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References from Ferroptosis-driven inflammaging in age-associated degenerative disorders: Molecular mechanisms and therapeutic potential of natural products. Local targets link to admitted publications; unresolved targets remain external evidence.
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Ferroptosis contributes to catecholamine-induced cardiotoxicity and pathological remodeling
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Ferroptosis: an iron-dependent form of nonapoptotic cell death
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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
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Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells
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Aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress
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Ferroptosis as a target for protection against cardiomyopathy
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Nobiletin induces ferroptosis in human skin melanoma cells through the GSK3β-mediated Keap1/Nrf2/HO-1 signalling pathway
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Ferroptosis is an autophagic cell death process
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Glutaminolysis and transferrin regulate ferroptosis
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Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation
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Ferroptosis suppressor protein 1 (FSP1) and coenzyme Q10 cooperatively suppress ferroptosis
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SnapShot: ferroptosis
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10.1155/jare/8832992 · 2025 · External reference
Co-delivery of dihydroartemisinin and pyropheophorbide-iron elicits ferroptosis to potentiate cancer immunotherapy
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Apigenin ameliorates di(2-ethylhexyl) phthalate-induced ferroptosis: Activation of glutathione peroxidase 4 and suppression of iron intake
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A delicate balance: iron metabolism and diseases of the brain
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10.1038/nrd4510 · 2015 · External reference
Targeting ferroptosis to iron out cancer
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Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
10.1016/j.bbcan.2020.188381 · 2020 · External reference
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Biochanin A protects against iron overload-associated knee osteoarthritis via regulating iron levels and the NRF2/System xc−/GPX4 axis
10.1016/j.biopha.2022.113915 · 2023 · External reference
Methionine deprivation reveals the pivotal roles of cell cycle progression in ferroptosis that is induced by cysteine starvation
10.3390/cells11101603 · 2022 · External reference
Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway
10.1111/bph.15834 · 2022 · External reference
Berberine inhibits erastin-induced ferroptosis of mouse hippocampal neuronal cells possibly by activating the Nrf2-HO-1/GPX4 pathway
2022 · External reference
Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO-1/GPX4 pathway
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Resveratrol protects BEAS-2B cells against erastin-induced ferroptosis through the Nrf2/Keap1 pathway
10.1055/a-1923-4399 · 2023 · External reference
Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis
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Ferroptotic stress facilitates smooth muscle cell dedifferentiation in arterial remodelling by disrupting mitochondrial homeostasis
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Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury
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Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers
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Ferroptosis: mechanisms, biology and role in disease
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The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway
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Targeting ferroptosis as a potential prevention and treatment strategy for aging-related diseases
10.1016/j.phrs.2024.107370 · 2024 · External reference
Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis
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Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system
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Ferroptosis: emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation
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Neuroprotective effect of baicalein against oxaliplatin-induced peripheral neuropathy: Impact on oxidative stress, neuroinflammation and WNT/β-catenin signaling
10.1007/s12035-022-02858-8 · 2022 · External reference
Oxidized arachidonic and adrenic phosphatidylethanolamines navigate cells to ferroptosis
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The tumor suppressor protein p53 and the ferroptosis network
10.1016/j.freeradbiomed.2018.05.074 · 2019 · External reference
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure–activity correlations with related alkaloids
10.1016/j.bmc.2004.10.020 · 2005 · External reference
Mechanisms of NLRP3 priming in inflammaging and age-related diseases
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Effect of echinochrome A on submandibular gland dysfunction in ovariectomized rats
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Identification and validation of ferroptosis-related biomarkers and the related pathogenesis in precancerous lesions of gastric cancer
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Targeting ferroptosis to eliminate senescent cells: Mechanisms and therapeutic potential
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Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11
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Phase III trial comparing paclitaxel poliglumex (CT-2103, PPX) in combination with carboplatin versus standard paclitaxel and carboplatin in the treatment of PS 2 patients with chemotherapy-naive advanced non-small cell lung cancer
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The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
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Quercetin alleviates ferroptosis of pancreatic β cells in type 2 diabetes
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Baicalein exerts neuroprotective effects in FeCl₃-induced posttraumatic epileptic seizures via suppressing ferroptosis
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Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis
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Resveratrol alleviated 5-FU-induced cardiotoxicity by attenuating GPX4-dependent ferroptosis
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Targeting ferroptosis as a novel approach to alleviate aortic dissection
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The emerging nexus of STING signaling and ferroptosis: from mechanisms to therapeutic opportunities
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p53 in ferroptosis regulation: the new weapon for the old guardian
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Ferroptosis as a potential therapeutic target for age-related macular degeneration
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Ferroptosis and renal fibrosis: mechanistic insights and emerging therapeutic targets
