Research graph
References from Spleen-targeted ultrasound restores gut–brain homeostasis in colitis via vagal neuroimmune modulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathophysiology of inflammatory bowel disease: innate immune system
10.3390/ijms24021526 · 2023 · External reference
Systemic consequences of inflammatory bowel disease beyond immune-mediated manifestations
10.3390/jcm14227984 · 2025 · External reference
Microalgae‐based hydrogel for inflammatory bowel disease and its associated anxiety and depression
10.1002/adma.202312275 · 2024 · External reference
Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis
10.1016/j.pharmthera.2025.108831 · 2025 · External reference
Chronic intestinal inflammation suppresses brain activity by inducing neuroinflammation in mice
10.1016/j.ajpath.2021.09.006 · 2022 · External reference
The vagus nerve at the interface of the microbiota-gut-brain axis
10.3389/fnins.2018.00049 · 2018 · External reference
The gut-brain connection in inflammatory bowel disease: Mechanisms, mental health, and therapeutic horizons
2026 · External reference
Ultrasound neuromodulation of an anti-inflammatory pathway at the spleen improves experimental pulmonary hypertension
10.1161/circresaha.123.323679 · 2024 · External reference
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
10.1038/nature01339 · 2003 · External reference
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
10.1038/35013070 · 2000 · External reference
Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside
10.1186/s40035-024-00404-1 · 2024 · External reference
Non-invasive vagus nerve stimulation in anti-inflammatory therapy: mechanistic insights and future perspectives
10.3389/fnins.2024.1490300 · 2024 · External reference
The locus coeruleus—noradrenergic system in the healthy and diseased brain: a narrative review
10.1111/ene.70337 · 2025 · External reference
10.1007/978-3-031-89525-8_2
10.1007/978-3-031-89525-8_2 · External reference
Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit
10.1186/s13020-025-01230-x · 2025 · External reference
Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice
10.1172/jci.insight.161874 · 2023 · External reference
The Locus Coeruleus: Anatomy, Physiology, and Stress‐Related Neuropsychiatric Disorders
10.1111/ejn.70111 · 2025 · External reference
Non-invasive vagal nerve stimulation decreases brain activity during trauma scripts
10.1016/j.brs.2020.07.002 · 2020 · External reference
Vagus nerve stimulation modulates hippocampal inflammation caused by continuous stress in rats
10.1186/s12974-022-02396-z · 2022 · External reference
Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation
10.1038/s41467-019-08750-9 · 2019 · External reference
Noninvasive ultrasound stimulation to treat myocarditis through splenic neuro-immune regulation
10.1186/s12974-023-02773-2 · 2023 · External reference
A pooled analysis of the side effects of non-invasive Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
10.3389/fnhum.2025.1539416 · 2025 · External reference
Low-intensity pulsed ultrasound attenuates LPS-induced neuroinflammation and memory impairment by modulation of TLR4/NF-κB signaling and CREB/BDNF expression
10.1093/cercor/bhy039 · 2019 · External reference
Unveiling the mechanism of abdominal and transcranial ultrasound stimulation against DSS-induced colitis based on proteomic analysis
10.1186/s13036-025-00619-4 · 2026 · External reference
Neural control of the spleen as an effector of immune responses to inflammation: mechanisms and treatments
10.1152/ajpregu.00151.2022 · 2022 · External reference
Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway
10.1681/asn.2013010084 · 2013 · External reference
Abdominal ultrasound stimulation alleviates DSS-induced colitis and behavioral disorders in mice by restoring balance in the microbiota–gut–brain axis
10.1016/j.neurot.2024.e00494 · 2025 · External reference
Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway
10.1016/j.ebiom.2019.06.033 · 2019 · External reference
Twenty years of research on cytokine-induced sickness behavior
10.1016/j.bbi.2006.09.006 · 2007 · External reference
A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a Hopx-associated program
10.1038/s41467-026-70062-6 · 2026 · External reference
Alternations of the gut microbiota and the Firmicutes/Bacteroidetes ratio after biologic treatment in inflammatory bowel disease
10.1016/j.jmii.2024.09.006 · 2025 · External reference
Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation
10.1186/s12974-023-03001-7 · 2024 · External reference
Serum lipopolysaccharide binding protein (LBP) and metabolic syndrome: a systematic review and meta-analysis
10.1186/s13098-025-01847-w · 2025 · External reference
