Research graph
References from Reanalysis of a published cryo-EM dataset reveals domain-level variability in the Hrd1-Hrd3 complex. Local targets link to admitted publications; unresolved targets remain external evidence.
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex
2020 · External reference
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum
2011 · External reference
Endoplasmic reticulum stress in diseases
10.1002/mco2.701 · 2024 · External reference
Navigating misfolded terrain: ER-associated degradation of membrane proteins
2026 · External reference
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis
2022 · External reference
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
2006 · External reference
Disulfide-crosslink analysis of the ubiquitin ligase Hrd1 complex during endoplasmic reticulum-associated protein degradation
10.1016/j.jbc.2022.102373 · 2022 · External reference
Mechanisms of substrate processing during ER-associated protein degradation
2023 · External reference
Mechanistic insights into ER-associated protein degradation
10.1016/j.ceb.2018.04.004 · 2018 · External reference
Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD
2016 · External reference
Direct and essential function for Hrd3 in ER-associated degradation
10.1073/pnas.1603079113 · 2016 · External reference
Key steps in ERAD of luminal ER proteins reconstituted with purified components
2014 · External reference
ER-associated degradation: protein quality control and beyond
2014 · External reference
Finding the will and the way of ERAD substrate retrotranslocation
10.1016/j.ceb.2012.05.010 · 2012 · External reference
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 · External reference
Roodmus: a toolkit for benchmarking heterogeneous electron cryo-microscopy reconstructions - PubMed
2024 · External reference
Methods for Cryo-EM single particle reconstruction of macromolecules having continuous heterogeneity
10.1016/j.jmb.2023.168020 · 2023 · External reference
EMPIAR: the electron microscopy public image archive
10.1093/nar/gkac1062 · 2023 · External reference
EMPIAR: a public archive for raw electron microscopy image data
2016 · External reference
Conformational heterogeneity and probability distributions from single-particle cryo-electron microscopy
10.1016/j.sbi.2023.102626 · 2023 · External reference
Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries
10.1371/journal.pbio.3003124 · 2025 · External reference
Cryo-EM structure of ALC1 in an open conformation bound to a PARylated nucleosome - PubMed
2026 · External reference
Signal enhancement for two-dimensional cryo-EM data processing - PubMed
2023 · External reference
Principles of cryo-EM single-particle image processing
2016 · External reference
Classification of helical polymers with deep-learning language models
10.1016/j.jsb.2023.108041 · 2023 · External reference
