Research graph
References from TCF3 transcription factor isoforms E12 and E47 activate endogenous SCX while repressing pCMV-driven transgene expression. Local targets link to admitted publications; unresolved targets remain external evidence.
The human transcription factors
10.1016/j.cell.2018.09.045 · 2018 · External reference
Helix-loop-helix proteins and the advent of cellular diversity: 30 years of discovery
10.1101/gad.320663.118 · 2019 · External reference
Homodimeric and heterodimeric interactions among vertebrate basic helix-loop-helix transcription factors
10.3390/ijms222312855 · 2021 · External reference
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms
10.1128/mcb.20.2.429-440.2000 · 2000 · External reference
An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers
10.1016/0092-8674(91)90653-g · 1991 · External reference
Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
10.1084/jem.20090756 · 2009 · External reference
The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development
2017 · External reference
The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype
10.1186/s12915-016-0243-8 · 2016 · External reference
The transcription factor SCX is a potential serum biomarker of fibrotic diseases
10.3390/ijms21145012 · 2020 · External reference
Regulation of scleraxis function by interaction with the bHLH protein E47
10.1006/mcbr.2000.0195 · 2000 · External reference
Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription
10.1016/j.biocel.2009.10.003 · 2010 · External reference
Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts
10.1074/jbc.m610113200 · 2007 · External reference
The direct and individual transcriptional function of the human homodimeric and heterodimeric basic helix-loop-helix transcription factors E47 and scleraxis
10.1096/fj.202403318rr · 2025 · External reference
The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis
10.1016/j.yjmcc.2009.03.024 · 2009 · External reference
Regulation of fibronectin gene expression in cardiac fibroblasts by scleraxis
10.1007/s00441-016-2439-1 · 2016 · External reference
The role of scleraxis in fate determination of mesenchymal stem cells for tenocyte differentiation
2015 · External reference
Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins
10.1128/mcb.17.10.5888 · 1997 · External reference
E47 and Id1 interplay in epithelial-mesenchymal transition
10.1371/journal.pone.0059948 · 2013 · External reference
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
10.1016/s0092-8674(85)80025-8 · 1985 · External reference
Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells
10.1002/biot.202200062 · 2022 · External reference
Systematic comparison of constitutive promoters and the doxycycline-inducible promoter
10.1371/journal.pone.0010611 · 2010 · External reference
Altered expression pattern of immune response-related genes and isoforms in hypersensitivity pneumonitis lung fibroblasts
10.1038/s41598-024-74267-x · 2024 · External reference
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
10.1373/clinchem.2008.112797 · 2009 · External reference
The transcriptional effect of WT1 is modulated by choice of expression vector
10.1074/jbc.270.50.29976 · 1995 · External reference
Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication
10.1016/s0378-1119(00)00334-6 · 2000 · External reference
Influence of promoter potency on the transcriptional effects of YY1, SRF and Msx-1 in transient transfection analysis
10.1093/nar/26.13.3215 · 1998 · External reference
High guanine and cytosine content increases mRNA levels in mammalian cells
10.1371/journal.pbio.0040180 · 2006 · External reference
Comparative analysis of codon optimization tools: advancing toward a multi-criteria framework for synthetic gene design
10.4014/jmb.2411.11066 · 2025 · External reference
Codon usage is an important determinant of gene expression levels largely through its effects on transcription
10.1073/pnas.1606724113 · 2016 · External reference
Effects of codon usage on gene expression are promoter context dependent
10.1093/nar/gkaa1253 · 2021 · External reference
Interference in transcription of overexpressed genes by promoter-proximal downstream sequences
10.1038/srep30735 · 2016 · External reference
Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12
10.1002/prot.21638 · 2008 · External reference
MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state
10.1101/gad.1765109 · 2009 · External reference
Substitution of basic amino acids in the basic region stabilizes DNA binding by E12 homodimers
10.1093/nar/24.10.1921 · 1996 · External reference
Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells
10.1074/jbc.272.47.29880 · 1997 · External reference
Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator
10.1186/s11658-016-0025-x · 2016 · External reference
Synonymous codon usage affects the expression of wild type and F508del CFTR
10.1016/j.jmb.2015.02.003 · 2015 · External reference
Highly optimized DNA vaccine targeting human telomerase reverse transcriptase stimulates potent antitumor immunity
10.1158/2326-6066.cir-13-0001 · 2013 · External reference
Multiparameter RNA and codon optimization: a standardized tool to assess and enhance autologous mammalian gene expression
10.1371/annotation/039deb02-bbe7-406c-a876-341cc4f3fefa · 2011 · External reference
ENCODE: the human encyclopaedia
10.1038/489046a · 2012 · External reference
The scleraxis transcription factor directly regulates multiple distinct molecular and cellular processes during early tendon cell differentiation
