Research graph
References from Overlapping evidence of innate immune dysfunction in psychotic and affective disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
Macrophage cytokines: involvement in immunity and infectious diseases
10.3389/fimmu.2014.00491 · 2014 · External reference
Attenuated inflammatory response of monocyte-derived macrophage from patients with BD: a preliminary report
10.1186/s40345-019-0148-x · 2019 · External reference
Monocyte and lymphocyte activation in bipolar disorder: a new piece in the puzzle of immune dysfunction in mood disorders
10.1093/ijnp/pyu021 · 2014 · External reference
Evidence for activation of microglia in patients with psychiatric illnesses
10.1016/s0304-3940(99)00545-5 · 1999 · External reference
Inflammatory monocyte gene expression: trait or state marker in bipolar disorder?
2015 · External reference
Microglial activity in people at ultra high risk of psychosis and in schizophrenia: an [(11)C]PBR28 PET brain imaging study
10.1176/appi.ajp.2015.14101358 · 2016 · External reference
Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia
10.1038/tp.2014.46 · 2014 · External reference
Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism
10.1002/dneu.22024 · 2012 · External reference
Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?
10.1016/j.bbi.2012.08.005 · 2012 · External reference
Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring
10.1176/appi.ajp.2013.13070943 · 2014 · External reference
Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder
10.1038/tp.2013.118 · 2014 · External reference
Overview of the immune response
10.1016/j.jaci.2009.12.980 · 2010 · External reference
The value of interleukin 6 as a peripheral diagnostic marker in schizophrenia
10.1186/s12888-016-0866-x · 2016 · External reference
Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [(11)C]PBR28
10.1038/mp.2016.247 · 2017 · External reference
In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [11C]DPA-713 PET and analysis of CSF and plasma
10.1038/tp.2016.40 · 2016 · External reference
Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice
10.1002/jnr.23242 · 2013 · External reference
Microglia regulate the number of neural precursor cells in the developing cerebral cortex
10.1523/jneurosci.3441-12.2013 · 2013 · External reference
The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production
10.1016/j.euroneuro.2007.04.005 · 2008 · External reference
Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder
10.1016/j.jad.2009.04.027 · 2010 · External reference
Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages
10.3389/fimmu.2014.00683 · 2015 · External reference
PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia
10.1038/tp.2017.193 · 2017 · External reference
Neuroinflammation in schizophrenia-related psychosis: a PET study
10.2967/jnumed.109.066647 · 2009 · External reference
A meta-analysis of cytokines in major depression
10.1016/j.biopsych.2009.09.033 · 2010 · External reference
An activated set point of T-cell and monocyte inflammatory networks in recent-onset schizophrenia patients involves both pro- and anti-inflammatory forces
10.1017/s1461145710001653 · 2011 · External reference
The activation of monocyte and T cell networks in patients with bipolar disorder
10.1016/j.bbi.2011.03.013 · 2011 · External reference
Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients
10.1017/s1461145710000799 · 2010 · External reference
Mitochondrial DAMPs induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction
10.1371/journal.pone.0095073 · 2014 · External reference
Depression and Mania induce pro-inflammatory activation of macrophages following application of serum from individuals with bipolar disorder
10.9758/cpn.2018.16.1.103 · 2018 · External reference
Microglia control neuronal network excitability via BDNF signalling
10.1155/2013/429815 · 2013 · External reference
Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia
10.1038/mp.2012.110 · 2013 · External reference
Tissue-resident macrophage ontogeny and homeostasis
10.1016/j.immuni.2016.02.024 · 2016 · External reference
A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression
10.1038/mp.2016.3 · 2016 · External reference
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
10.1038/nature13989 · 2015 · External reference
Clinical characteristics of inflammation-associated depression: monocyte gene expression is age-related in major depressive disorder
10.1016/j.bbi.2014.08.004 · 2015 · External reference
Deficiencies of the T and natural killer cell system in major depressive disorder. T regulatory cell defects are associated with inflammatory monocyte activation
10.1016/j.bbi.2015.12.003 · 2016 · External reference
Neuroinflammation in bipolar disorder - a [(11)C]-(R)-PK11195 positron emission tomography study
10.1016/j.bbi.2014.03.016 · 2014 · External reference
Imaging microglial activation in untreated first-episode psychosis: a PET study with [(18)F]FEPPA
10.1176/appi.ajp.2016.16020171 · 2017 · External reference
