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References from Mitophagy-related gene signatures predict prognosis and therapeutic response in hepatocellular carcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2021 · External reference
Epidemiology of hepatocellular carcinoma
10.1002/hep.31288 · 2021 · External reference
Emerging therapies for hepatocellular carcinoma (HCC)
10.3390/cancers14112798 · 2022 · External reference
Hepatocellular carcinoma: a narrative review on current knowledge and future prospects
10.1007/s11864-023-01098-9 · 2023 · External reference
10.1097/hep.0000000000001229
10.1097/hep.0000000000001229 · 2025 · External reference
Multi-omics spatial characteristics of CD8(+)TRM cells in hepatocellular carcinoma and immunotherapy response prediction
2025 · External reference
Integrative bioinformatics analysis for targeting hub genes in hepatocellular carcinoma treatment
10.2174/0113892029308243240709073945 · 2025 · External reference
Upregulation of miR-3130-5p enhances hepatocellular carcinoma growth by suppressing ferredoxin 1 : miR-3130-5p enhances HCC growth via inhibiting FDX1
2024 · External reference
Cardiovascular disease: mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation
10.1016/j.phrs.2024.107258 · 2024 · External reference
Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK
10.1016/j.phymed.2021.153884 · 2022 · External reference
Mitophagy
10.1042/bse0550093 · 2013 · External reference
Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction
10.1002/hep.29184 · 2017 · External reference
Mitochondria and cancer
10.1016/j.cell.2016.07.002 · 2016 · External reference
MEK5-ERK5 pathway mediates mitophagy by regulating Nur77 to promote tumorigenesis of osteosarcoma cells
10.1186/s40001-025-02312-0 · 2025 · External reference
Utilizing multi-omics analysis to elucidate the role of mitochondrial gene defects in Gastric cancer progression
10.1371/journal.pone.0325520 · 2025 · External reference
HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy
10.1038/s41418-019-0404-8 · 2020 · External reference
A multi-omics analysis of a mitophagy-related signature in pan-cancer
10.3390/ijms26020448 · 2025 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
Watch what you (Self-) eat: Autophagic mechanisms that modulate metabolism
10.1016/j.cmet.2019.03.003 · 2019 · External reference
NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria
10.1016/j.cell.2015.12.057 · 2016 · External reference
The role of mitochondrial dynamics and mitophagy in carcinogenesis, metastasis and therapy
10.3389/fcell.2020.00413 · 2020 · External reference
The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics
10.1016/j.semcancer.2019.07.015 · 2020 · External reference
Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6
10.1038/s41569-020-0431-7 · 2021 · External reference
PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage
10.1038/cdd.2013.19 · 2013 · External reference
Mitophagy: therapeutic potentials for liver disease and beyond
10.5487/tr.2014.30.4.243 · 2014 · External reference
Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention
10.4161/cbt.22958 · 2013 · External reference
Mitophagy: link to cancer development and therapy
10.1016/j.bbrc.2016.10.088 · 2017 · External reference
Parkin and mitophagy in cancer
10.1038/onc.2016.302 · 2017 · External reference
Inhibition of the PINK1-Parkin pathway enhances the lethality of sorafenib and regorafenib in hepatocellular carcinoma
2022 · External reference
Mechanism and regulation of mitophagy in liver diseases: a review
2025 · External reference
CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARalpha pathways
10.1016/j.jhep.2015.07.039 · 2015 · External reference
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma
10.1186/s13046-020-01647-2 · 2020 · External reference
Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy
10.1038/cddis.2017.251 · 2017 · External reference
CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway
10.1186/s12885-023-11724-2 · 2023 · External reference
CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway
10.1016/j.jhep.2014.04.035 · 2014 · External reference
CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma
10.1002/iub.11 · 2008 · External reference
Metabolic function and therapeutic potential of CD147 for hematological malignancies: an overview
10.3390/ijms25179178 · 2024 · External reference
Enhanced glucose metabolism mediated by CD147 contributes to immunosuppression in hepatocellular carcinoma
10.1007/s00262-019-02457-y · 2020 · External reference
Important functional roles of basigin in thymocyte development and T cell activation
10.7150/ijbs.6818 · 2013 · External reference
Basigin promotes cardiac fibrosis and failure in response to chronic pressure overload in mice
10.1161/atvbaha.115.306686 · 2016 · External reference
Serine related gene CCT6A promotes metastasis of hepatocellular carcinoma via interacting with RPS3
10.1007/s10142-024-01497-7 · 2024 · External reference
Overexpressing CCT6A contributes to cancer cell growth by affecting the G1-To-S phase transition and predicts A negative prognosis in hepatocellular carcinoma
10.2147/ott.s229231 · 2019 · External reference
CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis
10.1186/s12967-024-05284-7 · 2024 · External reference
Bibliometric and visualized analysis of mitophagy in liver cancer from 1998 to 2024
10.1007/s12672-025-03098-7 · 2025 · External reference
Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma
2025 · External reference
The roles of mutated SWI/SNF complexes in the initiation and development of hepatocellular carcinoma and its regulatory effect on the immune system: a review
10.1111/cpr.12791 · 2020 · External reference
Mitochondrial metabolic signatures in hepatocellular carcinoma
10.3390/cells10081901 · 2021 · External reference
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling
10.1186/s12964-017-0208-8 · 2017 · External reference
MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
10.1002/jcb.30449 · 2023 · External reference
Lnc-TPT1-AS1/CBP/ATIC axis mediated purine metabolism activation promotes breast cancer progression
10.1111/cas.70045 · 2025 · External reference
ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival
10.7150/ijbs.65669 · 2021 · External reference
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
10.1182/blood-2008-06-161018 · 2009 · External reference
The mTOR pathway is necessary for survival of mice with short telomeres
10.1038/s41467-020-14962-1 · 2020 · External reference
Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy
10.1080/15548627.2015.1017180 · 2015 · External reference
mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy
10.1038/s41419-019-1752-5 · 2019 · External reference
Activation of TLR4 induces severe acute pancreatitis-associated spleen injury via ROS-disrupted mitophagy pathway
10.1016/j.molimm.2021.12.012 · 2022 · External reference
