Research graph
References from Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1. Local targets link to admitted publications; unresolved targets remain external evidence.
Transient receptor potential channels: targeting pain at the source
10.1038/nrd2757 · 2009 · External reference
Mammalian transient receptor potential TRPA1 channels: from structure to disease
10.1152/physrev.00005.2019 · 2019 · External reference
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
10.1113/jp270935 · 2016 · External reference
Mouse TRPA1 function and membrane localization is modulated by direct interactions with cholesterol
10.7554/elife.46084 · 2019 · External reference
Lipid raft destabilization impairs mouse TRPA1 responses to cold and bacterial lipopolysaccharides
10.3390/ijms21113826 · 2020 · External reference
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel
10.1016/j.ceca.2020.102255 · 2020 · External reference
Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity
10.1038/srep28763 · 2016 · External reference
The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain
10.1038/s41467-022-33876-8 · 2022 · External reference
Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain
10.1073/pnas.1412689111 · 2014 · External reference
Statin use in prostate Cancer: an update
10.4137/nmi.s38362 · 2016 · External reference
Statins and colorectal cancer
10.1016/j.cgh.2012.08.037 · 2013 · External reference
Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis
10.1038/s41598-018-24248-8 · 2018 · External reference
The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms
10.1186/s40035-018-0110-3 · 2018 · External reference
The pharmacology of statins
10.1016/j.phrs.2014.03.002 · 2014 · External reference
The essential role of transient receptor potential vanilloid 1 in simvastatin-induced activation of endothelial nitric oxide synthase and angiogenesis
10.1111/apha.12378 · 2014 · External reference
Statins activate temperature-gated transient receptor potential ion channels
10.1016/j.ejphar.2025.178206 · 2025 · External reference
The agonist action of Alkylphenols on TRPA1 relates to their effects on membrane lipid order: implications for TRPA1-mediated Chemosensation
10.3390/ijms22073368 · 2021 · External reference
TRP channels as sensors of chemically-induced changes in cell membrane mechanical properties
10.3390/ijms20020371 · 2019 · External reference
Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation
10.1038/s41598-018-30534-2 · 2018 · External reference
Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence
10.1016/s0006-3495(91)82041-0 · 1991 · External reference
Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order
10.1016/s0005-2736(02)00514-x · 2002 · External reference
The increase in bilayer fluidity of rat liver plasma membranes achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes
10.1016/s0021-9258(19)85523-0 · 1980 · External reference
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
10.1038/nature05544 · 2007 · External reference
TRP channel activation by reversible covalent modification
10.1073/pnas.0609598103 · 2006 · External reference
Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor
2023 · External reference
Ligustilide: a novel TRPA1 modulator
10.1007/s00424-011-1021-7 · 2011 · External reference
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels
10.1523/jneurosci.2772-08.2008 · 2008 · External reference
Activation of Drosophila melanogaster TRPA1 isoforms by citronellal and menthol
10.3390/ijms222010997 · 2021 · External reference
Structure of the TRPA1 ion channel suggests regulatory mechanisms
10.1038/nature14871 · 2015 · External reference
Identification of the TRPA1 cannabinoid-binding site
10.1016/j.phrs.2024.107444 · 2024 · External reference
Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein
10.1074/jbc.m114.586891 · 2014 · External reference
Evidence for the role of lipid rafts and sphingomyelin in Ca2+−gating of transient receptor potential channels in trigeminal sensory neurons and peripheral nerve terminals
10.1016/j.phrs.2015.07.028 · 2015 · External reference
Cyclodextrin derivatives decrease transient receptor potential vanilloid 1 and ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion
10.3389/fcell.2024.1334130 · 2024 · External reference
Cyclodextrins inhibit TRPV1 and TRPA1 activation-induced nociception via cholesterol depletion
10.1016/j.jlr.2025.100844 · 2025 · External reference
Statins-from fungi to pharmacy
10.3390/ijms25010466 · 2023 · External reference
To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions
10.1007/s00424-018-2205-1 · 2019 · External reference
What is a relevant statin concentration in cell experiments claiming pleiotropic effects?
10.1111/j.1365-2125.2011.03907.x · 2011 · External reference
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
1996 · External reference
Pharmacokinetics of high-dose simvastatin in refractory and relapsed chronic lymphocytic leukemia patients
10.1007/s00280-013-2326-3 · 2013 · External reference
TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine
10.1074/jbc.m609600200 · 2007 · External reference
Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner
10.1007/s00424-011-1069-4 · 2012 · External reference
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
10.1038/s41586-020-2480-9 · 2020 · External reference
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
10.1084/jem.20201637 · 2021 · External reference
A non-covalent ligand reveals biased Agonism of the TRPA1 Ion Channel
10.1016/j.neuron.2020.10.014 · 2021 · External reference
Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential Ankyrin 1 (TRPA1) for activation by Eudesmol, an oxygenized Sesquiterpene in hop essential oil
10.1074/jbc.m114.600932 · 2015 · External reference
Bimodal action of menthol on the transient receptor potential channel TRPA1
10.1523/jneurosci.2221-07.2007 · 2007 · External reference
The role of structure and biophysical properties in the pleiotropic effects of statins
10.3390/ijms21228745 · 2020 · External reference
Trp12, a novel Trp related protein from kidney
10.1016/s0014-5793(00)02212-2 · 2000 · External reference
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
10.1016/s0092-8674(03)00158-2 · 2003 · External reference
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
10.1002/emmm.201100134 · 2011 · External reference
A new generation of Ca2+ indicators with greatly improved fluorescence properties
10.1016/s0021-9258(19)83641-4 · 1985 · External reference
Alterations in membrane fluidity and dynamics in experimental colon cancer and its chemoprevention by diclofenac
10.1007/s11010-010-0441-6 · 2010 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
Differentiation of 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors by their relative lipophilicity
10.1211/146080899128734820 · 1999 · External reference
