Research graph
References from Type I IFN coordinates resistance and tolerance against Zika virus disease by inducing NK cell recruitment and limiting neutrophil-driven neuropathology in the brain. Local targets link to admitted publications; unresolved targets remain external evidence.
Structure and function of the blood-brain barrier
10.1016/j.nbd.2009.07.030 · 2010 · External reference
Role of neutrophils in regulating vascular permeability in inflammatory and autoimmune diseases
10.1007/s00011-025-02157-7 · 2026 · External reference
Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA
10.4049/jimmunol.1200409 · 2012 · External reference
Immunomodulation by endothelial cells - partnering up with the immune system?
10.1038/s41577-022-00694-4 · 2022 · External reference
Type I interferon pathway in CNS homeostasis and neurological disorders
10.1002/glia.23154 · 2017 · External reference
Zika virus antagonizes type I interferon responses during infection of human dendritic cells
10.1371/journal.ppat.1006164 · 2017 · External reference
Zika Virus Infection in Pregnant Women in Rio de Janeiro
10.1056/nejmoa1602412 · 2016 · External reference
Guillain-Barré Syndrome, acute disseminated encephalomyelitis and encephalitis associated with zika virus infection in Brazil: detection of viral RNA and isolation of virus during late infection
10.4269/ajtmh.17-0106 · 2017 · External reference
Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study
10.1016/s1474-4422(20)30232-5 · 2020 · External reference
Comparison of the effect of peripheral nerve injury by crushing or transection on lumbar spinal cord synaptic plasticity and microglial dynamics
10.1016/j.ibneur.2021.05.002 · 2021 · External reference
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor
10.1084/jem.180.4.1395 · 1994 · External reference
Zika virus associated with meningoencephalitis
10.1056/nejmc1602964 · 2016 · External reference
Unresolved reference
2026 · External reference
Dynamics of neutrophilia at the neurovascular unit arising from repeated pulmonary inflammation
10.1186/s12974-026-03771-w · 2026 · External reference
Interleukin-6 as a multifunctional regulator: inflammation, immune response, and fibrosis
10.5301/jsrd.5000265 · 2017 · External reference
Development of standard methods for Zika virus propagation, titration, and purification
10.1016/j.jviromet.2017.04.011 · 2017 · External reference
Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease
10.7554/elife.73853 · 2022 · External reference
Neurologic complications associated with the zika virus in Brazilian adults
10.1001/jamaneurol.2017.1703 · 2017 · External reference
The influence of cytokines on the integrity of the blood-brain barrier in vitro
10.1016/0165-5728(95)00148-4 · 1996 · External reference
Measuring the strength of mice
2013 · External reference
Type I/II interferon balance in the regulation of brain physiology and pathology
10.1016/j.it.2016.01.006 · 2016 · External reference
Lifetime exposure to a low dose of RoundUp® glyphosatebased herbicide causes intestinal damage, intestinal dysbiosis and behavioral changes in mice
10.3390/ijms23105583 · 2022 · External reference
An in vivo blood-brain barrier permeability assay in mice using fluorescence-labeled markers
10.3791/57038 · 2018 · External reference
Zika virus. I. Isolations and serological specificity
10.1016/0035-9203(52)90042-4 · 1952 · External reference
Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury
10.1038/sj.jcbfm.9600229 · 2006 · External reference
Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice
10.1161/01.str.0000259709.16654.8f · 2007 · External reference
A susceptible mouse model for zika virus infection
10.1371/journal.pntd.0004658 · 2016 · External reference
A rhesus macaque model of Asian-lineage Zika virus infection
10.1038/ncomms12204 · 2016 · External reference
Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice
10.1002/brb3.915 · 2018 · External reference
TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection
10.15252/embr.201540473 · 2015 · External reference
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
10.1038/s41467-019-11866-7 · 2019 · External reference
Zika virus targets human STAT2 to inhibit type I interferon signaling
10.1016/j.chom.2016.05.009 · 2016 · External reference
Neutrophils and viral-induced neurologic disease
10.1016/j.clim.2016.05.009 · 2018 · External reference
Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation
10.1016/j.nbd.2006.02.006 · 2006 · External reference
Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia
10.3389/fimmu.2022.1035532 · 2022 · External reference
NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells
10.4049/jimmunol.0802806 · 2009 · External reference
Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice
10.1016/j.antiviral.2017.08.007 · 2017 · External reference
CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection
10.1371/journal.ppat.0020049 · 2006 · External reference
Zika virus neuropathogenesis: the different brain cells, host factors and mechanisms involved
