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References from Interplay between ferroptosis and cuproptosis in chronic kidney disease: Mechanisms and regulatory crosstalk. Local targets link to admitted publications; unresolved targets remain external evidence.
Cognitive disorders in patients with chronic kidney disease: approaches to prevention and treatment
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Copper homeostasis in chronic kidney disease and its crosstalk with ferroptosis
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Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application
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Potential role of copper in diabetes and diabetic kidney disease
10.3390/metabo13010017 · 2022 · External reference
Ferroptosis: molecular mechanisms and health implications
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Regulated cell death: a multidimensional regulatory network in the pathogenesis of renal fibrosis
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Cross-talk among novel programmed cell death pathways: a decisive network in renal ischemia-reperfusion injury
10.3389/fimmu.2026.1844850 · 2026 · External reference
Programmed cell death in kidney disease: integrated crosstalk among ferroptosis, pyroptosis, apoptosis, and cuproptosis
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New anti-cancer explorations based on metal ions
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Ferroptosis: an iron-dependent form of nonapoptotic cell death
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10.1038/s41598-018-31457-8 · 2018 · External reference
Ferroptosis involves in renal tubular cell death in diabetic nephropathy
10.1016/j.ejphar.2020.173574 · 2020 · External reference
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
10.1038/nchembio.2238 · 2017 · External reference
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
10.1038/s41401-023-01156-w · 2024 · External reference
The role of oxidative stress in patients with chronic kidney disease
10.36740/wlek202305110 · 2023 · External reference
Glutathione peroxidase 4 is a predictor of diabetic kidney disease progression in type 2 diabetes mellitus
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STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease
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Nephroprotective effects of Amomum kravanh essential oil by inhibition of ferroptosis regulated by Nrf2/HO-1 signaling pathway
10.1016/j.phymed.2025.156762 · 2025 · External reference
Diosmin attenuates UUO-induced renal ferroptosis and fibrosis by inhibiting the HIF-1α/FABP4 signaling axis
10.1016/j.phymed.2025.156738 · 2025 · External reference
The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy
10.1038/s41418-024-01357-8 · 2024 · External reference
CNPY2 aggravates renal tubular cell ferroptosis in diabetic nephropathy by regulating PERK/ATF4/CHAC1 pathway and MAM integrity
2025 · External reference
High glucose induces podocyte ferroptosis through BAP1/SLC7A11 pathway
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Copper induces cell death by targeting lipoylated TCA cycle proteins
10.1126/science.abf0529 · 2022 · External reference
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Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis
10.1016/j.abb.2007.04.021 · 2007 · External reference
The divalent elements changes in early stages of chronic kidney disease
10.1007/s12011-017-1228-3 · 2018 · External reference
Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis
10.1136/bmjdrc-2024-004454 · 2024 · External reference
Oxidized-LDL aggravates renal injury via tubular cuproptosis
10.1016/j.cellsig.2025.111839 · 2025 · External reference
Systematic pan-cancer analysis identifies SLC31A1 as a biomarker in multiple tumor types
10.1186/s12920-023-01489-9 · 2023 · External reference
The copper transporter, SLC31A1, transcriptionally activated by ELF3, imbalances copper homeostasis to exacerbate cisplatin-induced acute kidney injury through mitochondrial dysfunction
10.1016/j.cbi.2024.110943 · 2024 · External reference
Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins
10.1002/biof.1837 · 2022 · External reference
Mitochondrial copper overload promotes renal fibrosis via inhibiting pyruvate dehydrogenase activity
10.1007/s00018-024-05358-1 · 2024 · External reference
Elevated intracellular copper contributes a unique role to kidney fibrosis by lysyl oxidase mediated matrix crosslinking
10.1038/s41419-020-2404-5 · 2020 · External reference
Cuproptosis associated cytoskeletal destruction contributes to podocyte injury in chronic kidney disease
10.1152/ajpcell.00497.2023 · 2024 · External reference
Copper homeostasis and cuproptosis in health and disease
2024 · External reference
FDX1 regulates cellular protein lipoylation through direct binding to LIAS
