Research graph
References from Protective effects of oral α-pinene pretreatment against acetic acid-induced colitis in rats: effects on oxidative stress and Nrf2, HO-1, and NQO1 mRNA expression. Local targets link to admitted publications; unresolved targets remain external evidence.
Striking essential oil: tapping into a largely unexplored source for drug discovery
10.1038/s41598-020-59332-5 · 2020 · External reference
Finding new molecular targets of familiar natural products using in silico target prediction
10.3390/ijms21197102 · 2020 · External reference
Antimicrobial activity of some essential oils—present status and future perspectives
10.3390/medicines4030058 · 2017 · External reference
Biological activities of α-pinene and β-pinene enantiomers
10.3390/molecules17066305 · 2012 · External reference
Alpha pinene modulates UVA-induced oxidative stress, DNA damage and apoptosis in human skin epidermal keratinocytes
10.1016/j.lfs.2018.10.004 · 2018 · External reference
Alpha-pinene exhibits anti-inflammatory activity through the suppression of MAPKs and the NF-κb pathway in mouse peritoneal macrophages
10.1142/s0192415x15500457 · 2015 · External reference
The effects of alpha-pinene on the Nrf2-HO1 signaling pathway in gastric damage in rats
10.1007/s11033-023-08765-y · 2023 · External reference
The effects of alpha-pinene on inflammatory responses and oxidative stress in the formalin test
10.1016/j.brainresbull.2023.110774 · 2023 · External reference
The effects of alpha-pinene against paracetamol-induced liver damage in male rats
10.14814/phy2.70227 · 2025 · External reference
Alpha-pinene ameliorate behavioral deficit induced by early postnatal hypoxia in the rat: study the inflammatory mechanism
10.1038/s41598-024-56756-1 · 2024 · External reference
Effects of alpha-pinene on oxidative stress and inflammatory response in acute gastric ulcers in rats
2024 · External reference
Alpha-pinene protects rat liver against acetaminophen-induced oxidative stress and apoptosis
10.1007/s00210-025-04168-x · 2025 · External reference
Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species
10.4103/0973-1296.149725 · 2015 · External reference
The role of alpha-pinene on the NLRP3-Caspase 1 pathway in the ulcerative colitis model in rats
10.1016/j.tice.2025.103085 · 2025 · External reference
Genetics and pathogenesis of inflammatory bowel disease
10.1038/nature10209 · 2011 · External reference
Medical progress ulcerative colitis
10.1056/nejmra1102942 · 2011 · External reference
Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
10.1053/j.gastro.2004.01.063 · 2004 · External reference
Novel strategies for the treatment of inflammatory bowel disease: selective inhibition of cytokines and adhesion molecules
10.3748/wjg.v12.i29.4628 · 2006 · External reference
Biologic therapy for inflammatory bowel disease
10.2165/00003495-200565160-00002 · 2005 · External reference
Oxidative stress-related biomarkers in inflammatory bowel disease: dual tools for remission assessment and prediction of treatment outcome
10.3390/antiox14101183 · 2025 · External reference
Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: a systematic review and meta-analysis
10.1016/j.redox.2024.103380 · 2024 · External reference
Oxidative stress in ulcerative colitis: an old concept but a new concern
10.3109/10715762.2012.717692 · 2012 · External reference
AGA clinical practice guidelines on the management of mild-to-moderate ulcerative colitis
10.1053/j.gastro.2018.12.009 · 2019 · External reference
Oxidative stress in inflammation-based gastrointestinal tract diseases: challenges and opportunities
10.1111/j.1440-1746.2012.07108.x · 2012 · External reference
The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
10.3389/fimmu.2023.1200111 · 2023 · External reference
Mechanistic studies of the Nrf2-Keap1 signaling pathway
10.1080/03602530600971974 · 2006 · External reference
Improving bioscience research reporting: the ARRIVE Guidelines for reporting animal research, osteoarthritis and cartilage /OARS
