Research graph
References from Coralyne enhances radiosensitivity of A549 cells by suppressing radiation-induced pro-survival transcriptional programs. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Current treatments for non-small cell lung cancer
2022 · External reference
Update 2025: management of non-small-cell lung cancer
10.1007/s00408-025-00801-x · 2025 · External reference
Recent progress in targeted therapy for non-small cell lung cancer
10.3389/fphar.2023.1125547 · 2023 · External reference
Current landscape of therapeutic resistance in lung cancer and promising strategies to overcome resistance
10.3390/cancers14194562 · 2022 · External reference
Mechanisms of resistance to targeted therapy and immunotherapy in non-small cell lung cancer: promising strategies to overcoming challenges
10.3389/fimmu.2024.1366260 · 2024 · External reference
Overcoming cancer resistance: strategies and modalities for effective treatment
10.3390/biomedicines12081801 · 2024 · External reference
Cell signaling pathways that promote radioresistance of cancer cells
2022 · External reference
Radiation resistance: a matter of transcription factors
2021 · External reference
Radiation-induced signaling pathways that promote cancer cell survival (review)
10.3892/ijo.2014.2614 · 2014 · External reference
Exploring synergistic interactions between natural compounds and conventional chemotherapeutic drugs in preclinical models of lung cancer
10.3390/ph17050598 · 2024 · External reference
Berberine reverses breast cancer multidrug resistance based on fluorescence pharmacokinetics in vitro and in vivo
10.1021/acsomega.0c06288 · 2021 · External reference
Natural alkaloids in cancer therapy: berberine, sanguinarine and chelerythrine against colorectal and gastric cancer
10.3390/ijms25158375 · 2024 · External reference
DNA-binding cytotoxic alkaloids: comparative study of the energetics of binding of berberine, palmatine, and coralyne
10.1089/dna.2008.0779 · 2008 · External reference
RNA targeting through binding of small molecules: studies on t-RNA binding by the cytotoxic protoberberine alkaloid coralyne
10.1039/b816480k · 2009 · External reference
Topoisomerase inhibitor coralyne photosensitizes DNA, leading to elicitation of Chk2-dependent S-phase checkpoint and p53-independent apoptosis in cancer cells
10.1089/ars.2009.2508 · 2010 · External reference
Binding of alkaloids berberine, palmatine and coralyne to lysozyme: a combined structural and thermodynamic study
10.1039/c3ra46053c · 2014 · External reference
The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage
10.1093/nar/29.20.4224 · 2001 · External reference
Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons
10.1016/0968-0896(96)00054-5 · 1996 · External reference
Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne
10.1021/tx950080y · 1996 · External reference
Coralyne has a preference for intercalation between TA·T triples in intramolecular DNA triple helices
10.1093/nar/25.10.1890 · 1997 · External reference
Complete disproportionation of duplex poly(dT)·poly(dA) into triplex poly(dT)·poly(dA)·poly(dT) and poly(dA)
10.1093/nar/30.4.983 · 2002 · External reference
New aspects of the interaction of the antibiotic coralyne with RNA: coralyne induces triple helix formation in poly(rA)·poly(rU)
10.1093/nar/gkp1146 · 2009 · External reference
Coralyne: intercalation with DNA as a possible mechanism of antileukemic action
10.1021/jm00232a020 · 1976 · External reference
Coralyne, a protoberberine alkaloid, causes robust photosensitization of cancer cells through ATR–p38 MAPK–BAX and JAK2–STAT1–BAX pathways
10.1016/j.cbi.2018.02.032 · 2018 · External reference
Mechanism of coralyne-mediated DNA photo-nicking process
10.1016/j.jphotobiol.2019.03.011 · 2019 · External reference
An overview of potential natural photosensitizers in cancer photodynamic therapy
10.3390/biomedicines11010224 · 2023 · External reference
Synergistic enhancement of apoptosis by coralyne and paclitaxel in combination on MDA-MB-231 a triple-negative breast cancer cell line
10.1002/jcb.29114 · 2019 · External reference
Coralyne radiosensitizes A549 cells by upregulation of CDKN1A expression to attenuate radiation induced G2/M block of the cell cycle
10.3390/ijms22115791 · 2021 · External reference
Differential responses by human respiratory epithelial cell lines to respiratory syncytial virus reflect distinct patterns of infection control
10.1128/jvi.02202-17 · 2018 · External reference
Different sensitivity of advanced bronchial and alveolar mono- and coculture models for hazard assessment of nanomaterials
10.3390/nano13030407 · 2023 · External reference
Integrative analysis of gene expression in response to low-dose ionizing radiation in a human skin model
10.1007/s12032-015-0621-z · 2015 · External reference
The DNA damage-induced cell death response: a roadmap to kill cancer cells
10.1007/s00018-016-2130-4 · 2016 · External reference
Chromatin modifications and the DNA damage response to ionizing radiation
2013 · External reference
Ionizing radiation and translation control: a link to radiation hormesis?
