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References from EP3 is the only prostaglandin E receptor required for lipopolysaccharide-induced fever. Local targets link to admitted publications; unresolved targets remain external evidence.
Inflammation-induced fever depends on prostaglandin E2 production by brain endothelial cells and EP3 receptors in the median preoptic nucleus of the hypothalamus
10.1111/apha.14238 · 2024 · External reference
Neural mechanisms of inflammation-induced fever
10.1177/1073858418760481 · 2018 · External reference
G protein–coupled prostanoid receptors and the kidney
10.1146/annurev.physiol.63.1.579 · 2001 · External reference
Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues
10.1002/dvg.20226 · 2006 · External reference
Distribution of the EP3 prostaglandin E(2) receptor subtype in the rat brain: relationship to sites of interleukin-1-induced cellular responsiveness
10.1002/1096-9861(20001204)428:1<5::aid-cne2>3.0.co;2-m · 2000 · External reference
Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells
10.1210/en.2012-1375 · 2012 · External reference
Prostaglandin production in brain endothelial cells during the initiation of fever
10.1080/19420889.2023.2166237 · 2023 · External reference
Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2
10.1152/ajprenal.1998.275.6.f955 · 1998 · External reference
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
10.1038/nn1949 · 2007 · External reference
Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation
10.1152/ajpregu.00023.2012 · 2012 · External reference
EP3R-Expressing glutamatergic preoptic neurons mediate inflammatory fever
10.1523/jneurosci.2887-19.2020 · 2020 · External reference
Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system
10.1002/(sici)1096-9861(20000612)421:4<543::aid-cne6>3.0.co;2-3 · 2000 · External reference
Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse
10.1172/jci200113640 · 2001 · External reference
The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth
10.1038/36342 · 1997 · External reference
The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep
10.1016/j.bbi.2014.11.019 · 2015 · External reference
Prostaglandin E2 may induce hyperthermia through EP1 receptor in the anterior wall of the third ventricle and neighboring preoptic regions
10.1016/s0006-8993(97)00562-3 · 1997 · External reference
PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1beta-induced fever in rats
1998 · External reference
Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors
10.1113/jphysiol.2003.048140 · 2003 · External reference
Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats
10.1016/s0006-8993(03)02268-6 · 2003 · External reference
The EP3 and EP4 receptor subtypes both mediate the fever-producing effects of prostaglandin E2 in the rostral ventromedial preoptic area of the hypothalamus in rats
10.1016/j.neuroscience.2022.05.001 · 2022 · External reference
Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus
10.1523/jneurosci.23-13-05607.2003 · 2003 · External reference
Methodology of fever research: why are polyphasic fevers often thought to be biphasic?
1998 · External reference
Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature
10.1152/ajpregu.00370.2005 · 2005 · External reference
Generation of a conditional allele of the mouse prostaglandin EP4 receptor
10.1002/gene.20048 · 2004 · External reference
Prostaglandin production selectively in brain endothelial cells is both necessary and sufficient for eliciting fever
10.1073/pnas.2122562119 · 2022 · External reference
The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure
10.1172/jci6749 · 2001 · External reference
Prostaglandin E receptors
10.1074/jbc.r600038200 · 2007 · External reference
Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor
10.1172/jci6579 · 1999 · External reference
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
10.1038/12703 · 1999 · External reference
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
10.1038/26233 · 1998 · External reference