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References from Dietary advanced glycation end products are associated with anxiety- and depression-like behavior in male mice via gut microbiota mediated disruption of tryptophan metabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
10.1016/j.chom.2018.05.003 · 2018 · External reference
The Microbiota-Gut-Brain Axis in the Pathophysiology of Major Depressive Disorder: a Mechanistic Review
10.1002/cph4.70100 · 2026 · External reference
The aryl hydrocarbon receptor and the gut-brain axis
10.1038/s41423-020-00585-5 · 2021 · External reference
Unresolved reference
2009 · External reference
The effect of Short-Term Consumption of Lactic Acid Bacteria on the Gut Microbiota in Obese People
10.3390/nu14163384 · 2022 · External reference
10.3390/ijms27010465
10.3390/ijms27010465 · 2026 · External reference
Tryptophan in health and disease
10.1016/bs.acc.2019.08.005 · 2020 · External reference
Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms
10.1186/s12916-024-03248-8 · 2024 · External reference
The Microbiota-Gut-Brain Axis
10.1152/physrev.00018.2018 · 2019 · External reference
From inflammation to sickness and depression: when the immune system subjugates the brain
10.1038/nrn2297 · 2008 · External reference
Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study
10.1038/s41366-021-01049-0 · 2022 · External reference
Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain
10.1080/19490976.2020.1869501 · 2021 · External reference
Advanced Glycation End Products Promote Melanogenesis by Activating NLRP3 Inflammasome in Human Dermal Fibroblasts
2022 · External reference
On determining sample size in experiments involving laboratory animals
10.1177/0023677217738268 · 2018 · External reference
Gut microbiota composition in depressive disorder: a systematic review, meta-analysis, and meta-regression
10.1038/s41398-023-02670-5 · 2023 · External reference
Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis
10.1016/j.coph.2019.08.004 · 2019 · External reference
Amino Acid Trp: the Far out Impacts of host and Commensal Tryptophan Metabolism
10.3389/fimmu.2021.653208 · 2021 · External reference
Bifidobacterium bifidum Ameliorates DSS-Induced Colitis in mice by Regulating Microbial Metabolome and Targeting Gut Microbiota
10.1021/acs.jafc.4c00365 · 2024 · External reference
Relationship between Obesity, Gut Microbiome and Hepatocellular Carcinoma Development
10.1159/000371679 · 2015 · External reference
Neuroimmune dysregulation in Alzheimer's disease: Mechanisms and therapeutic strategies
10.1016/j.arr.2026.103055 · 2026 · External reference
Dietary glycation compounds - implications for human health
10.1080/10408444.2024.2362985 · 2024 · External reference
Serotonin, Kynurenine, and Indole Pathways of Tryptophan Metabolism in Humans in Health and Disease
10.3390/nu18030507 · 2026 · External reference
Potential Impact of Microbial Dysbiosis and Tryptophan Metabolites in Advanced Stages of Colorectal Cancer
10.3390/biomedicines14010026 · 2025 · External reference
You've got male: sex and the microbiota-gut-brain axis across the lifespan
10.1016/j.yfrne.2019.100815 · 2020 · External reference
Unresolved reference
2021 · External reference
The importance of BDNF and RAGE in diabetes-induced dementia
10.1016/j.phrs.2020.105083 · 2020 · External reference
Sex differences in Gut Microbiota
10.5534/wjmh.190009 · 2020 · External reference
Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies
10.1016/j.jep.2025.119393 · 2025 · External reference
Behavioural assays to model cognitive and affective dimensions of depression and anxiety in rats
10.1111/j.1365-2826.2008.01772.x · 2008 · External reference
Enhanced expression of indoleamine 2,3-dioxygenase in Helicobacter pylori-infected human gastric mucosa modulates Th1/Th2 pathway and interleukin 17 production
10.1111/hel.12174 · 2015 · External reference
AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation
10.1016/j.neurobiolaging.2011.02.003 · 2012 · External reference
Multi-omics analysis of the biological mechanism of the pathogenesis of non-alcoholic fatty liver disease
10.3389/fmicb.2024.1379064 · 2024 · External reference
Multi-omics reveals an association of the gut butyrate-IDO1-tryptophan axis with Yinchenhaotang plus Zexietang-ameliorated NASH in a microbiota-dependent manner
10.1186/s13020-025-01304-w · 2026 · External reference
Global, regional, and national burden of five major mental disorders in working-age population, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/j.jad.2026.121243 · 2026 · External reference
Integrated colon microbiome and metabolomics to elucidate the antidepressant mechanisms of the Radix Bupleuri-Radix Paeoniae Alba herb pair
10.1007/s11011-024-01450-4 · 2024 · External reference
Dietary Advanced Glycation End Products Induced Anxiety- and Depression-like Behaviors in Female C57BL/6 mice and the Ameliorative Effects of Quercetin
2026 · External reference
Advanced glycation end products (AGEs) and in vitro and in vivo approaches to study their mechanisms of action and the protective properties of natural compounds
10.1016/j.phymed.2026.157772 · 2026 · External reference
The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation
