decrease serum immunoglobulin-E levels in patients with severe atopic dermatitis
10.1111/j.1365-2133.2010.09904.x · 2010 · External reference
Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis
10.1016/j.jaci.2021.07.025 · 2022 · External reference
Skin-resident innate lymphoid cells - cutaneous innate guardians and regulators
10.1016/j.it.2019.12.004 · 2020 · External reference
ILC2s in skin disorders
10.1016/j.alit.2023.01.002 · 2023 · External reference
Efficacy and safety of systemic targeted therapies for atopic dermatitis in children: a systematic review and meta-analysis
10.1016/j.alit.2024.11.007 · 2025 · External reference
Biologics for allergic and immunologic diseases
10.1016/j.jaci.2022.08.009 · 2022 · External reference
Comprehensive analysis of type 2 innate lymphoid cell (ILC2) heterogeneity and identification of CD81 as a marker for pathogenic IL-13(+) ILC2s in atopic dermatitis skin
10.1111/all.70077 · 2026 · External reference
Integrative omics redefining allergy mechanisms and precision medicine
10.1016/j.alit.2025.08.007 · 2025 · External reference
An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis
10.1038/s41467-025-59340-x · 2025 · External reference
In search of the holy grail in atopic dermatitis: will dupilumab become the first disease-modifying atopic dermatitis drug?
10.1016/j.jaci.2022.12.824 · 2023 · External reference
Disease modification in inflammatory skin disorders: opportunities and challenges
10.1038/s41573-023-00735-0 · 2023 · External reference
From sprinters to marathoners: rethinking therapeutic speed and disease modification in atopic dermatitis
10.1111/all.70395 · 2026 · External reference
