Research graph
References from Lipid metabolic regulation and targeting strategies in the brain metastasis tumor microenvironment. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of brain metastases and leptomeningeal disease
10.1093/neuonc/noab101 · 2021 · External reference
Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis
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Population-based estimates of survival among elderly patients with brain metastases
10.1093/neuonc/noaa233 · 2021 · External reference
Targeted modulation of the meningeal lymphatic reverse pathway for immunotherapy of breast Cancer brain metastases
10.1021/acsnano.4c15860 · 2025 · External reference
Adipose tissue aging as a risk factor for metabolic organ abnormalities: mechanistic insights and the role of exercise interventions
10.1186/s12944-025-02695-3 · 2025 · External reference
Postoperative Tongqi formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder
10.1016/j.heliyon.2024.e41217 · 2025 · External reference
An innovative Lipidomic workflow to investigate the lipid profile in a cystic fibrosis cell line
10.3390/cells9051197 · 2020 · External reference
Effects of regular exercise on the biochemical, oxidative, and inflammatory profiles and quality of life in older Spaniards with metabolic syndrome
10.3390/antiox13040450 · 2024 · External reference
NF-κB-mediated cytokine secretion and glutamate metabolic reprogramming converge in breast cancer brain tropism
10.1016/j.canlet.2025.217907 · 2025 · External reference
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases
2023 · External reference
Metabolic adaptations of brain metastasis
10.1038/s41568-025-00848-1 · 2025 · External reference
AS602801 treatment suppresses breast cancer metastasis to the brain by interfering with gap-junction communication by regulating Cx43 expression
10.1002/ddr.22124 · 2023 · External reference
Influence of exosomes on astrocytes in the pre-metastatic niche of lung Cancer brain metastases
10.1186/s12575-023-00192-4 · 2023 · External reference
Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers
10.1186/s13045-021-01179-y · 2021 · External reference
Emerging role of metabolic reprogramming in the immune microenvironment and immunotherapy of thyroid cancer
10.1016/j.intimp.2024.113702 · 2025 · External reference
SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma
10.4251/wjgo.v17.i7.107971 · 2025 · External reference
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux
10.1016/j.jare.2024.01.028 · 2025 · External reference
Tumour cell-expressed PD-L1 reprograms lipid metabolism via EGFR/ITGB4/SREBP1c signalling in liver cancer
10.1016/j.jhepr.2024.101009 · 2024 · External reference
Crosstalk between stromal, immune, and ovarian cancer cells in lipid-rich tumor microenvironment exhibits proliferative features
2025 · External reference
Metabolic reprogramming and cancer progression
10.1126/science.aaw5473 · 2020 · External reference
Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma
2025 · External reference
Reshaping the tumor immune microenvironment to improve CAR-T cell-based cancer immunotherapy
10.1186/s12943-024-02079-8 · 2024 · External reference
Ubiquitination in lipid metabolism reprogramming: implications for pediatric solid tumors
2025 · External reference
ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway
10.1016/j.canlet.2020.12.019 · 2021 · External reference
Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia
10.1016/j.freeradbiomed.2024.01.028 · 2024 · External reference
Stimulation of neutral lipid synthesis via viral growth factor signaling and ATP citrate lyase during vaccinia virus infection
10.1128/jvi.01103-24 · 2024 · External reference
Effect of heterologous expression of key enzymes involved in Astaxanthin and lipid synthesis on lipid and carotenoid production in Aurantiochytrium sp
10.3390/md23040164 · 2025 · External reference
Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy
10.1016/j.apsb.2024.07.021 · 2024 · External reference
Integrated transcriptome and metabolome analysis reveals the regulatory mechanisms of FASN in geese granulosa cells
10.3390/ijms232314717 · 2022 · External reference
DHA suppresses hormone-sensitive and castration-resistant prostate cancer growth by decreasing de novo lipogenesis
2025 · External reference
Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids
10.1038/s41556-023-01136-6 · 2023 · External reference
SCD1-mediated lipid metabolism alleviates neuronal Ferroptosis in subarachnoid hemorrhage: role of oleic acid supplementation
