Research graph
References from USP36-mediated stabilization of NAT10 promotes osteosarcoma progression via ac4C-dependent KIF23 mRNA stabilization. Local targets link to admitted publications; unresolved targets remain external evidence.
Advancing therapy for osteosarcoma
10.1038/s41571-021-00519-8 · 2021 · External reference
Musculoskeletal diseases: mechanisms and therapeutic advances
2025 · External reference
Bone cancer, version 2.2025, NCCN clinical practice guidelines in oncology
2025 · External reference
The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy
10.1186/s13045-022-01365-6 · 2022 · External reference
Protein degradation: expanding the toolbox to restrain cancer drug resistance
10.1186/s13045-023-01398-5 · 2023 · External reference
Deubiquitinases: from mechanisms to their inhibition by small molecules
10.1016/j.molcel.2021.10.027 · 2022 · External reference
Functional analysis of deubiquitylating enzymes in tumorigenesis and development
10.1016/j.bbcan.2019.188312 · 2019 · External reference
Emerging role of DUBs in tumor metastasis and apoptosis: therapeutic implication
10.1016/j.pharmthera.2017.03.001 · 2017 · External reference
The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis
10.15252/embr.202050684 · 2021 · External reference
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36
10.1038/s41589-023-01388-1 · 2023 · External reference
MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma
10.1182/blood.2019000381 · 2019 · External reference
USP36 promotes tumorigenesis and drug sensitivity of glioblastoma by deubiquitinating and stabilizing ALKBH5
10.1093/neuonc/noac238 · 2023 · External reference
The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc
10.1073/pnas.1411713112 · 2015 · External reference
Epigenetic and epitranscriptomic regulation of viral replication
10.1038/s41579-020-0382-3 · 2020 · External reference
Post-transcriptional gene regulation by mRNA modifications
10.1038/nrm.2016.132 · 2017 · External reference
RNA N4-acetylcytidine modification and its role in health and diseases
2025 · External reference
Acetylation of cytidine in mRNA promotes translation efficiency
10.1016/j.cell.2018.10.030 · 2018 · External reference
Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyond
10.1186/s43556-025-00286-3 · 2025 · External reference
The role and mechanism of NAT10-mediated ac4C modification in tumor development and progression
2024 · External reference
Targeting signaling pathways in osteosarcoma: mechanisms and clinical studies
2023 · External reference
Mechanistic insights into Wnt-β-catenin pathway activation and signal transduction
10.1038/s41580-024-00823-y · 2025 · External reference
Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
10.1186/s13046-022-02373-7 · 2022 · External reference
Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac(4)C acetylation of KIF23 mRNA
10.1186/s13046-022-02551-7 · 2022 · External reference
USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
10.1038/s41467-023-42257-8 · 2023 · External reference
Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates
10.1016/j.chembiol.2024.05.001 · 2024 · External reference
Beyond K48 and K63: non-canonical protein ubiquitination
10.1186/s11658-020-00245-6 · 2021 · External reference
Synthesis and identification of a novel selective USP7 degrader that inhibits the migration of upper gastrointestinal cancer cells without affecting proliferation
10.1016/j.ejmech.2025.118488 · 2026 · External reference
