Research graph
References from Influenza vaccination as a modulator of inflammaging: Trained tolerance as a mechanistic lens on heterologous effects in age-related diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Influenza vaccination blunts the inflammatory response in patients undergoing cardiopulmonary Bypass
10.1016/j.athoracsur.2020.07.052 · 2021 · External reference
Association of influenza vaccination with cardiovascular risk: a meta-analysis
10.1001/jamanetworkopen.2022.8873 · 2022 · External reference
Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes
10.1161/atvbaha.114.303887 · 2014 · External reference
Influenza vaccination promotes stable atherosclerotic plaques in apoE knockout mice
10.1016/j.atherosclerosis.2011.03.019 · 2011 · External reference
Impact of influenza vaccination on survival of patients with advanced cancer receiving immune checkpoint inhibitors (INVIDIa-2): final results of the multicentre, prospective, observational study
10.1016/j.eclinm.2023.102044 · 2023 · External reference
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
10.1038/s41423-023-00974-6 · 2023 · External reference
High-dose influenza vaccine is associated with reduced mortality among older adults with breakthrough influenza even when there is poor vaccine-strain match
10.1093/cid/ciad322 · 2023 · External reference
Influenza vaccination is associated with lower risk of acute coronary syndrome in elderly patients with chronic kidney disease
2016 · External reference
Effect of annual influenza vaccination on reducing lung cancer in patients with chronic obstructive pulmonary disease from a population-based cohort study
2019 · External reference
Western Diet Triggers NLRP3-dependent innate immune reprogramming
10.1016/j.cell.2017.12.013 · 2018 · External reference
Induction of trained immunity by influenza vaccination - impact on COVID-19
10.1371/journal.ppat.1009928 · 2021 · External reference
Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
10.1016/j.cell.2018.05.003 · 2018 · External reference
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis
10.1161/circulationaha.120.046464 · 2021 · External reference
A natural experiment on the effect of herpes zoster vaccination on dementia
10.1038/s41586-025-08800-x · 2025 · External reference
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
10.1038/s41569-018-0064-2 · 2018 · External reference
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
10.1038/s41574-018-0059-4 · 2018 · External reference
Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
10.1161/circulationaha.121.057042 · 2021 · External reference
Chronic inflammation in the etiology of disease across the life span
10.1038/s41591-019-0675-0 · 2019 · External reference
Comparative effectiveness of high-dose versus standard-dose influenza vaccination on numbers of US nursing home residents admitted to hospital: a cluster-randomised trial
10.1016/s2213-2600(17)30235-7 · 2017 · External reference
The degree of frailty as a translational measure of health in aging
10.1038/s43587-021-00099-3 · 2021 · External reference
Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
10.1038/s41598-021-84285-8 · 2021 · External reference
BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis
10.1016/j.cell.2017.12.031 · 2018 · External reference
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
10.1016/j.cell.2017.05.018 · 2017 · External reference
Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults
10.1016/j.vaccine.2017.11.045 · 2018 · External reference
The Impact of Influenza Vaccination on Hospitalizations and Mortality Among Frail Older People
10.1016/j.jamda.2013.12.003 · 2014 · External reference
Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors
10.1007/s00018-020-03719-0 · 2021 · External reference
Atherosclerosis
10.1038/s41572-019-0106-z · 2019 · External reference
Influenza vaccine to reduce adverse vascular events in patients with heart failure: a multinational randomised, double-blind, placebo-controlled trial
10.1016/s2214-109x(22)00432-6 · 2022 · External reference
Association between vaccinations and risk of dementia: a systematic review and meta-analysis
10.1093/ageing/afaf331 · 2025 · External reference
The protective effect of pneumococcal vaccination on cardiovascular disease in adults: A systematic review and meta-analysis
10.1016/j.ijid.2020.07.038 · 2020 · External reference
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
10.1016/j.cell.2017.11.034 · 2018 · External reference
Defining trained immunity and its role in health and disease
10.1038/s41577-020-0285-6 · 2020 · External reference
Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer
10.1073/pnas.1904022116 · 2020 · External reference
Influenza vaccine immune response in patients with high-risk cardiovascular disease: a secondary analysis of the INVESTED randomized clinical trial
10.1001/jamacardio.2024.0468 · 2024 · External reference
Herpes Zoster Vaccination and Dementia Occurrence
10.1001/jama.2025.5013 · 2025 · External reference
Adjuvanted Recombinant Zoster Vaccine is Effective Against Herpes Zoster Ophthalmicus, and is Associated With Lower Risk of Acute Myocardial Infarction and Stroke in Adults Aged ≥50 Years
10.1093/cid/ciaf440 · 2025 · External reference
