Research graph
References from BTRC aggravates FFA-induced lipid accumulation in MASLD via G3BP1 degradation and subsequent SIRT6 mRNA destabilization. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology and diagnosis of metabolic dysfunction-associated fatty liver disease
10.1007/s12072-024-10704-3 · 2024 · External reference
Caffeic acid ameliorates metabolic dysfunction-associated steatotic liver disease via alleviating oxidative damage and lipid accumulation in hepatocytes through activating Nrf2 via targeting Keap1
10.1016/j.freeradbiomed.2024.08.038 · 2024 · External reference
Association between triglyceride-glucose related indices and mortality among individuals with non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease
10.1186/s12933-024-02343-7 · 2024 · External reference
SIRT6 in health and diseases: from molecular mechanisms to therapeutic prospects
10.1016/j.phrs.2025.107984 · 2025 · External reference
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation
10.1016/j.molcel.2022.09.018 · 2022 · External reference
Diosgenin attenuates non-alcoholic fatty liver disease in type 2 diabetes through regulating SIRT6-related fatty acid uptake
10.1016/j.phymed.2023.154661 · 2023 · External reference
LncRNA MEG3 up-regulates SIRT6 by ubiquitinating EZH2 and alleviates nonalcoholic fatty liver disease
10.1038/s41420-022-00889-7 · 2022 · External reference
Impaired SUMOylation of FoxA1 promotes nonalcoholic fatty liver disease through down-regulation of Sirt6
10.1038/s41419-024-07054-1 · 2024 · External reference
Geniposidic acid alleviated metabolic dysfunction-associated steatotic liver disease by exciting SIRT6 signaling
10.1016/j.phymed.2025.157140 · 2025 · External reference
Application of stress granule core element G3BP1 in various diseases: a review
2024 · External reference
G3BP1, a stress granule core protein, ameliorates metabolic dysfunction-associated fatty liver disease by attenuating hepatocyte lipid deposition
10.1111/dom.16302 · 2025 · External reference
Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease
10.1038/s41467-025-63022-z · 2025 · External reference
Beta-transducin repeats-containing proteins as an anticancer target
10.3390/cancers15174248 · 2023 · External reference
The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase
10.1093/jmcb/mjad064 · 2024 · External reference
Knockdown of Gfi1 increases BMSCs exosomal miR-150-3p to inhibit osteoblast ferroptosis in steroid-induced osteonecrosis of the femoral head through BTRC/Nrf2 axis
10.1507/endocrj.ej24-0306 · 2025 · External reference
CircMALAT1 promotes cancer stem-like properties and chemoresistance via regulating Musashi-2/c-Myc axis in esophageal squamous cell carcinoma
2024 · External reference
10.1186/s12935-025-04029-w · 2026 · Admitted local publication
The roles of G3BP1 in human diseases (review)
10.1016/j.gene.2022.146294 · 2022 · External reference
G3BP1 binds to guanine quadruplexes in mRNAs to modulate their stabilities
10.1093/nar/gkab873 · 2021 · External reference
Structure-mediated RNA decay by UPF1 and G3BP1
10.1016/j.molcel.2020.01.021 · 2020 · External reference
The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
2013 · External reference
SIRT6: therapeutic target for nonalcoholic fatty liver disease
10.1016/j.tem.2022.10.004 · 2022 · External reference
Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells
10.1002/hep.31418 · 2021 · External reference
SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
10.26508/lsa.202201448 · 2023 · External reference
