Research graph
References from Redox–mitochondrial crosstalk in neurotoxicity: Regulated cell death pathways and neuroprotective strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
Generation of hydrogen peroxide in cancer cells: advancing therapeutic approaches for cancer treatment
10.3390/cancers16122171 · 2024 · External reference
GDNF, NGF and BDNF as therapeutic options for neurodegeneration
10.1016/j.pharmthera.2013.01.004 · 2013 · External reference
Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease, and Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis – an updated review
10.1016/j.mito.2023.05.007 · 2023 · External reference
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
10.1073/pnas.1405158111 · 2014 · External reference
Targeting mitophagy in neurodegenerative diseases
10.1038/s41573-024-01105-0 · 2025 · External reference
Glutathione in the brain
10.3390/ijms22095010 · 2021 · External reference
Neurotoxicity assays
2022 · External reference
Blood catalase, superoxide dismutase, and glutathione peroxidase activities in alcohol- and opioid-addicted patients
10.3390/medicina61020204 · 2025 · External reference
Death receptors: signaling and modulation
10.1126/science.281.5381.1305 · 1998 · External reference
Reactive oxygen species and cell signaling
10.1016/j.bbamcr.2023.119573 · 2024 · External reference
The antioxidant glutathione
10.1016/bs.vh.2022.09.002 · 2023 · External reference
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal
10.1155/2014/360438 · 2014 · External reference
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
10.1038/nature03434 · 2005 · External reference
Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target
10.1016/j.bbadis.2006.03.008 · 2006 · External reference
N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities
10.1002/brb3.208 · 2014 · External reference
Current trends in neurodegeneration: cross talks between oxidative stress, cell death, and inflammation
10.3390/ijms22147432 · 2021 · External reference
Insight into a neuron’s preferential susceptibility to oxidative stress
10.1042/bst20130245 · 2013 · External reference
Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions
10.1038/s41418-023-01187-0 · 2023 · External reference
Mutant huntingtin and mitochondrial dysfunction
10.1016/j.tins.2008.09.004 · 2008 · External reference
Oxidative stress and mitochondrial damage in the pathogenesis of ALS: new perspectives
10.1016/j.neulet.2016.04.065 · 2017 · External reference
Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling
10.1016/j.freeradbiomed.2016.04.001 · 2016 · External reference
Brain oxidative stress from a phospholipid perspective
2009 · External reference
Regulation of the Apaf-1–caspase-9 apoptosome
10.1242/jcs.073643 · 2010 · External reference
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
10.1186/1471-2121-14-32 · 2013 · External reference
Glutathione peroxidases
10.1016/j.bbagen.2012.11.020 · 2013 · External reference
Cell biology of Parkinson’s disease: mechanisms of synaptic, lysosomal, and mitochondrial dysfunction
10.1016/j.conb.2024.102841 · 2024 · External reference
Edaravone efficacy in amyotrophic lateral sclerosis with reduced forced vital capacity: post-hoc analysis of Study 19 (MCI186-19) [clinical trial NCT01492686]
10.1371/journal.pone.0258614 · 2022 · External reference
Model studies of the iron-catalysed Haber–Weiss cycle and the ascorbate-driven Fenton reaction
10.3109/10715769009149895 · 1990 · External reference
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
10.1038/s41583-019-0132-6 · 2019 · External reference
Selective ferroptosis inhibitor liproxstatin-1 attenuates neurological deficits and neuroinflammation after subarachnoid hemorrhage
10.1007/s12264-020-00620-5 · 2021 · External reference
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration
10.1186/1478-811x-8-31 · 2010 · External reference
Neuroprotective effects of natural compounds on neurotoxin-induced oxidative stress and cell apoptosis
10.1080/1028415x.2020.1840035 · 2022 · External reference
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
10.1016/j.tcb.2008.01.007 · 2008 · External reference
Excitotoxic cell death
10.1002/neu.480230915 · 1992 · External reference
Calcium and excitotoxic neuronal injury
10.1111/j.1749-6632.1994.tb44407.x · 1994 · External reference
CIDE domains form functionally important higher-order assemblies for DNA fragmentation
10.1073/pnas.1705949114 · 2017 · External reference
Mitochondrial DNA damage and its consequences for mitochondrial gene expression
10.1016/j.bbagrm.2012.06.002 · 2012 · External reference
Mitochondrial targeting of quinones: therapeutic implications
10.1016/j.mito.2007.02.007 · 2007 · External reference
vitro approaches to developmental neurotoxicity
2011 · External reference
The unsaturated brain: an evolutionary compromise?
