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References from 4-octyl itaconate inhibits porcine epidemic diarrhea virus replication by modulating the ferroptosis axis and the autophagy pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma
10.1038/s41419-024-07209-0 · 2024 · External reference
The aqueous leaf extract of M. oleifera inhibits PEDV replication through suppressing oxidative stress-mediated apoptosis
2022 · External reference
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
10.1038/s42255-022-00577-x · 2022 · External reference
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
10.1038/s41556-022-00853-8 · 2022 · External reference
Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate
10.4161/auto.7.11.16642 · 2011 · External reference
The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic State in neurons
10.1016/j.immuni.2018.11.017 · 2019 · External reference
Metabolic control of autophagy
10.1016/j.cell.2014.11.006 · 2014 · External reference
Glycyrrhizin inhibits PEDV infection and proinflammatory cytokine secretion via the HMGB1/TLR4-MAPK p38 pathway
10.3390/ijms21082961 · 2020 · External reference
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury
10.1038/s41420-021-00807-3 · 2022 · External reference
Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway
10.1111/bph.15834 · 2022 · External reference
The multi-faceted role of autophagy during animal virus infection
10.3389/fcimb.2022.858953 · 2022 · External reference
Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence
10.1023/a:1011831902219 · 2001 · External reference
Structure, function, and evolution of Coronavirus Spike proteins
10.1146/annurev-virology-110615-042301 · 2016 · External reference
Inhibition of porcine epidemic diarrhea virus replication and viral 3C-Like protease by quercetin
10.3390/ijms21218095 · 2020 · External reference
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
10.1038/s41467-019-13078-5 · 2019 · External reference
Nonstructural protein 6 of porcine epidemic diarrhea virus induces autophagy to promote viral replication via the PI3K/Akt/mTOR axis
10.1016/j.vetmic.2020.108684 · 2020 · External reference
Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance
10.1016/j.ccell.2024.10.010 · 2024 · External reference
Xanthohumol is a potent pan-inhibitor of coronaviruses targeting main protease
10.3390/ijms222212134 · 2021 · External reference
N (6)-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication
10.1126/science.aax4468 · 2019 · External reference
Autophagy and viral infection
10.1007/978-981-15-0606-2_5 · 2019 · External reference
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
10.1038/nature25986 · 2018 · External reference
Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase
10.1038/s42255-024-01145-1 · 2024 · External reference
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
10.1038/s41467-020-18764-3 · 2020 · External reference
Itaconate derivative 4-OI inhibits PRRSV proliferation and associated inflammatory response
10.1016/j.virol.2022.10.007 · 2022 · External reference
Porcine epidemic diarrhea virus infection induces autophagosome Formation but inhibits autolysosome Formation during replication
10.3390/v14051050 · 2022 · External reference
The role of itaconate in host defense and inflammation
10.1172/jci148548 · 2022 · External reference
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate
10.1038/s41589-019-0323-5 · 2019 · External reference
Chemoproteomic profiling of itaconation by bioorthogonal probes in inflammatory macrophages
10.1021/jacs.9b11962 · 2020 · External reference
Itaconic acid induces ferroptosis by activating ferritinophagy
10.1016/j.bbrc.2021.10.054 · 2021 · External reference
xCT/SLC7A11 antiporter function inhibits HIV-1 infection
10.1016/j.virol.2021.01.008 · 2021 · External reference
4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1
10.1128/jvi.01325-23 · 2023 · External reference
Autophagy regulation by nutrient signaling
10.1038/cr.2013.166 · 2014 · External reference
Nrf2 as a master regulator of tissue damage control and disease tolerance to infection
10.1042/bst20150054 · 2015 · External reference
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection
2022 · External reference
Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways
10.1016/j.vetmic.2020.108959 · 2021 · External reference
DHA and EPA inhibit porcine coronavirus replication by alleviating ER stress
10.1128/jvi.01209-23 · 2023 · External reference
S1 subunit of spike protein from a Current highly virulent porcine epidemic diarrhea virus is an important determinant of virulence in piglets
