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References from Lifelong Epstein-Barr virus persistence as a stress test of ageing immune surveillance: From infectious mononucleosis to chronic active EBV disease and virus-associated malignancy. Local targets link to admitted publications; unresolved targets remain external evidence.
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MicroRNAs of Epstein-Barr virus control innate and adaptive antiviral immunity
10.1128/jvi.01667-16 · 2017 · External reference
Strategies of Epstein-Barr virus to evade innate antiviral immunity of its human host
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10.1111/ctr.13652 · 2019 · External reference
Epstein-Barr Virus-Associated Post-transplant Lymphoproliferative Disease
2021 · External reference
Novel Therapeutics for Epstein⁻Barr Virus
2019 · External reference
Advances in the study of chronic active Epstein-Barr virus infection: clinical features under the 2016 WHO classification and mechanisms of development
10.3389/fped.2019.00014 · 2019 · External reference
Long-term caloric restriction ameliorates T cell immunosenescence in mice
10.1016/j.mad.2022.111710 · 2022 · External reference
Infectious mononucleosis
10.1038/cti.2015.1 · 2015 · External reference
The interplay between immunosenescence and age-related diseases
10.1007/s00281-020-00806-z · 2020 · External reference
Epstein-Barr virus-associated lymphomas decoded
10.1111/bjh.19255 · 2024 · External reference
Human T cell immunosenescence and inflammation in aging
10.1189/jlb.3ri0716-335r · 2017 · External reference
Defining 'T cell exhaustion
10.1038/s41577-019-0221-9 · 2019 · External reference
How I treat T-cell chronic active Epstein-Barr virus disease
10.1182/blood-2018-03-785931 · 2018 · External reference
T-cell therapy in the treatment of post-transplant lymphoproliferative disease
10.1038/nrclinonc.2012.111 · 2012 · External reference
Co-Occurrence of EBV-Positive Mucocutaneous Ulcer (EBV-MCU) and CLL/SLL in the Head and Neck Region
10.3390/curroncol29040224 · 2022 · External reference
Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions
10.3390/cells11061017 · 2022 · External reference
EBV-positive diffuse large b-cell lymphoma in association with polyurethane textured breast implants: case report and literature overview
10.1007/s00266-023-03377-0 · 2023 · External reference
Cytomegalovirus and latency: an overview
10.1007/bf02915131 · 1993 · External reference
Comprehensive molecular characterization of gastric adenocarcinoma
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Age-Associated B Cells
10.1146/annurev-immunol-092419-031130 · 2020 · External reference
EBV-positive diffuse large B-cell lymphoma of the elderly: what we know so far
10.1634/theoncologist.2010-0213 · 2011 · External reference
Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus
10.1002/ana.21902 · 2010 · External reference
Epstein-Barr Virus encephalitis associated hemophagocytic lymphohistiocytosis in childhood-onset systemic lupus erythematosus: a case-based review
10.1186/s12969-024-01025-8 · 2024 · External reference
Nasopharyngeal carcinoma
10.1016/s0140-6736(19)30956-0 · 2019 · External reference
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
10.1038/s41422-020-0374-x · 2020 · External reference
Primary Nodal Epstein-Barr Virus-Positive T-Cell/NK-Cell Lymphoma: Real-World Experience
10.1159/000537962 · 2024 · External reference
Epstein-Barr virus strain heterogeneity impairs human T-cell immunity
10.1007/s00262-018-2118-z · 2018 · External reference
Epstein-Barr virus infection
10.1056/nejm200008173430707 · 2000 · External reference
Epstein-barr virus vaccines
10.1038/cti.2014.27 · 2015 · External reference
Vaccine Development for Epstein-Barr Virus
10.1007/978-981-10-7230-7_22 · 2018 · External reference
Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States