10.1007/s12035-025-05006-0 · 2025 · External reference
FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination
10.1186/s13046-025-03548-8 · 2025 · External reference
P. gingivalis infection upregulates PD-L1 expression on dendritic cells, suppresses CD8+ T-cell responses, and aggravates oral cancer
10.1158/2326-6066.cir-22-0541 · 2023 · External reference
Porphyromonas gingivalis potentiates stem-like properties of oral squamous cell carcinoma by modulating SCD1-dependent lipid synthesis via NOD1/KLF5 axis
10.1038/s41368-024-00342-8 · 2025 · External reference
Cholesterol sulfate as a negative regulator of cellular cholesterol homeostasis
2025 · External reference
SREBP-2 promotes cancer progression through the mevalonate-Akt pathway in non-small cell lung cancer
10.1038/s41598-025-07437-0 · 2025 · External reference
Assaying sterol-regulated ER-to-Golgi transport of SREBP cleavage-activating protein using immunofluorescence microscopy
2023 · External reference
Key events in cancer: dysregulation of SREBPs
2023 · External reference
Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression
10.1038/s41598-024-81746-8 · 2024 · External reference
NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway
2023 · External reference
Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer
10.1136/gutjnl-2024-334361 · 2025 · External reference
Effects of aerobic exercise on the regulation of mitochondrial carrier homolog-2 and its influence on the catabolic and anabolic activity of lipids in the mesenteric adipose tissue of obese mice
10.1016/j.lfs.2024.122567 · 2024 · External reference
Citrate promotes excessive lipid biosynthesis and senescence in tumor cells for tumor therapy
10.1002/advs.202101553 · 2021 · External reference
Hypoxia expedites the progression of papillary thyroid carcinoma by promoting the CPT1A-mediated fatty acid oxidative pathway
10.1002/ddr.22168 · 2024 · External reference
High levels of Erucic acid cause lipid deposition, decreased antioxidant and immune abilities via inhibiting lipid catabolism and increasing lipogenesis in black carp (Mylopharyngodon piceus)
10.3390/ani14142102 · 2024 · External reference
Triacylglycerol uptake and handling by macrophages: from fatty acids to lipoproteins
10.1016/j.plipres.2023.101250 · 2023 · External reference
Macropinocytosis at the crossroad between nutrient scavenging and metabolism in cancer
10.1016/j.ceb.2024.102359 · 2024 · External reference
Fatty acid-binding protein 4 in cardiovascular and metabolic diseases
10.5551/jat.48710 · 2019 · External reference
Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma
10.4251/wjgo.v17.i1.98409 · 2025 · External reference
SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia
10.1038/s41598-024-58689-1 · 2024 · External reference
Combined blockade of lipid uptake and synthesis by CD36 inhibitor and SCD1 siRNA is beneficial for the treatment of refractory prostate cancer
10.1002/advs.202412244 · 2024 · External reference
Gankyrin-deficiency reprograms intrahepatic glucose and lipid metabolism to delay liver regeneration
10.3724/abbs.2025086 · 2025 · External reference
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication
10.1038/s41556-018-0250-9 · 2019 · External reference
Exosomal FABP5 drives HCC progression via macrophage lipid metabolism and immune microenvironment remodeling
10.3389/fimmu.2025.1644645 · 2025 · External reference
Exosomal NAT10 from esophageal squamous cell carcinoma cells modulates macrophage lipid metabolism and polarization through ac4C modification of FASN
10.1016/j.tranon.2024.101934 · 2024 · External reference
Emerging roles for the epigenetic modifiers PBRM1 SETD2 and BAP1 in clear cell renal cell carcinoma pathogenesis and prognosis beyond VHL
2026 · External reference
The AHCY–adenosine complex rewires mRNA methylation to enhance fatty acid biosynthesis and tumorigenesis
10.1038/s41422-025-01213-5 · 2026 · External reference
Acetyl-CoA metabolism in cancer
10.1038/s41568-022-00543-5 · 2023 · External reference
ATP citrate lyase promotes the progression of hepatocellular carcinoma by activating the REGgamma-proteasome pathway
10.1002/mc.23777 · 2024 · External reference
Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor developmen
2022 · External reference
Metabolism: an important player in glioma survival and development
2024 · External reference
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling
10.1038/s41467-025-67534-6 · 2025 · External reference
Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma
10.1080/15592294.2022.2069386 · 2022 · External reference
S-Adenosylmethionine: a multifaceted regulator in cancer pathogenesis and therapy
10.3390/cancers17030535 · 2025 · External reference
Deficiencies in one-carbon metabolism led to increased neurological disease risk and worse outcome: homocysteine is a marker of disease state
10.3389/fnut.2024.1285502 · 2024 · External reference
Mammalian SIRT6 represses invasive Cancer cell phenotypes through ATP citrate Lyase (ACLY)-dependent histone acetylation
10.3390/genes12091460 · 2021 · External reference
Targeting sirtuins for cancer therapy: epigenetics modifications and beyond
10.7150/thno.100667 · 2024 · External reference
Pirfenidone reverts global DNA Hypomethylation, promoting DNMT1/UHRF/PCNA coupling complex in experimental Hepatocarcinoma
10.3390/cells13121013 · 2024 · External reference
The epigenetic landscape of brain metastasis
10.1038/s41388-025-03315-1 · 2025 · External reference
Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes
10.1016/j.trecan.2024.08.005 · 2024 · External reference
The brain microenvironment induces DNMT1 suppression and indolence of metastatic cancer cells
10.1016/j.isci.2020.101480 · 2020 · External reference
The emerging intertwined activities of metabolism and epigenetics unveils culprits and prospects in cancer
10.1038/s12276-025-01537-7 · 2025 · External reference
Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis
10.1186/s12967-023-04403-0 · 2023 · External reference
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma
10.1111/jcmm.18129 · 2024 · External reference
Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
10.1038/s12276-023-01020-1 · 2023 · External reference
Lipid metabolism analysis in esophageal cancer and associated drug discovery
10.1016/j.jpha.2023.08.019 · 2024 · External reference
Understanding the cell survival mechanism of anoikis-resistant cancer cells during different steps of metastasis
10.1007/s10585-022-10172-9 · 2022 · External reference
ASS1 enhances anoikis resistance via AMPK/CPT1A-mediated fatty acid metabolism in ovarian cancer
10.1016/j.canlet.2024.217082 · 2025 · External reference
PERK-mediated cholesterol excretion from IDH mutant glioma determines anti-Tumoral polarization of microglia. Advanced
2023 · External reference
Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential
10.1080/14728222.2023.2255377 · 2023 · External reference
The IGF2BP3–FASN axis drives lipid metabolic reprogramming to promote brain colonization in non-small cell lung cancer
2025 · External reference
Lung cancer cells upregulate stearoyl-CoA desaturase 1 in microglia by activating the STAT3 pathway to change microglial inflammatory response in lung-to-brain metastases
10.1038/s41419-025-08003-2 · 2025 · External reference
Fatty acid synthesis is required for breast cancer brain metastasis
2021 · External reference
Comparison of immune microenvironments between primary tumors and brain metastases in patients with breast cancer
10.18632/oncotarget.22110 · 2017 · External reference
A comprehensive profiling of the immune microenvironment of breast cancer brain metastases
10.1093/neuonc/noac136 · 2022 · External reference
Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI. Nature
2025 · External reference
Melanoma-secreted amyloid Beta suppresses neuroinflammation and promotes brain metastasis
10.1158/2159-8290.cd-21-1006 · 2022 · External reference
FASN promotes lipid metabolism and progression in colorectal cancer via the SP1/PLA2G4B axis
2025 · External reference
Emerging roles for fatty acid oxidation in cancer
2025 · External reference
Self-amplified ROS production from fatty acid oxidation enhanced tumor immunotherapy by atorvastatin/PD-L1 siRNA lipopeptide nanoplexes
10.1016/j.biomaterials.2022.121902 · 2022 · External reference
A HIF-1alpha inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells
10.1186/s40170-023-00328-w · 2023 · External reference
Targeting fatty acid oxidation enhances response to HER2-targeted therapy
10.1038/s41467-024-50998-3 · 2024 · External reference
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
10.1038/nchembio.2239 · 2017 · External reference
Driving factors of neuronal ferroptosis
10.1016/j.tcb.2024.01.010 · 2024 · External reference
ACSS2 suppresses Ferroptosis to drive breast Cancer brain metastasis
10.1158/0008-5472.can-25-3006 · 2026 · External reference
ANG peptide-modified exosomes loaded with oleanolic acid target GPX4 for enhanced breast cancer brain metastasis therapy
10.1007/s11060-025-05375-5 · 2025 · External reference