10.3389/fimmu.2022.773191 · 2022 · External reference
Zika virus inhibits type-I interferon production and downstream signaling
10.15252/embr.201642627 · 2016 · External reference
Long-term outcome in neuroZika: when biological diagnosis matters
10.1212/wnl.0000000000007536 · 2019 · External reference
A mouse model of zika virus pathogenesis
10.1016/j.chom.2016.03.010 · 2016 · External reference
Viral infection of the central nervous system and neuroinflammation precede blood-brain barrier disruption during Japanese encephalitis virus infection
10.1128/jvi.00143-15 · 2015 · External reference
Neutrophilia with damage to the blood-brain barrier and neurovascular unit following acute lung injury
2023 · External reference
Distinct ZIKV strain signatures and type I IFN modulation reveal a protective role of brain endothelial interferon signaling in vitro and in vivo
2025 · External reference
Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection
10.1038/s41467-018-05519-4 · 2018 · External reference
Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide
10.1084/jem.20150712 · 2016 · External reference
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response
10.1186/s12974-022-02668-8 · 2022 · External reference
A sex-biased response of the adult brain to Zika virus infection: from down-regulation of neuronal IRF3 to enhanced pathology in adult female mice
10.1186/s12964-026-02719-0 · 2026 · External reference
Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo
10.4049/jimmunol.180.3.1592 · 2008 · External reference
Disease tolerance as a defense strategy
10.1126/science.1214935 · 2012 · External reference
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series
10.1371/journal.pntd.0006212 · 2018 · External reference
Congenital Zika virus infection: beyond neonatal microcephaly
10.1001/jamaneurol.2016.3720 · 2016 · External reference
Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning
10.1016/s0165-6147(99)01308-5 · 1999 · External reference
Initial description of the presumed congenital zika syndrome
10.2105/ajph.2016.303115 · 2016 · External reference
Zika virus associated with microcephaly
10.1056/nejmoa1600651 · 2016 · External reference
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
10.1038/nm.4200 · 2016 · External reference
Pathways exploited by flaviviruses to counteract the blood-brain barrier and invade the central nervous system
10.3389/fmicb.2019.00525 · 2019 · External reference
Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses
10.1371/journal.ppat.1009788 · 2021 · External reference
A new In vivo model to study protective immunity to zika virus infection in mice with intact type I interferon signaling
10.3389/fimmu.2018.00593 · 2018 · External reference
NK cells and interferons
10.1016/j.cytogfr.2014.11.003 · 2015 · External reference
Zika virus infects, activates, and crosses brain microvascular endothelial cells, without barrier disruption
10.3389/fmicb.2017.02557 · 2017 · External reference
Sex-specific effect of antenatal Zika virus infection on murine fetal growth, placental nutrient transporters, and nutrient sensor signaling pathways
10.1096/fj.202301951rr · 2024 · External reference
Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall
10.1161/circresaha.107.151860b · 2007 · External reference
Matrix metalloproteinases in neuroinflammation
10.1002/glia.10108 · 2002 · External reference
Blood-brain barrier permeability towards small and large tracers in a mouse model of osmotic demyelination syndrome
10.1016/j.neulet.2021.135665 · 2021 · External reference
The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
2022 · External reference
Decidual NK cells kill Zika virus-infected trophoblasts
10.1073/pnas.2115410118 · 2021 · External reference
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice
10.1371/journal.ppat.1001304 · 2011 · External reference
Type I interferon-mediated regulation of antiviral capabilities of neutrophils
10.3390/ijms22094726 · 2021 · External reference
Natural killer cell depletion in vivo (mouse)
2022 · External reference
A novel zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses
10.1371/journal.ppat.1006258 · 2017 · External reference
Reversal of west nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor
10.1016/j.virol.2009.10.036 · 2010 · External reference
Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo
10.4049/jimmunol.174.3.1213 · 2005 · External reference
IP-10 promotes blood-brain barrier damage by inducing tumor necrosis factor alpha production in Japanese encephalitis
10.3389/fimmu.2018.01148 · 2018 · External reference
Type I interferon therapy limits CNS autoimmunity by inhibiting CXCR3-Mediated trafficking of pathogenic effector T cells
10.1016/j.celrep.2019.06.021 · 2019 · External reference
Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin
10.1038/nm.3913 · 2015 · External reference
Interleukin-37 mediates the antitumor activity in hepatocellular carcinoma: role for CD57+ NK cells
10.1038/srep05177 · 2014 · External reference