10.1016/j.jbc.2023.105046 · 2023 · External reference
Human mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) both bind cysteine desulfurase and donate electrons for iron-sulfur cluster biosynthesis
10.1021/acs.biochem.6b00447 · 2017 · External reference
Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population
10.1016/j.humimm.2015.09.044 · 2015 · External reference
Association between CCDC132, FDX1 and TNFSF13 gene polymorphisms and the risk of IgA nephropathy
10.1111/nep.12611 · 2015 · External reference
Integrated multi-omics and experimental validation reveal FDX1/LIAS-mediated cuproptosis as a potential driver of diabetic kidney disease
10.1007/s12011-025-04798-5 · 2026 · External reference
Quercetin attenuates acute kidney injury caused by cisplatin by inhibiting ferroptosis and cuproptosis
10.1007/s12013-024-01379-6 · 2024 · External reference
Cellular and molecular mechanisms of renal fibrosis
10.1038/nrneph.2011.149 · 2011 · External reference
CKD progression and mortality among men and women: a nationwide study in Sweden
10.1053/j.ajkd.2020.11.026 · 2021 · External reference
Chronic kidney disease combined with metabolic syndrome is a non-negligible risk factor
10.1177/20420188241252309 · 2024 · External reference
The Warburg effect in diabetic kidney disease
10.1016/j.semnephrol.2018.01.002 · 2018 · External reference
Advanced glycation end products and reactive oxygen species: uncovering the potential role of ferroptosis in diabetic complications
10.1186/s10020-024-00905-9 · 2024 · External reference
ATF3/SPI1/SLC31A1 signaling promotes cuproptosis induced by advanced glycosylation end products in diabetic myocardial injury
10.3390/ijms24021667 · 2023 · External reference
The key role of altered tubule cell lipid metabolism in kidney disease development
10.1016/j.kint.2024.02.025 · 2024 · External reference
The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease
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Defective mitochondrial fatty acid oxidation and lipotoxicity in kidney diseases
10.3389/fmed.2020.00065 · 2020 · External reference
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10.3390/ijms232213933 · 2022 · External reference
Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and Sphingosine-1-Phoshate
10.3390/ijms16035076 · 2015 · External reference
ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis
10.3389/fphar.2025.1594419 · 2025 · External reference
Generation, clearance, toxicity, and monitoring possibilities of unaccounted uremic toxins for improved dialysis prescriptions
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Classification of uremic toxins and their role in kidney failure
10.2215/cjn.02660221 · 2021 · External reference
The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair
10.1111/j.1523-1755.2004.00399.x · 2004 · External reference
Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells
10.1159/000191468 · 2009 · External reference
p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase
10.1038/ki.2012.448 · 2013 · External reference
Protein-bound uremic toxins impaired mitochondrial dynamics and functions
10.18632/oncotarget.20773 · 2017 · External reference
p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells
10.1093/ndt/gfs133 · 2013 · External reference
Inhibition of indoxyl sulfate-induced reactive oxygen species-related ferroptosis alleviates renal cell injury in vitro and chronic kidney disease progression in vivo
10.3390/antiox12111931 · 2023 · External reference
Inflammation and oxidative stress in chronic kidney disease—potential therapeutic role of minerals, vitamins and plant-derived metabolites
10.3390/ijms21010263 · 2019 · External reference
Kidney fibrosis: emerging diagnostic and therapeutic strategies
10.1016/j.mam.2023.101206 · 2023 · External reference
Tangeretin ameliorates glucose-induced podocyte injury through blocking epithelial to mesenchymal transition caused by oxidative stress and hypoxia
10.3390/ijms21228577 · 2020 · External reference
Hypoxia and renal fibrosis
10.1152/ajpcell.00201.2023 · 2023 · External reference
Hypoxia and chronic kidney disease
10.1016/j.ebiom.2022.103942 · 2022 · External reference
Shen-Shuai-II-Recipe suppresses hypoxia-induced oxidative stress and ferroptosis via Nrf2 activation to ameliorate renal fibrosis in chronic kidney disease
10.1016/j.jep.2025.120783 · 2026 · External reference
Phosphodiesterase inhibitor improves renal tubulointerstitial hypoxia of the diabetic rat kidney
10.3904/kjim.2012.27.2.163 · 2012 · External reference
Unresolved reference
2026 · External reference
Upregulated copper transporters in hypoxia-induced pulmonary hypertension
10.1371/journal.pone.0090544 · 2014 · External reference
Copper transport into the secretory pathway is regulated by oxygen in macrophages
