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References from All-trans retinoic acid-driven immune remodeling in esophageal squamous cell carcinoma revealed by single-cell transcriptomics. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2021 · External reference
The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: new estimates from GLOBOCAN 2020
10.1053/j.gastro.2022.05.054 · 2022 · External reference
Epidemiology of esophageal squamous cell carcinoma
10.1053/j.gastro.2017.08.023 · 2018 · External reference
Nivolumab combination therapy in advanced esophageal squamous-cell carcinoma
10.1056/nejmoa2111380 · 2022 · External reference
Effect of Camrelizumab vs placebo added to chemotherapy on survival and progression-free survival in patients with advanced or metastatic esophageal squamous cell carcinoma: the ESCORT-1st randomized clinical trial
10.1001/jama.2021.12836 · 2021 · External reference
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
10.1038/s41467-021-25539-x · 2021 · External reference
Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment
10.1038/s41467-021-27599-5 · 2021 · External reference
YY2 serves as a novel prognostic biomarker correlated with immune microenvironment and glycolysis in esophageal carcinoma
10.2174/0113892029358348250124064940 · 2025 · External reference
The success and the challenge of all-trans retinoic acid in the treatment of cancer
10.1080/10408398.2018.1509201 · 2019 · External reference
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
10.1038/s41392-021-00670-9 · 2021 · External reference
All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients
10.1158/0008-5472.can-06-1690 · 2006 · External reference
Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with Ipilimumab
10.1016/j.intimp.2018.08.007 · 2018 · External reference
Tumor-derived retinoic acid regulates intratumoral monocyte differentiation to promote immune suppression
10.1016/j.cell.2020.02.042 · 2020 · External reference
All-trans retinoic acid promotes a tumor suppressive OTUD6B-beta-TrCP-SNAIL axis in esophageal squamous cell carcinoma and enhances immunotherapy
2023 · External reference
The multifaceted roles of the invariant chain CD74--more than just a chaperone
10.1016/j.bbamcr.2016.03.026 · 2016 · External reference
Neutrophil profiling illuminates anti-tumor antigen-presenting potency
10.1016/j.cell.2024.02.005 · 2024 · External reference
Emt
10.1016/j.cell.2016.06.028 · 2016 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
10.1016/j.ccell.2023.02.014 · 2023 · External reference
CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer
10.1158/1078-0432.ccr-07-0842 · 2007 · External reference
Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance
10.1038/s41698-024-00522-z · 2024 · External reference
SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration
10.1038/s41416-024-02683-x · 2024 · External reference
Tumour-associated neutrophils in patients with cancer
10.1038/s41571-019-0222-4 · 2019 · External reference
Association of immunosuppressive CD45(+)CD33(+)CD14(−) CD10(−)HLA-DR(−/low) neutrophils with poor prognosis in patients with lymphoma and their expansion and activation through STAT3/arginase-1 pathway in vitro
10.25259/cytojournal_165_2024 · 2024 · External reference
Single-cell transcriptomic analysis reveals the landscape of epithelial-mesenchymal transition molecular heterogeneity in esophageal squamous cell carcinoma
10.1016/j.canlet.2024.216723 · 2024 · External reference
Update on epithelial-mesenchymal plasticity in cancer progression
10.1146/annurev-pathmechdis-051222-122423 · 2024 · External reference
Ubiquitination and deubiquitination in the regulation of epithelial-mesenchymal transition in cancer: shifting gears at the molecular level
10.1016/j.bbamcr.2022.119261 · 2022 · External reference
Targeting MDSC differentiation using ATRA: A Phase I/II clinical trial combining pembrolizumab and all-trans retinoic acid for metastatic melanoma
10.1158/1078-0432.ccr-22-2495 · 2023 · External reference
Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma (RATIONALE-306): a global, randomised, placebo-controlled, phase 3 study
10.1016/s1470-2045(23)00108-0 · 2023 · External reference
All-trans retinoic acid potentiates the chemotherapeutic effect of cisplatin by inducing differentiation of tumor initiating cells in liver cancer
10.1016/j.jhep.2013.07.009 · 2013 · External reference
Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells
10.1158/0008-5472.can-07-2593 · 2007 · External reference
A new mouse esophageal cancer cell line (mEC25)-derived pre-clinical syngeneic tumor model for immunotherapy
10.1002/cac2.12066 · 2020 · External reference