10.1186/s12916-025-04002-4 · 2025 · External reference
Estrous cycle effects on behavior of C57BL/6J and BALB/cByJ female mice: implications for phenotyping strategies
10.1111/j.1601-183x.2006.00249.x · 2007 · External reference
Macrophage membrane-functionalized nanofibrous mats and their immunomodulatory effects on macrophage polarization
10.1016/j.actbio.2021.12.026 · 2022 · External reference
The kynurenine pathway in major depressive disorder under different disease states: a systematic review and meta-analysis
10.1016/j.jad.2023.07.078 · 2023 · External reference
Sex differences in Tryptophan Metabolism: a Systematic Review Focused on Neuropsychiatric Disorders
10.3390/ijms24066010 · 2023 · External reference
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
10.1038/s41573-019-0016-5 · 2019 · External reference
Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities
10.1124/pharmrev.124.000239 · 2024 · External reference
Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation
2024 · External reference
Dietary advanced glycation end products modify gut microbial composition and partially increase colon permeability in rats
10.1002/mnfr.201700118 · 2017 · External reference
Advanced Glycation End Products in Neurodegenerative Diseases
10.1007/s12031-024-02297-1 · 2024 · External reference
Monchaux de Oliveira C, Helbling JC, Lévy É, Chevalier G, Leboyer M, Eberl G, Layé S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaudéry M: Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner
10.1016/j.bbi.2019.03.006 · 2019 · External reference
The gut virome is associated with stress-induced changes in behaviour and immune responses in mice
10.1038/s41564-023-01564-y · 2024 · External reference
Unresolved reference
2021 · External reference
The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease
10.1038/s41577-019-0125-8 · 2019 · External reference
Dietary Advanced Glycation End Products (dAGEs): Pathogenesis and nutritional strategies for health longevity-a critical view
10.1016/j.numecd.2025.104538 · 2026 · External reference
Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases
10.1186/s13293-023-00490-2 · 2023 · External reference
The kynurenine pathway: a finger in every pie
10.1038/s41380-019-0414-4 · 2020 · External reference
Association between dietary patterns and adult depression symptoms based on principal component analysis, reduced-rank regression and partial least-squares
10.1016/j.clnu.2019.12.011 · 2020 · External reference
Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-beta1-42 peptide in mice
10.1016/j.bbi.2016.03.002 · 2016 · External reference
Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice
10.1016/j.bbi.2022.08.003 · 2022 · External reference
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
10.1038/s41577-019-0165-0 · 2019 · External reference
Dietary Advanced Glycation End Products Shift the Gut Microbiota Composition and Induce Insulin Resistance in mice
10.2147/dmso.s346411 · 2022 · External reference
Exploring the microbiota-Alzheimer's disease linkage using short-term antibiotic treatment followed by fecal microbiota transplantation
10.1016/j.bbi.2021.06.003 · 2021 · External reference
Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding
10.1186/s40168-024-01750-y · 2024 · External reference
Indole derivatives ameliorated the methamphetamine-induced depression and anxiety via aryl hydrocarbon receptor along “microbiota-brain” axis
10.1080/19490976.2025.2470386 · 2025 · External reference
Gut microbiota-derived indole metabolites in depression: mechanisms and therapeutic potential
10.1016/j.ejphar.2026.178720 · 2026 · External reference
LC-MS/MS-based quantification of tryptophan metabolites and neurotransmitters in the serum and brain of mice
10.1016/j.jchromb.2019.02.021 · 2019 · External reference
Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder
10.1186/s40168-023-01635-6 · 2023 · External reference
Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice
10.1038/s41467-022-34054-6 · 2022 · External reference
Unveiling the dynamic processes of dietary advanced glycation end-products (dAGEs) in absorption, accumulation, and gut microbiota metabolism
10.1039/d4fo01545b · 2024 · External reference
Lactobacillus johnsonii and 3-indolepropionic acid improve the depression-like behaviors via inhibiting neuroinflammation
10.1016/j.phrs.2026.108158 · 2026 · External reference
Tryptophan and its Metabolite Serotonin Impact Metabolic and Mental Disorders via the Brain-Gut-Microbiome Axis: a Focus on sex differences
10.3390/cells14050384 · 2025 · External reference
New aspects characterizing non-obese NAFLD by the analysis of the intestinal flora and metabolites using a mouse model
10.1128/msystems.01027-23 · 2024 · External reference
Associations of dietary advanced glycation end products and the risk of depression and anxiety
10.1007/s00394-025-03818-3 · 2025 · External reference
Dietary advanced glycation products combined with chronic restraint stress induced anxiety-like and depression-like behaviors in male mice. NPJ Sci
2026 · External reference
Fecal microbiota transplantation from high caloric-fed donors alters glucose metabolism in recipient mice, independently of adiposity or exercise status
10.1152/ajpendo.00037.2020 · 2020 · External reference