Research progress on ferroptosis in diabetic kidney disease
10.3389/fendo.2022.945976 · 2022 · External reference
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
10.1038/s41586-019-1705-2 · 2019 · External reference
Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models
10.1038/s42003-025-07977-1 · 2025 · External reference
Nodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance
10.1038/s41419-023-05756-6 · 2023 · External reference
Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer
2021 · External reference
Molecular signaling network and therapeutic developments in breast cancer brain metastasis
10.1016/j.adcanc.2022.100079 · 2023 · External reference
Polyunsaturated fatty acids from astrocytes activate PPARγ signaling in cancer cells to promote brain metastasis
10.1158/2159-8290.cd-19-0270 · 2019 · External reference
Metabolic partitioning in the brain and its hijacking by glioblastoma
10.1101/gad.350693.123 · 2023 · External reference
Integrated transcriptome profiling and Pan-Cancer analyses reveal oncogenic networks and tumor-immune modulatory roles for FABP7 in brain cancers
10.3390/ijms252212231 · 2024 · External reference
Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis
10.1186/s12943-023-01741-x · 2023 · External reference
Central nervous system cholesterol metabolism in health and disease
10.1002/iub.2662 · 2022 · External reference
CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes
10.7554/elife.44702 · 2019 · External reference
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
10.1038/s41593-024-01749-6 · 2024 · External reference
An overview of oligodendrocyte metabolism
2025 · External reference
Identification of hub genes significantly linked to tuberous sclerosis related-epilepsy and lipid metabolism via bioinformatics analysis
10.3389/fneur.2024.1354062 · 2024 · External reference
Unveiling microglia heterogeneity in intracerebral hemorrhage
10.1016/j.neuroscience.2024.07.039 · 2024 · External reference
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke
10.1038/s42255-025-01379-7 · 2025 · External reference
Metabolic adaptation of myeloid cells in the glioblastoma microenvironment
10.3389/fimmu.2024.1431112 · 2024 · External reference
The brain-penetrant Pan-ErbB inhibitor Poziotinib effectively targets HER2+ breast cancer brain metastases
10.1158/0008-5472.can-24-1793 · 2025 · External reference
The vicious cycle of melanoma-microglia crosstalk: inter-melanoma variations in the brain-metastasis-promoting IL-6/JAK/STAT3 signaling pathway
10.3390/cells12111513 · 2023 · External reference
PI3K: a master regulator of brain metastasis-promoting macrophages/microglia
10.1002/glia.23485 · 2018 · External reference
Biological profile of breast cancer brain metastasis. Acta Neuropathologica
2025 · External reference
Sphingolipid metabolism in glioblastoma and metastatic brain tumors: a review of sphingomyelinases and Sphingosine-1-phosphate
10.3390/biom10101357 · 2020 · External reference
The role of sphingosine-1-phosphate in inflammation and cancer progression
10.1111/cas.13802 · 2018 · External reference
Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice
10.1111/acel.14047 · 2023 · External reference
Mitochondrial fatty acid oxidase CPT1A ameliorates postoperative cognitive dysfunction by regulating astrocyte ferroptosis
10.1016/j.brainres.2024.149424 · 2025 · External reference
CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
10.1186/s13293-023-00498-8 · 2023 · External reference
Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells
10.1039/d1bm00689d · 2021 · External reference
Melatonin inhibiting neuronal cells Ferroptosis through lipid metabolic reprogramming
10.1007/s12035-025-05035-9 · 2025 · External reference
Tumor metabolic reprogramming by Adipokines as a critical driver of obesity-associated cancer progression
10.3390/ijms22031444 · 2021 · External reference
Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression. Nature
2018 · External reference
Co-option of neutrophil fates by tissue environments
10.1016/j.cell.2020.10.003 · 2020 · External reference
Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis
10.1016/j.apsb.2023.01.020 · 2023 · External reference
Ovarian cancer-intrinsic fatty acid synthase prevents anti-tumor immunity by disrupting tumor-infiltrating dendritic cells
10.3389/fimmu.2018.02927 · 2018 · External reference
Dendritic cell-based in situ nanovaccine for reprogramming lipid metabolism to boost tumor immunotherapy
10.1021/acsnano.3c06784 · 2023 · External reference
