Research graph
References from Intracellular polyphosphate as a cell-intrinsic regulator of metabolism, inflammation, and thromboinflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Inorganic polyphosphate: a molecule of many functions
10.1146/annurev.biochem.68.1.89 · 1999 · External reference
Polyphosphate–an ancient energy source and active metabolic regulator
10.1186/1475-2859-10-63 · 2011 · External reference
Polyphosphate modulates blood coagulation and fibrinolysis
10.1073/pnas.0507195103 · 2006 · External reference
Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation. Blood
2012 · External reference
The concept of thromboinflammation
10.1055/a-2178-6491 · 2024 · External reference
Mitochondrial inorganic polyphosphate (polyP) is a potent regulator of mammalian bioenergetics in SH-SY5Y cells: a proteomics and metabolomics study
10.3389/fcell.2022.833127 · 2022 · External reference
Inorganic polyphosphate and the regulation of mitochondrial physiology
10.1042/bst20230735 · 2023 · External reference
Polyphosphate, platelets, and coagulation
10.1111/ijlh.12349 · 2015 · External reference
Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes
10.1074/jbc.m406261200 · 2004 · External reference
Myeloma cells contain high levels of inorganic polyphosphate which is associated with nucleolar transcription
10.3324/haematol.2011.051409 · 2012 · External reference
Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes
10.1074/jbc.m112.385823 · 2012 · External reference
Polyphosphate exerts differential effects on blood clotting, depending on polymer size. Blood
2010 · External reference
Polyphosphate accelerates factor V activation by factor XIa
10.1160/th14-06-0515 · 2015 · External reference
Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
10.1016/j.cell.2009.11.001 · 2009 · External reference
Factor XII as a therapeutic target in thromboembolic and inflammatory diseases
10.1161/atvbaha.116.308595 · 2017 · External reference
Thrombosis as an intravascular effector of innate immunity
10.1038/nri3345 · 2013 · External reference
Inorganic polyphosphate in mammalian cells and tissues (∗)
10.1074/jbc.270.11.5818 · 1995 · External reference
Inorganic polyphosphate and energy metabolism in mammalian cells
10.1074/jbc.m109.013011 · 2010 · External reference
Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death
10.1073/pnas.0708959104 · 2007 · External reference
Inorganic polyphosphate's role in energy production and mitochondrial permeability transition pore opening in tick mitochondria
10.1002/arch.22029 · 2023 · External reference
Inorganic polyphosphate: essential for growth and survival
10.1146/annurev.biochem.77.083007.093039 · 2009 · External reference
Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria
10.1042/bcj20200042 · 2020 · External reference
Mammalian inorganic polyphosphatases: current understanding and open questions
2016 · External reference
Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
10.1523/jneurosci.4468-06.2007 · 2007 · External reference
In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8
10.1021/cb5000696 · 2014 · External reference
Role of mitochondrial polyphosphate in respiratory chain function
2014 · External reference
Mitochondrial Ca2+ uptake pathways
10.1007/s10863-016-9676-6 · 2017 · External reference
Polyphosphate: a new player in the field of hemostasis
10.1097/moh.0000000000000069 · 2014 · External reference
Inorganic polyphosphate in the origin and survival of species
10.1073/pnas.0406909101 · 2004 · External reference
Polyphosphate as a mediator of hemostasis and thrombosis
2010 · External reference
Unresolved reference
External reference
Configuration-dependent nanoarchitectonic effects of linear and cyclic calcium polyphosphates on mitochondrial energy metabolism and osteogenic differentiation
10.1021/acsami.6c08066 · 2026 · External reference
Role of inorganic polyphosphate in mammalian cells: from signal transduction and mitochondrial metabolism to cell death
10.1042/bst20150223 · 2016 · External reference
Preparation of amorphous calcium phosphate nanoparticles using small organic molecules for biomimetic mineralization of dentin
10.1039/d5ra10131j · 2026 · External reference
Inorganic polyphosphate and the regulation of mitochondrial physiology
10.1042/bst20230735 · 2023 · External reference
Energetic calcium phosphate nanominerals for osteoporosis treatment
10.1002/adfm.202415906 · 2025 · External reference
Contribution of inorganic polyphosphate towards regulation of mitochondrial free calcium
10.1016/j.bbagen.2016.03.020 · 2016 · External reference
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
10.1038/nri2725 · 2010 · External reference
Functional role of mitochondrial reactive oxygen species in physiology
10.1016/j.freeradbiomed.2016.06.005 · 2016 · External reference
A guide to immunometabolism for immunologists
10.1038/nri.2016.70 · 2016 · External reference
Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore
10.1042/bst20150206 · 2016 · External reference
A role for mitochondria in NLRP3 inflammasome activation
10.1038/nature09663 · 2011 · External reference
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
10.1126/science.aah4573 · 2017 · External reference
Van den Bossche J. Immunometabolism in the single-cell era
10.1016/j.cmet.2020.09.013 · 2020 · External reference
Interplay between inflammation and thrombosis in cardiovascular pathology
10.1038/s41569-021-00552-1 · 2021 · External reference
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
10.1038/s41577-021-00536-9 · 2021 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Current best practices in single-cell RNA-seq analysis: a tutorial
10.15252/msb.20188746 · 2019 · External reference
Unresolved reference
2020 · External reference
Protocol to quantify polyphosphate in human cell lines using a tagged PPBD peptide
10.1016/j.xpro.2022.101363 · 2022 · External reference
Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules
10.26508/lsa.201900385 · 2019 · External reference
Mitochondrial DNA in innate immune responses and inflammatory pathology
10.1038/nri.2017.21 · 2017 · External reference
COVID-19 is, in the end, an endothelial disease
10.1093/eurheartj/ehaa623 · 2020 · External reference
Energetic calcium phosphate nanominerals for osteoporosis treatment
10.1002/adfm.202415906 · ExternalCitation · doi-reference
Inorganic polyphosphate's role in energy production and mitochondrial permeability transition pore opening in tick mitochondria
10.1002/arch.22029 · ExternalCitation · doi-reference
Mitochondrial Ca2+ uptake pathways
10.1007/s10863-016-9676-6 · ExternalCitation · doi-reference
Contribution of inorganic polyphosphate towards regulation of mitochondrial free calcium
10.1016/j.bbagen.2016.03.020 · ExternalCitation · doi-reference
Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
10.1016/j.cell.2009.11.001 · ExternalCitation · doi-reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · ExternalCitation · doi-reference
Van den Bossche J. Immunometabolism in the single-cell era
10.1016/j.cmet.2020.09.013 · ExternalCitation · doi-reference
Functional role of mitochondrial reactive oxygen species in physiology
10.1016/j.freeradbiomed.2016.06.005 · ExternalCitation · doi-reference
Protocol to quantify polyphosphate in human cell lines using a tagged PPBD peptide
10.1016/j.xpro.2022.101363 · ExternalCitation · doi-reference
Configuration-dependent nanoarchitectonic effects of linear and cyclic calcium polyphosphates on mitochondrial energy metabolism and osteogenic differentiation
10.1021/acsami.6c08066 · ExternalCitation · doi-reference
In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8
10.1021/cb5000696 · ExternalCitation · doi-reference
A role for mitochondria in NLRP3 inflammasome activation
10.1038/nature09663 · ExternalCitation · doi-reference
A guide to immunometabolism for immunologists
10.1038/nri.2016.70 · ExternalCitation · doi-reference
Mitochondrial DNA in innate immune responses and inflammatory pathology
10.1038/nri.2017.21 · ExternalCitation · doi-reference
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
10.1038/nri2725 · ExternalCitation · doi-reference
Thrombosis as an intravascular effector of innate immunity
10.1038/nri3345 · ExternalCitation · doi-reference
Interplay between inflammation and thrombosis in cardiovascular pathology
10.1038/s41569-021-00552-1 · ExternalCitation · doi-reference
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
10.1038/s41577-021-00536-9 · ExternalCitation · doi-reference
Preparation of amorphous calcium phosphate nanoparticles using small organic molecules for biomimetic mineralization of dentin
10.1039/d5ra10131j · ExternalCitation · doi-reference
Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria
10.1042/bcj20200042 · ExternalCitation · doi-reference
Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore
10.1042/bst20150206 · ExternalCitation · doi-reference
Role of inorganic polyphosphate in mammalian cells: from signal transduction and mitochondrial metabolism to cell death
10.1042/bst20150223 · ExternalCitation · doi-reference
Inorganic polyphosphate and the regulation of mitochondrial physiology
10.1042/bst20230735 · ExternalCitation · doi-reference
The concept of thromboinflammation
10.1055/a-2178-6491 · ExternalCitation · doi-reference
Inorganic polyphosphate in the origin and survival of species
10.1073/pnas.0406909101 · ExternalCitation · doi-reference
Polyphosphate modulates blood coagulation and fibrinolysis
10.1073/pnas.0507195103 · ExternalCitation · doi-reference
Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death
10.1073/pnas.0708959104 · ExternalCitation · doi-reference
Inorganic polyphosphate in mammalian cells and tissues (∗)
10.1074/jbc.270.11.5818 · ExternalCitation · doi-reference
Inorganic polyphosphate and energy metabolism in mammalian cells
10.1074/jbc.m109.013011 · ExternalCitation · doi-reference
Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes
10.1074/jbc.m112.385823 · ExternalCitation · doi-reference
Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes
10.1074/jbc.m406261200 · ExternalCitation · doi-reference
COVID-19 is, in the end, an endothelial disease
10.1093/eurheartj/ehaa623 · ExternalCitation · doi-reference
Polyphosphate: a new player in the field of hemostasis
10.1097/moh.0000000000000069 · ExternalCitation · doi-reference
Polyphosphate, platelets, and coagulation
10.1111/ijlh.12349 · ExternalCitation · doi-reference
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
10.1126/science.aah4573 · ExternalCitation · doi-reference
Inorganic polyphosphate: a molecule of many functions
10.1146/annurev.biochem.68.1.89 · ExternalCitation · doi-reference
Inorganic polyphosphate: essential for growth and survival
10.1146/annurev.biochem.77.083007.093039 · ExternalCitation · doi-reference
Polyphosphate accelerates factor V activation by factor XIa
10.1160/th14-06-0515 · ExternalCitation · doi-reference
Factor XII as a therapeutic target in thromboembolic and inflammatory diseases
10.1161/atvbaha.116.308595 · ExternalCitation · doi-reference
Polyphosphate–an ancient energy source and active metabolic regulator
10.1186/1475-2859-10-63 · ExternalCitation · doi-reference
Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
10.1523/jneurosci.4468-06.2007 · ExternalCitation · doi-reference
Current best practices in single-cell RNA-seq analysis: a tutorial
10.15252/msb.20188746 · ExternalCitation · doi-reference
Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules
10.26508/lsa.201900385 · ExternalCitation · doi-reference
Myeloma cells contain high levels of inorganic polyphosphate which is associated with nucleolar transcription
10.3324/haematol.2011.051409 · ExternalCitation · doi-reference
Mitochondrial inorganic polyphosphate (polyP) is a potent regulator of mammalian bioenergetics in SH-SY5Y cells: a proteomics and metabolomics study
10.3389/fcell.2022.833127 · ExternalCitation · doi-reference