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
10.1016/j.biopsych.2003.11.006 · 2004 · External reference
The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [(1)(1)C]PBR28 PET study
10.1016/j.bbi.2013.06.010 · 2013 · External reference
Pro-inflammatory monocyte phenotype and cell-specific steroid signaling alterations in unmedicated patients with major depressive disorder
10.3389/fimmu.2018.02693 · 2018 · External reference
Differential effects on T-cell function following exposure to serum from schizophrenia smokers
10.1038/mp.2008.120 · 2010 · External reference
Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder
10.1503/jpn.130277 · 2014 · External reference
Circulating monocytes exhibit an endotoxin tolerance status after acute ischemic stroke: mitochondrial DNA as a putative explanation for poststroke infections
10.4049/jimmunol.1601594 · 2017 · External reference
Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: a positron emission tomography study
10.1016/j.biopsych.2017.08.005 · 2018 · External reference
Microglia: the constant gardeners
10.1038/485570a · 2012 · External reference
From monocytes to M1/M2 macrophages: phenotypical vs. Functional differentiation
10.3389/fimmu.2014.00514 · 2014 · External reference
Imaging neuroinflammation in gray and white matter in schizophrenia: an in-vivo PET study with [18F]-FEPPA
10.1093/schbul/sbu157 · 2015 · External reference
Sex differences in immune responses
10.1038/nri.2016.90 · 2016 · External reference
Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms
10.1186/s12974-018-1197-2 · 2018 · External reference
Microglia and macrophages in brain homeostasis and disease
10.1038/nri.2017.125 · 2018 · External reference
Microglia promote the death of developing Purkinje cells
10.1016/s0896-6273(04)00069-8 · 2004 · External reference
Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies
10.1017/s0033291718003057 · 2019 · External reference
Neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio in non-affective psychosis: a meta-analysis and systematic review
2019 · External reference
Epidemiology-driven neurodevelopmental animal models of schizophrenia
10.1016/j.pneurobio.2009.10.018 · 2010 · External reference
The case for adjunctive monoclonal antibody immunotherapy in schizophrenia
2016 · External reference
Prenatal inflammation and neurodevelopment in schizophrenia: a review of human studies
10.1016/j.pnpbp.2012.03.010 · 2013 · External reference
Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies
10.1016/j.biopsych.2013.01.007 · 2013 · External reference
Pathogen recognition and inflammatory signaling in innate immune defenses
10.1128/cmr.00046-08 · 2009 · External reference
Causes, consequences, and reversal of immune system aging
10.1172/jci64096 · 2013 · External reference
Cytokines in bipolar disorder: a systematic review and meta-analysis
10.1016/j.jad.2012.06.010 · 2013 · External reference
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
10.1038/nn.3922 · 2015 · External reference
Increased frequency of activated lymphocytes in the cerebrospinal fluid of patients with acute schizophrenia
10.1016/s0920-9964(99)00218-2 · 2001 · External reference
Resting microglial cells are highly dynamic surveillants of brain Parenchyma in vivo
10.1126/science.1110647 · 2005 · External reference
Adjunctive use of nonsteroidal anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trials
10.1093/schbul/sbt070 · 2013 · External reference
Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia
10.1038/mp.2016.248 · 2017 · External reference
Glial reduction in the subgenual prefrontal cortex in mood disorders
10.1073/pnas.95.22.13290 · 1998 · External reference
Maternal immune activation leads to activated inflammatory macrophages in offspring
10.1016/j.bbi.2014.02.007 · 2014 · External reference
Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis
10.1111/acps.12944 · 2018 · External reference
Characterization of macrophages from schizophrenia patients
10.1038/s41537-017-0042-4 · 2017 · External reference
A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes
2008 · External reference
Gestational influenza and bipolar disorder in adult offspring
10.1001/jamapsychiatry.2013.896 · 2013 · External reference
DAMPening inflammation by modulating TLR signalling
10.1155/2010/672395 · 2010 · External reference
A meta-analysis of immune parameters, variability, and assessment of modal distribution in psychosis and test of the immune Subgroup hypothesis
10.1093/schbul/sby160 · 2019 · External reference
Positron emission tomography studies of the glial cell marker translocator protein in patients with psychosis: a meta-analysis using individual participant data
10.1016/j.biopsych.2018.02.1171 · 2018 · External reference
Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
10.1016/s0006-3223(01)01080-0 · 2001 · External reference
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue
10.1016/s0006-3223(99)00041-4 · 1999 · External reference
A polarizing question: do M1 and M2 microglia exist?