Targeting CD36-mediated lipid metabolism by selective inhibitor-augmented antitumor immune responses in Oral Cancer
10.3390/ijms25179438 · 2024 · External reference
The impact of lipids on the cancer–immunity cycle and strategies for modulating lipid metabolism to improve cancer immunotherapy
10.1016/j.apsb.2022.10.027 · 2023 · External reference
Impaired natural killer cell maturation in lung adenocarcinoma driven by FABP4 and SPON2 downregulation through disrupted lipid metabolism
10.21037/tlcr-24-1027 · 2025 · External reference
MEF2C regulates NK cell effector functions through control of lipid metabolism
10.1038/s41590-024-01811-2 · 2024 · External reference
Astrocyte involvement in brain metastasis: from biological mechanisms to therapeutic strategies
10.1007/s10555-025-10276-0 · 2025 · External reference
Serpins promote cancer cell survival and vascular co-option in brain metastasis
10.1016/j.cell.2014.01.040 · 2014 · External reference
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis
10.1038/s41556-023-01273-y · 2023 · External reference
CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma
10.1016/j.immuni.2023.07.015 · 2023 · External reference
Oligodendroglial myelination requires astrocyte-derived lipids
2017 · External reference
Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity
10.1016/j.cell.2019.04.001 · 2019 · External reference
Lipid metabolism in microglia: emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (review)
10.3892/ijmm.2025.5580 · 2025 · External reference
Glioma-astrocyte connexin43 confers temozolomide resistance through activation of the E2F1/ERCC1 axis
10.1093/neuonc/noae237 · 2025 · External reference
Normobaric hyperoxia plays a neuroprotective role after cerebral ischemia by maintaining the redox homeostasis and the level of connexin43 in astrocytes
10.1111/cns.13875 · 2022 · External reference
Gastrodin liposomes block crosstalk between astrocytes and glioma cells via downregulating Cx43 to improve Antiglioblastoma efficacy of Temozolomide
10.1021/acs.bioconjchem.4c00300 · 2024 · External reference
Carcinoma–astrocyte gap junction interruption by a dual-targeted biomimetic liposomal system to attenuate chemoresistance and treat brain metastasis
10.1021/acsnano.4c09996 · 2024 · External reference
Inhibitory effects of miRNAs in astrocytes on C6 glioma progression via connexin 43
10.1007/s11010-021-04118-0 · 2021 · External reference
ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism
10.1016/j.celrep.2020.108572 · 2021 · External reference
Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer
10.1186/s12967-022-03510-8 · 2022 · External reference
Region-specific CD16+ neutrophils promote colorectal Cancer progression by inhibiting natural killer cells
10.1002/advs.202403414 · 2024 · External reference
Lipids in the tumor microenvironment: from cancer progression to treatment
10.1016/j.plipres.2020.101055 · 2020 · External reference
First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors
10.1016/j.eclinm.2021.100797 · 2021 · External reference
Phase II investigation of TVB-2640 (Denifanstat) with bevacizumab in patients with first relapse high-grade astrocytoma
10.1158/1078-0432.ccr-22-2807 · 2023 · External reference
A brain-penetrant Stearoyl-CoA desaturase inhibitor reverses alpha-Synuclein toxicity
10.1007/s13311-022-01199-7 · 2022 · External reference
Non-clinical pharmacology of YTX-7739: a clinical stage Stearoyl-CoA desaturase inhibitor being developed for Parkinson's disease
10.1007/s12035-021-02695-1 · 2022 · External reference
A CD36-targeting thermosensitive Berberine Nanogel blocks tumor lipid hijacking and potentiates anti-PD-L1 immunotherapy in triple-negative breast Cancer
10.1021/acs.molpharmaceut.5c01378 · 2026 · External reference
CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability
10.1016/j.cmet.2021.02.015 · 2021 · External reference
PLT012, a humanized CD36-blocking antibody, is effective for unleashing antitumor immunity against liver Cancer and liver metastasis
10.1158/2159-8290.cd-24-1409 · 2025 · External reference
The dual role of CD36 in cancer: from lipid metabolism to tumor microenvironment regulation
10.1007/s11033-025-10885-6 · 2025 · External reference
FABP5+ lipid-loaded macrophages process tumour-derived unsaturated fatty acid signal to suppress T-cell antitumour immunity
10.1016/j.jhep.2024.09.029 · 2025 · External reference
ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells
10.1016/j.apsb.2023.09.005 · 2023 · External reference
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism
10.1038/nature17412 · 2016 · External reference
Enhanced doxorubicin delivery to the brain administered through glutathione PEGylated liposomal doxorubicin (2B3–101) as compared with generic Caelyx,((R))/Doxil((R))--a cerebral open flow microperfusion pilot study
10.1002/jps.23994 · 2014 · External reference
Phase 1/2A study of glutathione Pegylated liposomal doxorubicin (2B3-101) in patients with brain metastases (Bm) from solid tumors or recurrent high grade gliomas (Hgg)
10.1093/annonc/mdu331.32 · 2014 · External reference
Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101)
10.1371/journal.pone.0082331 · 2014 · External reference
Cavitation feedback control of focused ultrasound blood-brain barrier opening for drug delivery in patients with Parkinson's disease
10.3390/pharmaceutics14122607 · 2022 · External reference
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases
10.1126/scitranslmed.abj4011 · 2021 · External reference
Hypoxia-related CircARSB modulates lipid metabolism and innate immune crosstalk to influence immune checkpoint inhibitor response in hepatocellular carcinoma
10.1016/j.canlet.2025.218188 · 2026 · External reference
The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy
10.1016/j.cclet.2024.109996 · 2025 · External reference
Biomimetic nanocomposites camouflaged with hybrid cell membranes for accurate therapy of early-stage glioma
2023 · External reference
Treatment of Parkinson's disease with biologics that penetrate the blood-brain barrier via receptor-mediated transport
10.3389/fnagi.2023.1276376 · 2023 · External reference
Abdominal manual therapy repairs interstitial cells of Cajal and increases colonic c-kit expression when treating bowel dysfunction after spinal cord injury
10.1155/2017/1492327 · 2017 · External reference
The isolated brain microvessel: a versatile experimental model of the blood-brain barrier
10.3389/fphys.2020.00398 · 2020 · External reference
Smuggling drugs into the brain: an overview of ligands targeting transcytosis for drug delivery across the blood-brain barrier
10.3390/pharmaceutics6040557 · 2014 · External reference
Current chemical, biological, and physiological views in the development of successful brain-targeted pharmaceutics
10.1007/s13311-022-01228-5 · 2022 · External reference
Overcoming the blood-brain barrier: successes and challenges in developing nanoparticle-mediated drug delivery Systems for the Treatment of brain Tumours
10.2147/ijn.s231479 · 2020 · External reference
Fabrication of hairpin DNA-functionalized polydopamine-coated gold nanoparticles as a theranostic nanoplatform for effective delivery of daunorubicin: binding affinity, drug release and cytotoxicity study
10.1016/j.jddst.2026.107982 · 2026 · External reference
Biomimetic nanovesicle co-delivery system impairs energy metabolism for cancer treatment
10.1186/s12951-023-02061-4 · 2023 · External reference
Restoring antitumor immunity by reprogramming abnormal lipid metabolism in the tumor microenvironment using irisin-manganese co-loaded nanoparticles
10.1016/j.actbio.2026.01.011 · 2026 · External reference
Discovery and pharmacological characterization of SAR707 as novel and selective small molecule inhibitor of stearoyl-CoA desaturase (SCD1)
10.1016/j.ejphar.2013.03.019 · 2013 · External reference
Brain cholesterol homeostasis and its association with neurodegenerative diseases
10.1016/j.neuint.2023.105635 · 2023 · External reference
Hyperpolarized 13C MRI: path to clinical translation in oncology
10.1016/j.neo.2018.09.006 · 2019 · External reference
Harnessing nanoparticles for Alzheimer's disease: innovations in drug delivery and pathology-specific treatments
10.1177/13872877251374149 · 2025 · External reference
Systematic screening of metabolic pathways to identify two breast cancer subtypes with divergent immune characteristics
2025 · External reference
Combined widely targeted Metabolomic, transcriptomic, and spatial Metabolomic analysis reveals the potential mechanism of coloration and fruit quality formation in Actinidia chinensis cv. Hongyang
10.3390/foods13020233 · 2024 · External reference
Prognostic risk modeling of endometrial cancer using programmed cell death-related genes: a comprehensive machine learning approach
2025 · External reference
Fungal Coculture: unlocking the potential for efficient bioconversion of lignocellulosic biomass
10.3390/jof11060458 · 2025 · External reference
Metabolism in the progression and metastasis of brain tumors
10.1016/j.canlet.2022.215713 · 2022 · External reference