Vaccines for the prevention of seasonal influenza in patients with diabetes: systematic review and meta-analysis
10.1186/s12916-015-0295-6 · 2015 · External reference
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
10.1056/nejmoa1707914 · 2017 · External reference
Frailty defined by deficit accumulation and geriatric medicine defined by frailty
10.1016/j.cger.2010.08.008 · 2011 · External reference
High-dose influenza vaccines for the prevention of hospitalization due to cardiovascular events in older adults in the nursing home: Post-hoc analysis of a cluster-randomized trial
10.1016/j.vaccine.2022.09.085 · 2022 · External reference
Biomarkers of ageing immune system and their association with frailty: a systematic review
2022 · External reference
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
10.1038/s43587-021-00082-y · 2021 · External reference
Association of an inflammaging score based on IL-6, IL-10 and CXCL9, and frailty with long-term mortality in hospitalized older adults
2025 · External reference
Association of Influenza Vaccination and Dementia Risk: A Meta-Analysis of Cohort Studies
10.3233/jad-221036 · 2023 · External reference
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
10.1038/s41541-025-01172-3 · 2025 · External reference
Effect of high-dose trivalent vs standard-dose quadrivalent influenza vaccine on mortality or cardiopulmonary hospitalization in patients with high-risk cardiovascular disease: a randomized clinical trial (INVESTED)
10.1001/jama.2020.23649 · 2021 · External reference
Influenza vaccination reduces dementia risk: a systematic review and meta-analysis
10.1016/j.arr.2021.101534 · 2022 · External reference
Fostering healthy aging: The interdependency of infections, immunity and frailty
10.1016/j.arr.2021.101351 · 2021 · External reference
Impact of Influenza Vaccination on Mortality in the Oldest Old: A Propensity Score-Matched Cohort Study
10.3390/vaccines8030356 · 2020 · External reference
The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination
10.1016/j.cell.2021.05.039 · 2021 · External reference
Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring
10.1016/j.bbi.2014.06.202 · 2014 · External reference
Influenza vaccination and risk of dementia: a systematic review and meta-analysis
10.1093/ageing/afaf169 · 2025 · External reference
Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells
10.1186/s12974-020-01741-4 · 2020 · External reference
Effects of influenza vaccine on mortality and cardiovascular outcomes in patients with cardiovascular disease: a systematic review and meta-analysis
10.1161/jaha.120.019636 · 2021 · External reference
Role of annual influenza vaccination against lung cancer in type 2 diabetic patients from a population-based cohort study
10.3390/jcm10153434 · 2021 · External reference
Effect of high-dose trivalent vs standard-dose quadrivalent influenza vaccine on mortality or cardiopulmonary hospitalization in patients with high-risk cardiovascular disease: a randomized clinical trial (INVESTED)
10.1001/jama.2020.23649 · ExternalCitation · doi-reference
Herpes Zoster Vaccination and Dementia Occurrence
10.1001/jama.2025.5013 · ExternalCitation · doi-reference
Influenza vaccine immune response in patients with high-risk cardiovascular disease: a secondary analysis of the INVESTED randomized clinical trial
10.1001/jamacardio.2024.0468 · ExternalCitation · doi-reference
Association of influenza vaccination with cardiovascular risk: a meta-analysis
10.1001/jamanetworkopen.2022.8873 · ExternalCitation · doi-reference
Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors
10.1007/s00018-020-03719-0 · ExternalCitation · doi-reference
Fostering healthy aging: The interdependency of infections, immunity and frailty
10.1016/j.arr.2021.101351 · ExternalCitation · doi-reference
Influenza vaccination reduces dementia risk: a systematic review and meta-analysis
10.1016/j.arr.2021.101534 · ExternalCitation · doi-reference
Influenza vaccination promotes stable atherosclerotic plaques in apoE knockout mice
10.1016/j.atherosclerosis.2011.03.019 · ExternalCitation · doi-reference
Influenza vaccination blunts the inflammatory response in patients undergoing cardiopulmonary Bypass
10.1016/j.athoracsur.2020.07.052 · ExternalCitation · doi-reference
Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring
10.1016/j.bbi.2014.06.202 · ExternalCitation · doi-reference
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
10.1016/j.cell.2017.05.018 · ExternalCitation · doi-reference
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
10.1016/j.cell.2017.11.034 · ExternalCitation · doi-reference
Western Diet Triggers NLRP3-dependent innate immune reprogramming
10.1016/j.cell.2017.12.013 · ExternalCitation · doi-reference
BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis
10.1016/j.cell.2017.12.031 · ExternalCitation · doi-reference
Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
10.1016/j.cell.2018.05.003 · ExternalCitation · doi-reference
The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination
10.1016/j.cell.2021.05.039 · ExternalCitation · doi-reference
Frailty defined by deficit accumulation and geriatric medicine defined by frailty
10.1016/j.cger.2010.08.008 · ExternalCitation · doi-reference
