Research graph
References from Alzheimer's disease as progressive failure of dynamic memory architecture and conscious integration. Local targets link to admitted publications; unresolved targets remain external evidence.
Sex and gender differences in cognitive resilience to aging and Alzheimer's disease
10.1002/alz.13844 · 2024 · External reference
Unresolved reference
1988 · External reference
Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment
10.1016/j.neuron.2012.03.023 · 2012 · External reference
Unresolved reference
1932 · External reference
Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning
10.1016/j.neuron.2010.05.013 · 2010 · External reference
A synaptic model of memory: long-term potentiation in the hippocampus
10.1038/361031a0 · 1993 · External reference
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
10.1007/s00401-006-0127-z · 2006 · External reference
The brain's default network: anatomy, function, and relevance to disease
10.1196/annals.1440.011 · 2008 · External reference
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
10.1523/jneurosci.2177-05.2005 · 2005 · External reference
Theta oscillations in the hippocampus
10.1016/s0896-6273(02)00586-x · 2002 · External reference
Hippocampal sharp wave-ripple: a cognitive biomarker for episodic memory and planning
10.1002/hipo.22488 · 2015 · External reference
Electrophysiological insights into Alzheimer's disease: a review of human and animal studies
10.1016/j.neubiorev.2024.105987 · 2025 · External reference
Hippocampal replay in the awake state: a potential substrate for memory and planning
10.1038/nn.2732 · 2011 · External reference
Rhythms of the hippocampal network
10.1038/nrn.2016.21 · 2016 · External reference
The construction of autobiographical memories in the self-memory system
10.1037/0033-295x.107.2.261 · 2000 · External reference
Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat
10.1523/jneurosci.19-01-00274.1999 · 1999 · External reference
Unresolved reference
2014 · External reference
Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
2001 · External reference
Experimental and theoretical approaches to conscious processing
10.1016/j.neuron.2011.03.018 · 2011 · External reference
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
10.1212/01.wnl.0000171450.97464.49 · 2005 · External reference
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria
10.1016/j.jalz.2016.02.002 · 2016 · External reference
Maintaining and regaining episodic memory in Alzheimer disease: A circuit-based perspective
10.1038/s41582-026-01189-9 · 2026 · External reference
Synaptic tagging and long-term potentiation
10.1038/385533a0 · 1997 · External reference
The free-energy principle: A unified brain theory?
10.1038/nrn2787 · 2010 · External reference
Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation
10.1038/s41467-026-72783-0 · 2026 · External reference
Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties
10.1038/338334a0 · 1989 · External reference
TREM2 variants in Alzheimer's disease
10.1056/nejmoa1211851 · 2013 · External reference
Reduced overnight memory consolidation and associated alterations in sleep spindles and slow oscillations in early Alzheimer's disease
10.1016/j.nbd.2023.106378 · 2024 · External reference
Alzheimer's disease: the amyloid cascade hypothesis
10.1126/science.1566067 · 1992 · External reference
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
10.1126/science.1072994 · 2002 · External reference
Neuroinflammation in Alzheimer's disease
10.1016/s1474-4422(15)70016-5 · 2015 · External reference
Gamma frequency entrainment attenuates amyloid load and modifies microglia
10.1038/nature20587 · 2016 · External reference
Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice
10.1126/science.aah6205 · 2016 · External reference
NIA-AA research framework: toward a biological definition of Alzheimer's disease
10.1016/j.jalz.2018.02.018 · 2018 · External reference
Cognitive resilience in Alzheimer's disease: mechanism and potential clinical intervention
10.1016/j.arr.2025.102711 · 2025 · External reference
Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model
10.1016/j.celrep.2019.10.056 · 2019 · External reference
Variant of TREM2 associated with the risk of Alzheimer's disease
10.1056/nejmoa1211103 · 2013 · External reference
Finding the engram
10.1038/nrn4000 · 2015 · External reference
The molecular biology of memory storage: A dialogue between genes and synapses
10.1126/science.1067020 · 2001 · External reference
Cognitive neuroscience of emotional memory
10.1038/nrn1825 · 2006 · External reference
Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
10.1073/pnas.95.11.6448 · 1998 · External reference
Synaptic protein degradation underlies destabilization of retrieved fear memory
10.1126/science.1150541 · 2008 · External reference
The theta-gamma neural code
10.1016/j.neuron.2013.03.007 · 2013 · External reference
Reconstruction of automobile destruction: An example of the interaction between language and memory
10.1016/s0022-5371(74)80011-3 · 1974 · External reference
Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease
10.1126/scitranslmed.aau6550 · 2019 · External reference