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Ferroptosis: a frontier in osteoporosis
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Alpha-synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition
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Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimer's disease compared with healthy elderly participants
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Baicalein ameliorates cognitive deficits in epilepsy-like tremor rat
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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
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The molecular mechanism of ferroptosis and its role in chronic obstructive pulmonary disease
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Ferroptosis in diabetic nephropathy: mechanisms and therapeutic implications
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The role of ferroptosis in osteoporosis: A cellular perspective on osteoblast, osteoclast and osteocyte dysfunction
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Phase separation of FSP1 promotes ferroptosis
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Resveratrol inhibits ferroptosis via activating NRF2/GPX4 pathway in mice with spinal cord injury
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Ferroptosis and tumor drug resistance: Current status and major challenges
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Nobiletin alleviates vascular alterations through modulation of Nrf2/HO-1 and MMP pathways in L-NAME-induced hypertensive rats
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Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death
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High intestinal iron absorption induced by decreased hepcidin leads to imbalance of iron metabolism in aging mice
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Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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Ferroptosis and EMT: Key targets for combating cancer progression and therapy resistance. Cell. Mol. Life Sci
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Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture
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Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer
10.18632/oncotarget.2402 · 2014 · External reference
A novel taxane, difluorovinyl-ortataxel, effectively overcomes paclitaxel resistance in breast cancer cells
10.1016/j.canlet.2020.06.025 · 2020 · External reference
Fighting age-related orthopedic diseases: focusing on ferroptosis
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CRISPR-mediated induction of neuron-enriched mitochondrial proteins boosts direct glia-to-neuron conversion
10.1016/j.stem.2020.11.017 · 2021 · External reference
Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity
10.1016/j.cbi.2022.109875 · 2022 · External reference
Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells
10.1152/ajpheart.00559.2019 · 2020 · External reference
The role of NCOA4-mediated ferritinophagy in health and disease
10.3390/ph11040114 · 2018 · External reference
Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial
10.1016/j.diabet.2018.05.010 · 2019 · External reference
Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy
10.1016/j.ebiom.2021.103560 · 2021 · External reference
Anti-ferroptotic effects of Nrf2: beyond the antioxidant response
10.14348/molcells.2023.0005 · 2023 · External reference
Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO-1-mediated ferroptosis pathway
10.3892/ijmm.2022.5144 · 2022 · External reference
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis
10.1186/s10020-023-00694-7 · 2023 · External reference
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
10.1038/nchembio.2079 · 2016 · External reference
Iron and diabetes risk
10.1016/j.cmet.2013.02.007 · 2013 · External reference
Effect of doxycycline in chronic obstructive pulmonary disease—An exploratory study
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Acacetin, a flavone with diverse therapeutic potential in cancer, inflammation, infections and other metabolic disorders
10.1016/j.fct.2020.111708 · 2020 · External reference
Oxidative stress drives vascular smooth muscle cell damage in acute Stanford type A aortic dissection through HIF-1α/HO-1-mediated ferroptosis
10.1016/j.heliyon.2023.e22857 · 2023 · External reference
Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina
10.1016/j.freeradbiomed.2012.04.020 · 2012 · External reference
Ferroptosis as a novel determinant of β-cell death in diabetic conditions
10.1155/2022/3873420 · 2022 · External reference
Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications
10.1016/j.cell.2022.06.003 · 2022 · External reference
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology and disease
10.1016/j.cell.2017.09.021 · 2017 · External reference
Nuciferine protects against high-fat diet-induced hepatic steatosis via modulation of gut microbiota and bile acid metabolism in rats
10.1021/acs.jafc.2c04817 · 2022 · External reference
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence
10.1038/s41467-024-45823-w · 2024 · External reference
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase
10.1073/pnas.1618657114 · 2017 · External reference
Ferroptosis: molecular mechanisms and health implications
10.1038/s41422-020-00441-1 · 2021 · External reference
The molecular machinery of regulated cell death
10.1038/s41422-019-0164-5 · 2019 · External reference
The multifunctional protein HMGB1: 50 years of discovery
10.1038/s41577-023-00894-6 · 2023 · External reference
Astragaloside IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2
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Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons
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Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
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Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells
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Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress
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Lipid peroxidation and ferroptosis: the role of GPX4
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Advances in β-cell replacement therapy for the treatment of type 1 diabetes
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Polyphenol-based nanoparticles: A promising frontier for enhanced colorectal cancer treatment
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Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis
10.1016/j.freeradbiomed.2023.01.006 · 2023 · External reference
Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms
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Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis
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Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis
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Mitochondria regulation in ferroptosis
10.1016/j.ejcb.2019.151058 · 2020 · External reference
Mitochondrial ferritin deficiency promotes osteoblastic ferroptosis via mitophagy in type 2 diabetic osteoporosis
10.1007/s12011-021-02627-z · 2022 · External reference
Iron-chelating drugs enhance cone photoreceptor survival in a mouse model of retinitis pigmentosa
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Quercetin alleviates acute kidney injury by inhibiting ferroptosis
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