10.3390/v10090467 · 2018 · External reference
Porcine epidemic diarrhoea virus (PEDV) infection activates AMPK and JNK through TAK1 to induce autophagy and enhance virus replication
10.1080/21505594.2022.2127192 · 2022 · External reference
Natural hyperoside extracted from hawthorn exhibits antiviral activity against porcine epidemic diarrhea virus in vitro and in vivo
10.1016/j.virol.2024.110037 · 2024 · External reference
ALDH1L1 suppresses the replication of porcine epidemic diarrhea virus by degrading viral nucleocapsid and envelope proteins
2025 · External reference
Ferroptosis in viral infection: the unexplored possibility
10.1038/s41401-021-00814-1 · 2022 · External reference
Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease
10.1186/s13567-020-00865-y · 2020 · External reference
NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
10.1371/journal.ppat.1011506 · 2023 · External reference
NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism
10.1038/s42003-026-09724-6 · 2026 · External reference
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
10.1038/s41467-019-12894-z · 2019 · External reference
Significant inhibition of porcine epidemic diarrhea virus in vitro by Remdesivir, its parent nucleoside and β-D-N(4)-hydroxycytidine
10.1007/s12250-021-00362-2 · 2021 · External reference
Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo
10.1016/j.vetmic.2020.108849 · 2020 · External reference
1,25-Dihydroxyvitamin D(3) inhibits porcine epidemic diarrhea virus replication by regulating cell cycle resumption in IPEC-J2 porcine epithelial cells
10.1016/j.micpath.2021.105017 · 2021 · External reference
Using CRISPR/Cas9 to knock out amylase in Acinar cells decreases pancreatitis-induced autophagy
10.1155/2018/8719397 · 2018 · External reference
Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane
10.1038/s41392-024-02077-8 · 2024 · External reference
In vitro antiviral activities of Salinomycin on porcine epidemic diarrhea virus
10.3390/v13040580 · 2021 · External reference
The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response
2025 · External reference
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol
10.1016/j.vetmic.2019.03.004 · 2019 · External reference
Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS
10.1038/s41598-021-97352-x · 2021 · External reference
Porcine epidemic diarrhea virus ORF3 protein causes endoplasmic reticulum stress to facilitate autophagy
10.1016/j.vetmic.2019.07.005 · 2019 · External reference
Autophagy and viral infection
10.1007/978-981-15-0606-2_5 · ExternalCitation · doi-reference
Significant inhibition of porcine epidemic diarrhea virus in vitro by Remdesivir, its parent nucleoside and β-D-N(4)-hydroxycytidine
10.1007/s12250-021-00362-2 · ExternalCitation · doi-reference
Itaconic acid induces ferroptosis by activating ferritinophagy
10.1016/j.bbrc.2021.10.054 · ExternalCitation · doi-reference
Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance
10.1016/j.ccell.2024.10.010 · ExternalCitation · doi-reference
Metabolic control of autophagy
10.1016/j.cell.2014.11.006 · ExternalCitation · doi-reference
The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic State in neurons
10.1016/j.immuni.2018.11.017 · ExternalCitation · doi-reference
1,25-Dihydroxyvitamin D(3) inhibits porcine epidemic diarrhea virus replication by regulating cell cycle resumption in IPEC-J2 porcine epithelial cells
10.1016/j.micpath.2021.105017 · ExternalCitation · doi-reference
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol
10.1016/j.vetmic.2019.03.004 · ExternalCitation · doi-reference
Porcine epidemic diarrhea virus ORF3 protein causes endoplasmic reticulum stress to facilitate autophagy
10.1016/j.vetmic.2019.07.005 · ExternalCitation · doi-reference
Nonstructural protein 6 of porcine epidemic diarrhea virus induces autophagy to promote viral replication via the PI3K/Akt/mTOR axis
10.1016/j.vetmic.2020.108684 · ExternalCitation · doi-reference
Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo
10.1016/j.vetmic.2020.108849 · ExternalCitation · doi-reference
Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways
10.1016/j.vetmic.2020.108959 · ExternalCitation · doi-reference
xCT/SLC7A11 antiporter function inhibits HIV-1 infection
10.1016/j.virol.2021.01.008 · ExternalCitation · doi-reference
Itaconate derivative 4-OI inhibits PRRSV proliferation and associated inflammatory response
10.1016/j.virol.2022.10.007 · ExternalCitation · doi-reference
Natural hyperoside extracted from hawthorn exhibits antiviral activity against porcine epidemic diarrhea virus in vitro and in vivo
10.1016/j.virol.2024.110037 · ExternalCitation · doi-reference