10.1182/blood-2010-11-316745 · 2011 · External reference
Epstein Barr Virus: development of vaccines and immune cell therapy for EBV-associated diseases
10.3389/fimmu.2021.734471 · 2021 · External reference
The transcription factor ZEB2 drives the formation of age-associated B cells
10.1126/science.adf8531 · 2024 · External reference
Epstein-Barr virus: biology and clinical disease
10.1016/j.cell.2022.08.026 · 2022 · External reference
TNFRSF13B Variant-Induced TACI Dysregulation Underlies CAEBV Pathogenesis
10.1007/s10875-025-01973-0 · 2026 · External reference
Abundant PD-L1 expression in Epstein-Barr virus-infected gastric cancers
10.18632/oncotarget.9076 · 2016 · External reference
Post-Transplant Lymphoproliferative Disorders
10.1016/j.semnephrol.2024.151503 · 2024 · External reference
Post-transplantation lymphoproliferative disorders in adults
10.1056/nejmra1702693 · 2018 · External reference
Dissecting the host response to a gamma-herpesvirus
2001 · External reference
EBV-positive mucocutaneous ulcer: a study of 26 cases associated with various sources of immunosuppression
10.1097/pas.0b013e3181cf8622 · 2010 · External reference
How compelling are the data for Epstein-Barr virus being a trigger for systemic lupus and other autoimmune diseases?
10.1097/bor.0000000000000289 · 2016 · External reference
Epstein-Barr virus and systemic lupus erythematosus
10.1155/2012/370516 · 2012 · External reference
Haemophagocytic lymphohistiocytosis and Epstein-Barr virus: a complex relationship with diverse origins, expression and outcomes
10.1111/bjh.17638 · 2022 · External reference
EBV and post-transplant lymphoproliferative disorder: a complex relationship
10.1182/hematology.2024000583 · 2024 · External reference
Epstein-Barr Virus and Cancer
10.1146/annurev-pathmechdis-012418-013023 · 2019 · External reference
EBV Positive Mucocutaneous Ulcer (EBVMCU): Single Center Series of Three Cases and Review of Literature
2021 · External reference
The role of microRNAs in Epstein-Barr virus latency and lytic reactivation
10.1016/j.micinf.2011.07.007 · 2011 · External reference
Inflammaging: a new immune-metabolic viewpoint for age-related diseases
10.1038/s41574-018-0059-4 · 2018 · External reference
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination
10.1186/s12979-020-00210-z · 2020 · External reference
B Cell Immunosenescence
10.1146/annurev-cellbio-011620-034148 · 2020 · External reference
Thirty years of Epstein-Barr virus-associated gastric carcinoma
10.1007/s00428-019-02724-4 · 2020 · External reference
Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes?
10.3389/fimmu.2017.01960 · 2017 · External reference
PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis
10.3389/fimmu.2021.632667 · 2021 · External reference
Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction
10.1038/s41467-023-37614-6 · 2023 · External reference
Understanding immunosenescence to improve responses to vaccines
10.1038/ni.2588 · 2013 · External reference
Adoptive T-Cell Immunotherapy
2026 · External reference
Immunosenescence: aging and Immune System Decline
10.3390/vaccines12121314 · 2024 · External reference
Proteostasis in T cell aging
10.1016/j.smim.2023.101838 · 2023 · External reference
Epstein-Barr virus-associated lymphomas
10.1053/j.seminoncol.2014.12.030 · 2015 · External reference
MYC Controls the Epstein-Barr Virus Lytic Switch
10.1016/j.molcel.2020.03.025 · 2020 · External reference
Methionine metabolism controls the B cell EBV epigenome and viral latency
10.1016/j.cmet.2022.08.008 · 2022 · External reference
Advanced technologies for the development of infectious disease vaccines
10.1038/s41573-024-01041-z · 2024 · External reference
Extranodal natural killer/T-cell lymphoma, nasal type: basic science and clinical progress
10.3389/fped.2019.00141 · 2019 · External reference
Frequent co-reactivation of Epstein-Barr virus in patients with cytomegalovirus viremia under immunosuppressive therapy and/or chemotherapy