10.1242/jcs.043216 · 2009 · External reference
Nitroxyl relieves acute kidney injury by suppressing SLC31A1-mediated cuproptosis in renal tubular epithelial cells
10.1016/j.lfs.2026.124502 · 2026 · External reference
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
10.1016/j.cmet.2009.08.015 · 2009 · External reference
Neutrophil extracellular traps license macrophage production of chemokines to facilitate CD8+ T cell infiltration in obstruction-induced renal fibrosis
2025 · External reference
Inflammatory processes in renal fibrosis
10.1038/nrneph.2014.114 · 2014 · External reference
Impact of inflammation on ferritin, hepcidin and the management of iron deficiency anemia in chronic kidney disease
10.3390/nu10091173 · 2018 · External reference
Crosstalk between ferroptosis and innate immune in diabetic kidney disease: mechanisms and therapeutic implications
2025 · External reference
A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity
10.1074/jbc.m109.070201 · 2009 · External reference
Analysis of the primary structure of collagen for the origins of molecular packing
10.1016/0022-2836(73)90275-1 · 1973 · External reference
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10.1371/journal.pone.0166392 · 2016 · External reference
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10.1016/s0344-0338(11)80995-7 · 1994 · External reference
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10.1074/jbc.271.2.1096 · 1996 · External reference
Kidney-specific Interleukin-17 responses during infection and injury
10.1146/annurev-immunol-052523-015141 · 2024 · External reference
Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets
10.1016/j.ejphar.2017.12.016 · 2018 · External reference
Macrophages: versatile players in renal inflammation and fibrosis
10.1038/s41581-019-0110-2 · 2019 · External reference
Ferroptosis and renal fibrosis: mechanistic insights and emerging therapeutic targets
10.1080/0886022x.2025.2498629 · 2025 · External reference
Oxidative stress and the role of redox signalling in chronic kidney disease
10.1038/s41581-023-00775-0 · 2024 · External reference
Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression
2025 · External reference
Mitochondria-targeting therapeutic strategies for chronic kidney disease
10.1016/j.bcp.2024.116669 · 2025 · External reference
Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS
10.1016/j.redox.2025.103795 · 2025 · External reference
Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms
2025 · External reference
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
10.1038/s41392-024-01969-z · 2024 · External reference
H2S protects from rotenone-induced ferroptosis by stabilizing Fe-S clusters in rat cardiac cells
10.3390/cells13050371 · 2024 · External reference
IHD from copper deficiency: a unified theory
10.1017/s0954422416000093 · 2016 · External reference
Emerging role of ferroptosis in diabetic kidney disease: molecular mechanisms and therapeutic opportunities
10.7150/ijbs.81892 · 2023 · External reference
Regulated necrosis: disease relevance and therapeutic opportunities
10.1038/nrd.2015.6 · 2016 · External reference
Sodium aescinate induces renal toxicity by promoting Nrf2/GPX4-mediated ferroptosis
10.1016/j.cbi.2024.110892 · 2024 · External reference
Sodium selenite prevents matrine-induced nephrotoxicity by suppressing ferroptosis via the GSH-GPX4 antioxidant system
10.1007/s12011-023-04044-w · 2024 · External reference
Suppression of ferroptosis through the SLC7A11/glutathione/glutathione peroxidase 4 axis contributes to the therapeutic action of the Tangshenning formula on diabetic renal tubular injury
10.1186/s13020-024-01007-8 · 2024 · External reference
Copper-induced cell death
10.1126/science.abo3959 · 2022 · External reference
Diallyl trisulfide from garlic regulates RAB18 phase separation to inhibit lipophagy and induce cuproptosis in hepatic stellate cells for antifibrotic effects
2025 · External reference
Activation of the ROS/HO-1/NQO1 signaling pathway contributes to the copper-induced oxidative stress and autophagy in duck renal tubular epithelial cells
10.1016/j.scitotenv.2020.143753 · 2021 · External reference
Copper as the driver of the lncRNA-TCONS-6251/miR-novel-100/TC2N axis: unraveling ferroptosis in duck kidney
10.1016/j.ijbiomac.2024.136797 · 2024 · External reference
Copper exposure promotes ferroptosis of chicken (Gallus gallus) kidney cells and causes kidney injury
10.1016/j.jtemb.2024.127501 · 2024 · External reference
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
10.1080/15548627.2023.2165323 · 2023 · External reference
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
10.1038/s41388-018-0315-z · 2018 · External reference
p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases
10.1038/s41580-025-00842-3 · 2025 · External reference
Cuproptosis: p53-regulated metabolic cell death?
