Research graph
References from Microglial GPR56 in synaptic pruning: mechanisms, comparative receptor biology, and context-dependent roles in brain disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration
10.3389/fncel.2019.00063 · 2019 · External reference
Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning
10.4103/1673-5374.385854 · 2024 · External reference
Complement and microglia dependent synapse elimination in brain development
2022 · External reference
Microglia regulate neuronal circuits in homeostatic and high-fat diet-induced inflammatory conditions
10.3389/fncel.2021.722028 · 2021 · External reference
Microglia and aging: the role of the TREM2–DAP12 and CX3CL1-CX3CR1 axes
10.3390/ijms19010318 · 2018 · External reference
TREM2 in CNS homeostasis and neurodegenerative disease
10.1186/s13024-015-0040-9 · 2015 · External reference
TREM2 in Alzheimer's disease: microglial survival and energy metabolism
10.3389/fnagi.2018.00395 · 2018 · External reference
Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells
10.7554/elife.33385 · 2018 · External reference
Adhesion G protein-coupled receptors in nervous system development and disease
10.1038/nrn.2016.86 · 2016 · External reference
Structural basis for regulation of GPR56/ADGRG1 by its alternatively spliced extracellular domains
10.1016/j.neuron.2016.08.022 · 2016 · External reference
Mechanosensitive adhesion G protein-coupled receptors: insights from health and disease
2025 · External reference
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
10.15252/embj.2019104136 · 2020 · External reference
GPR56 S4 variant is required for microglia-mediated synaptic pruning
10.1002/glia.24293 · 2023 · External reference
Genetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5
10.1038/s41419-025-07501-7 · 2025 · External reference
GPR56/ADGRG1 is associated with response to antidepressant treatment
10.1038/s41467-020-15423-5 · 2020 · External reference
A specific GPR56/ADGRG1 splicing isoform is associated with antidepressant response in major depressive disorder
10.1016/j.euroneuro.2025.01.001 · 2025 · External reference
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits
10.1126/sciadv.abm2545 · 2022 · External reference
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation
10.1016/j.neuron.2025.06.020 · 2025 · External reference
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation
10.1016/j.neuron.2025.10.029 · 2025 · External reference
The role of GPR56/ADGRG1 in health and disease
2021 · External reference
GPR56: A potential therapeutic target for neurological and psychiatric disorders
10.1016/j.bcp.2024.116395 · 2024 · External reference
Synaptic pruning by microglia: lessons from genetic studies in mice
10.1159/000541379 · 2025 · External reference
G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination
10.1073/pnas.1104821108 · 2011 · External reference
G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors
10.1007/s00018-024-05416-8 · 2024 · External reference
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning
10.1126/science.1244392 · 2014 · External reference
Disease-Associated Mutations Prevent GPR56-Collagen III Interaction
2012 · External reference
The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development
10.1038/ncomms7121 · 2015 · External reference
Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway
10.1074/jbc.m708919200 · 2008 · External reference
The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity
10.1074/jbc.m111.247973 · 2011 · External reference
GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration
10.1007/s12035-012-8343-0 · 2013 · External reference
GPR56-related bilateral frontoparietal polymicrogyria: further evidence for an overlap with the cobblestone complex
10.1093/brain/awq259 · 2010 · External reference
GPR56 regulates pial basement membrane integrity and cortical lamination
10.1523/jneurosci.0853-08.2008 · 2008 · External reference
The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA
10.1038/ncomms7122 · 2015 · External reference
Adhesion G-protein coupled receptors and extracellular matrix proteins: roles in myelination and glial cell development
10.1002/dvdy.24473 · 2017 · External reference
GPR56-regulated granule cell adhesion is essential for rostral cerebellar development
10.1523/jneurosci.1182-09.2009 · 2009 · External reference
Massively-parallel single nucleus RNA-seq with DroNc-seq
10.1038/nmeth.4407 · 2017 · External reference
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
10.1523/jneurosci.1860-14.2014 · 2014 · External reference
A combination of ontogeny and CNS environment establishes microglial identity
10.1016/j.neuron.2018.05.014 · 2018 · External reference
Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
10.1084/jem.20180247 · 2018 · External reference
Diverse requirements for microglial survival, specification, and function revealed by defined-medium cultures
10.1016/j.neuron.2017.04.043 · 2017 · External reference
An environment-dependent transcriptional network specifies human microglia identity