10.1177/0300060520972880 · 2020 · External reference
The impact of ageing on natural killer cell function and potential consequences for health in older adults
10.1016/j.arr.2013.04.003 · 2013 · External reference
Review on natural killer/T-cell lymphoma
10.1002/hon.2944 · 2023 · External reference
Properties of end-stage human T cells defined by CD45RA re-expression
10.1016/j.coi.2012.04.001 · 2012 · External reference
Cellular responses to viral infection in humans: lessons from Epstein-Barr virus
10.1146/annurev.immunol.25.022106.141553 · 2007 · External reference
An EBNA1-YAP signaling axis drives immune escape through CD276 in EBV-associated gastric cancer
10.1038/s41419-025-08251-2 · 2025 · External reference
A predictive model for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
10.3389/fimmu.2024.1503118 · 2024 · External reference
Virus-triggered secondary hemophagocytic lymphohistiocytosis
10.1111/apa.15973 · 2021 · External reference
Lupus and Epstein-Barr
10.1097/bor.0b013e3283535801 · 2012 · External reference
Epstein Barr Virus Interleukin 10 Suppresses Anti-inflammatory Phenotype in Human Monocytes
10.3389/fimmu.2018.02198 · 2018 · External reference
EBV-Encoded Latent Genes
10.1007/978-981-10-7230-7_17 · 2018 · External reference
Updated guidelines for chronic active Epstein-Barr virus disease
10.1007/s12185-023-03660-5 · 2023 · External reference
Regulation of the latent-lytic switch in Epstein-Barr virus
10.1016/j.semcancer.2014.01.002 · 2014 · External reference
Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer
10.1038/s41591-018-0101-z · 2018 · External reference
Intratumoral Immune Response to Gastric Cancer Varies by Molecular and Histologic Subtype
10.1097/pas.0000000000001253 · 2019 · External reference
Gastric Carcinoma
2025 · External reference
Chronic active Epstein-Barr virus disease
10.3389/fimmu.2017.01867 · 2017 · External reference
Chronic active Epstein-Barr virus disease: molecular pathogenesis, evolving concepts, and emerging therapies
10.1182/blood.2025032277 · 2026 · External reference
The many ways Epstein-Barr virus takes advantage of the RNA tool kit
10.1080/15476286.2021.1875184 · 2021 · External reference
Clinicopathological characteristics and prognosis of Epstein-Barr virus-associated gastric cancer
10.1007/s00705-024-06033-3 · 2024 · External reference
Epstein-Barr virus DNA seropositivity links distinct tumoral heterogeneity and immune landscape in nasopharyngeal carcinoma
2023 · External reference
Single-Cell Analysis Reveals Malignant Cells Reshape the Cellular Landscape and Foster an Immunosuppressive Microenvironment of Extranodal NK/T-Cell Lymphoma
2023 · External reference
Immunosenescence: a key player in cancer development
10.1186/s13045-020-00986-z · 2020 · External reference
Nasopharyngeal carcinoma: current views on the tumor microenvironment's impact on drug resistance and clinical outcomes
10.1186/s12943-023-01928-2 · 2024 · External reference
T cell-mediated immunity during Epstein-Barr virus infections in children
10.1016/j.meegid.2023.105443 · 2023 · External reference
Nivolumab treatment of relapsed/refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults
10.1182/blood.2019003886 · 2020 · External reference
Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution
10.1038/s41467-021-21043-4 · 2021 · External reference
Immunosenescence: molecular mechanisms and diseases
10.1038/s41392-023-01451-2 · 2023 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Efficacy of NKG2D CAR-T cells with IL-15/IL-15Rα signaling for treating Epstein-Barr virus-associated lymphoproliferative disorder
10.1186/s40164-024-00553-z · 2024 · External reference
EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2022 update on diagnosis, risk-stratification, and management
10.1002/ajh.26579 · 2022 · External reference