Impact of influenza vaccination on survival of patients with advanced cancer receiving immune checkpoint inhibitors (INVIDIa-2): final results of the multicentre, prospective, observational study
10.1016/j.eclinm.2023.102044 · ExternalCitation · doi-reference
The protective effect of pneumococcal vaccination on cardiovascular disease in adults: A systematic review and meta-analysis
10.1016/j.ijid.2020.07.038 · ExternalCitation · doi-reference
The Impact of Influenza Vaccination on Hospitalizations and Mortality Among Frail Older People
10.1016/j.jamda.2013.12.003 · ExternalCitation · doi-reference
Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults
10.1016/j.vaccine.2017.11.045 · ExternalCitation · doi-reference
High-dose influenza vaccines for the prevention of hospitalization due to cardiovascular events in older adults in the nursing home: Post-hoc analysis of a cluster-randomized trial
10.1016/j.vaccine.2022.09.085 · ExternalCitation · doi-reference
Comparative effectiveness of high-dose versus standard-dose influenza vaccination on numbers of US nursing home residents admitted to hospital: a cluster-randomised trial
10.1016/s2213-2600(17)30235-7 · ExternalCitation · doi-reference
Influenza vaccine to reduce adverse vascular events in patients with heart failure: a multinational randomised, double-blind, placebo-controlled trial
10.1016/s2214-109x(22)00432-6 · ExternalCitation · doi-reference
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
10.1038/s41423-023-00974-6 · ExternalCitation · doi-reference
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
10.1038/s41541-025-01172-3 · ExternalCitation · doi-reference
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
10.1038/s41569-018-0064-2 · ExternalCitation · doi-reference
Atherosclerosis
10.1038/s41572-019-0106-z · ExternalCitation · doi-reference
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
10.1038/s41574-018-0059-4 · ExternalCitation · doi-reference
Defining trained immunity and its role in health and disease
10.1038/s41577-020-0285-6 · ExternalCitation · doi-reference
A natural experiment on the effect of herpes zoster vaccination on dementia
10.1038/s41586-025-08800-x · ExternalCitation · doi-reference
Chronic inflammation in the etiology of disease across the life span
10.1038/s41591-019-0675-0 · ExternalCitation · doi-reference
Influenza vaccination reduces incidence of peripheral arterial occlusive disease in elderly patients with chronic kidney disease
10.1038/s41598-021-84285-8 · ExternalCitation · doi-reference
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
10.1038/s43587-021-00082-y · ExternalCitation · doi-reference
The degree of frailty as a translational measure of health in aging
10.1038/s43587-021-00099-3 · ExternalCitation · doi-reference
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
10.1056/nejmoa1707914 · ExternalCitation · doi-reference
Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer
10.1073/pnas.1904022116 · ExternalCitation · doi-reference
Influenza vaccination and risk of dementia: a systematic review and meta-analysis
10.1093/ageing/afaf169 · ExternalCitation · doi-reference
Association between vaccinations and risk of dementia: a systematic review and meta-analysis
10.1093/ageing/afaf331 · ExternalCitation · doi-reference
High-dose influenza vaccine is associated with reduced mortality among older adults with breakthrough influenza even when there is poor vaccine-strain match
10.1093/cid/ciad322 · ExternalCitation · doi-reference
Adjuvanted Recombinant Zoster Vaccine is Effective Against Herpes Zoster Ophthalmicus, and is Associated With Lower Risk of Acute Myocardial Infarction and Stroke in Adults Aged ≥50 Years
10.1093/cid/ciaf440 · ExternalCitation · doi-reference
Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes
10.1161/atvbaha.114.303887 · ExternalCitation · doi-reference
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis
10.1161/circulationaha.120.046464 · ExternalCitation · doi-reference
Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
10.1161/circulationaha.121.057042 · ExternalCitation · doi-reference
Effects of influenza vaccine on mortality and cardiovascular outcomes in patients with cardiovascular disease: a systematic review and meta-analysis
10.1161/jaha.120.019636 · ExternalCitation · doi-reference
Vaccines for the prevention of seasonal influenza in patients with diabetes: systematic review and meta-analysis
10.1186/s12916-015-0295-6 · ExternalCitation · doi-reference
Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells
10.1186/s12974-020-01741-4 · ExternalCitation · doi-reference
Induction of trained immunity by influenza vaccination - impact on COVID-19
10.1371/journal.ppat.1009928 · ExternalCitation · doi-reference
Association of Influenza Vaccination and Dementia Risk: A Meta-Analysis of Cohort Studies
10.3233/jad-221036 · ExternalCitation · doi-reference
Role of annual influenza vaccination against lung cancer in type 2 diabetic patients from a population-based cohort study
10.3390/jcm10153434 · ExternalCitation · doi-reference
Impact of Influenza Vaccination on Mortality in the Oldest Old: A Propensity Score-Matched Cohort Study
10.3390/vaccines8030356 · ExternalCitation · doi-reference