Gut vagal sensory signaling regulates hippocampus function through multi-order pathways
10.1038/s41467-018-04639-1 · 2018 · External reference
Role of PKA/CREB/BDNF signaling in PM2. 5-induced neurodevelopmental damage to the hippocampal neurons of rats
10.1016/j.ecoenv.2021.112005 · 2021 · External reference
Vagus nerve stimulation (VNS): recent advances and future directions
10.1007/s10286-024-01065-w · 2024 · External reference
RhANP attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota–brain axis
10.1186/s12974-021-02356-z · 2021 · External reference
Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus
10.7150/thno.52574 · 2021 · External reference
Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans
10.1016/j.brs.2023.04.003 · 2023 · External reference
The role of the α7 nicotinic acetylcholine receptor in promoting M2 macrophage polarization at inflammatory sites
10.1038/s41598-026-35757-2 · 2026 · External reference
Protective effect of α7 nicotinic acetylcholine receptor activation on experimental colitis and its mechanism
10.1186/s10020-022-00532-2 · 2022 · External reference
Expression and function of the cholinergic system in immune cells
10.3389/fimmu.2017.01085 · 2017 · External reference
Selection strategy of dextran sulfate sodium-induced acute or chronic colitis mouse models based on gut microbial profile
10.1186/s12866-021-02342-8 · 2021 · External reference
A critical perspective on the supplementation of Akkermansia muciniphila: benefits and harms
10.3390/life13061247 · 2023 · External reference
A Probiotic Mixture Neuralli™-CORE Attenuates DSS-Induced Colitis by Enhancing Gut Microbiota Resilience in mice
10.3390/ijms27115108 · 2026 · External reference
Gut microbiota drives disease variability in the DSS colitis mouse model
2022 · External reference
The solitary nucleus connectivity to key autonomic regions in humans
10.1111/ejn.15691 · 2022 · External reference
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans
10.2174/157015908785777193 · 2008 · External reference
Interaction of the vagus nerve and serotonin in the gut–brain axis
10.3390/ijms26031160 · 2025 · External reference
Adrenergic signaling in circadian control of immunity
10.3389/fimmu.2020.01235 · 2020 · External reference
Adrenergic responses to stress: transcriptional and post‐transcriptional changes
10.1196/annals.1410.048 · 2008 · External reference
cAMP-dependent Plasticity at Excitatory Cholinergic Synapses inDrosophila Neurons: Alterations in the memory MutantDunce
10.1523/jneurosci.20-06-02104.2000 · 2000 · External reference
Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice
10.1523/jneurosci.20-17-06459.2000 · 2000 · External reference
ERK/MAPK signalling in the developing brain: Perturbations and consequences
10.1016/j.neubiorev.2021.10.009 · 2021 · External reference
CREB: a promising therapeutic target for treating psychiatric disorders
10.2174/1570159x22666240206111838 · 2024 · External reference
Dual‐frequency ultrasound enhances functional neuron differentiation from neural stem cells by modulating Ca2+ dynamics and the ERK1/2 signaling pathway
10.1002/jcp.30911 · 2023 · External reference
A perspective profile of ADCY1 in cAMP signaling with drug-resistance in lung cancer
10.7150/jca.36614 · 2019 · External reference
P70. 18 distribution of GNAS Mutations in chinese patients with Non-Small Cell Lung Cancer
2021 · External reference
Disruption of a regulatory loop between DUSP1 and p53 contributes to hepatocellular carcinoma development and progression
10.1016/j.jhep.2014.12.033 · 2015 · External reference
MAP2K2 delays recovery in murine models of acute lung injury and associates with acute respiratory distress syndrome outcome
10.1165/rcmb.2021-0252oc · 2022 · External reference
Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival
10.1016/s0143-4160(03)00140-4 · 2003 · External reference
Esketamine mitigates cognitive impairment following exposure to LPS by modulating the intestinal flora/subdiaphragmatic vagus nerve/spleen axis
10.1016/j.intimp.2023.111284 · 2024 · External reference
Parameter-Determined Effects: advances in Transcranial Focused Ultrasound for Modulating Neural Excitation and Inhibition
10.3390/bioengineering13010020 · 2025 · External reference
Neuromodulation techniques–from non-invasive brain stimulation to deep brain stimulation
10.1016/j.neurot.2024.e00330 · 2024 · External reference
Neuroprotection by abdominal ultrasound in lipopolysaccharide-induced systemic inflammation
10.3390/ijms24119329 · 2023 · External reference
Transcranial ultrasound stimulation ameliorates dextran sulphate sodium-induced colitis and behavioural disorders by suppressing the inflammatory response in the brain. Brain
2025 · External reference