Epstein-Barr virus and hemophagocytic lymphohistiocytosis
10.3389/fimmu.2017.01902 · 2018 · External reference
Reactivation of latent epstein-barr virus: a comparison after exposure to gamma, proton, carbon, and iron radiation
10.3390/ijms19102961 · 2018 · External reference
Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection
10.1007/s13365-024-01223-w · 2024 · External reference
Hallmarks of T cell aging
10.1038/s41590-021-00927-z · 2021 · External reference
A pathogen penalty? Associations between Persistent Infections and Biological Aging in the US
2025 · External reference
Role of human natural killer cells during Epstein-Barr virus infection
10.1615/critrevimmunol.2014012312 · 2014 · External reference
Human natural killer cell responses to Epstein-Barr virus infection
10.3389/fimmu.2017.01658 · 2017 · External reference
Regulation of Epstein-Barr virus reactivation from latency
10.1111/1348-0421.12155 · 2014 · External reference
MicroRNAs of Epstein-Barr Virus Attenuate T-Cell-Mediated Immune Control In Vivo
10.1128/mbio.01941-18 · 2019 · External reference
Natural killer cell-based senotherapy: a promising strategy for healthy aging
2025 · External reference
Outlooks on Epstein-Barr virus associated gastric cancer
10.1016/j.ctrv.2018.03.006 · 2018 · External reference
The twilight of immunity: emerging concepts in aging of the immune system
10.1038/s41590-017-0006-x · 2018 · External reference
Known unknowns: how might the persistent herpesvirome shape immunity and aging?
10.1016/j.coi.2017.07.011 · 2017 · External reference
Herpesvirus antibodies are correlated with greater expression of p16 in the T cells of humans
10.1093/ofid/ofae693 · 2024 · External reference
Immunosenescence and immunogenetics of human longevity
10.1159/000156466 · 2008 · External reference
Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients
10.1158/1078-0432.ccr-06-2823 · 2007 · External reference
Age and immunity: what is immunosenescence?
10.1016/j.exger.2017.10.024 · 2018 · External reference
Cytomegalovirus and human immunosenescence
10.1002/rmv.598 · 2009 · External reference
The IPTA Nashville Consensus Conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: III - Consensus guidelines for Epstein-Barr virus load and other biomarker monitoring
10.1111/petr.14471 · 2024 · External reference
Dynamic Epstein-Barr virus gene expression on the path to B-cell transformation
10.1016/b978-0-12-800098-4.00006-4 · 2014 · External reference
Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation
10.1172/jci121127 · 2020 · External reference
Epstein-Barr virus-positive T- and NK-cell lymphoproliferative disorders: Report from the 2023 SH/EA4HP Lymphoma Workshop
10.1093/ajcp/aqaf020 · 2025 · External reference
Autologous Epstein-Barr virus-specific adoptive T-cell therapy in a patient with lupus nephritis
10.1002/cti2.70015 · 2024 · External reference
Immune Evasion by Epstein-Barr Virus
2015 · External reference
Diagnostic and therapeutic challenges of EBV-positive mucocutaneous ulcer: a case report and systematic review of the literature
10.1186/s40164-016-0042-5 · 2016 · External reference
Epstein-Barr virus as a potentiator of autoimmune diseases
10.1038/s41584-024-01167-9 · 2024 · External reference
Age-associated B cells: a T-bet-dependent effector with roles in protective and pathogenic immunity
2017 · External reference
The immune system in extreme longevity
10.1016/j.exger.2007.06.008 · 2008 · External reference
EBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions
2019 · External reference
EBV-positive mucocutaneous ulcer arising in methotrexate-treated rheumatoid arthritis patients: a clinicopathological study of 12 cases with analysis of PD-L1 expression
10.3960/jslrt.22048 · 2023 · External reference
Inverted CD8 T-cell exhaustion and co-stimulation marker balance differentiate aviremic HIV-2-infected from seronegative individuals
