Research graph
References from DHA increases Angptl4 gene expression and reduces LPL activity in a PPARγ-dependent manner in adipocytes. Local targets link to admitted publications; unresolved targets remain external evidence.
An improvement of cardiovascular risk factors by omega-3 polyunsaturated fatty acids
10.14740/jocmr3362w · 2018 · External reference
Science behind the cardio-metabolic benefits of omega-3 polyunsaturated fatty acids: biochemical effects vs. clinical outcomes
10.1039/c8fo00348c · 2018 · External reference
Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis
10.1016/j.jhep.2011.08.018 · 2012 · External reference
Omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases
2024 · External reference
Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies
10.1097/00043798-199604000-00014 · 1996 · External reference
Triglycerides and cardiovascular risk
10.2174/157340309788970315 · 2009 · External reference
Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies
10.1186/s12933-019-0851-z · 2019 · External reference
Triglycerides and risk of atherosclerotic cardiovascular disease: an update
10.1016/j.acvd.2020.11.006 · 2021 · External reference
Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure
10.1038/s41467-025-56790-1 · 2025 · External reference
Marine omega-3 supplementation and cardiovascular disease: an updated meta-analysis of 13 randomized controlled trials involving 127 477 participants
10.1161/jaha.119.013543 · 2019 · External reference
Effect of omega-3 fatty acids on cardiovascular outcomes: a systematic review and meta-analysis
10.1016/j.eclinm.2021.100997 · 2021 · External reference
Omega-3 polyunsaturated fatty acid biomarkers and risk of type 2 diabetes, cardiovascular disease, cancer, and mortality
10.1016/j.clnu.2022.06.034 · 2022 · External reference
EPA/DHA but not ALA reduces visceral adiposity and adipocyte size in high fat diet-induced obese delta-6 desaturase knockout mice
2024 · External reference
The impact of fasting on adipose tissue metabolism
2023 · External reference
Omega-3 fatty acid regulation of lipoprotein lipase and FAT/CD36 and its impact on white adipose tissue lipid uptake
10.1186/s12944-024-02376-7 · 2024 · External reference
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
10.1152/ajpendo.00195.2021 · 2021 · External reference
Angiopoietin-like proteins and postprandial partitioning of fatty acids
10.1097/mol.0000000000000798 · 2022 · External reference
Associations of circulating ANGPTL3, C-terminal domain-containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 complexes with LPL activity, diabetes, inflammation, and cardiovascular mortality
10.1161/circulationaha.124.069272 · 2025 · External reference
Angiopoietin-like protein 4 overexpression in visceral adipose tissue from obese subjects with impaired glucose metabolism and relationship with lipoprotein lipase
10.3390/ijms21197197 · 2020 · External reference
Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation
10.1038/s41387-018-0032-2 · 2018 · External reference
Plasma ANGPTL-4 is associated with obesity and glucose tolerance: cross-sectional and longitudinal findings
10.1002/mnfr.201800060 · 2018 · External reference
The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding
10.1073/pnas.2026650118 · 2021 · External reference
ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain
10.1194/jlr.ilr120000780 · 2020 · External reference
The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding
2016 · External reference
Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin
10.1194/jlr.m047860 · 2014 · External reference
Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor β/δ and protects against fatty acid-induced oxidative stress
10.1161/circresaha.110.217380 · 2010 · External reference
Omega-3 long-chain fatty acids strongly induce angiopoietin-like 4 in humans
10.1194/jlr.m030049 · 2013 · External reference
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
10.1074/jbc.m004029200 · 2000 · External reference
ANGPTL4 mediates the protective role of PPARγ activators in the pathogenesis of preeclampsia
10.1038/cddis.2017.419 · 2017 · External reference
Plant and marine N3-PUFA regulation of fatty acid trafficking along the adipose tissue-liver axis varies according to nutritional state
10.1016/j.jnutbio.2022.108940 · 2022 · External reference
Characterization of sexual dimorphism in ANGPTL4 levels and function
10.1016/j.jlr.2024.100526 · 2024 · External reference
TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4
10.1016/j.bbalip.2017.02.005 · 2017 · External reference
An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes
10.1080/21623945.2015.1111972 · 2016 · External reference
Impact of oral lipid and glucose tolerance tests on the postprandial concentrations of angiopoietin-like proteins (Angptl) 3 and 4
10.1007/s00394-021-02748-0 · 2022 · External reference
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
10.1172/jci.insight.97918 · 2018 · External reference
Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice
10.1038/s41598-021-87020-5 · 2021 · External reference
Omega-3 supplementation and diabetes: a systematic review and meta-analysis
10.1080/10408398.2021.1875977 · 2022 · External reference
Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor α
10.1016/j.jmgm.2008.04.008 · 2008 · External reference
The serum levels of angiopoietin-like protein 3 and 4 in type 2 diabetic patients with and without metabolic syndrome compared to the control group
10.1002/edm2.466 · 2024 · External reference
Peroxisome proliferator-activated receptor γ-mediated up-regulation of syndecan-1 by n−3 fatty acids promotes apoptosis of human breast cancer cells
10.1158/0008-5472.can-07-2305 · 2008 · External reference
15-Lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival
2012 · External reference
Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells
10.1002/jcp.24288 · 2013 · External reference
Regulation of angiopoietin-like protein 4/fasting-induced adipose factor (Angptl4/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytes
10.1017/s0007114507882961 · 2008 · External reference
PPARγ activators down-regulate the expression of PPARγ in 3T3-L1 adipocytes
10.1016/s0014-5793(99)00268-9 · 1999 · External reference
Oleic and palmitic acids induce hepatic angiopoietin-like 4 expression predominantly via PPAR-γ in Larimichthys crocea
10.1017/s000711452100386x · 2023 · External reference
Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue
10.1016/j.molmet.2020.101033 · 2020 · External reference
Peroxisome proliferator activated receptor γ and oxidized docosahexaenoic acids as new class of ligand
10.1007/s00210-007-0251-x · 2008 · External reference
Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels
10.1016/s0021-9258(18)81898-1 · 1989 · External reference