10.1038/nn.4338 · 2016 · External reference
Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients
10.1038/mp.2009.47 · 2010 · External reference
PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects
10.1186/s13550-018-0401-9 · 2018 · External reference
Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation
10.1016/j.bbi.2016.11.020 · 2017 · External reference
Co-occurring psychotic and addictive disorders: neurobiology and diagnosis
10.1097/wnf.0b013e318261e193 · 2012 · External reference
Immunological dysfunction in schizophrenia: a systematic approach
10.1159/000026501 · 1998 · External reference
Medical comorbidity in bipolar disorder: the link with metabolic-inflammatory systems
10.1016/j.jad.2016.12.059 · 2017 · External reference
Microglia of prefrontal white matter in suicide
10.1097/nen.0000000000000107 · 2014 · External reference
Major depressive disorder is associated with elevated monocyte counts
10.1111/j.1600-0447.1996.tb09849.x · 1996 · External reference
Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study
10.1016/s2215-0366(18)30048-8 · 2018 · External reference
Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes
10.1001/jamapsychiatry.2014.2427 · 2015 · External reference
Prevalence and impact of substance use among emerging adults with serious mental health conditions
10.2975/35.3.2012.235.243 · 2012 · External reference
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
10.1016/j.brainresbull.2011.10.004 · 2012 · External reference
Maternal immune activation alters fetal brain development through interleukin-6
10.1523/jneurosci.2178-07.2007 · 2007 · External reference
Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated
10.1038/s41398-019-0490-x · 2019 · External reference
S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study
10.1016/j.jpsychires.2007.10.001 · 2008 · External reference
Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide
10.1016/j.jpsychires.2006.10.013 · 2008 · External reference
Damage-associated molecular patterns and immune activation in bipolar disorder
10.1111/acps.12417 · 2015 · External reference
Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106
10.1017/s1461145710000313 · 2010 · External reference
The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder
10.1016/j.pnpbp.2008.10.020 · 2009 · External reference
Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
10.1016/j.bbi.2014.05.007 · 2014 · External reference
Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review
10.1038/mp.2016.90 · 2016 · External reference
Cytokine function in medication-naive first episode psychosis: a systematic review and meta-analysis
10.1016/j.schres.2014.03.005 · 2014 · External reference
Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study
10.1016/j.biopsych.2008.04.025 · 2008 · External reference
In vivo (R)-[11C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis
10.1038/npjschz.2016.31 · 2016 · External reference
Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies
10.1038/tp.2017.4 · 2017 · External reference
Molecular imaging of microglia/macrophages in the brain
10.1002/glia.22357 · 2013 · External reference
Metabolic issues in patients affected by schizophrenia: clinical characteristics and medical management
10.3389/fnins.2015.00297 · 2015 · External reference
Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
10.1523/jneurosci.4363-08.2009 · 2009 · External reference
Meta-analysis of cerebrospinal fluid cytokine and tryptophan catabolite alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder, and depression
10.1093/schbul/sbx035 · 2018 · External reference
Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: markers of vulnerability or disease?
10.1016/0006-3223(95)00598-6 · 1996 · External reference