2021 · External reference
Intrinsically disordered regions direct transcription factor in vivo binding specificity
10.1016/j.molcel.2020.05.032 · 2020 · External reference
Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells
10.1002/biot.202200062 · ExternalCitation · doi-reference
Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12
10.1002/prot.21638 · ExternalCitation · doi-reference
Regulation of scleraxis function by interaction with the bHLH protein E47
10.1006/mcbr.2000.0195 · ExternalCitation · doi-reference
Regulation of fibronectin gene expression in cardiac fibroblasts by scleraxis
10.1007/s00441-016-2439-1 · ExternalCitation · doi-reference
An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers
10.1016/0092-8674(91)90653-g · ExternalCitation · doi-reference
Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription
10.1016/j.biocel.2009.10.003 · ExternalCitation · doi-reference
The human transcription factors
10.1016/j.cell.2018.09.045 · ExternalCitation · doi-reference
Synonymous codon usage affects the expression of wild type and F508del CFTR
10.1016/j.jmb.2015.02.003 · ExternalCitation · doi-reference
Intrinsically disordered regions direct transcription factor in vivo binding specificity
10.1016/j.molcel.2020.05.032 · ExternalCitation · doi-reference
The basic helix-loop-helix transcription factor scleraxis regulates fibroblast collagen synthesis
10.1016/j.yjmcc.2009.03.024 · ExternalCitation · doi-reference
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
10.1016/s0092-8674(85)80025-8 · ExternalCitation · doi-reference
Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication
10.1016/s0378-1119(00)00334-6 · ExternalCitation · doi-reference
ENCODE: the human encyclopaedia
10.1038/489046a · ExternalCitation · doi-reference
Altered expression pattern of immune response-related genes and isoforms in hypersensitivity pneumonitis lung fibroblasts
10.1038/s41598-024-74267-x · ExternalCitation · doi-reference
Interference in transcription of overexpressed genes by promoter-proximal downstream sequences
10.1038/srep30735 · ExternalCitation · doi-reference
Codon usage is an important determinant of gene expression levels largely through its effects on transcription
10.1073/pnas.1606724113 · ExternalCitation · doi-reference
The transcriptional effect of WT1 is modulated by choice of expression vector
10.1074/jbc.270.50.29976 · ExternalCitation · doi-reference
Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells
10.1074/jbc.272.47.29880 · ExternalCitation · doi-reference
Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts
10.1074/jbc.m610113200 · ExternalCitation · doi-reference
Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
10.1084/jem.20090756 · ExternalCitation · doi-reference
Substitution of basic amino acids in the basic region stabilizes DNA binding by E12 homodimers
10.1093/nar/24.10.1921 · ExternalCitation · doi-reference
Influence of promoter potency on the transcriptional effects of YY1, SRF and Msx-1 in transient transfection analysis
10.1093/nar/26.13.3215 · ExternalCitation · doi-reference
Effects of codon usage on gene expression are promoter context dependent
10.1093/nar/gkaa1253 · ExternalCitation · doi-reference
The direct and individual transcriptional function of the human homodimeric and heterodimeric basic helix-loop-helix transcription factors E47 and scleraxis
10.1096/fj.202403318rr · ExternalCitation · doi-reference
MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state
10.1101/gad.1765109 · ExternalCitation · doi-reference
Helix-loop-helix proteins and the advent of cellular diversity: 30 years of discovery
10.1101/gad.320663.118 · ExternalCitation · doi-reference
Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins
10.1128/mcb.17.10.5888 · ExternalCitation · doi-reference
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms
10.1128/mcb.20.2.429-440.2000 · ExternalCitation · doi-reference
Highly optimized DNA vaccine targeting human telomerase reverse transcriptase stimulates potent antitumor immunity
10.1158/2326-6066.cir-13-0001 · ExternalCitation · doi-reference
Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator
10.1186/s11658-016-0025-x · ExternalCitation · doi-reference
The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype
10.1186/s12915-016-0243-8 · ExternalCitation · doi-reference
Multiparameter RNA and codon optimization: a standardized tool to assess and enhance autologous mammalian gene expression
10.1371/annotation/039deb02-bbe7-406c-a876-341cc4f3fefa · ExternalCitation · doi-reference
High guanine and cytosine content increases mRNA levels in mammalian cells
10.1371/journal.pbio.0040180 · ExternalCitation · doi-reference
Systematic comparison of constitutive promoters and the doxycycline-inducible promoter
10.1371/journal.pone.0010611 · ExternalCitation · doi-reference
E47 and Id1 interplay in epithelial-mesenchymal transition
10.1371/journal.pone.0059948 · ExternalCitation · doi-reference
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
10.1373/clinchem.2008.112797 · ExternalCitation · doi-reference
The transcription factor SCX is a potential serum biomarker of fibrotic diseases
10.3390/ijms21145012 · ExternalCitation · doi-reference
Homodimeric and heterodimeric interactions among vertebrate basic helix-loop-helix transcription factors
10.3390/ijms222312855 · ExternalCitation · doi-reference
Comparative analysis of codon optimization tools: advancing toward a multi-criteria framework for synthetic gene design
10.4014/jmb.2411.11066 · ExternalCitation · doi-reference
