Research graph
References from Anti-inflammatory IL-4 shapes the architecture of presynaptic glutamatergic puncta of human and murine sensory neurons for pain sensitivity. Local targets link to admitted publications; unresolved targets remain external evidence.
Dual PI3Kδ/γ Inhibitor Duvelisib Prevents Development of Neuropathic Pain in Model of Paclitaxel-Induced Peripheral Neuropathy
10.1523/jneurosci.1324-21.2021 · 2022 · External reference
Changes in immune and glial markers in the CSF of patients with complex Regional Pain Syndrome
10.1016/j.bbi.2006.10.009 · 2007 · External reference
IL-4 and IL-13: regulators and Effectors of Wound Repair
10.1146/annurev-immunol-101921-041206 · 2023 · External reference
Electrical excitability of the soma of sensory neurons is required for spike invasion of the soma, but not for through-conduction
10.1016/s0006-3495(03)75024-3 · 2003 · External reference
Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury
10.7150/thno.65203 · 2021 · External reference
10.1101/2025.03.24.645122
10.1101/2025.03.24.645122 · External reference
Interleukin-4 mediates the analgesia produced by low-intensity exercise in mice with neuropathic pain
10.1097/j.pain.0000000000001109 · 2018 · External reference
Candidate genes for the progression of malignant gliomas identified by microarray analysis
10.1007/s10143-007-0107-3 · 2008 · External reference
The Transcription factor p63 is a direct effector of IL-4- and IL-13-mediated repression of keratinocyte differentiation
10.1016/j.jid.2020.09.009 · 2021 · External reference
Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control
10.1016/j.neuron.2014.01.018 · 2014 · External reference
Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
10.1016/j.mcn.2005.10.006 · 2006 · External reference
Interleukin-4 and interleukin-13 evoke scratching behaviour in mice
10.1111/exd.14034 · 2019 · External reference
Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor
10.1523/jneurosci.4479-12.2013 · 2013 · External reference
Nociception and pain: lessons from optogenetics
10.3389/fnbeh.2014.00069 · 2014 · External reference
Requirements of IL-4 during the Generation of B Cell memory
10.4049/jimmunol.2200922 · 2023 · External reference
mTOR inhibition rescues osteopenia in mice with systemic sclerosis
10.1084/jem.20140643 · 2015 · External reference
Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4
10.1038/sj.bjp.0702266 · 1999 · External reference
Interleukin-4 blocks proliferation of retinal progenitor cells and increases rod photoreceptor differentiation through distinct signaling pathways
10.1016/j.jneuroim.2008.03.003 · 2008 · External reference
Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL
10.18632/oncotarget.4116 · 2015 · External reference
Metabolic regulation of type 2 immune response during tissue repair and regeneration
10.1002/jlb.3mr0422-665r · 2022 · External reference
Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
10.1016/j.bbi.2011.10.003 · 2012 · External reference
Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain
10.1073/pnas.94.11.5866 · 1997 · External reference
IL-4 in the brain: a cytokine to remember
10.4049/jimmunol.1202246 · 2012 · External reference
Type 2 immunity in tissue repair and fibrosis
10.1038/nri.2017.90 · 2018 · External reference
Network model of nociceptive processing in the superficial spinal dorsal horn reveals mechanisms of hyperalgesia, allodynia, and spinal cord stimulation
10.1152/jn.00186.2023 · 2023 · External reference
Mechanisms for dysregulation of excitatory-inhibitory balance underlying allodynia in dorsal horn neural subcircuits
10.1371/journal.pcbi.1012234 · 2025 · External reference
Engineering human skin model innervated with itch sensory neuron-like cells differentiated from induced pluripotent stem cells
10.1002/btm2.10247 · 2022 · External reference
Growth-Promoting Treatment Screening for Corticospinal Neurons in Mouse and man
10.1007/s10571-020-00820-7 · 2020 · External reference
Interleukin-4 receptor signaling modulates neuronal network activity
10.1084/jem.20211887 · 2022 · External reference
HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain
10.1186/1744-8069-2-6 · 2006 · External reference
Insights into Spinal Dorsal Horn Circuit Function and Dysfunction using Optical Approaches
10.3389/fncir.2020.00031 · 2020 · External reference
Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn
10.1186/s12974-021-02335-4 · 2021 · External reference
Three-dimensional organotypic mouse brain slices to study Alzheimer's disease pathologies: a review
10.3389/frdem.2025.1585124 · 2025 · External reference
Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments
10.7554/elife.51254 · 2020 · External reference
Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy
10.1016/j.bbi.2014.08.010 · 2015 · External reference
T-helper cells and their cytokines in pathogenesis and treatment of asthma
10.3389/fimmu.2023.1149203 · 2023 · External reference
The Impact of Systemic Inflammation on Neurodevelopment
10.1016/j.molmed.2018.06.008 · 2018 · External reference
Protocol to prepare mouse spinal cord for patch-clamp and histology experiments
10.1016/j.xpro.2023.102345 · 2023 · External reference
Microglia M2A Polarization as potential link between Food Allergy and Autism Spectrum Disorders
10.3390/ph10040095 · 2017 · External reference
Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer
10.1016/j.omtn.2025.102670 · 2025 · External reference
Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling
10.1074/jbc.271.39.23634 · 1996 · External reference
In Leishmania major-induced inflammation, interleukin-13 reduces hyperalgesia, down-regulates IL-1β and up-regulates IL-6 in an IL-4 independent mechanism
10.1016/j.exppara.2013.02.005 · 2013 · External reference
Non-canonical alternatives: what a macrophage is 4
10.1084/jem.20120295 · 2012 · External reference
Human assembloid model of the ascending neural sensory pathway
10.1038/s41586-025-08808-3 · 2025 · External reference
CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice
10.1096/fj.10-155317 · 2010 · External reference
Reduced acute nociception and chronic pain in Shank2-/- mice
10.1177/1744806916647056 · 2016 · External reference
Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA
10.1186/ar3934 · 2012 · External reference
Descending modulation of pain: the GABA disinhibition hypothesis of analgesia
10.1016/j.conb.2014.07.010 · 2014 · External reference
Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia
10.1111/febs.14498 · 2018 · External reference
Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells
10.1016/j.jneuroim.2011.01.005 · 2011 · External reference
Enhanced spinal neuronal responses as a mechanism for the increased nociceptive sensitivity of interleukin-4 deficient mice
10.1016/j.expneurol.2015.06.011 · 2015 · External reference
Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses
10.1016/j.neuron.2026.06.014 · 2026 · External reference
Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
10.1038/s41392-022-00885-4 · 2022 · External reference
Growth factor receptor expression varies among high-grade gliomas and normal brain: epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy
2003 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Substantia Gelatinosa neurons in defined-medium organotypic slice culture are similar to those in acute slices from young adult rats
10.1016/j.pain.2006.01.009 · 2006 · External reference
OLFML2A Downregulation Inhibits Glioma Proliferation through suppression of Wnt/β-Catenin Signaling
10.3389/fonc.2021.717917 · 2021 · External reference
Characterisation of Immune and Neuroinflammatory changes Associated with Chemotherapy-Induced Peripheral Neuropathy
10.1371/journal.pone.0170814 · 2017 · External reference
Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression
10.1523/jneurosci.5161-13.2014 · 2014 · External reference
Th2 Modulation of Transient Receptor potential Channels: an Unmet Therapeutic intervention for Atopic Dermatitis
10.3389/fimmu.2021.696784 · 2021 · External reference
Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties
10.1523/jneurosci.1948-20.2021 · 2021 · External reference
SHANK proteins: roles at the synapse and in autism spectrum disorder
10.1038/nrn.2016.183 · 2017 · External reference
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP
10.15252/embr.202153659 · 2022 · External reference
StemBANCC: Governing Access to Material and Data in a Large Stem Cell Research Consortium
10.1007/s12015-015-9599-3 · 2015 · External reference
Standardization of a Novel Semi-Automatic Software for Neurite Outgrowth Measurement
10.3791/67163 · 2024 · External reference
Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors
10.1016/j.bmc.2006.10.015 · 2007 · External reference
Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
10.7554/elife.71752 · 2021 · External reference
Activity-induced changes of spine morphology
10.1002/hipo.10095 · 2002 · External reference
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
10.1016/j.cell.2017.08.006 · 2017 · External reference
IL-4 expressing cells are recruited to nerve after injury and promote regeneration
10.1016/j.expneurol.2021.113909 · 2022 · External reference
Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways
10.1073/pnas.2009647118 · 2021 · External reference
Neuroprotective modulation of microglia effector functions following priming with interleukin 4 and 13: current limitations in understanding their mode-of-action
10.1016/j.bbi.2020.03.023 · 2020 · External reference
Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130
10.1523/jneurosci.1209-13.2014 · 2014 · External reference
Protein kinase C activity in the nucleus tractus solitarii is critically involved in the acute hypoxic ventilatory response, but is not required for intermittent hypoxia-induced phrenic long-term facilitation in adult rats
10.1113/expphysiol.2007.038489 · 2007 · External reference
Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury
10.1016/j.neuron.2020.07.026 · 2020 · External reference
Neuromodulation by the immune system: a focus on cytokines
10.1038/s41577-021-00508-z · 2021 · External reference
Inflammation in CRPS: role of the sympathetic supply
10.1016/j.autneu.2013.12.011 · 2014 · External reference
Selected Ionotropic Receptors and Voltage-Gated Ion Channels: more Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors
10.3390/brainsci10060344 · 2020 · External reference
Presynaptic α(2)δ subunits are key organizers of glutamatergic synapses
10.1073/pnas.1920827118 · 2021 · External reference
Involvement of IL-4, IL-13 and their Receptors in Pancreatic Cancer
10.3390/ijms22062998 · 2021 · External reference
IL-4 increases GABAergic phenotype in rat retinal cell cultures: involvement of muscarinic receptors and protein kinase C
10.1016/s0165-5728(02)00327-2 · 2002 · External reference
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy
10.1093/brain/awaf125 · 2025 · External reference
A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies
10.1016/j.devcel.2021.06.013 · 2021 · External reference
Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn
10.1177/1744806917693003 · 2017 · External reference
Gain control mechanisms in the nociceptive system
10.1097/j.pain.0000000000000499 · 2016 · External reference
Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation
10.1523/jneurosci.0348-14.2014 · 2014 · External reference
Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices
10.3390/biom12020163 · 2022 · External reference
Differential expression patterns of cytokines in complex regional pain syndrome
10.1016/j.pain.2007.07.031 · 2007 · External reference
IL-4 deficiency is associated with mechanical hypersensitivity in mice
10.1371/journal.pone.0028205 · 2011 · External reference
Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain
10.1002/art.22026 · 2006 · External reference
Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells
10.1038/s41598-020-60036-z · 2020 · External reference
Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats
10.1124/jpet.102.038703 · 2003 · External reference
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease
10.1146/annurev-immunol-032712-095906 · 2013 · External reference
Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation
10.1126/scitranslmed.aao2304 · 2018 · External reference
The gate control theory of pain mechanisms. A re-examination and re-statement
10.1093/brain/101.1.1 · 1978 · External reference
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
10.1172/jci82458 · 2015 · External reference
Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain
10.1038/s41422-021-00479-9 · 2021 · External reference
Circuitry and plasticity of the dorsal horn–toward a better understanding of neuropathic pain
10.1016/j.neuroscience.2015.05.020 · 2015 · External reference
Untangling the complex web of IL-4- and IL-13-mediated signaling pathways
10.1126/scisignal.1.51.pe55 · 2008 · External reference
Type 2 cytokines: mechanisms and therapeutic strategies
10.1038/nri3831 · 2015 · External reference
Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain
10.1016/j.celrep.2023.112010 · 2023 · External reference
NOCICEPTRA: Gene and microRNA Signatures and their Trajectories Characterizing Human iPSC-derived Nociceptor Maturation
2021 · External reference
The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury
10.1371/journal.pbio.3000330 · 2019 · External reference
Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control
10.1152/jn.00147.2015 · 2015 · External reference
T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production
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Established and emerging roles of protein kinases in regulating primary sensory neurons in injury-and inflammation-associated pain
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