10.1002/jcb.23152 · 2011 · External reference
Mitochondrial dysfunction in Alzheimer’s disease
10.1016/j.arr.2025.102713 · 2025 · External reference
Neuronal caspase-3 signaling: not only cell death
10.1038/cdd.2009.180 · 2010 · External reference
The ubiquitin–proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution
10.3389/fnmol.2014.00070 · 2014 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Metabolism and functions of glutathione in brain
10.1016/s0301-0082(99)00060-x · 2000 · External reference
How neurons cope with oxidative stress
10.1515/hsz-2024-0146 · 2025 · External reference
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
10.1038/s41593-018-0332-9 · 2019 · External reference
Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies
10.1016/j.lfs.2011.05.019 · 2011 · External reference
Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review
10.1007/s11356-020-09045-z · 2020 · External reference
Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities
10.1111/bph.12416 · 2014 · External reference
Biochemistry of peroxynitrite and protein tyrosine nitration
10.1021/acs.chemrev.7b00568 · 2018 · External reference
Chemical biology of peroxynitrite: kinetics, diffusion, and radicals
10.1021/cb800279q · 2009 · External reference
Toxicity of lead: a review with recent updates
10.2478/v10102-012-0009-2 · 2012 · External reference
Molecular mechanisms of pesticide-induced neurotoxicity: relevance to Parkinson’s disease
10.1016/j.cbi.2010.06.003 · 2010 · External reference
Apoptosis and caspases in neurodegenerative diseases
10.1056/nejmra022366 · 2003 · External reference
Mechanism of oxidative stress in neurodegeneration
10.1155/2012/428010 · 2012 · External reference
Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation
10.1074/jbc.m311129200 · 2004 · External reference
Insights on aspects of apoptosis in neurodegenerative disorders: a comprehensive review
10.37349/emed.2024.00208 · 2024 · External reference
Oxidative stress and neurodegeneration: where are we now?
10.1111/j.1471-4159.2006.03907.x · 2006 · External reference
Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
10.1016/j.redox.2017.01.021 · 2017 · External reference
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
10.1038/nrn2911 · 2010 · External reference
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
10.1016/j.tibs.2014.02.002 · 2014 · External reference
Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions
10.1002/alz.13847 · 2024 · External reference
Role of necroptosis in traumatic brain and spinal cord injuries
10.1016/j.jare.2021.12.002 · 2022 · External reference
Molecular mechanisms of parthanatos and its role in diverse diseases
10.3390/ijms23137292 · 2022 · External reference
Enzymatic antioxidants and its role in oral diseases
10.4103/0975-7406.163438 · 2015 · External reference
The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
10.1016/j.redox.2013.12.008 · 2014 · External reference
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
10.1038/nchembio727 · 2005 · External reference
BCL-2 family proteins: changing partners in the dance towards death
10.1038/cdd.2017.186 · 2018 · External reference
The role of oxidative stress in neurodegenerative diseases
10.5607/en.2015.24.4.325 · 2015 · External reference
Caspase-3 is required in the apoptotic disintegration of the nuclear matrix
10.1016/j.yexcr.2005.08.006 · 2005 · External reference
Targeting parthanatos in ischemic stroke
10.3389/fneur.2021.662034 · 2021 · External reference
Restoration of mitochondrial dynamics and synaptic function by mitophagy enhancers in a tauopathy cell model
10.1016/j.mito.2026.102184 · 2026 · External reference
Excitotoxicity and stroke: identifying novel targets for neuroprotection
10.1016/j.pneurobio.2013.11.006 · 2014 · External reference
Regulation of CD95/Fas signaling at the DISC
10.1038/cdd.2011.155 · 2012 · External reference
Neuroprotective effect of antioxidants in the brain
10.3390/ijms21197152 · 2020 · External reference
Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis
10.1016/s0092-8674(00)81590-1 · 1998 · External reference
Caspases in apoptosis and beyond
10.1038/onc.2008.297 · 2008 · External reference
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10.1016/s0092-8674(00)80434-1 · 1997 · External reference