10.1126/science.aal3222 · 2017 · External reference
The adhesion G protein-coupled receptor GPR56/ADGRG1 in cytotoxic lymphocytes
10.1111/bcpt.13841 · 2023 · External reference
G Protein-Coupled Receptor 56 Characterizes CTLs and Reflects the Progression of Lung Cancer Patients
10.4049/jimmunol.2101048 · 2023 · External reference
Orphan G protein coupled receptors in affective disorders
10.3390/genes11060694 · 2020 · External reference
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
10.1016/j.neuron.2012.03.026 · 2012 · External reference
Neuron-glia signaling in synapse elimination
10.1146/annurev-neuro-070918-050306 · 2019 · External reference
An apoptotic “Eat Me” signal: phosphatidylserine exposure
10.1016/j.tcb.2015.08.003 · 2015 · External reference
Getting to the outer leaflet: physiology of phosphatidylserine exposure at the plasma membrane
10.1152/physrev.00020.2015 · 2016 · External reference
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
10.15252/embj.2020105380 · 2020 · External reference
Microglial MERTK eliminates phosphatidylserine-displaying inhibitory post-synapses
10.15252/embj.2020107121 · 2021 · External reference
CD47 protects synapses from excess microglia-mediated pruning during development
10.1016/j.neuron.2018.09.017 · 2018 · External reference
Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons
10.7554/elife.28360 · 2017 · External reference
Unveiling mechanical activation: GAIN domain unfolding and dissociation in adhesion GPCRs
10.1021/acs.nanolett.3c01163 · 2023 · External reference
The tethered peptide activation mechanism of adhesion GPCRs
10.1038/s41586-022-04575-7 · 2022 · External reference
Complement and microglia mediate early synapse loss in Alzheimer mouse models
10.1126/science.aad8373 · 2016 · External reference
Schizophrenia risk from complex variation of complement component 4
10.1038/nature16549 · 2016 · External reference
The classical complement cascade mediates CNS synapse elimination
10.1016/j.cell.2007.10.036 · 2007 · External reference
Synaptic pruning by microglia is necessary for normal brain development
10.1126/science.1202529 · 2011 · External reference
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior
10.1038/nn.3641 · 2014 · External reference
A unique microglia type associated with restricting development of Alzheimer's disease
10.1016/j.cell.2017.05.018 · 2017 · External reference
The microglial innate immune receptor TREM2 is required for synapse elimination and normal brain connectivity
10.1016/j.immuni.2018.04.016 · 2018 · External reference
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases
10.1016/j.immuni.2017.08.008 · 2017 · External reference
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
10.1038/nature12776 · 2013 · External reference
Biology of the TAM receptors
10.1101/cshperspect.a009076 · 2013 · External reference
A complement-microglial axis drives synapse loss during virus-induced memory impairment
10.1038/nature18283 · 2016 · External reference
What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior
10.3389/fncel.2022.1022431 · 2022 · External reference
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
10.1016/j.cell.2015.01.049 · 2015 · External reference
TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia
10.1016/j.neuron.2016.06.015 · 2016 · External reference
TREM2 variants in Alzheimer's disease
10.1056/nejmoa1211851 · 2013 · External reference
Megf10 is a receptor for C1Q that mediates clearance of apoptotic cells by astrocytes
10.1523/jneurosci.3850-15.2016 · 2016 · External reference
Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia
10.1038/ncomms5046 · 2014 · External reference
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
10.1038/nature06329 · 2007 · External reference
Single-cell transcriptomic analysis of Alzheimer's disease
10.1038/s41586-019-1195-2 · 2019 · External reference
Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist
10.1073/pnas.1421785112 · 2015 · External reference
Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region
10.1073/pnas.1708810114 · 2017 · External reference
Dihydromunduletone is a small-molecule selective adhesion G protein-coupled receptor antagonist
10.1124/mol.116.104828 · 2016 · External reference
Hexahydroquinoline derivatives are selective agonists for the adhesion G protein-coupled receptor ADGRG1/GPR56
10.1124/molpharm.123.000688 · 2023 · External reference
GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force
10.1073/pnas.2008921117 · 2020 · External reference
The adhesion G protein-coupled receptor GPR56/ADGRG1 is an inhibitory receptor on human NK cells
10.1016/j.celrep.2016.04.053 · 2016 · External reference
GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues
10.1093/intimm/dxp116 · 2010 · External reference
Astrocyte-derived Interleukin-33 promotes microglial synapse engulfment and neural circuit development
10.1126/science.aal3589 · 2018 · External reference
Biological studies of post-traumatic stress disorder
10.1038/nrn3339 · 2012 · External reference
