Research graph
References from CSN-associated c-Cbl control alternative NF-κB/RelB activity in Helicobacter pylori infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Helicobacter pylori and cancer: what's the link?
10.2147/ceg.s495588 · 2026 · External reference
Pathogenicity and virulence of Helicobacter pylori: a paradigm of chronic infection
10.1080/21505594.2024.2438735 · 2025 · External reference
ADP-heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori
10.1096/fj.201802555r · 2019 · External reference
Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose
10.1038/s41586-018-0433-3 · 2018 · External reference
TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-κB pathways
10.15252/embr.202152878 · 2021 · External reference
The SCF β-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro
10.1101/gad.13.3.270 · 1999 · External reference
The COP9 signalosome: a versatile regulatory hub of Cullin-RING ligases
10.1016/j.tibs.2022.08.003 · 2023 · External reference
The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth
10.1038/s41418-019-0402-x · 2020 · External reference
The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1
10.1016/j.cub.2005.05.059 · 2005 · External reference
CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha
10.1038/sj.emboj.7601600 · 2007 · External reference
USP48 and A20 synergistically promote cell survival in helicobacter pylori infection
10.1007/s00018-022-04489-7 · 2022 · External reference
A20 undermines alternative NF-κB activity and expression of anti-apoptotic genes in Helicobacter pylori infection
10.1007/s00018-022-04139-y · 2022 · External reference
Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100
10.1074/jbc.c200151200 · 2002 · External reference
beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870
10.1016/j.cellsig.2005.10.011 · 2006 · External reference
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase
10.1038/sj.emboj.7601489 · 2007 · External reference
CSN-associated USP48 confers stability to nuclear NF-κB/RelA by trimming K48-linked Ub-chains
10.1016/j.bbamcr.2014.11.028 · 2015 · External reference
Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defense against infection
10.1136/gutjnl-2017-314540 · 2019 · External reference
Transcription of the RelB gene is regulated by NF-kappaB
10.1038/sj.onc.1204868 · 2001 · External reference
RelA repression of RelB activity induces selective gene activation downstream of TNF receptors
10.1073/pnas.0507342102 · 2005 · External reference
RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF
10.1093/emboj/cdg004 · 2003 · External reference
Cooperation between classical and alternative NF-κB pathways regulates proinflammatory responses in epithelial cells
10.1165/rcmb.2012-0014oc · 2012 · External reference
Human gastric fibroblasts ameliorate A20-dependent cell survival in co-cultured gastric epithelial cells infected by Helicobacter pylori
10.1016/j.bbamcr.2022.119364 · 2022 · External reference
Bacterial ADP-heptose triggers stem cell regeneration in intestinal epithelium following injury
10.1016/j.stem.2025.06.009 · 2025 · External reference
CYLD-TRAF6 interaction promotes ADP-heptose induced NF-κB signaling in H. Pylori infection
10.1038/s44319-025-00480-y · 2025 · External reference
Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis
10.15252/embj.2021109996 · 2022 · External reference
EGF and BMPs govern differentiation and patterning in human gastric glands
10.1053/j.gastro.2021.04.062 · 2021 · External reference
Promoter methylation in head and neck squamous cell carcinoma cell lines is significantly different than methylation in primary tumors and xenografts
10.1371/journal.pone.0020584 · 2011 · External reference
DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity
10.1186/s13148-022-01406-4 · 2022 · External reference
Dynamic regulation of the COP9 signalosome in response to DNA damage
10.1128/mcb.01598-13 · 2014 · External reference
Post-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc/Lin28B/let-7 pathway
10.1016/j.jmb.2011.04.041 · 2011 · External reference
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
10.1038/nature07884 · 2009 · External reference
p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα
10.1111/jcmm.12702 · 2016 · External reference
Differential dysregulation of β-TRCP1 and −2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells
2023 · External reference
The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells
10.1158/1078-0432.ccr-13-0987 · 2014 · External reference
PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
10.1038/ni1464 · 2007 · External reference
E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation
10.1126/sciadv.abe5171 · 2021 · External reference
The emerging roles of non-canonical ubiquitination in proteostasis and beyond
10.1083/jcb.202311171 · 2024 · External reference
The nuclear export signal of IκBα drives RelB oscillations in the noncanonical NF-κB pathway
10.1111/gtc.70135 · 2026 · External reference
C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6
2019 · External reference
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
10.1038/nsmb.2231 · 2012 · External reference
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
10.1074/jbc.m404114200 · 2004 · External reference
Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins
10.1074/jbc.m102219200 · 2001 · External reference
