Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from A20/TNFAIP3 heterozygosity predisposes to behavioral symptoms in a mouse model for neuropsychiatric lupus. Local targets link to admitted publications; unresolved targets remain external evidence.
The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes
10.1002/1529-0131(199904)42:4<599::aid-anr2>3.0.co;2-f · 1999 · External reference
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
10.1038/ng.766 · 2011 · External reference
Acute psychosis in systemic lupus erythematosus
10.1007/s00296-007-0410-x · 2008 · External reference
Neuroinflammation in the normal aging hippocampus
10.1016/j.neuroscience.2015.03.007 · 2015 · External reference
From systemic inflammation to neuroinflammation: the case of neurolupus
10.3390/ijms19113588 · 2018 · External reference
New tools for studying microglia in the mouse and human CNS
10.1073/pnas.1525528113 · 2016 · External reference
Gene expression changes in the course of normal brain aging are sexually dimorphic
10.1073/pnas.0806883105 · 2008 · External reference
Combined oral contraceptive use and the risk of systemic lupus erythematosus
10.1002/art.24398 · 2009 · External reference
The white blood cell and differential count
1990 · External reference
Attribution of neuropsychiatric manifestations to systemic lupus erythematosus
10.3389/fmed.2018.00068 · 2018 · External reference
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kB signaling
10.1016/j.molcel.2010.10.009 · 2010 · External reference
Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury
10.1016/j.expneurol.2005.10.020 · 2006 · External reference
The molecular basis of the host response to lipopolysaccharide
10.1038/nrmicro2266 · 2010 · External reference
The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in
10.7326/0003-4819-142-12_part_1-200506210-00004 · 2005 · External reference
Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice
10.1523/jneurosci.1497-06.2006 · 2006 · External reference
LPA 5 receptor plays a role in pain sensitivity , emotional
10.1111/j.1601-183x.2012.00840.x · 2012 · External reference
Reproductive and menopausal factors and risk of systemic lupus erythematosus in women
10.1002/art.22510 · 2007 · External reference
Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus
10.1242/dmm.016451 · 2014 · External reference
Applications of the Morris water maze in the study of learning and memory
10.1016/s0165-0173(01)00067-4 · 2001 · External reference
Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis
2005 · External reference
Age-related alterations in the dynamic behavior of microglia
10.1111/j.1474-9726.2010.00660.x · 2011 · External reference
The deubiquitinase activity of A20 is dispensable for NF-kB signaling
10.15252/embr.201338305 · 2014 · External reference
An in vivo blood-brain barrier permeability assay in mice using fluorescently labeled tracers
2018 · External reference
Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions
10.1016/j.neubiorev.2017.01.044 · 2017 · External reference
A de novo frameshift mutation in TNFAIP3 impairs A20 deubiquitination function to cause neuropsychiatric systemic lupus erythematosus
10.1007/s10875-019-00695-4 · 2019 · External reference
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
10.1042/bj20031377 · 2004 · External reference
Haematological manifestations of lupus
10.1136/lupus-2014-000078 · 2015 · External reference
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
10.1038/nature03104 · 2004 · External reference
The mouse in aging research
2007 · External reference
Mechanisms of neuropsychiatric lupus : the relative roles of the blood- cerebrospinal fl uid barrier versus blood-brain barrier
10.1016/j.jaut.2018.03.001 · 2018 · External reference
The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling
2013 · External reference
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
10.1038/ng.200 · 2008 · External reference
A20 deficiency causes spontaneous neuroinflammation in mice
10.1186/1742-2094-11-122 · 2014 · External reference
Diagnosis and management of neuropsychiatric SLE
10.1038/nrrheum.2014.15 · 2014 · External reference
Management of neuropsychiatric lupus
10.1016/j.berh.2005.04.003 · 2005 · External reference
Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus an international inception cohort study
10.1002/art.22305 · 2007 · External reference
Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus
10.1136/ard.2008.106351 · 2010 · External reference
qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data
10.1186/gb-2007-8-2-r19 · 2007 · External reference
Modulation of autoimmune rheumatic diseases by oestrogen and progesterone
10.1038/nrrheum.2014.144 · 2014 · External reference
Neuropsychiatric systemic lupus erythematosus : pathogenesis and biomarkers
10.1038/nrneurol.2014.148 · 2014 · External reference
BCL-2 family proteins: changing partners in the dance towards death
10.1038/cdd.2017.186 · 2018 · External reference
Systemic lupus erythematosus
10.1038/nrdp.2016.39 · 2016 · External reference
Sex differences in immune responses
10.1038/nri.2016.90 · 2016 · External reference
Prepulse inhibition in psychiatric disorders - apart from schizophrenia
10.1016/j.jpsychires.2012.11.018 · 2013 · External reference
Failure to regulate TNF-induced NF-kB and cell death responses in A20-deficient mice
10.1126/science.289.5488.2350 · 2000 · External reference
Microglia and macrophages in brain homeostasis and disease
10.1038/nri.2017.125 · 2017 · External reference
Neurobiology of Disease Tauroursodeoxycholic acid ( TUDCA ) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice
10.1016/j.nbd.2012.09.003 · 2013 · External reference
Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders: prevalence and clinical significance
10.7326/0003-4819-112-9-682 · 1990 · External reference
Article dimerization and ubiquitin mediated recruitment of A20 , a complex deubiquitinating enzyme
10.1016/j.immuni.2013.03.008 · 2013 · External reference
A20: linking a complex regulator of ubiquitylation to immunity and human disease
10.1038/nri3313 · 2012 · External reference
Are serum autoantibodies associated with brain changes in systemic lupus erythematosus? MRI data from the Leiden NP-SLE cohort
10.1177/0961203318816819 · 2019 · External reference
Clinical implications of neuropsychiatric systemic lupus erythematosus
10.1192/apt.bp.108.005785 · 2009 · External reference
Sexually divergent induction of microglial- associated neuroinflammation with hippocampal aging
10.1186/s12974-017-0920-8 · 2017 · External reference
Reduced prepulse inhibition as a biomarker of schizophrenia
10.3389/fnbeh.2016.00202 · 2016 · External reference
Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus
10.1016/j.jaut.2018.08.005 · 2019 · External reference
Prevalence and pattern of cognitive impairment in systemic lupus erythematosus patients with and without overt neuropsychiatric manifestations
10.1016/s0022-510x(00)00492-5 · 2001 · External reference
The effects of corticosteroids on cognitive flexibility and decision-making in women with lupus
10.1177/0961203316642313 · 2016 · External reference
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
10.1038/ng.202 · 2008 · External reference
Automated apparatus for quantitation of social approach behaviors in mice
10.1111/j.1601-183x.2004.00071.x · 2004 · External reference
Nocturnal hyperactivity , increased social novelty preference and delayed extinction of fear responses in post-weaning socially isolated mice
10.1016/j.brainresbull.2011.03.027 · 2011 · External reference
Vglut2 haploinsufficiency enhances behavioral sensitivity to MK-801 and amphetamine in mice
10.1016/j.pnpbp.2011.03.023 · 2011 · External reference
Microglia priming with aging and stress
10.1038/npp.2016.185 · 2017 · External reference
Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function
10.1016/s0306-4522(99)00285-7 · 1999 · External reference
Microglial priming in neurodegenerative disease
10.1038/nrneurol.2014.38 · 2014 · External reference
Epidemiology of systemic lupus erythematosus
10.1053/berh.2002.0259 · 2002 · External reference
Depression and cognitive impairment in newly diagnosed systemic lupus erythematosus
10.3899/jrheum.091366 · 2010 · External reference
Neuropsychiatric SLE: from animal model to human
10.1177/0961203317694261 · 2017 · External reference
Unresolved reference
2019 · External reference
The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies
10.1093/rheumatology/kex260 · 2017 · External reference
Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency
10.1182/blood-2014-03-564286 · 2014 · External reference
The role of infections in neuropsychiatric lupus
10.1177/0961203317691375 · 2017 · External reference
Genetic and hormonal factors in female-biased autoimmunity
10.1016/j.autrev.2010.02.008 · 2010 · External reference
Sexual dimorphism in autoimmunity
10.1172/jci78082 · 2015 · External reference
Analyzing real-time PCR data by the comparative C(T) method
10.1038/nprot.2008.73 · 2008 · External reference
Neuropsychiatric lupus: new mechanistic insights and future treatment directions
10.1038/s41584-018-0156-8 · 2019 · External reference
Identification of common transcriptional regulatory elements in interleukin-17 target genes
10.1074/jbc.m604597200 · 2006 · External reference
Relationship between clinical factors and neuropsychiatric manifestations in systemic lupus erythematosus
10.1007/s10067-004-1060-y · 2005 · External reference
Direct, noncatalytic mechanism of IKK inhibition by A20
10.1016/j.molcel.2011.09.015 · 2011 · External reference
The watermaze
1993 · External reference
Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice
10.1186/s12974-015-0423-4 · 2015 · External reference
Neuropsychiatric lupus, the blood brain barrier, and the TWEAK/Fn14 pathway
10.3389/fimmu.2013.00484 · 2013 · External reference
Dystrophic microglia in the aging human brain
10.1002/glia.10319 · 2004 · External reference
Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration
10.1038/cdd.2015.52 · 2015 · External reference
Blood-Brain barrier: from physiology to disease and back
10.1152/physrev.00050.2017 · 2019 · External reference
Realistic expectations of prepulse inhibition in translational models for schizophrenia research
10.1007/s00213-008-1072-4 · 2008 · External reference
Psychiatric symptoms before systemic lupus erythematosus is diagnosed
10.1007/bf00300248 · 1994 · External reference
A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells
10.1038/sj.onc.1210269 · 2007 · External reference
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis
10.1084/jem.20092474 · 2010 · External reference
A20 inhibits LUBAC-mediated NF-kB activation by binding linear polyubiquitin chains via its zinc finger 7
10.1038/emboj.2012.240 · 2012 · External reference
Clinical associations of serum interleukin-17 in systemic lupus erythematosus
10.1186/ar4277 · 2013 · External reference
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
10.1038/s41467-018-04376-5 · 2018 · External reference
TALEN-mediated enhancer knockout in fluences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus
2016 · External reference
An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression
10.1371/journal.pgen.1003750 · 2013 · External reference
Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes
10.1007/s00401-013-1183-9 · 2013 · External reference
Genetic analysis of MRL/lpr mice: relationship of the Fas apoptotis gene to disease manifestations and renal disease-modifying loci
10.1084/jem.176.6.1645 · 1992 · External reference
B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus
10.1186/s12974-016-0537-3 · 2016 · External reference
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
10.1038/nature16165 · 2015 · External reference
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kB signaling
10.1038/nature02794 · 2004 · External reference
Standardization of real-time PCR gene expression data from independent biological replicates
10.1016/j.ab.2008.04.036 · 2008 · External reference
The IAP family: endogenous caspase inhibitors with multiple biological activities
10.1038/sj.cr.7290046 · 2000 · External reference
Genomic analysis of reactive astrogliosis
10.1523/jneurosci.6221-11.2012 · 2012 · External reference
Environment and lupus-related diseases
10.1177/0961203311426568 · 2012 · External reference
30 Years of NF-κB: a blossoming of relevance to human pathobiology
10.1016/j.cell.2016.12.012 · 2017 · External reference
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
10.1523/jneurosci.1860-14.2014 · 2014 · External reference
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
10.1038/ng.3459 · 2015 · External reference