Interactions between mitochondrial dysfunction and other hallmarks of aging: paving a path toward interventions that promote healthy old age
10.1111/acel.13942 · 2024 · External reference
Targeting the NLRP3 inflammasome in Alzheimer’s disease: mechanistic insights and therapeutic advances
10.1016/j.arr.2026.103273 · 2026 · External reference
ROS and p53: versatile partnership
10.1016/j.freeradbiomed.2008.01.011 · 2008 · External reference
Oxidative cell death in the central nervous system: mechanisms and therapeutic strategies
2025 · External reference
Oxidative stress: signaling pathways, biological functions, and disease
10.1002/mco2.70268 · 2025 · External reference
Oxidative stress: apoptosis in neuronal injury
10.2174/156720506778249515 · 2006 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
A review on oxidative stress in organophosphate-induced neurotoxicity
10.1016/j.biocel.2025.106735 · 2025 · External reference
Axonopathy underlying amyotrophic lateral sclerosis: unraveling complex pathways and therapeutic insights
10.1007/s12264-024-01267-2 · 2024 · External reference
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer’s disease neurons: implications for mitochondrial dysfunction and neuronal damage
10.1093/hmg/dds072 · 2012 · External reference
α-Synuclein pathology and mitochondrial dysfunction: toxic partners in Parkinson’s disease
10.1016/j.nbd.2025.106889 · 2025 · External reference
Role of oxidative stress and mitochondrial dysfunction in neurodegenerative disorders
2025 · External reference
How mitochondria produce reactive oxygen species
10.1042/bj20081386 · 2009 · External reference
Autosis: a new target to prevent cell death
10.1016/j.jacbts.2020.04.014 · 2020 · External reference
Mitochondrial dysfunction in neurological disorders: exploring mitochondrial transplantation
10.1038/s41536-020-00107-x · 2020 · External reference
Nitric oxide and peroxynitrite in health and disease
10.1152/physrev.00029.2006 · 2007 · External reference
Neurotrophin regulation of neural circuit development and function
10.1038/nrn3379 · 2013 · External reference
Necroptosis and its role in inflammation
10.1038/nature14191 · 2015 · External reference
Role of autophagy in environmental neurotoxicity
10.1016/j.envpol.2017.12.102 · 2018 · External reference
The CD95 (APO-1/Fas) DISC and beyond
10.1038/sj.cdd.4401186 · 2003 · External reference
The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration
10.1016/j.exger.2023.112203 · 2023 · External reference
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson’s disease
10.1016/j.neuron.2014.12.007 · 2015 · External reference
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis
10.1038/onc.2008.308 · 2008 · External reference
Oxidative stress in neurodegenerative diseases: therapeutic implications for superoxide dismutase mimetics
10.1517/14712598.3.1.127 · 2003 · External reference
Understanding the involvement of innate immunity and the Nrf2-NLRP3 axis on mitochondrial health in Parkinson’s disease
10.1016/j.arr.2023.101915 · 2023 · External reference
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer’s disease
10.1016/j.molmed.2007.12.002 · 2008 · External reference
Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer’s disease
10.1093/hmg/ddx052 · 2017 · External reference
Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington’s disease
10.1016/j.bbadis.2011.10.016 · 2012 · External reference
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer’s disease: implications to mitochondria-targeted antioxidant therapeutics
10.1016/j.bbadis.2011.10.011 · 2012 · External reference
Neurotrophin-regulated signalling pathways
10.1098/rstb.2006.1894 · 2006 · External reference
Structural basis for the inhibition of caspase-3 by XIAP
10.1016/s0092-8674(01)00274-4 · 2001 · External reference
Ca2+ transfer from the ER to mitochondria: when, how and why
10.1016/j.bbabio.2009.03.015 · 2009 · External reference
Oxidative stress and the central nervous system
10.1124/jpet.116.237503 · 2017 · External reference
Neurotoxic effects and biomarkers of lead exposure: a review
10.1515/reveh.2009.24.1.15 · 2009 · External reference
Biochemical and molecular pathways in neurodegenerative diseases: an integrated view
10.3390/cells12182318 · 2023 · External reference
Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson’s disease