Chemoproteomic profiling of itaconation by bioorthogonal probes in inflammatory macrophages
10.1021/jacs.9b11962 · ExternalCitation · doi-reference
Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence
10.1023/a:1011831902219 · ExternalCitation · doi-reference
Autophagy regulation by nutrient signaling
10.1038/cr.2013.166 · ExternalCitation · doi-reference
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
10.1038/nature25986 · ExternalCitation · doi-reference
Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane
10.1038/s41392-024-02077-8 · ExternalCitation · doi-reference
Ferroptosis in viral infection: the unexplored possibility
10.1038/s41401-021-00814-1 · ExternalCitation · doi-reference
LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma
10.1038/s41419-024-07209-0 · ExternalCitation · doi-reference
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury
10.1038/s41420-021-00807-3 · ExternalCitation · doi-reference
Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
10.1038/s41467-019-12894-z · ExternalCitation · doi-reference
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
10.1038/s41467-019-13078-5 · ExternalCitation · doi-reference
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
10.1038/s41467-020-18764-3 · ExternalCitation · doi-reference
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
10.1038/s41556-022-00853-8 · ExternalCitation · doi-reference
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate
10.1038/s41589-019-0323-5 · ExternalCitation · doi-reference
Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS
10.1038/s41598-021-97352-x · ExternalCitation · doi-reference
NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism
10.1038/s42003-026-09724-6 · ExternalCitation · doi-reference
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
10.1038/s42255-022-00577-x · ExternalCitation · doi-reference
Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase
10.1038/s42255-024-01145-1 · ExternalCitation · doi-reference
Nrf2 as a master regulator of tissue damage control and disease tolerance to infection
10.1042/bst20150054 · ExternalCitation · doi-reference
Porcine epidemic diarrhoea virus (PEDV) infection activates AMPK and JNK through TAK1 to induce autophagy and enhance virus replication
10.1080/21505594.2022.2127192 · ExternalCitation · doi-reference
Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway
10.1111/bph.15834 · ExternalCitation · doi-reference
N (6)-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication
10.1126/science.aax4468 · ExternalCitation · doi-reference
DHA and EPA inhibit porcine coronavirus replication by alleviating ER stress
10.1128/jvi.01209-23 · ExternalCitation · doi-reference
4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1
10.1128/jvi.01325-23 · ExternalCitation · doi-reference
Structure, function, and evolution of Coronavirus Spike proteins
10.1146/annurev-virology-110615-042301 · ExternalCitation · doi-reference
Using CRISPR/Cas9 to knock out amylase in Acinar cells decreases pancreatitis-induced autophagy
10.1155/2018/8719397 · ExternalCitation · doi-reference
The role of itaconate in host defense and inflammation
10.1172/jci148548 · ExternalCitation · doi-reference
Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease
10.1186/s13567-020-00865-y · ExternalCitation · doi-reference
NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
10.1371/journal.ppat.1011506 · ExternalCitation · doi-reference
The multi-faceted role of autophagy during animal virus infection
10.3389/fcimb.2022.858953 · ExternalCitation · doi-reference
Glycyrrhizin inhibits PEDV infection and proinflammatory cytokine secretion via the HMGB1/TLR4-MAPK p38 pathway
10.3390/ijms21082961 · ExternalCitation · doi-reference
Inhibition of porcine epidemic diarrhea virus replication and viral 3C-Like protease by quercetin
10.3390/ijms21218095 · ExternalCitation · doi-reference
Xanthohumol is a potent pan-inhibitor of coronaviruses targeting main protease
10.3390/ijms222212134 · ExternalCitation · doi-reference
S1 subunit of spike protein from a Current highly virulent porcine epidemic diarrhea virus is an important determinant of virulence in piglets
10.3390/v10090467 · ExternalCitation · doi-reference
In vitro antiviral activities of Salinomycin on porcine epidemic diarrhea virus
10.3390/v13040580 · ExternalCitation · doi-reference
Porcine epidemic diarrhea virus infection induces autophagosome Formation but inhibits autolysosome Formation during replication
10.3390/v14051050 · ExternalCitation · doi-reference
Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate
10.4161/auto.7.11.16642 · ExternalCitation · doi-reference