10.3390/ijms21186650 · 2020 · External reference
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
10.1038/s41392-023-01705-z · 2023 · External reference
A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALK fusion gene
10.1186/1471-2407-12-558 · 2012 · External reference
Therapeutic targeting of regulated signaling pathways of non-small cell lung carcinoma
10.1021/acsomega.3c02424 · 2023 · External reference
MAPK pathways in radiation responses
10.1038/sj.onc.1206701 · 2003 · External reference
Mitogen-activated protein kinases and their role in radiation response
2013 · External reference
Detection and clinical significance of intratumoral EGFR mutational heterogeneity in Chinese patients with advanced non-small cell lung cancer
2013 · External reference
Targeting K-Ras-mediated DNA damage response in radiation oncology: current status, challenges and future perspectives
2022 · External reference
Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines
10.1158/0008-5472.can-05-0513 · 2005 · External reference
Identification of key molecular pathways and associated genes as targets to overcome radiotherapy resistance using a combination of radiotherapy and immunotherapy in glioma patients
10.3390/ijms25053076 · 2024 · External reference
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
10.1038/s41392-020-0150-x · 2020 · External reference
Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress
10.1371/journal.pone.0182508 · 2017 · External reference
PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy
10.1186/s13578-022-00778-7 · 2022 · External reference
Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer
10.18632/oncotarget.12589 · 2016 · External reference
Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition
10.1038/cddis.2017.471 · 2017 · External reference
DNA double-strand break repair pathways in response to different types of ionizing radiation
10.3389/fgene.2021.738230 · 2021 · External reference
Detection and quantification of γ-H2AX using a dissociation enhanced lanthanide fluorescence immunoassay
10.1038/s41598-021-88296-3 · 2021 · External reference
DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis
10.1016/j.canlet.2012.01.007 · 2013 · External reference
Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
10.1093/mutage/15.4.289 · 2000 · External reference
Effect of hypothermia on radiation-induced micronuclei and delay of cell cycle progression in TK6 cells
10.3109/09553002.2014.887233 · 2014 · External reference
Radiation-induced cell death and its mechanisms
10.1097/hp.0000000000001601 · 2022 · External reference
Cell death: a review of the major forms of apoptosis, necrosis and autophagy
10.1002/cbin.11137 · 2019 · External reference
Life and death by death receptors
10.1096/fj.08-111005 · 2009 · External reference
Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications
10.3390/cells13221838 · 2024 · External reference
Ionizing radiation induces mild and dose-independent damage to mitochondria in newt cells
10.1016/j.yexcr.2025.114575 · 2025 · External reference
Mitochondrial mechanisms of Bcl-2 on ionizing radiation-induced apoptosis
1997 · External reference
Mitochondria–ROS crosstalk in the control of cell death and aging
2012 · External reference
Mitochondrial membrane potential
10.1016/j.ab.2017.07.009 · 2018 · External reference
Berberine increases glucose uptake and intracellular ROS levels by promoting sirtuin 3 ubiquitination
10.1016/j.biopha.2019.109563 · 2020 · External reference
The effects of berberine on reactive oxygen species production in human neutrophils and in cell-free assays
10.1515/intox-2017-0010 · 2017 · External reference
The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction
10.1038/sj.cdd.4401148 · 2003 · External reference
Advances in mitochondrial dysfunction in radiation tissue injury
2025 · External reference
Mitochondria-targeted strategies in cancer radiotherapy: from ROS regulation to immunogenic cell death
10.3389/fcell.2026.1861854 · 2026 · External reference
DNA damage response of U2OS cells to low doses of gamma radiation delivered at very low dose rate
10.1016/j.dnarep.2025.103875 · 2025 · External reference
Unresolved reference
2025 · External reference
Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole
10.1038/s41598-019-46224-6 · 2019 · External reference