10.1111/j.1471-4159.2006.04333.x · 2007 · External reference
Pyroptosis: gasdermin-mediated programmed necrotic cell death
10.1016/j.tibs.2016.10.004 · 2017 · External reference
Mutant huntingtin’s interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington’s disease
10.1093/hmg/ddr475 · 2012 · External reference
Physiological signaling functions of reactive oxygen species in stem cells: from flies to man
10.3389/fcell.2021.714370 · 2021 · External reference
Demyelination: the role of reactive oxygen and nitrogen species
10.1111/j.1750-3639.1999.tb00212.x · 1999 · External reference
Oxidative stress-induced diseases via the ASK1 signaling pathway
10.1155/2012/439587 · 2012 · External reference
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
10.1016/j.cell.2017.09.021 · 2017 · External reference
The chemistry and biology of ferroptosis
10.1016/j.chembiol.2020.03.013 · 2020 · External reference
Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis
10.1155/2019/5080843 · 2019 · External reference
First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
10.1111/bph.12461 · 2014 · External reference
Rotenone, paraquat, and Parkinson’s disease
10.1289/ehp.1002839 · 2011 · External reference
Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy
10.1111/j.2042-7158.2012.01526.x · 2012 · External reference
Vitamins C and E: beneficial effects from a mechanistic perspective
10.1016/j.freeradbiomed.2011.05.017 · 2011 · External reference
Nutritional modulation of the endogenous antioxidant system in the brain–gut axis following traumatic brain injury
10.3390/nu17213404 · 2025 · External reference
Copper induces cell death by targeting lipoylated TCA cycle proteins
10.1126/science.abf0529 · 2022 · External reference
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
10.1038/nrm3737 · 2014 · External reference
Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis
10.3389/fncel.2014.00126 · 2014 · External reference
NAD+ in aging, metabolism, and neurodegeneration
10.1126/science.aac4854 · 2015 · External reference
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
10.1016/j.bbadis.2013.10.015 · 2014 · External reference
Superoxide dismutases: dual roles in controlling ROS damage and regulating ROS signaling
10.1083/jcb.201708007 · 2018 · External reference
From pyroptosis, apoptosis and necroptosis to PANoptosis: a mechanistic compendium of programmed cell death pathways
10.1016/j.csbj.2021.07.038 · 2021 · External reference
Cuproptosis: a new form of programmed cell death
10.1038/s41423-022-00866-1 · 2022 · External reference
Modulation of inflammasome biology in age-associated neurodegenerative diseases: therapeutic potential of endogenous gasotransmitters and synthetic molecules
10.1016/j.arr.2026.103257 · 2026 · External reference
Oxidative stress and mitochondrial impairment: key drivers in neurodegenerative disorders
10.1016/j.arr.2025.102667 · 2025 · External reference
Mitochondrial DNA mutations and ageing
2023 · External reference
Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
10.1074/jbc.274.43.30651 · 1999 · External reference
Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons
10.1083/jcb.200708086 · 2007 · External reference
Ferroptosis: process and function
10.1038/cdd.2015.158 · 2016 · External reference
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
10.1073/pnas.94.2.514 · 1997 · External reference
PGC-1α mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration
10.1038/s41420-024-01953-0 · 2024 · External reference
The BCL-2 protein family: opposing activities that mediate cell death
10.1038/nrm2308 · 2008 · External reference
Pyroptosis: mechanisms and diseases
10.1038/s41392-021-00507-5 · 2021 · External reference
Necroptosis in neurodegenerative diseases: a potential therapeutic target
10.1038/cddis.2017.286 · 2017 · External reference
Iron and oxidizing species in oxidative stress and Alzheimer’s disease
10.1002/agm2.12074 · 2019 · External reference
Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway
2018 · External reference
On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death
10.1021/acscentsci.7b00028 · 2017 · External reference
Dimethyl fumarate as a versatile therapeutic agent: molecular mechanisms and potential clinical applications
10.1007/s11033-026-11478-7 · 2026 · External reference