10.1016/j.joca.2012.02.010 · 2012 · External reference
Effect of fecal microbiota transplantation on ulcerative colitis model in rats: the gut-brain axis
10.1016/j.heliyon.2025.e42430 · 2025 · External reference
The role of fecal microbiota transplantation on the NLRP3-caspase 1 pathway and anxiety like behavioral in the ulcerative colitis model in rats
2025 · External reference
Induction of experimental acute ulcerative colitis in rats by administration of dextran sulfate sodium at low concentration followed by intracolonic administration of 30% ethanol
10.1631/jzus.2007.b0632 · 2007 · External reference
Natural monoterpenes as potential therapeutic agents against atherosclerosis
10.3390/ijms24032429 · 2023 · External reference
Oral administration of geraniol ameliorates acute experimental murine colitis by inhibiting pro-inflammatory cytokines and NF-κb signaling
10.1039/c5fo00405e · 2015 · External reference
Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases
10.1007/s00210-014-0985-1 · 2014 · External reference
Oxidative stress in ulcerative colitis-associated carcinogenesis
10.1016/j.prp.2008.04.011 · 2008 · External reference
Transcriptional regulation by Nrf2
10.1089/ars.2017.7342 · 2018 · External reference
Nrf2/Keap1/ARE signaling: towards specific regulation
10.1016/j.lfs.2021.120111 · 2022 · External reference
Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
10.1016/j.redox.2022.102389 · 2022 · External reference
Nrf2-Keap1 signaling in oxidative and reductive stress
10.1016/j.bbamcr.2018.02.010 · 2018 · External reference
Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
10.1038/s41467-018-07859-7 · 2019 · External reference
The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1β protein
10.1007/s11033-020-05753-4 · 2020 · External reference
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis
10.1158/0008-5472.can-06-3562 · 2006 · External reference
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
10.1158/1940-6207.capr-08-0028 · 2008 · External reference
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment
10.1002/ijc.22943 · 2007 · External reference
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment
10.1002/ijc.22943 · ExternalCitation · doi-reference
Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases
10.1007/s00210-014-0985-1 · ExternalCitation · doi-reference
Alpha-pinene protects rat liver against acetaminophen-induced oxidative stress and apoptosis
10.1007/s00210-025-04168-x · ExternalCitation · doi-reference
The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1β protein
10.1007/s11033-020-05753-4 · ExternalCitation · doi-reference
The effects of alpha-pinene on the Nrf2-HO1 signaling pathway in gastric damage in rats
10.1007/s11033-023-08765-y · ExternalCitation · doi-reference
Nrf2-Keap1 signaling in oxidative and reductive stress
10.1016/j.bbamcr.2018.02.010 · ExternalCitation · doi-reference
The effects of alpha-pinene on inflammatory responses and oxidative stress in the formalin test
10.1016/j.brainresbull.2023.110774 · ExternalCitation · doi-reference
Effect of fecal microbiota transplantation on ulcerative colitis model in rats: the gut-brain axis
10.1016/j.heliyon.2025.e42430 · ExternalCitation · doi-reference
Improving bioscience research reporting: the ARRIVE Guidelines for reporting animal research, osteoarthritis and cartilage /OARS
10.1016/j.joca.2012.02.010 · ExternalCitation · doi-reference
Alpha pinene modulates UVA-induced oxidative stress, DNA damage and apoptosis in human skin epidermal keratinocytes
10.1016/j.lfs.2018.10.004 · ExternalCitation · doi-reference
Nrf2/Keap1/ARE signaling: towards specific regulation
10.1016/j.lfs.2021.120111 · ExternalCitation · doi-reference
Oxidative stress in ulcerative colitis-associated carcinogenesis
10.1016/j.prp.2008.04.011 · ExternalCitation · doi-reference
Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
10.1016/j.redox.2022.102389 · ExternalCitation · doi-reference
Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: a systematic review and meta-analysis
10.1016/j.redox.2024.103380 · ExternalCitation · doi-reference
The role of alpha-pinene on the NLRP3-Caspase 1 pathway in the ulcerative colitis model in rats
10.1016/j.tice.2025.103085 · ExternalCitation · doi-reference
Genetics and pathogenesis of inflammatory bowel disease
10.1038/nature10209 · ExternalCitation · doi-reference
Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
10.1038/s41467-018-07859-7 · ExternalCitation · doi-reference
Striking essential oil: tapping into a largely unexplored source for drug discovery
10.1038/s41598-020-59332-5 · ExternalCitation · doi-reference
Alpha-pinene ameliorate behavioral deficit induced by early postnatal hypoxia in the rat: study the inflammatory mechanism
10.1038/s41598-024-56756-1 · ExternalCitation · doi-reference
Oral administration of geraniol ameliorates acute experimental murine colitis by inhibiting pro-inflammatory cytokines and NF-κb signaling
10.1039/c5fo00405e · ExternalCitation · doi-reference
Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
10.1053/j.gastro.2004.01.063 · ExternalCitation · doi-reference
AGA clinical practice guidelines on the management of mild-to-moderate ulcerative colitis
10.1053/j.gastro.2018.12.009 · ExternalCitation · doi-reference
Medical progress ulcerative colitis
10.1056/nejmra1102942 · ExternalCitation · doi-reference
Mechanistic studies of the Nrf2-Keap1 signaling pathway
10.1080/03602530600971974 · ExternalCitation · doi-reference
Transcriptional regulation by Nrf2
10.1089/ars.2017.7342 · ExternalCitation · doi-reference
Oxidative stress in inflammation-based gastrointestinal tract diseases: challenges and opportunities
10.1111/j.1440-1746.2012.07108.x · ExternalCitation · doi-reference
Alpha-pinene exhibits anti-inflammatory activity through the suppression of MAPKs and the NF-κb pathway in mouse peritoneal macrophages
10.1142/s0192415x15500457 · ExternalCitation · doi-reference
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis
10.1158/0008-5472.can-06-3562 · ExternalCitation · doi-reference
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
10.1158/1940-6207.capr-08-0028 · ExternalCitation · doi-reference
The effects of alpha-pinene against paracetamol-induced liver damage in male rats
10.14814/phy2.70227 · ExternalCitation · doi-reference
Induction of experimental acute ulcerative colitis in rats by administration of dextran sulfate sodium at low concentration followed by intracolonic administration of 30% ethanol
10.1631/jzus.2007.b0632 · ExternalCitation · doi-reference
Biologic therapy for inflammatory bowel disease
10.2165/00003495-200565160-00002 · ExternalCitation · doi-reference
Oxidative stress in ulcerative colitis: an old concept but a new concern
10.3109/10715762.2012.717692 · ExternalCitation · doi-reference
The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
10.3389/fimmu.2023.1200111 · ExternalCitation · doi-reference
Oxidative stress-related biomarkers in inflammatory bowel disease: dual tools for remission assessment and prediction of treatment outcome
10.3390/antiox14101183 · ExternalCitation · doi-reference
Finding new molecular targets of familiar natural products using in silico target prediction
10.3390/ijms21197102 · ExternalCitation · doi-reference
Natural monoterpenes as potential therapeutic agents against atherosclerosis
10.3390/ijms24032429 · ExternalCitation · doi-reference
Antimicrobial activity of some essential oils—present status and future perspectives
10.3390/medicines4030058 · ExternalCitation · doi-reference
Biological activities of α-pinene and β-pinene enantiomers
10.3390/molecules17066305 · ExternalCitation · doi-reference
Novel strategies for the treatment of inflammatory bowel disease: selective inhibition of cytokines and adhesion molecules
10.3748/wjg.v12.i29.4628 · ExternalCitation · doi-reference
Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species
10.4103/0973-1296.149725 · ExternalCitation · doi-reference