β-Amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation
10.1038/nn.4035 · 2015 · External reference
Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease
10.1002/alz.13861 · 2024 · External reference
Episodic memory loss is related to hippocampal-mediated β-amyloid deposition in elderly subjects
10.1093/brain/awn320 · 2009 · External reference
Multisensory gamma stimulation promotes glymphatic clearance of amyloid
10.1038/s41586-024-07132-6 · 2024 · External reference
A single standard for memory: The case for reconsolidation
10.1038/nrn2590 · 2009 · External reference
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
10.1038/35021052 · 2000 · External reference
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
10.1097/nen.0b013e31825018f7 · 2012 · External reference
Hippocampal conjunctive encoding, storage, and recall: avoiding a trade-off
10.1002/hipo.450040605 · 1994 · External reference
Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform
10.1038/s41591-025-03622-w · 2025 · External reference
Cognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods
10.1002/alz.13744 · 2024 · External reference
Mitoenergetic failure in Alzheimer disease
10.1152/ajpcell.00232.2006 · 2007 · External reference
Amyloid-β as a modulator of synaptic plasticity
10.3233/jad-2010-101020 · 2010 · External reference
10.1038/s41591-026-04206-y
10.1038/s41591-026-04206-y · 2026 · External reference
Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer's Disease
10.14336/ad.2024.0286 · 2024 · External reference
Mitochondria in aging and Alzheimer's disease: focus on mitophagy
10.1177/10738584221139761 · 2024 · External reference
Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease
10.1002/1531-8249(199903)45:3<358::aid-ana12>3.0.co;2-x · 1999 · External reference
Making memories last: the synaptic tagging and capture hypothesis
10.1038/nrn2963 · 2011 · External reference
Unresolved reference
1992 · External reference
Creating false memories: remembering words not presented in lists
10.1037/0278-7393.21.4.803 · 1995 · External reference
Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease
10.1038/nature17172 · 2016 · External reference
Etiology and clinical significance of network hyperexcitability in Alzheimer's disease: unanswered questions and next steps
10.3233/jad-220983 · 2023 · External reference
Retrieval and reconsolidation: toward a neurobiology of remembering
10.1101/lm.7.2.73 · 2000 · External reference
Remembering the past to imagine the future: the prospective brain
10.1038/nrn2213 · 2007 · External reference
Electrophysiological insights into the nature of the semantic deficit in Alzheimer's disease
10.1016/0028-3932(95)00164-6 · 1996 · External reference
The amyloid hypothesis of Alzheimer's disease at 25 years
10.15252/emmm.201606210 · 2016 · External reference
Key circuits through which sleep affects memory and their role in Alzheimer's disease
10.1177/13872877261479999 · 2026 · External reference
Prefrontal phase locking to hippocampal theta oscillations
10.1016/j.neuron.2005.02.028 · 2005 · External reference
Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial
10.1001/jama.2023.13239 · 2023 · External reference
Neuronal synchrony: a versatile code for the definition of relations?
10.1016/s0896-6273(00)80821-1 · 1999 · External reference
The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer's disease and translational opportunities
10.1186/s40035-025-00511-7 · 2025 · External reference
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
10.1016/j.jalz.2011.03.003 · 2011 · External reference
Memory consolidation
10.1101/cshperspect.a021766 · 2015 · External reference
Small-world networks and functional connectivity in Alzheimer's disease
10.1093/cercor/bhj127 · 2007 · External reference
Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep
10.1038/nn.4119 · 2015 · External reference
Dendritic protein synthesis, synaptic plasticity, and memory
10.1016/j.cell.2006.09.014 · 2006 · External reference
The hippocampal memory indexing theory
10.1037/0735-7044.100.2.147 · 1986 · External reference
The role of engram cells in the systems consolidation of memory
10.1038/s41583-018-0031-2 · 2018 · External reference
An information integration theory of consciousness
10.1186/1471-2202-5-42 · 2004 · External reference
Consciousness: here, there and everywhere?
10.1098/rstb.2014.0167 · 2015 · External reference
Episodic memory: from mind to brain
10.1146/annurev.psych.53.100901.135114 · 2002 · External reference
Lecanemab in early Alzheimer's disease
10.1056/nejmoa2212948 · 2023 · External reference
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model
10.1016/j.cell.2012.02.046 · 2012 · External reference
Effect of levetiracetam on cognition in patients with Alzheimer disease with and without epileptiform activity: a randomized clinical trial
10.1001/jamaneurol.2021.3310 · 2021 · External reference
Reactivation of hippocampal ensemble memories during sleep
10.1126/science.8036517 · 1994 · External reference
Sleep drives metabolite clearance from the adult brain
10.1126/science.1241224 · 2013 · External reference
Pattern separation in the hippocampus
10.1016/j.tins.2011.06.006 · 2011 · External reference