10.3389/fimmu.2021.744530 · 2021 · External reference
Epstein-Barr viral gene expression in B-lymphocytes
10.3109/10428199809050935 · 1998 · External reference
The control of lytic replication of Epstein-Barr virus in B lymphocytes (Review)
10.3892/ijmm.1.1.137 · 1998 · External reference
Systemic chronic active Epstein-Barr virus disease
2025 · External reference
Recombinant gp350 vaccine for infectious mononucleosis: a phase 2, randomized, double-blind, placebo-controlled trial
10.1086/523813 · 2007 · External reference
CMV and immunosenescence: from basics to clinics
10.1186/1742-4933-9-23 · 2012 · External reference
Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans
10.1016/j.smim.2012.04.008 · 2012 · External reference
T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence
10.1111/acel.12716 · 2018 · External reference
Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging
10.1146/annurev-immunol-101721-064501 · 2023 · External reference
Long-term efficacy of epstein-barr virus-specific t cells for Epstein-Barr virus-associated post-transplantation lymphoproliferative disorder after allogeneic stem cell transplantation: a real-world study
10.1016/j.jtct.2025.08.017 · 2025 · External reference
Single-Cell Transcriptomic Analysis of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis
10.1007/s10875-024-01701-0 · 2024 · External reference
Genetic Profiling Reveals the Distinctions Among MTX-Associated DLBCL, EBV-Positive Mucocutaneous Ulcer, and EBV + DLBCL
10.1111/cas.70111 · 2025 · External reference
The Microenvironment in Epstein-Barr Virus-Associated Malignancies
2018 · External reference
Immunosenescence: limitations of natural killer cell-based cancer immunotherapy
10.1007/s00262-016-1882-x · 2017 · External reference
Contributions of age-related thymic involution to immunosenescence and inflammaging
10.1186/s12979-020-0173-8 · 2020 · External reference
Aged-associated cytomegalovirus and Epstein-Barr virus reactivation and cytomegalovirus relationship with the frailty syndrome in older women
10.1371/journal.pone.0180841 · 2017 · External reference
Applications of cell therapy in the treatment of virus-associated cancers
10.1038/s41571-024-00930-x · 2024 · External reference
Epstein-Barr virus infection and nasopharyngeal carcinoma
10.1098/rstb.2016.0270 · 2017 · External reference
The diagnosis and management of NK/T-cell lymphomas
10.1186/s13045-017-0452-9 · 2017 · External reference
How we treat NK/T-cell lymphomas
10.1186/s13045-022-01293-5 · 2022 · External reference
Chronic active Epstein-Barr virus (CAEBV) enteritis
2019 · External reference
Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis
10.1016/j.cell.2023.11.015 · 2023 · External reference
Epstein-Barr virus infection of Langerhans cell precursors as a mechanism of oral epithelial entry, persistence, and reactivation
10.1128/jvi.02754-06 · 2007 · External reference
NK-/T-cell lymphomas
10.1038/s41375-021-01313-2 · 2021 · External reference
Chronic active Epstein-Barr virus disease originates from infected hematopoietic stem cells
10.1182/blood.2023021074 · 2024 · External reference
Molecular and cellular insights into T cell exhaustion
10.1038/nri3862 · 2015 · External reference
Unresolved reference
External reference
Glucocorticoids activate Epstein Barr virus lytic replication through the upregulation of immediate early BZLF1 gene expression
10.1016/j.bbi.2010.04.013 · 2010 · External reference
Immunity and Immune Evasion Mechanisms of Epstein-Barr Virus
10.1089/vim.2022.0200 · 2023 · External reference
Epstein-Barr virus: 40 years on
10.1038/nrc1452 · 2004 · External reference
Epstein-Barr virus: more than 50 years old and still providing surprises
10.1038/nrc.2016.92 · 2016 · External reference
Epstein-Barr virus-mediated immune evasion in tumor promotion
10.1016/j.it.2025.03.007 · 2025 · External reference
Immune Evasion by Epstein-Barr Virus
2025 · External reference
