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References from Identification of cathepsin L and urokinase-type plasminogen activator in plasma-derived small extracellular vesicles of breast cancer patients. Local targets link to admitted publications; unresolved targets remain external evidence.
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Emerging biomarkers in liquid biopsy: the small extracellular vesicles
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Plasma small-extracellular vesicles' proteomic signature in neoadjuvant chemotherapy–naïve breast cancer patients
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Large extracellular vesicle-derived latent MMP-8 and gelatinolytically active MMP-2 as potential circulating markers for lymph node metastasis in breast cancer
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Harnessing protease activity to improve Cancer care
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2021 · External reference
A simple and available measurement of onco-sEV dsDNA to protein ratio as a potential tumor marker
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SDC2 and FN as cargo proteins in circulating extracellular vesicles in obese breast cancer patients with lymph node metastasis
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FBLN2 is associated with basal cell markers Krt14 and ITGB1 in mouse mammary epithelial cells and has a preferential expression in molecular subtypes of human breast cancer
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Detecting protein-protein interactions by far western blotting
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Gelatin zymography using leupeptin for the detection of various cathepsin L forms
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10.1016/j.csbj.2021.07.014 · 2021 · Admitted local publication
Unresolved reference
2019 · External reference
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10.1245/s10434-018-6486-6 · 2018 · External reference
Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
10.1186/s13045-022-01305-4 · 2022 · External reference
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10.1186/1478-811x-8-22 · 2010 · External reference
Hormonal-receptor positive breast cancer: IL-6 augments invasion and lymph node metastasis via stimulating cathepsin B expression
10.1016/j.jare.2016.06.007 · 2016 · External reference
Cathepsin L is a potential marker for triple-negative breast cancer
2019 · External reference
Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas
2020 · External reference
Key matrix remodeling enzymes: functions and targeting in cancer
10.3390/cancers13061441 · 2021 · External reference
Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer
10.1186/s12967-022-03329-3 · 2022 · External reference
Breast cancer-derived exosomes: tumor progression and therapeutic agents
10.1002/jcp.29668 · 2020 · External reference
CTSL, a prognostic marker of breast cancer, that promotes proliferation, migration, and invasion in cells in triple-negative breast cancer
2023 · External reference
Multiplex Zymography captures stage-specific activity profiles of Cathepsins K, L, and S in human breast, lung, and cervical Cancer
10.1186/1479-5876-9-109 · 2011 · External reference
Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers
10.18632/oncotarget.13569 · 2016 · External reference
Therapeutic strategies targeting urokinase and its receptor in cancer
10.3390/cancers14030498 · 2022 · External reference
Multifaceted role of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR): diagnostic, prognostic, and therapeutic applications
10.3389/fonc.2018.00024 · 2018 · External reference
Urokinase-type plasminogen activator receptor (uPAR) in inflammation and disease: a unique inflammatory pathway activator
10.3390/biomedicines12061167 · 2024 · External reference
Redefining the breast Cancer exosome proteome by tandem mass tag quantitative proteomics and multivariate cluster analysis
10.1021/acs.analchem.5b02586 · 2015 · External reference
uPAR-expressing melanoma exosomes promote angiogenesis by VE-cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells
10.1007/s00018-020-03707-4 · 2021 · External reference
Exosomes: a rising star in breast cancer (review)
10.3892/or.2020.7638 · 2020 · External reference
Heparanase activates the syndecan-syntenin-ALIX exosome pathway
10.1038/cr.2015.29 · 2015 · External reference
In silico investigation of heparanase-correlated genes in breast cancer subtypes
10.31744/einstein_journal/2020ao5447 · 2020 · External reference
Extracellular vesicles released during hypoxia transport heparanase and enhance macrophage migration, endothelial tube formation and cancer cell stemness
10.1002/pgr2.1 · 2023 · External reference
Heparanase promotes myeloma stemness and in vivo tumorigenesis
10.1016/j.matbio.2019.11.004 · 2020 · External reference
Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes
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Focus on molecules: Heparanase
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Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts
10.1242/jcs.115.10.2179 · 2002 · External reference
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment
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The uptake of Heparanase into mast cells is regulated by its enzymatic activity to degrade Heparan sulfate
2024 · External reference
Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells
10.1677/erc-09-0200 · 2010 · External reference
Elevated CTSL gene expression correlated with proinflammatory cytokines in omental adipose tissue of patients with obesity
10.2147/dmso.s373203 · 2022 · External reference
Interleukin-6 serves as a critical factor in various cancer progression and therapy
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Paracrine tumor signaling induces transdifferentiation of surrounding fibroblasts
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Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
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Revisiting the Syndecans: master signaling regulators with prognostic and targetable therapeutic values in breast carcinoma
10.3390/cancers15061794 · 2023 · External reference
Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway
10.1186/s13058-023-01672-x · 2023 · External reference