10.1038/s41418-023-01125-0 · 2023 · External reference
Ferroptosis as a p53-mediated activity during tumour suppression
10.1038/nature14344 · 2015 · External reference
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
10.1038/s41556-019-0305-6 · 2019 · External reference
Jingtian granule alleviates adenine-induced renal fibrosis in mice through SIRT3-mediated deacetylation of P53
10.3389/fphar.2025.1526414 · 2025 · External reference
CCS facilitates the progression of ovarian cancer by suppressing ferroptotic cell death via the modulation of p53-mediated expression of SLC7A11 and GPX4
10.1038/s41401-026-01816-7 · 2026 · External reference
p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation
2025 · External reference
Regulation of iron homeostasis by the p53-ISCU pathway
10.1038/srep16497 · 2015 · External reference
Role of nuclear factor erythroid 2-related factor 2 in the oxidative stress-dependent hypertension associated with the depletion of DJ-1
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Mechanism of myocardial ischemia/reperfusion-induced acute kidney injury through DJ-1/Nrf2 pathway in diabetic rats
2017 · External reference
MiR-122 regulates cell apoptosis and ROS by targeting DJ-1 in renal ischemic reperfusion injury rat models
2020 · External reference
The protective effect of glutaredoxin 1/DJ-1/HSP70 signaling in renal tubular epithelial cells injury induced by ischemia
10.1016/j.lfs.2019.03.015 · 2019 · External reference
Functional potato bioactive peptide intensifies Nrf2-dependent antioxidant defense against renal damage in hypertensive rats
10.1016/j.foodres.2019.108862 · 2020 · External reference
The imbalance of p53-Park7 signaling axis induces iron homeostasis dysfunction in doxorubicin-challenged cardiomyocytes
2023 · External reference
PARK7 protects against chronic kidney injury and renal fibrosis by inducing SOD2 to reduce oxidative stress
10.3389/fimmu.2021.690697 · 2021 · External reference
Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction
10.1111/cas.13701 · 2018 · External reference
Adaptative response to changes in pyruvate metabolism on the epigenetic landscapes and transcriptomics of bovine embryos
10.1038/s41598-023-38686-6 · 2023 · External reference
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
10.1073/pnas.1002459107 · 2010 · External reference
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity
10.1124/jpet.110.170084 · 2010 · External reference
Toward improved human health: Nrf2 plays a critical role in regulating ferroptosis
10.1039/d1fo01036k · 2021 · External reference
Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation
10.1186/s10020-023-00735-1 · 2023 · External reference
Bone marrow mesenchymal stem cells inhibit ferroptosis via regulating the Nrf2-keap1/p53 pathway to ameliorate chronic kidney disease injury in the rats
10.1080/10799893.2023.2185083 · 2023 · External reference
Atraric acid alleviates chronic intermittent hypoxia-induced renal fibrosis by inhibiting oxidative stress and ferroptosis in obstructive sleep apnea mice through the Nrf2/GPX4 pathway
10.1016/j.cellsig.2025.112040 · 2025 · External reference
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway
10.1038/s41420-023-01564-1 · 2023 · External reference
Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis
10.1016/j.ecoenv.2023.115542 · 2023 · External reference
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model
10.1002/ctm2.70100 · 2024 · External reference
NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism
10.1038/s41598-024-81317-x · 2024 · External reference
Association between copper exposure and renal fibrosis in patients with chronic kidney disease: evidence from Mendelian randomization and a retrospective study
2025 · External reference
Benefits and risks of essential trace elements in chronic kidney disease: a narrative review
10.21037/atm-22-5969 · 2022 · External reference
